Tag: 200-300

On May 12, 2016, Cook, James H., II; Zusi, F. Christopher; Hill, Matthew D. published a patent.Application In Synthesis of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one The title of the patent was Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands. And the patent contained the following:

The invention relates to preparation of spiro quinuclidine oxazoloazole derivatives of formula I wherein X and R are as defined in the disclosure, which bind to the nicotinic α7 receptor and may be useful for the treatment of disorders of the central nervous system. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Application In Synthesis of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

The Article related to spiro quinuclidine oxazoloazole preparation alpha7 nicotinic acetylcholine receptor ligand, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.Application In Synthesis of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 30, 2006, Yutilov, Yu. M.; Smolyar, N. N.; Lomov, D. A. published an article.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Synthesis of 1- and 3-substituted imidazo[4,5-b]pyridin-2-ones. And the article contained the following:

1- And 3-Substituted imidazo[4,5-b]pyridin-2-ones were synthesized by heating equimolar amounts of 3-amino-2-chloropyridine or 2-chloro-3-methylaminopyridine, urea, and the corresponding arylamine at 150-210°. The reaction of 3-amino-2-chloropyridine with urea and p-phenylenediamine or p,p’-diaminobiphenyl at a ratio of 2:2:1 under analogous conditions gave 1,4-bis-(2-oxoimidazo[4,5-b]pyridin-3-yl)benzene or 1,4-bis(2-oxoimidazo[4,5-b]pyridin-3-yl)biphenyl, resp. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to cyclization aminochloropyridine urea arylamine preparation imidazopyridinone, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 19, 2020, Akahoshi, Issei; Sumikawa, Yoshitake; Furuta, Sadayoshi; Fukushima, Keiichiro; Imazu, Takuya; Kotaka, Ryota published a patent.Quality Control of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid The title of the patent was Preparation of novel heteroaromatic amide derivatives and medicines containing them. And the patent contained the following:

The present invention provides novel heteroaromatic amide derivatives I [X1-X2 = N-C or C-N; Y1, Y2, Y3 and Y4 = independently single bond, -CH2-, -CR4aH-, CR4bH-, NR4c-, -O-, etc.; Z1 = single bond, -O-, -S-, etc.; ring A = a 3-7-membered monocyclic aromatic ring or an 8-12-membered bicyclic aromatic ring; R1a and R1b = H, halogen, alkyl, etc.; R2 = H, halogen, OH, etc.; R3a, R3b and R3c = independently H, halogen, CN, (un)substituted C1-6 alkyl, (un)substituted C1-6 haloalkyl, etc.; R4a, R4b, and R4c = independently (un)substituted C1-6 haloalkyl or C1-6 haloalkoxy, etc.; R5a = H, alkyl, etc.; R5b = H, alkyl, etc.; R5c = H, alkyl, etc.; R5a and R5b can join together to form -CH2O- or the like; R6a and R6b = independently H, halogen, alkyl, etc.; n = 1 or 2] and medicines containing them. For example, compound II (preparation given) was coupled with compound III to provide compound IV. The invention compounds selectively inhibit Nav1.7 rather than Nav1.5, and they are highly effective for various diseases associated with Nav1.7 such as pain. The experimental process involved the reaction of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid(cas: 1774893-22-9).Quality Control of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

The Article related to heteroaromatic amide derivative preparation nav inhibitor pain treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Quality Control of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 14, 2016, Tang, Long; Yin, Yue; Feng, Xiaoqing published a patent.Synthetic Route of 41010-50-8 The title of the patent was Method for synthesizing Pirenzepine hydrochloride key intermediate. And the patent contained the following:

The title method comprises the steps of: conducting rearrangement reaction on 1,3-dihydro-3-phenyl-2H-imidazo[4,5-B]pyridine-2-one under the action of an acidic catalyst to generate 5,11-dihydro-6H-pyrido[2,3-B][1,4]benzodiazepine-6-one, extracting with Et acetate, drying with anhydrous magnesium sulfate, and recrystallizing with anhydrous ethanol-petroleum ether mixed solvent. The method has the advantages of simple process and raw materials, little pollution, and high yield (above 99%), and recycles Et acetate and acidic catalyst, so as to save cost and protect environment. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Synthetic Route of 41010-50-8

The Article related to dihydro pyrido benzodiazepinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Synthetic Route of 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 16, 1976, Clark, Robert Long; Pessolano, Arsenio A.; Shen, Tsung-Ying published a patent.HPLC of Formula: 41010-50-8 The title of the patent was 1,3-Dihydroimidazo[4,5-b]pyridin-2-ones and thiones. And the patent contained the following:

Imidazopyridinones and thiones I [R = e.g. H, Pr, H2C:CHCH2, Me, PhCH2; R1 = e.g. Ph, 2,4-(MeO)2C6H3, 2,4-Me2C6H3, 3,4-(OCH2O)C6H3, 2-BrC6H4, 3-FC6H4, 2-methyl-6-pyridinyl, 1,3-dihydro-5-isobenzofuranyl; R2 = e.g. H, 6-Me, 6-NO2, 6-NH2; X = O, S], useful as analgesics, antipyretics and inflammation inhibitors (no data), are prepared by reaction of 2-chloro-3-nitropyridine (II) with an aniline, reduction of the resulting 2-anilino-3-nitropyridine to the 3-amino-2-anilinopyridine and cyclocondensation with COCl2 or CSCl2, for example. Thus, reaction of II with 3,4-methylenedioxyaniline gives 2-[3,4-(methylenedioxy)anilino]-3-nitropyridine, which is reduced and cyclocondensed with COCl2 to give I [R = R2 = H, R1 = 3,4-(OCH2O)C6H3, X = O]. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).HPLC of Formula: 41010-50-8

The Article related to imidazopyridinone, imidazopyridinethione, analgesic imidazopyridinone, antipyretic imidazopyridinone, antiinflammatory imidazopyridinone, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.HPLC of Formula: 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 6, 1973, Robison, Michael Mullen; Finch, Neville published a patent.Product Details of 41010-50-8 The title of the patent was 1-(Aminoalkyl)-2,3-dihydroimidazo[4,5-b]pyridines. And the patent contained the following:

About 15 title compounds (I; R = cyclohexyl, PhCH2, Ph, p-FC6H4, etc.; R1 = MeN, 4-methyl-1-piperazinyl; X = O, S; n = 2,3) were prepared Thus, 2-chloro-3-nitropyridine was treated with PhNH2 and the product hydrogenated (PdC ) to give 3-amino-2-(phenylamino) pyridine, which was treated with 1,1′-carbonyldiimidazole to give 2-oxo-3-phenyl-2,3- dihydroimidazo[4,5-b]pyridine followed by treatment with Me2NCH2- CH2Cl to give I (R = Ph, R1 = Me2N, X = O, n = 2) isolated as the dicyclohexylsulfamate salt. I were intidepressant at 2.5-100 mg/kg/day in higher animals. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Product Details of 41010-50-8

The Article related to imidazopyridine aminopropyl phenyl antidepressant, antidepressant aminopropylimidazopyridine, pyridine nitro chloro aniline addition, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 1976, Yutilov, Yu. M.; Svertilova, I. A. published an article.Computed Properties of 41010-50-8 The title of the article was New method for preparing condensed imidazolones. And the article contained the following:

Imidazoles I and II (X = CH, N; R = H, Cl; R1 = H, Me, Et, R2 = H, Me, Ph, CH2Ph) were obtained in 80-99% yields by treatment of the corresponding o-phenylenediamine or diaminopyridine with EtO2COCO2Et. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Computed Properties of 41010-50-8

The Article related to cyclocondensation phenylenediamine pyrocarbonate, pyridinediamine cyclocondensation polycarbonate, imidazolone condensed, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 17, 2006, Scott, Jeremy P. published an article.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Two-step synthesis of 3-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones. And the article contained the following:

One-pot tandem palladium-catalyzed amination and intramol. amidation of tert-Bu (2-chloropyridin-3-yl)carbamate with substituted primary anilines allows for the preparation of 3-arylated 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones (49-90% yield) in two steps from com. available materials. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to chloropyridinylcarbamate primary aniline tandem amination intramol amidation, imidazopyridinone dihydro preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Doan, Sengul Dilem; Ongun, Melike published an article in 2022, the title of the article was Copper catalyzed C-N bond formation and synthesis of imidazopyridinone derivatives.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one And the article contains the following content:

A series of novel imidazopyridinone derivatives were synthesized via copper-mediated C-N bond-forming reaction. This reaction takes place under mild conditions with high efficiency, step economy, and tolerance for a wide range of functional groups. All synthesized new compounds were analyzed by 1H NMR, 13C NMR and mass spectrometry. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to bromopyridylphenylurea copper iodide catalyst microwave intramol cyclization, imidazopyridinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 16, 2021, Akaboshi, Kazumasa; Sumikawa, Eiken; Furuta, Sadayoshi; Imazu, Takuya; Fukushima, Keiichiro; Furutaka, Ryota published a patent.Name: 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid The title of the patent was Preparation of heteroaromatic amide derivative for inhibiting Nav1.7. And the patent contained the following:

The present invention relates to a compound I [X-Y = N-C or C-N; Y1-Y4 = independently single bond, -CH2-, -CH2CH2-, etc.; Z1 = single bond, -O-, -S-, etc.; ring A = monocyclic aromatic ring or bicyclic aromatic ring; R1a, R1b = independently H, halo, hydroxy, etc.; R2 = H, halo, hydroxy, etc.; R3a, R3b, R3c = independently H, halo, cyano, etc.; combination of R5a, R5b, R5c, R6a, R6b and n is selected from (1), (2), (3), etc.; (1) R5b and R5c combine to form a single bond, -CH2-, -OCH2-, etc., R5a is H, alkyl, haloalkyl, etc., R6a and R6b each is H, halo, hydroxy, etc., and n is 1 or 2 (2) R5a and R6a combine to form -CH2-, -CH2CH2-, -CH2CH2O-, etc., R5b is H, alkyl or haloalkyl, R5c and R6b each is H, halo, hydroxy, etc. (or R5c and R6b may combine to form -(CH2)p-, -O(CH2)p-, -(CH2)pO-, etc. (p = 0-3)), and n is 1 (3) R5a is H, alkyl, haloalkyl, etc., R5b is H or alkyl, R5c is H, alkyl or halo, R6a and R6b each is H, halo, alkyl, etc. (or R6a and R6b, together with the carbon atom to which they are attached, may combine to form a monocyclic ring) and n is 1 or 2; or a salt thereof]. For example, compound II was prepared via cyclization of 5-(trifluoromethyl)pyridin-2-amine with Et bromopyruvate, hydrogenation, hydrolysis and HATU-mediated amidation with 6-fluorochroman-3-amine·HCl. Compound I shows selective inhibition of potential-dependent sodium channel Nav1.7 over Nav1.5, and is useful for the treatment of pain and various Nav1.7-related disease including pruritus and an autonomic nerve-related disease. The experimental process involved the reaction of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid(cas: 1774893-22-9).Name: 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

The Article related to heteroaromatic amide preparation voltage gated sodium channel blocker, analgesic heteroaromatic amide, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem