Tag: 100-200

On December 31, 2000, Petronzelli, Fiorella; Riccio, Antonio; Markham, George D.; Seeholzer, Steven H.; Genuardi, Maurizio; Karbowski, Mariola; Yeung, Anthony T.; Matsumoto, Yoshihiro; Bellacosa, Alfonso published an article.Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain. And the article contained the following:

The human DNA repair protein MED1 (also known as MBD4) was isolated as an interactor of the mismatch repair protein MLH1 in a yeast two-hybrid screening. MED1 has a tripartite structure with an N-terminal 5-methylcytosine binding domain (MBD), a central region, and a C-terminal catalytic domain with homol. to bacterial DNA damage-specific glycosylases/lyases. Indeed, MED1 acts as a mismatch-specific DNA N-glycosylase active on thymine, uracil, and 5-fluorouracil paired with guanine. The glycosylase activity of MED1 preferentially targets G:T mismatches in the context of CpG sites; this indicates that MED1 is involved in the repair of deaminated 5-methylcytosine. Interestingly, frameshift mutations of the MED1 gene have been reported in human colorectal, endometrial, and pancreatic cancers. For its putative role in maintaining genomic fidelity at CpG sites, it is important to characterize the biochem. properties and the substrate spectrum of MED1. Here we show that MED1 works under a wide range of temperature and pH, and has a limited optimum range of ionic strength. MED1 has a weak glycosylase activity on the mutagenic adduct 3,N4-ethenocytosine, a metabolite of vinyl chloride and Et carbamate. The differences in glycosylase activity on G:U and G:T substrates are not related to differences in substrate binding and likely result from intrinsic differences in the chem. step. Finally, the isolated catalytic domain of MED1 retains the preference for G:T and G:U substrates in the context of methylated or unmethylated CpG sites. This suggests that the catalytic domain is fundamental, and the 5-methylcytosine binding domain dispensable, in determining the substrate spectrum of MED1. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to dna glycosylase med1 catalytic domain substrate specificity, mbd4 dna glycosylase catalytic domain substrate specificity, Enzymes: Structure-Conformation-Active Site and other aspects.Reference of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tang, Shengzhuang; Chen, Jesse; Cannon, Jayme; Cao, Zhengyi; Baker, James R. Jr; Wang, Su He published an article in 2021, the title of the article was Dendrimer-based posaconazole nanoplatform for antifungal therapy.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:

We examined formulating a new antifungal agent, posaconazole (POS) and its derivatives, with different mol. vehicles. Several combinations of drug and carrier mols. were synthesized, and their antifungal activities were evaluated against Aspergillus fumigatus. Posaconazole and four of its derivatives were conjugated to either generation 5 (G5) dendrimers or partially modified G5 dendrimers. The in vitro antifungal activities of these compounds suggest that conjugates with specific chem. linkages showed better fungistatic activity than direct conjugates to POS. In particular, a polyethylene glycol (PEG)-imidazole modified G5 dendrimer demonstrated improved antifungal efficacy relative to the parent G5 mol. Further studies were then conducted with POS derived mols. coupled to PEG-imidazole modified G5 dendrimers to achieve a highly soluble and active conjugate of POS. This conjugated macromol. averaged 23 POS mols. per G5 and had a high solubility with 50 mg/mL, which improved the molar solubility of POS from less than 0.03 mg/mL to as high as 16 mg/mL in water. The primary release profile of the drug in human plasma was extended to over 72 h, which is reflected in the in vitro inhibition of A. fumigatus growth of over 96 h. These POS-polymer conjugates appear to be novel and efficient antifungal agents. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to posaconazole nanoplatform dendrimer antifungal therapy, demethylase inhibitor, antifungal drug, biocompatible, polymer, Placeholder for records without volume info and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2022, Guan, Qian; Lin, Huiran; Miao, Lei; Guo, Huiqin; Chen, Yongping; Zhuo, Zhenjian; He, Jing published an article.Name: N-Methyl-7H-purin-6-amine The title of the article was Functions, mechanisms, and therapeutic implications of METTL14 in human cancer. And the article contained the following:

A review. RNA modification plays a crucial role in many biol. functions, and its abnormal regulation is associated with the progression of cancer. Among them, N6-methyladenine (m6A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m6A methylated transferase complex, which is involved in the dynamic reversible process of m6A modification. METTL14 acts as both an oncogene and tumor suppressor gene to regulate the occurrence and development of various cancers. The abnormal m6A level induced by METTL14 is related to tumorigenesis, proliferation, metastasis, and invasion. To date, the mol. mechanism of METTL14 in various malignant tumors has not been fully studied. In this paper, we systematically summarize the latest research progress on METTL14 as a new biomarker for cancer diagnosis and its biol. function in human tumors and discuss its potential clin. application. This study aims to provide new ideas for targeted therapy and improved prognoses in cancer. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Name: N-Methyl-7H-purin-6-amine

The Article related to review cancer mettl14 rna modification biomarkers, cancer, drug discovery, mettl14, rna modification, m6a, Placeholder for records without volume info and other aspects.Name: N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Geping; Lu, Dandan; Yin, Keyang; Godbert, Nicolas; Dong, Renhao; Li, Hongguang; Hao, Jingcheng published an article in 2022, the title of the article was Alkylated, naphthalimide-containing ionic compounds with rich thermotropic behaviour and nonlinear optical response.Recommanded Product: 5036-48-6 And the article contains the following content:

Chem. functionalization of �conjugated units plays a key role in fine tuning their supramol. organizations and functions. Herein, five 1,8-naphthalimide derivatives were prepared where the naphthalimide moiety was attached to the imidazolium ring through a Pr linker. On the other side, the imidazolium ring was modified with either a branched aliphatic chain of 2-ethyl-hexyl (C2C6, 1), 2-hexyl-decyl (C6C10, 2) and 2-decyl-tetradecyl (C10C14, 3), or a linear aliphatic chain of octyl (C8, 1� and hexadecyl (C16, 2�. Temperature-dependent structural evolution of these alkylated, naphthalimide-modified imidazolium bromides (abbreviated to a-NaphImiBrs hereafter) were investigated in detail by differential scanning calorimetry and small-angle X-ray scattering measurements as well as polarized optical microscopy observations. The compound with the shortest branched aliphatic chain (1) self-organized into a columnar oblique (Colo) phase at room temperature, which changed to a columnar rectangular (Colr) phase upon heating. In comparison, its counterpart with a linear aliphatic chain of the same carbon number (1� formed a crystal at room temperature, which shifted to a Colo phase at elevated temperature The compound with a medium branched aliphatic chain (2) showed a columnar hexagonal (Colh) organization at room temperature, which changed to a smectic (Sm) phase upon heating. Compounds with longer aliphatic chains (2� 3), regardless of whether branched or linear, only exhibit the Sm phase. Films of a-NaphImiBrs formed at room temperature were subjected to evaluations for their nonlinear optical (NLO) responses where reverse saturated absorption was observed in all the cases. It was found that 2 showed the best NLO response with a third order nonlinear absorption coefficient of up to 0.49 cm W-1. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6

The Article related to alkylated naphthalimide containing ionic compound rich thermotropic behavior, nonlinear optical response, Placeholder for records without volume info and other aspects.Recommanded Product: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 1, 1999, Barrett, Tracey E.; Scharer, Orlando D.; Savva, Renos; Brown, Tom; Jiricny, Josef; Verdine, Gregory L.; Pearl, Laurence H. published an article.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Crystal structure of a thwarted mismatch glycosylase DNA repair complex. And the article contained the following:

The bacterial mismatch-specific uracil-DNA glycosylase (MUG) and eukaryotic thymine-DNA glycosylase (TDG) enzymes form a homologous family of DNA glycosylases that initiate base-excision repair of G:U/T mismatches. Despite low sequence homol., the MUG/TDG enzymes are structurally related to the uracil-DNA glycosylase enzymes, but have a very different mechanism for substrate recognition. We have now determined the crystal structure of the Escherichia coli MUG enzyme complexed with an oligonucleotide containing a non-hydrolysable deoxyuridine analog mismatched with guanine, providing the first structure of an intact substrate-nucleotide productively bound to a hydrolytic DNA glycosylase. The structure of this complex explains the preference for G:U over G:T mispairs, and reveals an essentially non-specific pyrimidine-binding pocket that allows MUG/TDG enzymes to excise the alkylated base, 3,N4-ethenocytosine. Together with structures for the free enzyme and for an abasic-DNA product complex, the MUG-substrate analog complex reveals the conformational changes accompanying the catalytic cycle of substrate binding, base excision and product release. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to crystal structure uracil dna glycosylase complex, dna uracil glycosylase conformation repair mechanism, Enzymes: Structure-Conformation-Active Site and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 15, 2021, Welzen, Pascal L. W.; Martinez Ciriano, Sydney W.; Cao, Shoupeng; Mason, Alexander F.; Welzen-Pijpers, Imke A. B.; van Hest, Jan C. M. published an article.Category: imidazoles-derivatives The title of the article was Reversibly self-assembled pH-responsive PEG-p(CL-g-TMC) polymersomes. And the article contained the following:

Polymersomes have gained much interest within the biomedical field as drug delivery systems due to their ability to transport and protect cargo from the harsh environment inside the body. For an improved drug efficacy, control over cargo release is however also an important factor to take into account. An often employed method is to incorporate pH sensitive groups in the vesicle membrane, which induce disassembly and content release when the particles have reached a target site in the body with the appropriate pH, such as the acidic microenvironment of tumor tissue or the endosome. In this paper, biodegradable poly(ethylene glycol)-poly(caprolactone-gradient-trimethylene carbonate)-based polymeric vesicles have been developed with disassembly features at mild acidic conditions. Modifying the polymer backbone with imidazole moieties results in vesicle disassembly upon protonation due to the lowered pH. Furthermore, upon increasing the pH efficient re-assembly into vesicles is observed due to the switchable amphiphilic nature of the polymer. When this re-assembly process is conducted in presence of cargo, enhanced encapsulation is achieved. Furthermore, the potency of the polymeric system for future biomedical applications such as adjuvant delivery is demonstrated. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Category: imidazoles-derivatives

The Article related to polyethylene glycol polycaprolactone gradient trimethylene carbonate polymersome selfassembly, Placeholder for records without volume info and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Chaokun; Chen, Yanglin; Qu, Ye; Zhang, Jiaxu; Sun, Jianmin published an article in 2021, the title of the article was Phase-controllable polymerized ionic liquids for CO2 fixation into cyclic carbonates.Electric Literature of 5036-48-6 And the article contains the following content:

A catalyst with activity comparable with homogeneous catalysts and easy separation like heterogeneous catalysts would be attractive for CO2 cycloaddition Here, a series of polymerized bis-imidazolium based ionic liquids (PBIL-m) were synthesized and could act as homogeneous catalysts during the CO2 cycloaddition to epoxide process. They could be separated as heterogeneous catalysts after the cycloaddition reaction. PBIL-m was highly active for the cycloaddition reaction due to functional groups such as the imidazole ring, amino group and Br-. Specifically, the solid-liquid transition behavior endowed the PBIL-m with comparable activity to its homogeneous monomer catalysts (BIL-m). Among these PBIL-m catalysts, poly(1-vinyl imidazole-3-hexyl-1-imidazole-3-aminopropyl)dibromide (PBIL-3) exhibited superior catalytic performance due to the appropriate bridge chain compared with other PBIL-m. Under the conditions of 80 掳C, 1.0 MPa and 24 h, 99% propylene carbonate yield and 99% selectivity were obtained. The PBIL-3 also showed excellent universality and recyclability. A reasonable reaction mechanism was deduced that the imidazole ring, amino group and Br- promoted the cycloaddition reaction under metal-, solvent-, and cocatalyst-free conditions. Therefore, the polymerized bis-imidazolium based ionic liquid with solid-liquid transition behavior is a promising candidate for smooth catalysis of CO2 conversion and utilization. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to carbon dioxide phase controllable polymerized ionicliquid cyclic carbonate fixation, Placeholder for records without volume info and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 2021, He, Shiqian; Kong, Liang; Chen, Jing published an article.Quality Control of N-Methyl-7H-purin-6-amine The title of the article was iDNA6mA-Rice-DL: A local web server for identifying DNA N6-methyladenine sites in rice genome by deep learning method. And the article contained the following:

Accurate detection of N6-methyladenine (6mA) sites by biochem. experiments will help to reveal their biol. functions, still, these wet experiments are laborious and expensive. Therefore, it is necessary to introduce a powerful computational model to identify the 6mA sites on a genomic scale, especially for plant genomes. In view of this, we proposed a model called iDNA6mA-Rice-DL for the effective identification of 6mA sites in rice genome, which is an intelligent computing model based on deep learning method. Traditional machine learning methods assume the preparation of the features for anal. However, our proposed model automatically encodes and extracts key DNA features through an embedded layer and several groups of dense layers. We use an independent dataset to evaluate the generalization ability of our model. An area under the receiver operating characteristic curve (auROC) of 0.98 with an accuracy of 95.96% was obtained. The experiment results demonstrate that our model had good performance in predicting 6mA sites in the rice genome. A user-friendly local web server has been established. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Quality Control of N-Methyl-7H-purin-6-amine

The Article related to rice genome web server deep learning, 6ma, dna, docker, deep learning, web server, Placeholder for records without volume info and other aspects.Quality Control of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 22, 1999, Lutsenko, Eugene; Bhagwat, Ashok S. published an article.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was The role of the Escherichia coli Mug protein in the removal of uracil and 3,N4-ethenocytosine from DNA. And the article contained the following:

The human thymine-DNA glycosylase has a sequence homolog in Escherichia coli that is described to excise uracils from U路G mismatches (Gallinari, P., and Jiricny, J. (1996) Nature 383, 735-738) and is named mismatched uracil glycosylase (Mug). It has also been described to remove 3,N4-ethenocytosine (蔚C) from 蔚C路G mismatches (Saparbaev, M., and Laval, J. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 8508-8513). We used a mug mutant to clarify the role of this protein in DNA repair and mutation avoidance. We find that inactivation of mug has no effect on C to T or 5-methylcytosine to T mutations in E. coli and that this contrasts with the effect of ung defect on C to T mutations and of vsr defect on 5-methylcytosine to T mutations. Even under conditions where it is overproduced in cells, Mug has little effect on the frequency of C to T mutations. Because uracil-DNA glycosylase (Ung) and Vsr are known to repair U路G and T路G mismatches, resp., we conclude that Mug does not repair U路G or T路G mismatches in vivo. A defect in mug also has little effect on forward mutations, suggesting that Mug does not play a role in avoiding mutations due to endogenous damage to DNA in growing E. coli. Cell-free extracts from mug+ ung cells show very little ability to remove uracil from DNA, but can excise 蔚C. The latter activity is missing in extracts from mug cells, suggesting that Mug may be the only enzyme in E. coli that can remove this mutagenic adduct. Thus, the principal role of Mug in E. coli may be to help repair damage to DNA caused by exogenous chem. agents such as chloroacetaldehyde. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to escherichia dna repair mismatched uracil glycosylase mug protein ethenocytosine, General Biochemistry: Subcellular Processes and other aspects.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 15, 2021, Guo, Huijuan; Sun, Weiming; Zhang, Quanli; Wu, Yang; Wu, Di; Liu, Yinghua; Yu, Bo; Yu, Qiangliang; Cai, Meirong published an article.Reference of N-(3-Aminopropyl)-imidazole The title of the article was Imidazolium ionic liquid bearing urea moiety as a new corrosion inhibitor of mild steel. And the article contained the following:

The ureido substituted imidazolium bromides (code M-n) were synthesized and their anti-corrosion performance on A3 steel in 5 M HCl solution was studied by weight loss test, electrochem. impedance spectroscopy (EIS), potentiodynamic polarization. The exptl. results reveal that the inhibitor are efficient mixed type corrosion inhibitors, and their inhibition efficiencies increase with increasing the concentration and alkyl chain. Thermodn. parameters were calculated and discussed, indicating the adsorption of M-n on steel surface obeys the Langmuir adsorption isotherm and spontaneous exothermic process. SEM (SEM), XPS and quantum chem. calculation further confirm the existence of an effective protective film of M-n on A3 steel surface. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Reference of N-(3-Aminopropyl)-imidazole

The Article related to imidazolium ionic liquid bearing corrosion inhibitor density functional theory, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem