Tag: 100-200

Pinyakit, Yuwaporn; Palaga, Tanapat; Kiatkamjornwong, Suda; Hoven, Voravee P. published an article in 2020, the title of the article was Sequential post-polymerization modification of a pentafluorophenyl ester-containing homopolymer: a convenient route to effective pH-responsive nanocarriers for anticancer drugs.Recommanded Product: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Recently, pH-responsive polymeric micelles have gained significant attention as effective carriers for anti-cancer drug delivery. Herein, pH-responsive polymeric micelles were constructed by a simple post-polymerization modification of a single homopolymer, poly(pentafluorophenyl acrylate) (PPFPA). The PPFPA was first subjected to modification with 1-amino-2-propanol yielding the amphiphilic copolymer of poly(pentafluorophenyl acrylate)-ran-poly(N-(2-hydroxypropyl acrylamide)). A series of amphiphilic random copolymers of different compositions could self-assemble into spherical micelles with a unimodal size distribution in aqueous solution Then, 1-(3-aminopropyl)imidazole (API), a reagent to introduce charge conversional entities, was reacted with the remaining PPFPA segment in the micellar core resulting in API-modified micelles which can encapsulate doxorubicin (DOX), a hydrophobic anti-cancer drug. As monitored by dynamic light scattering, the API-modified micelles underwent disintegration upon pH switching from 7.4 to 5.0, presumably due to imidazolyl group protonation. This pH-responsiveness of the API-modified micelles was responsible for the faster and greater in vitro DOX release in an acidic environment than neutral pH. Cellular uptake studies revealed that the developed carriers were internalized into MDA-MB-231 cells within 30 min via endocytosis and exhibited cytotoxicity in a dose-dependent manner. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to pentafluorophenyl ester ph responsive nanocarrier anticancer drug, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 4, 2021, Tanaka, Yuta; Tanaka, Yuta; Kikuchi, Fumiaki; Yamamoto, Takeshi; Nakamura, Minoru; Takami, Kazuaki; Murakami, Masataka; Daini, Masaki; Wada, Yasufumi; Kakegawa, Keiko; Kasahara, Takahito; Ohashi, Tomohiro; Wang, Junsi; Ikeda, Zenichi; Puenner, Florian; Seto, Masaki; Mikami, Satoshi; Sasaki, Minoru published a patent.Related Products of 50743-01-6 The title of the patent was Heterocyclic compound for Gaucher disease. And the patent contained the following:

Provided is a compound which has a glucosylceramide synthase-inhibiting activity and is expected to be useful as a prophylactic or therapeutic agent for a lysosomal storage disease (e.g., Gaucher disease, Fabry disease, GM1-gangliosidosis, GM2 activation factor deficiency disease, Tay-Sachs disease, Sandhoff disease), a neurodegenerative disease (e.g., Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy) and the like. The present invention relates to a compound represented by formula (I); or a salt thereof. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Related Products of 50743-01-6

The Article related to glucosylceramide synthase heterocyclic compound gaucher disease, Pharmaceuticals: Formulation and Compounding and other aspects.Related Products of 50743-01-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 1, 2012, Tudek, Barbara; Speina, Elzbieta published an article.Formula: C6H5N3O The title of the article was Oxidatively damaged DNA and its repair in colon carcinogenesis. And the article contained the following:

A review. Inflammation, high fat, high red meat and low fiber consumption have for long been known as the most important etiol. factors of sporadic colorectal cancers (CRC). Colon cancer originates from neoplastic transformation in a single layer of epithelial cells occupying colonic crypts, in which migration and apoptosis program becomes disrupted. This results in the formation of polyps and metastatic cancers. Mutational program in sporadic cancers involves APC gene, in which mutations occur most abundantly in the early phase of the process. This is followed by mutations in RAS, TP53, and other genes. Progression of carcinogenic process in the colon is accompanied by augmentation of the oxidative stress, which manifests in the increased level of oxidatively damaged DNA both in the colon epithelium, and in blood leukocytes and urine, already at the earliest stages of disease development. Defense mechanisms are deregulated in CRC patients: (i) antioxidative vitamins level in blood plasma declines with the development of disease; (ii) mRNA level of base excision repair enzymes in blood leukocytes of CRC patients is significantly increased; however, excision rate is regulated sep., being increased for 8-oxoGua, while decreased for lipid peroxidation derived ethenoadducts, 蔚Ade and 蔚Cyt; (iii) excision rate of 蔚Ade and 蔚Cyt in colon tumors is significantly increased in comparison to asymptomatic colon margin, and ethenoadducts level is decreased. This review highlights mechanisms underlying such deregulation, which is the driving force to colon carcinogenesis. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Formula: C6H5N3O

The Article related to review colon rectum cancer oxidative stress dna repair, Mammalian Pathological Biochemistry: Reviews and other aspects.Formula: C6H5N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tudek, Barbara; Winczura, Alicja; Janik, Justyna; Siomek, Agnieszka; Foksinski, Marek; Olinski, Ryszard published an article in 2010, the title of the article was Involvement of oxidatively damaged DNA and repair in cancer development and aging.Category: imidazoles-derivatives And the article contains the following content:

A review. DNA damage and DNA repair may mediate several cellular processes, like replication and transcription, mutagenesis and apoptosis and thus may be important factors in the development and pathol. of an organism, including cancer. DNA is constantly damaged by reactive oxygen species (ROS) and reactive nitrogen species (RNS) directly and also by products of lipid peroxidation (LPO), which form exocyclic adducts to DNA bases. A wide variety of oxidatively-generated DNA lesions are present in living cells. 8-Oxoguanine (8-oxoGua) is one of the best known DNA lesions due to its mutagenic properties. Among LPO-derived DNA base modifications the most intensively studied are ethenoadenine and ethenocytosine, highly miscoding DNA lesions considered as markers of oxidative stress and promutagenic DNA damage. Although at present it is impossible to directly answer the question concerning involvement of oxidatively damaged DNA in cancer etiol., it is likely that oxidatively modified DNA bases may serve as a source of mutations that initiate carcinogenesis and are involved in aging (i.e. they may be causal factors responsible for these processes). To counteract the deleterious effect of oxidatively damaged DNA, all organisms have developed several DNA repair mechanisms. The efficiency of oxidatively damaged DNA repair was frequently found to be decreased in cancer patients. The present work reviews the basis for the biol. significance of DNA damage, particularly effects of 8-oxoGua and ethenoadduct occurrence in DNA in the aspect of cancer development, drawing attention to the multiplicity of proteins with repair activities. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Category: imidazoles-derivatives

The Article related to review oxidative stress dna damage repair cancer aging, Mammalian Pathological Biochemistry: Reviews and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 2020, Feng, Jingxian; Xu, Minjun; Wang, Jiahao; Zhou, Songlei; Liu, Yipu; Liu, Shanshan; Huang, Yukun; Chen, Yu; Chen, Liang; Song, Qingxiang; Gong, Jingru; Lu, Huiping; Gao, Xiaoling; Chen, Jun published an article.Product Details of 5036-48-6 The title of the article was Sequential delivery of nanoformulated ä¼?mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer. And the article contained the following:

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease exhibiting the poorest prognosis among solid tumors. The efficacy of conventional therapies has been hindered largely due to the insufficient chemotherapeutic delivery to the dense desmoplastic tumor stroma, and the extremely high or toxic dose needed for chemotherapy. Traditional Chinese Medicine (TCM) contains effective components that can effectively regulate tumor microenvironment and kill tumor cells, providing promising alternatives to PDAC chemotherapy. In this study, two active drug monomers of TCM were screened out and a sequentially targeting delivery regimen was developed to realize the optimized combinational therapy. Transforming growth factor-å°?(TGF-å°? plays an indispensable role in promoting cancer-associated fibroblasts (CAFs) activation and proliferation, and CAFs have caused major phys. barriers for chemotherapeutic drug delivery. Herein, CAFs-targeting biodegradable polymer nanoparticle (CRE-NP(ä¼?M)) coated with CREKA peptide and loaded with TCM ä¼?mangostin (ä¼?M) was developed to modulate tumor microenvironment by interfering of TGF-å°?Smad signaling pathway. Low pH-triggered micelle modified with CRPPR peptide and loaded with another TCM triptolide was constructed to increase the therapeutic effect of triptolide at the tumor sites and reduced its damage to main organs. As expected, CRE-NP(ä¼?M) effectively inactived CAFs, reduced extracellular matrix production, promoted tumor vascular normalization and enhanced blood perfusion at the tumor site. The sequentially targeting drug delivery regimen, CRP-MC(Trip) following CRE-NP(ä¼?M) pretreatment, exhibited strong tumor growth inhibition effect in the orthotopic tumor model. Hence, sequentially targeting delivery of nanoformulated TCM offers an efficient approach to overcome the permeation obstacles and improve the effect of chemotherapy on PDAC, and provides a novel option to treat desmoplastic tumors. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to mangostin triptolide pancreatic cancer drug nanoformulation, acid-triggered micelles, pancreatic cancer, tgf-å°? traditional chinese medicine, triptolide, ä¼?mangostin, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Venkata Mallavadhani, Uppuluri; Vanga, Nagi Reddy; Balabhaskara Rao, Kancharana; Jain, Nishanth published an article in 2020, the title of the article was Synthesis and antiproliferative activity of novel (+)- usnic acid analogues.Name: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Twenty one novel (+)- usnic acid-based analogs belonging to three classes such as enamines, imines, and pyrazoles were synthesized. All the synthesized compounds were characterized by their spectral data (1H NMR, 13C NMR, IR, and HRMS). The synthesized compounds were evaluated for their antiproliferative activity against a panel of four human cancer cell lines including HeLa (cervix), MDA-MB-231 (breast), A549 (lung), and MiaPaca (pancreas) by employing SRB cell proliferation assay. Screening results indicated that all synthesized compounds showed enhanced activity than the parent compound Most significantly, compounds and showed potent antiproliferative activity against all the cancer cell lines tested. Compounds and arrested the cell cycle in G2/M phase and induced apoptosis in HeLa cells. In view of significant antiproevaliferative activity, compounds and can be considered as lead mols. for further development. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to cervical lung breast pancreatic cancer antiproliferative usnic acid, (+)- usnic acid, antiproliferative activity, apoptosis, cell cycle arrest, enamine, pyrazole, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 5, 2021, Qiu, Xiang; Wang, Shushu; Miao, Shanshan; Suo, Hongbo; Xu, Huajin; Hu, Yi published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Co-immobilization of laccase and ABTS onto amino-functionalized ionic liquid-modified magnetic chitosan nanoparticles for pollutants removal. And the article contained the following:

This work aims to achieve the co-immobilization of laccase and 2,2-binamine-di-3-ethylbenzothiazolin-6-sulfonic acid (ABTS) to improve removal capability of the biocatalyst for pollutants while avoiding potential pollution caused by ABTS. The laccase was immobilized on magnetic chitosan nanoparticles modified with amino-functionalized ionic liquid containing ABTS (MACS-NIL) based on Cu ion chelation (MACS-NIL-Cu-lac). The carrier was characterized by Fourier transform IR spectroscopy, thermogravimetric anal., x-ray diffraction and etc., and ESR confirmed the mediator mol. ABTS on the carrier could also play the role of electron transmission. MACS-NIL-Cu-lac presented relatively high immobilization capacity, enhanced activity (1.7-fold that of free laccase), improved pH and temperature adaptability, and increased thermal and storage stability. The removal performance assay found that MACS-NIL-Cu-lac had a good removal efficiency with 100.0 % for 2,4-dichlorophenol in water at 25 掳C, even when the concentration reached 50 mg/L. Reusability study showed that after six catalytic runs, the removal efficiency of 2,4-dichlorophenol by MACS-NIL-Cu-lac could still reach 93.2 %. Addnl., MACS-NIL-Cu-lac exhibited higher catalytic efficiencies with 100.0 %, 70.5 % and 93.3 % for bisphenol A, indole, and anthracene, resp. The high catalytic performance in pure water system obtained by the novel biocatalyst co-immobilizing laccase and electron mediator ABTS showed greater practical application value. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to laccase abts immobilization magnetic chitosan nanoparticle pollutant removal, abts, ionic liquid, laccase, magnetic chitosan nanoparticles, pollutants removal, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Yin; Gu, Jie; Xu, Fengkai; Zhu, Qiaoliang; Chen, Yiwei; Ge, Di; Lu, Chunlai published an article in 2021, the title of the article was Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma.Recommanded Product: N-Methyl-7H-purin-6-amine And the article contains the following content:

N6-methyladenosine (m6A) modification can regulate a variety of biol. processes. However, the implications of m6A modification in lung adenocarcinoma (LUAD) remain largely unknown. Here, we systematically evaluated the m6A modification features in more than 2400 LUAD samples by analyzing the multi-omics features of 23 m6A regulators.We depicted the genetic variation features of m6A regulators, and found mutations of FTO and YTHDF3 were linked to worse overall survival. Many m6A regulators were aberrantly expressed in tumors, among which FTO, IGF2BP3, YTHDF1 and RBM15 showed consistent alteration features across 11 independent cohorts. Besides, the regulator-pathway interaction network demonstrated that m6A modification was associated with various biol. pathways, including immune-related pathways. The correlation between m6A regulators and tumor microenvironment was also assessed.We found that LRPPRC was neg. correlated with most tumor-infiltrating immune cells. On the other hand, we established a scoring tool named m6Sig, which was pos. correlated with PD-L1 expression and could ref lect both the tumor microenvironment characterization and prognosis of LUAD patients. Comparison of CNV between high and low m6Sig groups revealed differences on chromosome 7. Application of m6Sig on an anti-PD-L1 immunotherapy cohort confirmed that the high m6Sig group demonstrated therapeutic advantages and clin. benefits. Our study indicated that m6A modification is involved in many aspects of LUAD and contributes to tumor microenvironment formation. A better understanding of m6A modification will provide more insights into the mol. mechanisms of LUAD and facilitate developing more effective personalized treatment strategies. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Recommanded Product: N-Methyl-7H-purin-6-amine

The Article related to lung adenocarcinoma tumor microenvironment biol function, pd-l1 immunotherapy, lung adenocarcinoma, m6a, prognosis, tumor microenvironment, web application, Placeholder for records without volume info and other aspects.Recommanded Product: N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2021, Nguyen, Trinh Trung Duong; Trinh, Van Ngu; Le, Nguyen Quoc Khanh; Ou, Yu-Yen published an article.Application of 443-72-1 The title of the article was Using k-mer embeddings learned from a Skip-gram based neural network for building a cross-species DNA N6-methyladenine site prediction model. And the article contained the following:

Key message: This study used k-mer embeddings as effective feature to identify DNA N6-Methyladenine sites in plant genomes and obtained improved performance without substantial effort in feature extraction, combination and selection. Identification of DNA N6-methyladenine sites has been a very active topic of computational biol. due to the unavailability of suitable methods to identify them accurately, especially in plants. Substantial results were obtained with a great effort put in extracting, heuristic searching, or fusing a diverse types of features, not to mention a feature selection step. In this study, we regarded DNA sequences as textual information and employed natural language processing techniques to decipher hidden biol. meanings from those sequences. In other words, we considered DNA, the human life book, as a book corpus for training DNA language models. K-mer embeddings then were generated from these language models to be used in machine learning prediction models. Skip-gram neural networks were the base of the language models and ensemble tree-based algorithms were the machine learning algorithms for prediction models. We trained the prediction model on Rosaceae genome dataset and performed a comprehensive test on 3 plant genome datasets. Our proposed method shows promising performance with AUC performance approaching an ideal value on Rosaceae dataset (0.99), a high score on Rice dataset (0.95) and improved performance on Rice dataset while enjoying an elegant, yet efficient feature extraction process. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application of 443-72-1

The Article related to neural network dna n6 methyladenine, dna n6-methyladenine site prediction, ensemble tree-based algorithms, natural language processing, k-mer embeddings, Placeholder for records without volume info and other aspects.Application of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 3, 2021, Zeng, Juan; Zhang, Heying; Tan, Yonggang; Wang, Zhe; Li, Yunwei; Yang, Xianghong published an article.Synthetic Route of 443-72-1 The title of the article was m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling. And the article contained the following:

Pancreatic cancer is the deadliest malignancy of the digestive system and is the seventh most common cause of cancer-related deaths worldwide. The incidence and mortality of pancreatic cancer continue to increase, and its 5-yr survival rate remains the lowest among all cancers. N6-methyladenine (m6A) is the most abundant reversible RNA modification in various eukaryotic messenger and long noncoding RNAs and plays crucial roles in the occurrence and development of cancers. However, the role of m6A in pancreatic cancer remains unclear. The present study aimed to explore the role of m6A and its regulators in pancreatic cancer and assess its underlying mol. mechanism associated with pancreatic cancer cell proliferation, invasion, and metastasis. Reduced expression of the m6A demethylase, fat mass and obesity-associated protein (FTO), was responsible for the high levels of m6A RNA modification in pancreatic cancer. Moreover, FTO demethylated the m6A modification of praja ring finger ubiquitin ligase 2 (PJA2), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, invasion, and metastasis of pancreatic cancer cells. Altogether, this study describes new, potential mol. therapeutic targets for pancreatic cancer that could pave the way to improve patient outcome. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Synthetic Route of 443-72-1

The Article related to m6a demethylase fto pancreatic cancer pja2 tumorigenesis wnt signaling, n6-methyladenine, pja2, wnt signaling, m6a demethylase fto, pancreatic cancer, Placeholder for records without volume info and other aspects.Synthetic Route of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem