Tag: 200-300

Formula: C8H15BF4N2In 2019 ,《The Solubility of Carbon Dioxide and Density for Binary Mixtures of 1-Butyl-3-methylimidazolium Acetate and 1-Butyl-3-methylimidazolium Tetrafluoroborate》 was published in Journal of Chemical & Engineering Data. The article was written by Shaahmadi, Fariborz; Hashemi Shahraki, Bahram; Farhadi, Asadollah. The article contains the following contents:

The gas sweetening process requires an efficient solvent with strong absorption capability to capture acid gases from flue gas. Absorption can be strong by a chem. formation (as “”chem.”” absorption) or simple with no chem. reactions (as “”phys.”” absorption). The purpose of the present study was to compare the CO2 solubility of the chem. absorbing ionic liquid, 1-butyl-3-methylimidazolium acetate ([Bmim][Ac]), with the phys. absorbing ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]), as a function of temperature at (298.15 to 318.15) K for pressure up to 50 bar. In addition, the CO2 solubility for binary mixtures containing 75% [Bmim][Ac] + 25% [Bmim][BF4], 50% [Bmim][Ac] + 50% [Bmim][BF4] and 25% [Bmim][Ac] + 75% [Bmim][BF4] are measured over the same temperature range. Henry’s law constants are reported for the solubility of CO2 in the studied pure and mixed ionic liquids The d. of mixed ionic liquids is exptl. measured in T = 298.15 K, 308.15 K, and 318.15 K. The partial molar thermodn. functions of solvation, Gibbs free energy, enthalpy, and entropy are evaluated based on the variation of Henry’s law constants (as a representative of solubility) with temperature In the experiment, the researchers used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Formula: C8H15BF4N2)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Formula: C8H15BF4N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 58-85-5In 2020 ,《Simultaneous Detection of Multiple Tumor Markers in Blood by Functional Liquid Crystal Sensors Assisted with Target-Induced Dissociation of Aptamer》 was published in Analytical Chemistry (Washington, DC, United States). The article was written by Qi, Lubin; Liu, Shuya; Jiang, Yifei; Lin, Jin-Ming; Yu, Li; Hu, Qiongzheng. The article contains the following contents:

Multiplex detection of tumor markers in blood with high specificity and high sensitivity is critical to cancer diagnosis, treatment, and prognosis. Herein, we demonstrate a strategy for simultaneous detection of multiple tumor markers in blood by functional liquid crystal (LC) sensors assisted with target-induced dissociation (TID) of an aptamer for the first time. Magnetic beads (MBs) coated with an aptamer (apt1) are employed to specifically capture target proteins in blood. After incubation of the obtained protein-coated MBs with duplexes of another aptamer (apt2) and signal DNA, sandwich complexes of apt1/protein/apt2 are formed on the MBs due to specific recognition of target proteins by apt2, which induces release of signal DNA into the aqueous solution Subsequently, signal DNA is specifically recognized by highly sensitive DNA-laden LC sensors. Using this strategy, a 3D printed optical cell was employed to enable simultaneous detection of multiple tumor markers such as carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and prostate specific antigen (PSA) with high specificity and high sensitivity. Overall, this effective and low-cost multiplex approach takes advantage of the easy separation of MBs, high specificity of aptamer-based recognition, and high sensitivity of functional LC sensors. Plus, it offers a performance that is competitive to that of com. ELISA kits without potential interference from hemolysis, which makes it very promising in multiplex detection of tumor markers in clin. applications. In the part of experimental materials, we found many familiar compounds, such as 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Related Products of 58-85-5)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Related Products of 58-85-5 And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Imidazolium-based ionic liquids cause mammalian cell death due to modulated structures and dynamics of cellular membrane》 was written by Bakshi, Karishma; Mitra, Saheli; Sharma, Veerendra Kumar; Jayadev, Magani Sri Krishna; Sakai, Victoria Garcia; Mukhopadhyay, Ramaprasad; Gupta, Ashish; Ghosh, Sajal Kumar. Category: imidazoles-derivatives And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2020. The article conveys some information:

Here, we report the toxic effects of various imidazolium-based ionic liquids (ILs) with varying hydrocarbon chain lengths, on different human cell lines. Multiple biol. assays have shown that the ILs with long hydrocarbon chains have stronger adverse effect especially on human liver cancer cells (Huh-7.5 cells). Further, our study has confirmed that the ILs induce necrosis dependent cell death and that it is related to cell membrane damage. To understand the mol. mechanism of such an effect, the cellular membranes were mimicked as lipid monolayers formed at the air-water interface and then as lipid bilayer vesicles. The pressure area-isotherms measured from the monolayer have shown that the interaction of ILs with the lipid layer is energetically favorable. The addition of these ILs reduces the in-plane elasticity of the self-assembled mol. layer. Quasielastic neutron scattering data clearly indicate that ILs in liver lipid vesicles significantly affects the dynamics of the lipid, in particular, the lateral motion of the lipids. It has been concluded that the mammalian cell death induced by these ILs is due to the modulated structure and altered phys. properties of the cellular membrane. In the part of experimental materials, we found many familiar compounds, such as 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Category: imidazoles-derivatives)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,International Journal of Heat and Mass Transfer included an article by Chu, Chunyan; Zhang, Fanbin; Zhu, Chunying; Fu, Taotao; Ma, Youguang. SDS of cas: 174501-65-6. The article was titled 《Mass transfer characteristics of CO2 absorption into 1-butyl-3-methylimidazolium tetrafluoroborate aqueous solution in microchannel》. The information in the text is summarized as follows:

The mass transfer characteristics of CO2 absorption into aqueous solution of ionic liquid in microchannel was investigated exptl. by a high speed camera. The influences of the ratio of gas and liquid flow rates (QG/QL) and the concentration of ionic liquid on the liquid side volumetric mass transfer coefficient (kLa), liquid side mass transfer coefficient (kL) and length of mass transfer zone (LM) were studied systematically. The results show that both kLa and kL increase but LM decreases with the increasing QG/QL and the concentration of ionic liquid Taking the enhancement of 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) on the mass transfer into account, a dimensionless correlation for predicting kLa was proposed. This work is conducive to the design, optimization and the application of the microchannel reactor for CO2 capture and removal. After reading the article, we found that the author used 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6SDS of cas: 174501-65-6)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. SDS of cas: 174501-65-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Artificial Cells, Nanomedicine, and Biotechnology included an article by Nosrati, Hamed; Barzegari, Parisa; Danafar, Hossein; Kheiri Manjili, Hamidreza. HPLC of Formula: 58-85-5. The article was titled 《Biotin-functionalized copolymeric PEG-PCL micelles for in vivo tumour-targeted delivery of artemisinin》. The information in the text is summarized as follows:

Artemisinin is used as an antimalarial and anticancer agent with minimal toxic effects on the host body. Biotin-PEG-PCL polymers have been used for targeted drug delivery to cancer, as well as to improve the pharmacokinetics of the drug and reduce its effects. In this study, biotin-conjugated copolymers were fabricated with polymerization of the ring opening method and the properties of copolymer and nanoparticles were investigated using various techniques. The toxicity of artemisinin and its nanoparticles have been investigated on MCF-7 and normal HFF2 cells. The results showed that the encapsulation efficacy of artemisinin in nanoparticles was 45.5 ± 0.41%. The release profile of the drug indicates that the release is slow and controlled and is approx. pH dependent. The results of artemisinin cell culture on human breast cancer cells showed that biotin-PEG-PCL nanoparticles had an inhibitory effect on MCF-7 cells and had no toxic effects on HFF2 cells. Anticancer activity in vivo in the 4T1 breast cancer model showed that tumor volumes were decreased up 40 mm3 by ART-loaded micelles and 76 mm3 by free ART, compared to the control group (2150 mm). In vivo results showed that this formulation significantly increases the accumulation of substances in the tumors. Therefore, the mol. formulation of ART-based copolymers can be a desirable process for cancer treatment purposes. The experimental part of the paper was very detailed, including the reaction process of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5HPLC of Formula: 58-85-5)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.HPLC of Formula: 58-85-5 The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Biotinylated photoactive Pt(II) anticancer complexes》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Shi, Huayun; Imberti, Cinzia; Huang, Huaiyi; Hands-Portman, Ian; Sadler, Peter J.. COA of Formula: C10H16N2O3S The article mentions the following:

Novel biotinylated diazido-Pt(II) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all-trans-[Pt(py)2(N3)2(biotin)(OH)] (2a) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphol. changes in human ovarian cancer cells treated with 2a. After reading the article, we found that the author used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5COA of Formula: C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.COA of Formula: C10H16N2O3S And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Absorptimetric and fluorimetric study of solvent dependence and prototropism of 2-substituted benzimidazole derivatives》 were Sinha, Hemant K.; Dogra, Sneh K.. And the article was published in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1987. Quality Control of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole The author mentioned the following in the article:

A study of the effects of solvents on the absorption and fluorescence spectra of 2-substituted benzimidazoles showed that the lowest-energy transition of the chloromethyl, dichloromethyl, and cyanomethyl derivatives is of π-π* character, and that of the 5-chloro-2-(trichloromethyl), 2-(trifluoromethyl), and 2-chloro derivatives is of charge-transfer character. In the case of the monocations and monoanions of these compounds, the lowest-energy transitions are of charge-transfer and π-π* nature, resp. The presence of the methylene group between the benzimidazole and the heteroatom substituent reduces direct interaction; this is apparent from the study of proton-transfer reaction as well as from the spectral changes. The pKa values for these reactions in the ground and excited states were determined and discussed. MeCN quenches the fluorescence of the mono-, di-, and trichloromethyl compounds The mechanism could involve charge-transfer complexation.5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Quality Control of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole) was used in this study.

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Quality Control of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acidIn 2019 ,《Making routine native SAD a reality: lessons from beamline X06DA at the Swiss Light Source》 was published in Acta Crystallographica, Section D: Structural Biology. The article was written by Basu, Shibom; Finke, Aaron; Vera, Laura; Wang, Meitian; Olieric, Vincent. The article contains the following contents:

Native single-wavelength anomalous dispersion (SAD) is the most attractive de novo phasing method in macromol. crystallog., as it directly utilizes intrinsic anomalous scattering from native crystals. However, the success of such an experiment depends on accurate measurements of the reflection intensities and therefore on careful data-collection protocols. Here, the low-dose, multiple-orientation data-collection protocol for native SAD phasing developed at beamline X06DA (PXIII) at the Swiss Light Source is reviewed, and its usage over the last four years on conventional crystals (>50μm) is reported. Being exptl. very simple and fast, this method has gained popularity and has delivered 45 de novo structures to date (13 of which have been published). Native SAD is currently the primary choice for exptl. phasing among X06DA users. The method can address challenging cases: here, native SAD phasing performed on a streptavidin-biotin crystal with P21 symmetry and a low Bijvoet ratio of 0.6% is highlighted. The use of intrinsic anomalous signals as sequence markers for model building and the assignment of ions is also briefly described. The experimental part of the paper was very detailed, including the reaction process of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Recommanded Product: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Recommanded Product: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《A biotin-guided fluorescent probe for dual-mode imaging of viscosity in cancerous cells and tumor tissues》 were Ren, Mingguang; Xu, Qingyu; Wang, Shoujuan; Liu, Lu; Kong, Fangong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2020. Recommanded Product: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid The author mentioned the following in the article:

A cancer cell targeted fluorescent viscosity probe has been designed and synthesized to specifically visualise viscosity changes in biotin receptor (BiR) pos. cells over biotin neg. cells via dual-mode fluorescence imaging: fluorescence intensity mode and fluorescence lifetime mode. In the experiment, the researchers used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Recommanded Product: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Recommanded Product: 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Thiol-Cleavable Biotin for Chemical and Enzymatic Biotinylation and Its Application to Mitochondrial TurboID Proteomics》 was written by Li, Haorong; Frankenfield, Ashley M.; Houston, Ryan; Sekine, Shiori; Hao, Ling. COA of Formula: C10H16N2O3SThis research focused onTurboID; cleavable biotin; mitochondrion; proximity labeling; streptavidin. The article conveys some information:

Protein biotinylation via chem. or enzymic reactions is often coupled with streptavidin-based enrichment and on-bead digestion in numerous biol. applications. However, the popular on-bead digestion method faces major challenges of streptavidin contamination, overwhelming signals from endogenous biotinylated proteins, the lost information on biotinylation sites, and limited sequence coverage of enriched proteins. Here, we explored thiol-cleavable biotin as an alternative approach to elute biotinylated proteins from streptavidin-coated beads for both chem. biotinylation and biotin ligase-based proximity labeling. All possible amino acid sites for biotinylation were thoroughly evaluated in addition to the primary lysine residue. We found that biotinylation at lysine residues notably reduces the trypsin digestion efficiency, which can be mitigated by the thiol-cleavable biotinylation method. We then evaluated the applicability of thiol-cleavable biotin as a substrate for proximity labeling in living cells, where TurboID biotin ligase was engineered onto the mitochondrial inner membrane facing the mitochondrial matrix. As a proof-of-principle study, thiol-cleavable biotin-assisted TurboID proteomics achieved remarkable intraorganelle spatial resolution with significantly enriched proteins localized in the mitochondrial inner membrane and mitochondrial matrix. In the experiment, the researchers used many compounds, for example, 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5COA of Formula: C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.COA of Formula: C10H16N2O3S And it has been used as a vitamin supplement for the growth of Bacillus species.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem