Tag: 200-300

Recommanded Product: 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazoleOn November 1, 2004 ,《Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Terzioglu, Nalan; van Rijn, Richard M.; Bakker, Remko A.; De Esch, Iwan J. P.; Leurs, Rob. The article conveys some information:

The structure-activity relationship for a series of ligands structurally related to the recently identified (5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone (I) as histamine H4 receptor (H4R) antagonists, is reported. Furthermore, related benzimidazoles was identified as lead compounds for the H4R. The ligands have been evaluated by radioligand displacement studies and functional assays for their interaction with both the human histamine H3 and H4 receptors and exhibit pKi values up to 7.5 at the human H4R. The experimental process involved the reaction of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Recommanded Product: 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole)

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Recommanded Product: 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Interference from high-dose biotin intake in immunoassays for potentially time-critical analytes by Roche. Evaluation of a countermeasure for worst-case scenarios》 was published in Archives of Pathology & Laboratory Medicine in 2020. These research results belong to Mrosewski, Ingo; Urbank, Matthias; Stauch, Thomas; Switkowski, Rafael. Category: imidazoles-derivatives The article mentions the following:

Context.-Immunoassays using the interaction between streptavidin and biotin are used for clin. chem. analytes on platforms by many different manufacturers. The design can be susceptible to interference from high-dose biotin intake in patients, which remains an often-overlooked confounder despite recently increased awareness. Objective.-To evaluate an easily implementable method of in vitro biotin depletion for the removal of biotin interference in immunoassays for potentially time-critical analytes. Design.-A biotin stock solution was made and deidentified patient samples were spiked to reach a biotin concentration of 1.126 x 106 pg/mL, the maximum reported biotin concentration 1 to 2 h after a single oral dose of 300 mg biotin. Then, the resulting interference in Elecsys immunoassays for cortisol, cyclosporine A, tacrolimus, digitoxin, TSH, free triiodothyronine, free thyroxine, C-peptide, insulin, Nterminal pro-β-type natriuretic peptide, troponin T high sensitive, human immunodeficiency virus, procalcitonin, β human chorionic gonadotropin, toxoplasma IgM, and toxoplasma IgG was evaluated before and after biotin depletion using streptavidin particles. Results.-All tested immunoassays, with the exception of toxoplasma IgM and toxoplasma IgG, suffered from significant biotin interference. The depletion protocol removed assay interference due to biotin and produced results that were close or identical to initial prespike measurements. Conclusions.-Despite an increase in turnaround times, biotin adsorption is a feasible countermeasure for biotin interference in Elecsys immunoassays. Until test kits with an increased resistance to the interference from high-dose biotin intake are distributed, the evaluated protocol can provide results properly reflecting the patient’s clin. condition. In addition to this study using 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, there are many other studies that have used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Category: imidazoles-derivatives) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Category: imidazoles-derivatives The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Toward an Understanding of the Forces Behind Extractive Desulfurization of Fuels with Ionic Liquids》 were Player, Lisa C.; Chan, Bun; Lui, Matthew Y.; Masters, Anthony F.; Maschmeyer, Thomas. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Product Details of 174501-65-6 The author mentioned the following in the article:

In this study, the extractive desulfurization of model fuel oil with ionic liquids (ILs) has been studied in an attempt to gain insights into the dominant forces controlling the extraction efficiencies of aromatic sulfur compounds, thiophene and dibenzothiophene. This work investigates the intrinsic properties of a series of common ILs based on a constant (molar) amount of IL to directly draw insights into the intrinsic properties of each IL’s extraction capability. Exptl. both the cation and anion size influenced the efficiency of extraction, following the trend pyridinium > imidazolium > pyrrolidinium for the cation and [NTf2]- > [OTf]- > [PF6]- > [BF4]- for the anion. Similar trends are observed for both thiophene and dibenzothiophene. D. functional theory modeling, using the APFD method, was employed to quantify the complexation energies and corresponding dispersion contributions between thiophene and the cations as well as between thiophene and the anions used in this work, showing a similar trend to the exptl. results. Through a combination of exptl. and computational analyses it is suggested that the dominant force in extraction is dispersion-driven binding between the ions and S-compounds In the experiment, the researchers used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Product Details of 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Product Details of 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C8H15BF4N2In 2019 ,《Fabrication of Hierarchical Porous Carbon Frameworks from Metal-Ion-Assisted Step-Activation of Biomass for Supercapacitors with Ultrahigh Capacitance》 appeared in ACS Sustainable Chemistry & Engineering. The author of the article were Chang, Chengshuai; Wang, He; Zhang, Yunqiang; Wang, Shulan; Liu, Xuan; Li, Li. The article conveys some information:

Advancement in the application of biomass-derived carbon is viewed as one of the most important drivers of sustainable and renewable technologies for energy storage. High-performance biochar with a well-defined structure is extremely attractive as a supercapacitor electrode material. Herein, carbon with an ultrahigh capacitance of 682 F/g at 0.2 A/g for biochar materials and remarkable cycling stability was synthesized from Chinese parasol fluff (CPF). Three-dimensional interconnected hierarchical porous carbon was fabricated via a feasible metal-ion-assisted step-activation method from the biomass precursor. CO2 was used to treat the carbonaceous material from CPF after molten KOH activation for pore structure tuning, while Co2+ was selected as the metal ion additive for directing graphitization. In addition to the extremely high capacitance, the as-synthesized carbon also delivered an energy d. of 46.38 W h/kg at a power d. of 300 W/kg in 1-butyl-3-Me imidazolium tetrafluoroborate/acetonitrile (BMIMBF4/AN) electrolyte, which is much better than for most reported biochar materials and about 10 times better than for com. supercapacitors. The current work points out an excellent sustainable source for fabrication of high-performance electrode materials and, more importantly, a feasible design strategy route for improvement of the electrochem. performance of energy storage devices. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6COA of Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. COA of Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Photochemistry and Photobiology, B: Biology included an article by Li, Ke; Dong, Wenyi; Liu, Qingzhu; Lv, Gaochao; Xie, Minhao; Sun, Xinchen; Qiu, Ling; Lin, Jianguo. Product Details of 58-85-5. The article was titled 《A biotin receptor-targeted silicon(IV) phthalocyanine for in vivo tumor imaging and photodynamic therapy》. The information in the text is summarized as follows:

Phthalocyanines (Pcs) are a kind of potential photosensitizers for fluorescence imaging and photodynamic therapy (PDT). However, the clin. application of Pcs is suffered from their poor solubility, high aggregation tendency and low tumor-specificity. To address these problems, two biotin moieties were linked to the axial positions of silicon(IV) phthalocyanine (SiPc) through hydrophilic polyethylene glycol (PEG) linkers to synthesize a new water-soluble and tumor-targeting photosensitizer (compound 1). The introduction of PEG linkers on SiPc markedly reduced the aggregation tendency of the conjugate. In vitro assays also proved that compound 1 could specifically accumulate in biotin receptor (BR) pos. Hela cells through the BR-mediated internalization. Owing to the good characteristics of water-solubility and low aggregation, the bioactivity of compound 1 was examined in the xenograft tumor model. In vivo imaging and tissue distribution studies showed that compound 1 selectively accumulated in the tumor tissue, with tolerable signals found in other organs of the tumor-bearing mice. Furthermore, compound 1 could significantly depress tumor progression in vivo under irradiation After 14 days of the treatment, the tumor volumes were even smaller than the beginning size. All these results reveal that compound 1 is a promising candidate, with low aggregation tendency, high tumor-specificity and water-solubility, for in vivo tumor diagnosis and PDT treatment.5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Product Details of 58-85-5) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Product Details of 58-85-5 The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kattnig, B. Y. Mladenova; Chumakova, N. A.; Kattnig, D. R.; Grigor’ev, I. A.; Grampp, G.; Kokorin, A. I. published their research in Journal of Physical Chemistry B in 2021. The article was titled 《Influence of electric charge of spin probes on their diffusion in room-temperature ionic liquids》.Recommanded Product: 174501-65-6 The article contains the following contents:

The rotational and translational diffusion of neg. charged and uncharged spin probes in five imidazolium-based room-temperature ionic liquids (RTILs), 1-ethyl-3-methylimidazolium tetrafluoroborate, emimBF4, 1-butyl-3-methylimidazolium tetrafluoroborate, bmimBF4, 1-octyl-3-methylimidazolium tetrafluoroborate, omimBF4, 1-octyl-3-methylimidazolium hexafluorophosphate, omimPF6, and 1-octyl-3-methylimidazolium chloride, omimCl, has been studied by means of ESR spectroscopy. Detailed analyses of the spin-Hamiltonian parameters and spin exchange interactions have been carried out. The temperature dependences of the line broadening induced by the electronic dipole-dipole interaction and the electron spin exchange coupling are determined The translational mobility of spin probes is semiquant. characterized and successfully explained in the framework of a hypothesis based on the assumption of polar and unpolar domains within the RTILs. In the experiment, the researchers used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Recommanded Product: 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Recommanded Product: 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Espiritu, Adrian I.; Remalante-Rayco, Patricia Pauline M. published their research in Multiple Sclerosis and Related Disorders in 2021. The article was titled 《High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials》.Computed Properties of C10H16N2O3S The article contains the following contents:

Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of ATP (ATP), which may be essential to prevent neurodegeneration. The purpose of this review was to determine the effectiveness and safety of high-dose biotin (HDB) in multiple sclerosis via a systematic review of randomized controlled trials. We searched the following electronic databases for relevant articles: MEDLINE, CENTRAL, EMBASE, Scopus, and ClinicalTrials.gov website until Apr. 2021. We considered randomized clin. trials (RCTs) that involved adult patients diagnosed with any phenotype of multiple sclerosis that conforms with the McDonald 2010/2017 criteria or the Lublin 2014 criteria. We included studies employing high-dose biotin or “”MD1003″” administered orally for at least 300 mg/day and given for at least three months. The methodol. quality assessment of the included studies was done using the Cochrane Risk of Bias (RoB) tool. The GRADE approach was used to assess the certainty of evidence [COE]. Out of 366 records identified, three RCTs involving 889 individuals diagnosed with MS (830 participants had progressive MS (PMS); 59 had RRMS) were pooled for analyses. The overall female:male ratio was 1.16:1. All included trials used HDB as an adjunctive treatment. The risks of bias in the three studies were low across the domains. At 12 to 15 mo, there is insufficient evidence that the HDB and placebo arms differed in terms of composite improvement of MS-related disability (relative risk (RR) 2.87; 95% CI 0.29-28.40; 2 trials; 796 participants; I2 = 66%) [low COE], improvement in expanded disability status scale (IEDSS) (RR 2.27; 95% CI 0.25-20.98; 2 trials; 796 participants; I2 = 63%) [low COE], and both IEDSS and improvement in 25-ft walk time (ITW25) (IEDSS-ITW25) (RR 0.58; 95% CI 0.17-2.00; 2 trials; 796 participants; I2 = 13%) [moderate COE] among patients with PMS. Pooled data for ITW25 at 12 to 15 mo yielded statistical significance (RR 2.06; 95% CI 1.04-4.09; 2 trials; 796 participants; I2 = 0%) [moderate COE] favoring HDB among patients with PMS. At 12 to 15 mo, no significant differences were found in terms of mean change in EDSS (MD -0.06; 95% CI -0.14-0.02; 2 studies; 796 participants; 889 participants; I2 = 68%) among patients with PMS. Synthesized data on incidence of any AEs (RR 0.98; 95% CI 0.92-1.04; 3 trials; I2 = 0%) [high COE] and any serious AEs (RR 0.98; 95% CI 0.77-1.24; 3 trials; 889 participants; I2 = 0%) [moderate COE] were not significantly different between HDB and placebo groups. Out of 662 pooled patients in the HDB group, 31 patients (4.7%) were found to have laboratory test interference compared to zero event in the pooled placebo group [high COE]. A moderate certainty of evidence suggests a potential benefit in favor of HDB administered for 12 to 15 mo in terms of ITW25 in patients with PMS. However, an important trade-off of this benefit is the high certainty of evidence suggesting an increased incidence of laboratory test interference when HDB is taken. After reading the article, we found that the author used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Computed Properties of C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Computed Properties of C10H16N2O3S And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Density, Refractive Index and Volumetric Properties of Water-Ionic Liquid Binary Systems with Imidazolium-Based Cations and Tetrafluoroborate, Triflate and Octylsulfate Anions at T = 293 to 343 K and p = 0.1 MPa》 were Carissimi, Guzman; Montalban, Mercedes G.; Diaz Banos, F. Guillermo; Villora, Gloria. And the article was published in Journal of Chemical & Engineering Data in 2019. Electric Literature of C8H15BF4N2 The author mentioned the following in the article:

The d. and refractive index of ionic liquids (ILs) + water binary mixtures were determined as a function of temperature (from 293.15 to 343.15 K) at atm. pressure over the whole composition range in which the mixtures were miscible. To carry out a systematic study, all of the ILs selected are imidazolium-based ILs with a different number of carbons in the alkyl chain of the cation and also different anions (tetrafluoroborate, triflate, and octylsulfate). Specifically, the studied ILs were 1-ethyl-3-methylimidazolium tetrafluoroborate [emim][BF4], 1-butyl-3-methylimidazolium tetrafluoroborate [bmim][BF4], 1-hexyl-3-methylimidazolium tetrafluoroborate [hmim][BF4], 1-methyl-3-octylimidazolium tetrafluoroborate [omim][BF4], 1-ethyl-3-methylimidazolium triflate [emim][TfO], 1-butyl-3-methylimidazolium triflate [bmim][TfO], and 1-butyl-3-methylimidazolium octylsulfate [bmim][OcSO4]. The excess molar volumes and the deviation in the molar refraction of the binary mixtures were calculated for a better understanding of the interactions that take place between the components and were successfully correlated by the Redlich-Kister empirical correlations. The Bahe-Varela model, which has a more phys. meaning, was also used to successfully correlate the excess molar volume values. Volumetric properties, such as apparent molar volumes, partial molar volumes, isobaric thermal expansion coefficients, partial molar volumes at infinite dilution and excess partial molar volumes at infinite dilution were also calculated in order to obtain information about the influence of composition and temperature on the thermodn. behavior of the selected ILs and water in the mixture The results are discussed in order to understand the formation of hydrogen bonds between components of the mixture and the possible packing effects that take place in the mixing process. The d. and refractive index exptl. data were correlated by the Lorentz-Lorenz, Wiener, Dale-Gladstone, and Eykman equations to determine the relationship between both parameters, and good agreement between the exptl. and calculated refractive index values was obtained. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Electric Literature of C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Electric Literature of C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Inherited Metabolic Disease included an article by Leon-Del-Rio, Alfonso. Computed Properties of C10H16N2O3S. The article was titled 《Biotin in metabolism, gene expression, and human disease》. The information in the text is summarized as follows:

A review. Biotin is a water-soluble vitamin that belongs to the vitamin B complex and which is an essential nutrient of all living organisms from bacteria to man. In eukaryotic cells biotin functions as a prosthetic group of enzymes, collectively known as biotin-dependent carboxylases that catalyze key reactions in gluconeogenesis, fatty acid synthesis, and amino acid catabolism. Enzyme-bound biotin acts as a vector to transfer a carboxyl group between donor and acceptor mols. during carboxylation reactions. In recent years, evidence has mounted that biotin also regulates gene expression through a mechanism beyond its role as a prosthetic group of carboxylases. These activities may offer a mechanistic background to a developing literature on the action of biotin in neurol. disorders. This review summarizes the role of biotin in activating carboxylases and proposed mechanisms associated with a role in gene expression and in ameliorating neurol. disease. The experimental part of the paper was very detailed, including the reaction process of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Computed Properties of C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Computed Properties of C10H16N2O3S The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Human papilloma virus DNA-biomarker analysis for cervical cancer: Signal enhancement by gold nanoparticle-coupled tetravalent streptavidin-biotin strategy》 were Lv, Qingfeng; Wang, Yongmei; Su, Cuijin; Lakshmipriya, Thangavel; Gopinath, Subash C. B.; Pandian, Kannaiyan; Perumal, Veeradasan; Liu, Ying. And the article was published in International Journal of Biological Macromolecules in 2019. Synthetic Route of C10H16N2O3S The author mentioned the following in the article:

Human papillomavirus (HPV) is a double-standard DNA virus, as well as the source of infection to the mucous membrane. It is a sexually transmitted disease that brings the changes in the cervix cells. Oncogenes, E6 and E7 play a pivotal role in the HPV infection. Identifying these genes to detect HPV strains, especially a prevalent HPV16 strain, will bring a great impact. Among different sensing strategies for pathogens, the dielec. electrochem. biosensor shows the potential due to its higher sensitivity. In this research, HPV16-E7 DNA sequence was detected on the carbodiimidazole-modified interdigitated electrode (IDE) surface with the detection limit of 1 fM. To enhance the sensitivity, the target sequence was conjugated on gold nanoparticle (GNP) and attained detection to the level of 10 aM. This produced ~100 folds improvement in detecting HPV16-E7 gene and 4 folds increment in the current flow. The stability of HPV16-E7 DNA sequences on GNP was verified by the salt-induced GNP aggregation. The current system has shown the higher specificity by comparing against non-complementary and triple-mismatched DNA sequences of HPV16-E7. This demonstration in detecting HPV16-E7 using dielec. IDE sensing system with a higher sensitivity can be recommended for detecting a wide range of disease-causing DNA-markers.5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Synthetic Route of C10H16N2O3S) was used in this study.

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Synthetic Route of C10H16N2O3S And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem