Tag: 100-200

On November 30, 2021, Liu, Zhifeng; Chen, Yonghan; Wang, Leilei; Ji, Suzhen published an article.Related Products of 443-72-1 The title of the article was ALKBH5 Promotes the Proliferation of Glioma Cells via Enhancing the mRNA Stability of G6PD. And the article contained the following:

To investigate the biol. role of 6-methyladenine (m6A) methylation in inducing the carcinogenesis of glioma and its proliferation. Relative levels of ALKBH5 and glucose-6-phosphate dehydrogenase (G6PD) in glioma tissues and cell lines were determined by quant real-time polymerase chain reaction (qRT-PCR) and Western blot. Gain-of-function and loss-of-function approaches were used to investigate the role of ALKBH5 in mediating proliferation and energy metabolism of glioma cells. The regulatory effect of ALKBH5 on G6PD was analyzed using m6A-qRT-PCR. Our showed that ALKBH5 was upregulated in glioma, which stimulated glioma cells to proliferate. Serving as a m6A eraser, ALKBH5 demethylated the target transcript G6PD and enhanced its mRNA stability, thereby promoting G6PD translation and activating the pentose phosphate pathway (PPP). Collectively, ALKBH5 stimulates glioma cells to proliferate through erasing the m6A methylation of G6PD, which can be utilized as a potential therapeutic target for glioma. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Related Products of 443-72-1

The Article related to alkbh5 g6pd glioma, alkbh5, g6pd, glioma, m6a modification, Mammalian Pathological Biochemistry: Oncology and other aspects.Related Products of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 30, 2003, Barbin, Alain; Ohgaki, Hiroko; Nakamura, Jun; Kurrer, Michael; Kleihues, Paul; Swenberg, James A. published an article.Recommanded Product: 55662-66-3 The title of the article was Endogenous deoxyribonucleic acid (DNA) damage in human tissues: A comparison of ethenobases with aldehydic DNA lesions. And the article contained the following:

Two types of endogenous DNA lesions, ethenobases [1,N6-ethenoadenine (蔚A), 3,N4-ethenocytosine (蔚C)] and aldehydic DNA lesions (ADLs), were measured in several tissues (liver, lung, kidney, colon, colon mucosa, cerebellum, and gray and white matter of the cerebrum) obtained postmortem during autopsy examinations of 12 individuals (6 males, 6 females; ages, 58-87 yr). Issues relating to changes in levels of DNA damage with disease and after death were addressed. The extent of DNA damage in autopsy samples was not associated with the length of the postmortem interval and was similar to levels observed in surgery samples, suggesting that endogenous, steady-state levels of etheno adducts and of ADLs are relatively stable during the hours immediately after death. In this limited series of samples, and with a few possible exceptions, the disease status before death was not associated with increased endogenous DNA damage in the affected tissue. DNA ethenobases were lowest in the cerebellum (median molar ratios: 蔚A/A = 1.0 x 10-8; 蔚C/C = 1.9 x 10-8) and highest in the gray matter (蔚A/A = 2.9 x 10-8; 蔚C/C = 4.8 x 10-8) and white matter (蔚A/A = 2.4 x 10-8; 蔚C/C = 5.2 x 10-8) of the cerebrum. In other tissues, median values were 1.2-1.9 x 10-8 for 蔚A/A and 2.0-3.3 x 10-8 for 蔚C/C. There was a good correlation between the levels of 蔚A and 蔚C (r = 0.80, P < 0.0001). Levels of ADLs were similar in the liver, lung, kidney, and white matter of the cerebrum (median values: 5.7-7.9 ADLs/106 nucleotides), higher in the colon (11.3 x 10-6) and gray matter of the cerebrum (9.0 x 10-6) and lower in the cerebellum (3.7 x 10-6). There was no correlation between levels of ethenobases and amounts of ADLs (蔚A vs. ADLs: r = 0.12, P = 0.33; 蔚C vs. ADLs: r = 0.024, P = 0.85). Although there was an interindividual variability in the extent of endogenous DNA damage (4-fold for 蔚A and 蔚C, 2-fold for ADLs), which may be determined, in part, by the capacity to repair DNA and may be related to the pathol. or treatment of the patients, these results suggest that the cerebrum contains higher endogenous DNA damage than the other tissues. These data are in line with previous studies showing that brain tissues are more susceptible to oxidative stress and lipid peroxidation than other tissues. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Recommanded Product: 55662-66-3

The Article related to dna damage aldehydic lesion ethenobase disease cancer, Mammalian Pathological Biochemistry: Oncology and other aspects.Recommanded Product: 55662-66-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2022, Xi, Lei; Yang, Ying; Xu, Ying; Zhang, Fangming; Li, Jinghui; Liu, Xiyang; Zhang, Zhenxi; Du, Quan published an article.Application of 443-72-1 The title of the article was The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells. And the article contained the following:

In contrast to the well-established genomic 5-methylcytosine (5mC), the existence of N6-methyladenine (6 mA) in eukaryotic genomes was discovered only recently. Initial studies found that it was actively regulated in cancer cells, suggesting its involvement in the process of carcinogenesis. However, the contribution of 6 mA in tongue squamous cell carcinoma (TSCC) still remains uncharacterized. In this study, a pan-cancer type anal. was first performed, which revealed enhanced 6 mA metabolism in diverse cancer types. The study was then focused on the regulation of 6 mA metabolism, as well as its effects on TSCC cells. To these aspects, genome 6 mA level was found greatly increased in TSCC tissues and cultured cells. By knocking down 6 mA methylases N6AMT1 and METTL4, the level of genomic 6 mA was decreased in TSCC cells. This led to suppressed colony formation and cell migration. By contrast, knockdown of 6 mA demethylase ALKBH1 resulted in an increased 6 mA level, enhanced colony formation, and cell migration. Further study suggested that regulation of the NF-魏B pathway might contribute to the enhanced migration of TSCC cells. Therefore, in the case of TSCC, we have shown that genomic 6 mA modification is involved in the proliferation and migration of cancer cells. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application of 443-72-1

The Article related to n6methyladenine tongue squamous cell carcinoma, Mammalian Pathological Biochemistry: Oncology and other aspects.Application of 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 28, 2020, Rizzo, Carla; Cancemi, Patrizia; Mattiello, Leonardo; Marullo, Salvatore; D’Anna, Francesca published an article.HPLC of Formula: 5036-48-6 The title of the article was Naphthalimide Imidazolium-Based Supramolecular Hydrogels as Bioimaging and Theranostic Soft Materials. And the article contained the following:

1,8-Naphthalimide-based imidazolium salts differing for the alkyl chain length and the nature of the anion were synthesized and characterized to obtain fluorescent probes for bioimaging applications. First, their self-assembly behavior and gelling ability were investigated in water and water/dimethyl sulfoxide binary mixtures Only salts having longer alkyl chains were able to give supramol. hydrogels, whose properties were investigated by using a combined approach of fluorescence, resonance light scattering, and rheol. measurements. Morphol. information was obtained by SEM. In addition, conductive properties of organic salts in solution and gel state were analyzed. Imidazolium salts were successfully tested for their possible application as bioimaging and cytotoxic agents toward three cancer cell lines and a nontumoral epithelial cell line. Characterization of their behavior was performed by MTT and cell-based assays. Finally, the biol. activity of hydrogels was also investigated. Collectively, our findings showed that naphthalimide-based imidazolium salts are promising theranostic agents and they were able to preserve their biol. properties also in the gel phase. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).HPLC of Formula: 5036-48-6

The Article related to naphthalimide imidazolium pharmaceutical hydrogel bioimaging fluorescent probe, bioimaging, fluorescence, imidazolium salts, naphthalimide, supramolecular hydrogels, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2020, Zhong, Hui; Tang, Hui-Fang; Kai, Yin published an article.SDS of cas: 443-72-1 The title of the article was N6-methyladenine RNA Modification (m6A): An Emerging Regulator of Metabolic Diseases. And the article contained the following:

A review. N6-methyladenine RNA modification (m6A) is an RNA methylation modification catalyzed by methyltransferase at the 6th position nitrogen atom of adenine (A), which is the most common chem. modification of eukaryotic mRNA (mRNA). Recently, m6A has been found to play an important role in the dynamic regulation of RNA, which is crucial for some physiol. and pathophysiol. processes such as adipogenesis, cell differentiation, and the immune/inflammatory response. Metabolic diseases are a series of chronic inflammatory disorders caused by metabolic dysfunction of proteins, glucose, and lipids. Emerging studies have shown that m6A plays an important role in the process of metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) via regulation of glucose/lipid metabolism and the immune/inflammatory response. In this review, we will summarize the role of m6A in metabolic diseases, which may provide new ideas for the prevention and treatment of metabolic diseases. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).SDS of cas: 443-72-1

The Article related to review methyladenine rna modification metabolic disease, n6-adenine methylation, cardiovascular diseases, metabolic diseases, obesity, type 2 diabetes mellitus, Mammalian Pathological Biochemistry: Reviews and other aspects.SDS of cas: 443-72-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bera, Amit; Lewis, Stephen M. published an article in 2020, the title of the article was Regulation of epithelial-to-mesenchymal transition by alternative translation initiation mechanisms and its implications for cancer metastasis.Safety of N-Methyl-7H-purin-6-amine And the article contains the following content:

A review. Translation initiation plays a critical role in the regulation of gene expression for development and disease conditions. During the processes of development and disease, cells select specific mRNAs to be translated by controlling the use of diverse translation initiation mechanisms. Cells often switch translation initiation from a cap-dependent to a cap-independent mechanism during epithelial-to-mesenchymal transition (EMT), a process that plays an important role in both development and disease. EMT is involved in tumor metastasis because it leads to cancer cell migration and invasion, and is also associated with chemoresistance. In this review we will provide an overview of both the internal ribosome entry site (IRES)-dependent and N6-methyladenosine (m6A)-mediated translation initiation mechanisms and discuss how cap-independent translation enables cells from primary epithelial tumors to achieve a motile mesenchymal-like phenotype, which in turn drives tumor metastasis. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Safety of N-Methyl-7H-purin-6-amine

The Article related to review epithelial mesenchymal cancer metastasis, ires, itaf, cancer, epithelial-to-mesenchymal transition (emt), m6a-mediated translation, metastasis, Mammalian Pathological Biochemistry: Reviews and other aspects.Safety of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2021, Hu, Yibo; Zhao, Xiaohui published an article.Application In Synthesis of N-Methyl-7H-purin-6-amine The title of the article was Role of m6A in osteoporosis, arthritis and osteosarcoma (Review). And the article contained the following:

A review. RNA modification is a type of post-transcriptional modification that regulates important cellular pathways, such as the processing and metabolism of RNA. The most abundant form of methylation modification is RNA N6-methyladenine (m6A), which plays various post-transcriptional regulatory roles in cellular biol. functions, including cell differentiation, embryonic development and disease occurrence. Bones play a pivotal role in the skeletal system as they support and protect muscles and other organs, facilitate movement and ensure haematopoiesis. The development and remodelling of bones require a delicate and accurate regulation of gene expression by epigenetic mechanisms that involve modifications of histone, DNA and RNA. The present review discusses the enzymes and proteins involved in mRNA m6A methylation modification and summarises current research progress and the mechanisms of mRNA m6A methylation in common orthopaedic diseases, including osteoporosis, arthritis and osteosarcoma. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application In Synthesis of N-Methyl-7H-purin-6-amine

The Article related to review osteoporosis arthritis osteosarcoma m6a, n6-methyladenine, common orthopaedic diseases, demethylase, methyltransferase, reader proteins, Mammalian Pathological Biochemistry: Reviews and other aspects.Application In Synthesis of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 6, 2020, Kim, Da Hye; Seo, Jeongdeok; Na, Kun published an article.Electric Literature of 5036-48-6 The title of the article was pH-Sensitive Carbon Dots for Enhancing Photomediated Antitumor Immunity. And the article contained the following:

Recent cancer immunotherapy has attracted much attention due to high specificity and recurrence prevention of tumor. Nevertheless, its therapeutic effects are still challenging in solid cancer. To establish superior antitumor immunity, chlorin e6 (Ce6)-loaded pH sensitive carbon dots were investigated (Ce6@IDCDs). At tumoral pH 6.5, Ce6 was released four times compared with the release at physiol. pH 7.4 due to an imbalance between hydrophilic and hydrophobic forces via protonation of imidazole groups in Ce6@IDCDs. This result led to the superior singlet oxygen generating activity of Ce6@IDCDs without Ce6 quenching. The maturation effects of dendritic cells after co-incubation with supernatant media obtained from Ce6@IDCDs with laser-treated cells at pH 6.5 were much higher than at physiol. pH. Furthermore, Ce6@IDCDs following a laser at pH 6.5 significantly promoted calreticulin exposure and high-mobility group box 1 release, as major immunogenic cell death markers. In bilateral CT-26-bearing mice model, the Ce6@IDCDs elicited significant antitumoral effects at laser treated-primary tumor regions via therapeutic reactive oxygen species. Furthermore, Ce6@IDCDs upon laser irradiation induced a large amount of activated CD8+ T cells, natural killer cells, and mature dendritic cells recruitment into tumoral tissue and hampered tumor growth even at untreated sites approx. four-fold compared with those of others. Overall, this pH-sensitive immunoinducer can accomplish primary and distant tumor ablation via photomediated cancer immunotherapy. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to ph carbon dot photomediated antitumor immunity, cancer immunotherapy, carbon dot, immunoinducer, ph sensitive, photomediated immunotherapy, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ryder, Alison S. H.; Cunningham, William B.; Ballantyne, George; Mules, Tom; Kinsella, Anna G.; Turner-Dore, Jacob; Alder, Catherine M.; Edwards, Lee J.; McKay, Blandine S. J.; Grayson, Matthew N.; Cresswell, Alexander J. published an article in 2020, the title of the article was Photocatalytic ä¼?Tertiary Amine Synthesis via C-H Alkylation of Unmasked Primary Amines.Related Products of 5036-48-6 And the article contains the following content:

A practical, catalytic entry to ä¼?ä¼?ä¼?trisubstituted (ä¼?tertiary) primary amines by C-H functionalization has long been recognized as a critical gap in the synthetic toolbox. The authors report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100% atom-economy. The authors’ strategy, which uses an organic photocatalyst in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, provides a direct synthesis of ä¼?tertiary amines, or their corresponding çº?lactams. The authors anticipate that this methodol. will inspire new retrosynthetic disconnections for substituted amine derivatives in organic synthesis, and particularly for challenging ä¼?tertiary primary amines. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Related Products of 5036-48-6

The Article related to photocatalyst alpha tertiary amine preparation alkylation, c鈭抙 activation, amines, photocatalysis, radicals, spiro compounds, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 2, 2020, McCann, Scott D.; Reichert, Elaine C.; Arrechea, Pedro Luis; Buchwald, Stephen L. published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability. And the article contained the following:

The authors have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room temperature The reaction development was guided by the idea that the productivity of catalysts employing BrettPhos-like ligands is limited by their lack of stability at room temperature Specifically, it was hypothesized that primary amine and N-heteroaromatic substrates can displace the phosphine ligand, leading to the formation of catalytically dormant palladium complexes that reactivate only upon heating. This notion was supported by the synthesis and kinetic study of a putative off-cycle Pd complex. Consideration of this off-cycle species, together with the identification of substrate classes that are not effectively coupled at room temperature using previous catalysts, led to the design of a new dialkylbiaryl monophosphine ligand. An Ot-Bu substituent was added ortho to the dialkylphosphino group of the ligand framework to improve the stability of the most active catalyst conformer. To offset the increased size of this substituent, the authors also removed the para i-Pr group of the non-phosphorus-containing ring, which allowed the catalyst to accommodate binding of even very large ä¼?tertiary primary amine nucleophiles. In comparison to previous catalysts, the GPhos-supported catalyst exhibits better reactivity both under ambient conditions and at elevated temperatures Its use allows for the coupling of a range of amine nucleophiles, including (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) ä¼?tertiary primary amines, each of which previously required a different catalyst to achieve optimal results. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to dialkylbiaryl monosphosphine ligand preparation amination coupling catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem