Tag: 200-300

《Biotin interference: evaluation of a new generation of electrochemiluminescent immunoassays for high-sensitive troponin T and thyroid-stimulating hormone testing》 was written by Mzougui, Samy; Favresse, Julien; Soleimani, Reza; Fillee, Catherine; Gruson, Damien. Related Products of 58-85-5This research focused ontroponinT TSH electrochemiluminescent immunoassay; biotin; immunoassays; interference; thyroid-stimulating hormone (TSH); troponin. The article conveys some information:

Biotin is currently a matter of concern for laboratories using biotin-streptavidin-based immunoassays. Biotin interferences have been reported for high-sensitive troponin T (hsTnT) and TSH (TSH) assays. We aimed to evaluate the new generation of hsTnT and TSH electrochemiluminescent immunoassays announced to be less sensitive to biotin. Firstly, we assessed the anal. performances of new generation assays (imprecision, bias, total error, limit of quantification) and compared previous and new generation assays in the absence of biotin. Secondly, we challenged both generations of assays with samples spiked with seven different biotin levels. The efficiency of new generation assays was also compared to the streptavidin beads treatment. New generation assays presented suitable anal. performances. Previous and new generations of hsTnT and TSH assays were commutable in the absence of biotin. In the presence of biotin, we confirmed that previous generation assays were affected by biotin concentration as low as 40.5 ng/mL and that new generation assays were not affected up to the announced tolerance threshold of 1200 ng/mL. After the streptavidin beads treatment, we observed a higher imprecision for both parameters and a constant 10% neg. bias for TSH compared to new generation assays. New generation of electrochemiluminescent immunoassays appears as a reliable systematic solution to prevent biotin interference for hsTnT and TSH testing.5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Related Products of 58-85-5) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Related Products of 58-85-5 And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C8H15BF4N2In 2020 ,《Microscopic understanding of the effect of ionic liquid on protein from molecular simulation studies》 appeared in Journal of Physical Chemistry B. The author of the article were Ghanta, Krishna Prasad; Pal, Tamisra; Mondal, Sandip; Bandyopadhyay, Sanjoy. The article conveys some information:

We have performed mol. dynamics (MD) simulations of the protein α-lactalbumin in aqueous solution containing the ionic liquid (IL) 1-butyl-3-Me imidazolium tetrafluoroborate ([BMIM][BF4]) as the cosolvent at different concentrations Attempts have been made to obtain quant. understanding of the effects of the IL on the conformational features of the protein as well as the distributions of the IL and water around it. The calculations revealed enhanced rigidity of the protein with reduced conformational fluctuations and increasingly correlated local motions in the presence of the IL. Nonuniform relative population of the BMIM+ and BF4- ions at the protein surface with respect to that in the bulk solution has been observed It is demonstrated that exchange of water by the IL around the protein results in rearrangement of the hydrogen bond network at the interface with breaking of protein-water hydrogen bonds and formation of protein-IL hydrogen bonds. Importantly, it is found that the protein forms increased number of stronger salt bridges in the presence of IL. This shows that the formation of a greater number of such stronger salt bridges is the origin behind the enhanced rigidity of the protein in the presence of the IL. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Computed Properties of C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Computed Properties of C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Densities, Ultrasonic Speeds, Viscosities, Refractive Indices, and Excess Properties of 1-Butyl-3-methylimidazolium Tetrafluoroborate + N-Methylacetamide Binary Mixtures at Different Temperatures》 was published in Journal of Chemical & Engineering Data in 2020. These research results belong to Chaudhary, Neha; Nain, Anil Kumar. COA of Formula: C8H15BF4N2 The article mentions the following:

The thermophys. properties, viz., densities, ρ, ultrasonic speeds, u, viscosities, η, and refractive indexes, nD, were measured for the binary liquid mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate [Bmim][BF4] with N-methylacetamide [NMA] over the whole concentration range, including those of pure liquids, at temperatures T/K = 293.15-318.15 and at pressure p = 101 kPa. Exptl. data were used to determine the excess molar volume, VmE, excess isentropic compressibility, κsE, excess speed of sound, uE, excess molar isentropic compressibility, Ks, mE, deviations in viscosity Δη, and deviations in refractive index, ΔϕnD. These parameters were fitted to the Redlich-Kister type polynomial equation. The partial molar volumes and partial molar compressibilities and excess partial molar volumes and excess partial molar compressibilities over the entire range of mole fraction and at infinite dilution were also determined The observed neg. values of VmE, κsE, Ks, mE, and Δη and pos. values uEand ΔϕnD indicate the strong interactions between the component mols. of these mixtures The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6COA of Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. COA of Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Effects of 1-butyl-3-methylimidazolium tetrafluoroborate and the oxygen concentration on the spontaneous combustion of coal》 were Xiao, Yang; Li, Da-Jiang; Lu, Hui-Fei; Yin, Lan; Shu, Chi-Min. And the article was published in Journal of Thermal Analysis and Calorimetry in 2019. Related Products of 174501-65-6 The author mentioned the following in the article:

Ionic liquids (ILs) are a type of environmentally friendly solvents. Several studies have proven that ILs can inhibit the spontaneous combustion of coal (SCC). In this study, a synchronous thermal analyzer was used to analyze the effects of the imidazolium-based IL [BMIM][BF4] on coal of three metamorphic grades. A coal sample exhibiting the optimal inhibiting result was selected to investigate the effect of the oxygen concentration on IL inhibition. The results revealed that the influence of IL on the mass loss process of the three metamorphic grades of coal varied considerably. However, the IL promoted the mass loss process in 1/3 coking coal and anthracite. The IL delayed the ignition temperature of lignite by 42°C, whereas those of 1/3 coking coal and anthracite were advanced by 10 and 8°C, resp. Furthermore, the initial exothermic temperature of the three treated coal samples was higher than those of the raw coal samples. Compared with the raw coal samples, the heat released per g of lignite, 1/3 coking coal, and anthracite was reduced by 1142, 353, and 226 J, resp. The results indicated that the IL had a prominent inhibiting effect on the exothermic properties of the three coal samples, and the inhibiting effect decreased with an increase in the metamorphic grade of coal. Moreover, the oxygen concentration did not alter the inhibition properties of the IL on the SCC. However, the inhibiting effect weakened as the oxygen concentration decreased. The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Related Products of 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Related Products of 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Applied Laboratory Medicine included an article by Bevins, Nicholas J.; Hubbard, Jacqueline A.; Fitzgerald, Robert L.; Kelner, Michael J.. HPLC of Formula: 58-85-5. The article was titled 《A dilution method to mitigate biotin interference in cardiac troponin T testing》. The information in the text is summarized as follows:

Background: Oral biotin supplementation is known to interfere with biotin-streptavidin-based immunoassays, including Roche’s fifth-generation cardiac troponin T (cTnT) assay, which plays a critical role in the diagnosis of myocardial infarction (MI). The utility of dilution, a quick and easy method to detect and remove interferences, has not been published for biotin interference. Methods: Concentrations of cTnT were measured in pooled serum from clin. samples. Serum samples were supplemented with biotin to known concentrations, then cTnT concentrations were remeasured to assess for biotin interference. Samples were then diluted to assess for effective removal of biotin interference. Results: At cTnT values near the critical reporting range for our institution (100 ng/L) we observed significant interference in measured values with added biotin concentrations above 50 ng/mL. In specimens without added biotin, autodilution at a 1:10 ratio yielded a mean 157% capture of measured cTnT, precluding the use of autodilution for detecting and mitigating biotin interference. A 1:10 dilution with serum containing 20-30 ng/L cTnT yielded a mean capture of 107%, which was suitable for detecting underlying biotin interference in supplemented samples. Conclusions: Biotin interference, at supraphysiol. concentrations, may create an artifactual reduction in measured cTnT to levels that could lead to delayed detection of an MI. Dilution with serum of known cTnT concentration of 20-30 ng/L is a fast and effective method to mitigate the anal. consequences of biotin interference. In addition to this study using 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, there are many other studies that have used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5HPLC of Formula: 58-85-5) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.HPLC of Formula: 58-85-5 And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Clinical Chemistry and Laboratory Medicine included an article by Saenger, Amy K.; Jaffe, Allan S.; Body, Richard; Collinson, Paul O.; Kavsak, Peter A.; Lam, Carolyn S. P.; Lefevre, Guillaume; Omland, Tobjorn; Ordonez-Llanos, Jordi; Pulkki, Kari; Apple, Fred S.. Category: imidazoles-derivatives. The article was titled 《Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)》. The information in the text is summarized as follows:

Two interferences recently brought to the forefront as patient safety issues include hemolysis (Hb) and biotin (vitamin B7). The International Federation for Clin. Chem. Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker anal. results that are discordant with the clin. situation. The results came from multiple reactions, including the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Category: imidazoles-derivatives)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Category: imidazoles-derivatives The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C8H15BF4N2In 2020 ,《Microscopic understanding of the effect of ionic liquid on protein from molecular simulation studies》 appeared in Journal of Physical Chemistry B. The author of the article were Ghanta, Krishna Prasad; Pal, Tamisra; Mondal, Sandip; Bandyopadhyay, Sanjoy. The article conveys some information:

We have performed mol. dynamics (MD) simulations of the protein α-lactalbumin in aqueous solution containing the ionic liquid (IL) 1-butyl-3-Me imidazolium tetrafluoroborate ([BMIM][BF4]) as the cosolvent at different concentrations Attempts have been made to obtain quant. understanding of the effects of the IL on the conformational features of the protein as well as the distributions of the IL and water around it. The calculations revealed enhanced rigidity of the protein with reduced conformational fluctuations and increasingly correlated local motions in the presence of the IL. Nonuniform relative population of the BMIM+ and BF4- ions at the protein surface with respect to that in the bulk solution has been observed It is demonstrated that exchange of water by the IL around the protein results in rearrangement of the hydrogen bond network at the interface with breaking of protein-water hydrogen bonds and formation of protein-IL hydrogen bonds. Importantly, it is found that the protein forms increased number of stronger salt bridges in the presence of IL. This shows that the formation of a greater number of such stronger salt bridges is the origin behind the enhanced rigidity of the protein in the presence of the IL. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Computed Properties of C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Computed Properties of C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Densities, Ultrasonic Speeds, Viscosities, Refractive Indices, and Excess Properties of 1-Butyl-3-methylimidazolium Tetrafluoroborate + N-Methylacetamide Binary Mixtures at Different Temperatures》 was published in Journal of Chemical & Engineering Data in 2020. These research results belong to Chaudhary, Neha; Nain, Anil Kumar. COA of Formula: C8H15BF4N2 The article mentions the following:

The thermophys. properties, viz., densities, ρ, ultrasonic speeds, u, viscosities, η, and refractive indexes, nD, were measured for the binary liquid mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate [Bmim][BF4] with N-methylacetamide [NMA] over the whole concentration range, including those of pure liquids, at temperatures T/K = 293.15-318.15 and at pressure p = 101 kPa. Exptl. data were used to determine the excess molar volume, VmE, excess isentropic compressibility, κsE, excess speed of sound, uE, excess molar isentropic compressibility, Ks, mE, deviations in viscosity Δη, and deviations in refractive index, ΔϕnD. These parameters were fitted to the Redlich-Kister type polynomial equation. The partial molar volumes and partial molar compressibilities and excess partial molar volumes and excess partial molar compressibilities over the entire range of mole fraction and at infinite dilution were also determined The observed neg. values of VmE, κsE, Ks, mE, and Δη and pos. values uEand ΔϕnD indicate the strong interactions between the component mols. of these mixtures The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6COA of Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. COA of Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Effects of 1-butyl-3-methylimidazolium tetrafluoroborate and the oxygen concentration on the spontaneous combustion of coal》 were Xiao, Yang; Li, Da-Jiang; Lu, Hui-Fei; Yin, Lan; Shu, Chi-Min. And the article was published in Journal of Thermal Analysis and Calorimetry in 2019. Related Products of 174501-65-6 The author mentioned the following in the article:

Ionic liquids (ILs) are a type of environmentally friendly solvents. Several studies have proven that ILs can inhibit the spontaneous combustion of coal (SCC). In this study, a synchronous thermal analyzer was used to analyze the effects of the imidazolium-based IL [BMIM][BF4] on coal of three metamorphic grades. A coal sample exhibiting the optimal inhibiting result was selected to investigate the effect of the oxygen concentration on IL inhibition. The results revealed that the influence of IL on the mass loss process of the three metamorphic grades of coal varied considerably. However, the IL promoted the mass loss process in 1/3 coking coal and anthracite. The IL delayed the ignition temperature of lignite by 42°C, whereas those of 1/3 coking coal and anthracite were advanced by 10 and 8°C, resp. Furthermore, the initial exothermic temperature of the three treated coal samples was higher than those of the raw coal samples. Compared with the raw coal samples, the heat released per g of lignite, 1/3 coking coal, and anthracite was reduced by 1142, 353, and 226 J, resp. The results indicated that the IL had a prominent inhibiting effect on the exothermic properties of the three coal samples, and the inhibiting effect decreased with an increase in the metamorphic grade of coal. Moreover, the oxygen concentration did not alter the inhibition properties of the IL on the SCC. However, the inhibiting effect weakened as the oxygen concentration decreased. The results came from multiple reactions, including the reaction of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Related Products of 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Related Products of 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 3584-66-5On September 30, 2014 ,《Molecular properties prediction and synthesis of new benzimidazole H4-receptor antagonists as anti-inflammatory agents》 was published in Indian Journal of Heterocyclic Chemistry. The article was written by Bai, S. Anuradha; Tangeda, Sarita Jyostna; Madhavi, M.; Garlapati, Achaiah. The article contains the following contents:

The design and calculation of mol. properties, drug likeness, lipophilicity and solubility parameters of substituted benzimidazolyl carbonyl piperazines/piperidines I (R1 = Cl, CH3; R2 = H, Cl; R3 = CH3, C2H5; X = N, CH2) using mol inspiration, mol soft, software’s and ALOPGPS 2.1 program were investigated. Toxicity parameters were calculated using Osiris software. All compounds were non toxic; fulfill the solubility requirements and passing oral bioavailability criteria. Most of the compounds exhibited significant anti-inflammatory activity. In addition to this study using 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole, there are many other studies that have used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Related Products of 3584-66-5) was used in this study.

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Related Products of 3584-66-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem