Tag: 200-300

The author of 《Synthesis of novel histamine H4 receptor antagonists》 were Lane, Charlotte A. L.; Hay, Duncan; Mowbray, Charles E.; Paradowski, Michael; Selby, Matthew D.; Swain, Nigel A.; Williams, David H.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2012. Formula: C8H4Cl4N2 The author mentioned the following in the article:

This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound I was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution. The experimental process involved the reaction of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Formula: C8H4Cl4N2)

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Formula: C8H4Cl4N2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kocadagistan, B.; Kocadagistan, E.; Topcu, N.; Demircioglu, N. published an article on January 31 ,2005. The article was titled 《Wastewater treatment with combined upflow anaerobic fixed-bed and suspended aerobic reactor equipped with a membrane unit》, and you may find the article in Process Biochemistry (Oxford, United Kingdom).Quality Control of 6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole The information in the text is summarized as follows:

A combined upflow anaerobic fixed-bed, using pumice as a biofilter material, and a suspended aerobic activated sludge bioreactor equipped with a microfiltration (MF) unit has been designed. This system exhibited high performance on the removal of organic matter. COD removal efficiencies were in the range of 94-98.7% with organic loading rates of 3.67-16.56 Kg COD/m3-day. Phosphorous and nitrogenous materials were removed from the wastewater as well as COD. High PO43–P removal efficiencies (96-97%) were achieved. NO2–N and NO3–N concentrations in the effluent of MF were <1.0 mg/L through most experiments Suspended solids in the effluent were below detectable levels. Biofilm development and microbial communities were studied using SEM. The experimental process involved the reaction of 6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole(cas: 3671-65-6Quality Control of 6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole)

6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole(cas: 3671-65-6) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Quality Control of 6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Transferable, Polarizable Force Field for Ionic Liquids》 were Goloviznina, Kateryna; Canongia Lopes, Jose N.; Costa Gomes, Margarida; Padua, Agilio A. H.. And the article was published in Journal of Chemical Theory and Computation in 2019. Name: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate The author mentioned the following in the article:

A general, transferable, polarizable force field for mol. simulation of ionic liquids (ILs) and their mixtures with mol. compounds is developed. This polarizable model is derived from the widely used CL&P fixed-charge force field that describes most families of ILs, in a form compatible with OPLS-AA, one of the major force fields for organic compounds Models for ILs with fixed, integer-ionic charges lead to pathol. slow dynamics, a problem that is corrected when polarization effects are included explicitly. In the model proposed here, Drude-induced dipoles are used with parameters determined from at. polarizabilities. The CL&P force field is modified upon inclusion of the Drude dipoles to avoid double-counting of polarization effects. This modification is based on first-principles calculations of the dispersion and induction contributions to the van der Waals interactions using symmetry-adapted perturbation theory (SAPT) for a set of dimers composed of pos., neg., and neutral fragments representative of a wide variety of ILs. The fragment approach provides transferability, allowing the representation of a multitude of cation and anion families, including different functional groups, without the need to reparametrize. Because SAPT calculations are expensive, an alternative predictive scheme was devised, requiring only mol. properties with a clear phys. meaning, namely, dipole moments and at. polarizabilities. The new polarizable force field, CL&Pol, describes a broad set of ILs and their mixtures with mol. compounds and is validated by comparisons with exptl. data on d., ion diffusion coefficients, and viscosity. The approaches proposed here can also be applied to the conversion of other fixed-charge force fields into polarizable versions. In the experimental materials used by the author, we found 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Name: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. Actually, lonic liquids as innovative fluids have received wide attention only during the past two decades. The number of SCI papers published on lonic liquids has exponentially increased from a few in 1996 to >5000 in 2016, exceeding the annual growth rates of other popular scientific areas. Name: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Avoiding Pre-Isolation Step in Exosome Analysis: Direct Isolation and Sensitive Detection of Exosomes Using Gold-Loaded Nanoporous Ferric Oxide Nanozymes》 were Boriachek, Kseniia; Masud, Mostafa Kamal; Palma, Carlos; Phan, Hoang-Phuong; Yamauchi, Yusuke; Hossain, Shahriar A. Md.; Nguyen, Nam-Trung; Salomon, Carlos; Shiddiky, Muhammad J. A.. And the article was published in Analytical Chemistry (Washington, DC, United States) in 2019. COA of Formula: C10H16N2O3S The author mentioned the following in the article:

Most of the current exosome-anal. strategies are time-consuming and largely dependent on com. extraction kit-based preisolation step, which requires extensive sample manipulations, costly isolation kits, reagents, tedious procedures, and sophisticated equipment and is prone to bias/artifacts. Herein we introduce a simple method for direct isolation and subsequent detection of a specific population of exosomes using an engineered superparamagnetic material with multifunctional properties, namely, gold-loaded ferric oxide nanocubes (Au-NPFe2O3NC). In this method, the Au-NPFe2O3NC were initially functionalized with a generic tetraspanin (exosomes-associated) antibody (i.e., CD63) and dispersed in sample fluids where they work as “”dispersible nanocarriers”” to capture the bulk population of exosomes. After magnetic collection and purification, Au-NPFe2O3NC-bound exosomes were transferred to the tissue-specific, antibody-modified, screen-printed electrode. As a proof of principle, we used a specific placental marker, placenta alk. phosphatase (PLAP), to detect exosomes secreted from placental cells. The peroxidase-like activity of Au-NPFe2O3NC was then used to accomplish an ELISA-based sensing protocol for naked-eye observation along with UV-visible and electrochem. detection of PLAP-specific exosomes present in placental cell-conditioned media. We demonstrated excellent agreement in anal. performance for the detection of placental cell-derived exosomes (i.e., linear dynamic range, 103-107 exosomes/mL; limit of detection, 103 exosomes/mL; relative standard deviation (%RSD) of <5.5% for n = 3) using with and without com. ""total exosome isolation kit""-based preisolation step. We envisage that this highly sensitive, rapid, and inexpensive assay could be useful in quantifying specific populations of exosomes for various clin. applications, focusing on pregnancy complications. The experimental process involved the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5COA of Formula: C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.COA of Formula: C10H16N2O3S And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gupta, Radhey S. published an article on February 27 ,1987. The article was titled 《Identification of 2-benzimidazolylurea as a new antimitotic compound based on cross resistance studies with nocodazole resistant mutants of CHO cells》, and you may find the article in Biochemical and Biophysical Research Communications.Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole The information in the text is summarized as follows:

The cross-resistance patterns of a set of nocodazole  [31430-18-9]-resistant (NocR) and podophyllotoxin  [518-28-5]-resistant (PodR) mutants of Chinese hamster ovary cells, which exhibit highly-specific cross-resistance toward compounds that show nocodazole-like antimitotic activity, towards a large number of benzimidazole derivatives was examined Of the various compounds examined, the NocR and the PodR mutants were found to exhibit increased cross-resistance towards only 2-benzimidazolylurea  [24370-25-0], indicating that this compound may possess similar biol. activity as nocodazole. The nocodazole-like antimitotic activity of 2-benzimidazolylurea was confirmed by its ability to block cells in mitosis, and by its competition of [3H]podophyllotoxin binding to microtubule proteins in cell extracts The nocodazole-like behavior of 2-benzimidazolylurea and lack of similar activity in other benzimidazole derivatives examined, provides valuable information regarding structural features that are required for this type of biol. activity. After reading the article, we found that the author used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole)

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Application In Synthesis of 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Flammability hazard analysis of imidazolium-based ionic liquid binary mixtures under high temperatures》 was written by Li, Yongheng; Pan, Yong; Huang, Gaosheng; Wang, Qingguo; Wei, Qian; Jiang, Juncheng. Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate And the article was included in Journal of Loss Prevention in the Process Industries in 2020. The article conveys some information:

Ionic liquid (IL) mixtures are promising because they can optimize the involved properties according to industrial needs. It has already been demonstrated that IL flammability is due mainly to IL decomposition generating flammable substances. Four different ILs, 1-Butylimidazolium tetrafluoroborate ([BIM][BF4]), 1-butylimidazolium nitrate ([BIM][NO3]), 1-butyl-3-methylimidazolium tetrafluoroborate([BMIM][BF4]), and 1-butyl-3-methylimidazolium nitrate ([BMIM][NO3]), were selected as the parent salts to form the different imidazolium-based IL binary mixtures These mixtures were tested via isothermal thermogravimetric analyzer (TGA) at different temperatures (120, 150, 180, 210, and 240°C), then tested by the flash point analyzer after isothermal heating pretreatment at the above temperatures Results show that the mixtures’ flash point values decrease with the heating temperature increase. Vaporization of the IL mixtures’ decomposition products results in a higher concentration of flammable gases and a flash point decrease, which lead to the flammability hazard increasing. Moreover, results show that the flash points of the studied binary imidazolium IL mixtures are more similar to those of the more unstable IL in their parent ILs. Also, the flammability hazard of IL binary mixtures may obviously increase under the high temperature environment for a long time. In the experiment, the researchers used many compounds, for example, 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Multiple sclerosis (Houndmills, Basingstoke, England) included an article by Couloume, Laura; Barbin, Laetitia; Leray, Emmanuelle; Wiertlewski, Sandrine; Le Page, Emmanuelle; Kerbrat, Anne; Ory, Solenn; Le Port, Damien; Edan, Gilles; Laplaud, David-Axel; Michel, Laure. Related Products of 58-85-5. The article was titled 《High-dose biotin in progressive multiple sclerosis: A prospective study of 178 patients in routine clinical practice.》. The information in the text is summarized as follows:

BACKGROUND: A recent controlled trial suggested that high-dose biotin supplementation reverses disability progression in patients with progressive multiple sclerosis. OBJECTIVE: To analyze the impact of high-dose biotin in routine clinical practice on disability progression at 12 months. METHODS: Progressive multiple sclerosis patients who started high-dose biotin at Nantes or Rennes Hospital between 3 June 2015 and 15 September 2017 were included in this prospective study. Disability outcome measures, patient-reported outcome measures, relapses, magnetic resonance imaging (MRI) data, and adverse events were collected at baseline, 6, and 12 months. RESULTS: A total of 178 patients were included. At baseline, patients were 52.0 ± 9.4 years old, mean Expanded Disability Status Scale (EDSS) score was 6.1 ± 1.3, mean disease duration was 16.9 ± 9.5 years. At 12 months, 3.8% of the patients had an improved EDSS score. Regarding the other disability scales, scores either remained stable or increased significantly. In total, 47.4% of the patients described stability, 27.6% felt an improvement, and 25% described a worsening. Four patients (2.2%) had a relapse. Of the 74 patients (41.6%) who underwent an MRI, 20 (27.0%) had new T2 lesions, 8 (10.8%) had gadolinium-enhancing lesions. Twenty-five (14%) reported adverse event. CONCLUSION: In this study, high-dose biotin did not seem to be associated with a clear improvement in disability. The experimental part of the paper was very detailed, including the reaction process of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Related Products of 58-85-5)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Related Products of 58-85-5 And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《2-(Trihalomethyl)benzazoles. I. Formation》 was published in Journal of the Chemical Society [Section] C: Organic in 1967. These research results belong to Holan, George; Samuel, Eva L.; Ennis, B. C.; Hinde, Ronald W.. Related Products of 3584-66-5 The article mentions the following:

Methods of preparation of 2-(trihalomethyl)benzimidazoles, -benzothiazoles, and -benzoxazoles were investigated. The reaction of the mono salts of o-phenylenediamines, o-aminophenols, and o-aminothiophenols with trichloroacetonitrile or trichloroacetimidate esters affords 2-(trichloromethyl)-substituted benzimidazoles, benzoaxazoles, and benzothiazoles. This method was extended to the preparation of 2-(trichloromethyl)-2-imidazolines. A general method of preparation of 2,2′-bibenzimidazolyl (I) derivatives is also described. 20 references. In the experiment, the researchers used 5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5Related Products of 3584-66-5)

5-Chloro-2-(trichloromethyl)-1H-benzo[d]imidazole(cas: 3584-66-5) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Related Products of 3584-66-5 In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Chemical Engineering Journal (Amsterdam, Netherlands) included an article by Polat, H. Mert; Zeeshan, Muhammad; Uzun, Alper; Keskin, Seda. Application In Synthesis of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate. The article was titled 《Unlocking CO2 separation performance of ionic liquid/CuBTC composites: Combining experiments with molecular simulations》. The information in the text is summarized as follows:

In this work, we propose a computational methodol. based on the state-of-the-art mol. simulations of IL/CuBTC composites composed of ILs having the same cation, 1-n-butyl-3-methylimidazolium ([BMIM]+), and various anions. Using grand canonical Monte Carlo (GCMC) simulations, we predicted CO2, CH4, and N2 uptakes of seven different IL/CuBTC composites and compared the simulation results with our exptl. gas uptake measurements to select the most appropriate force field that best represents the exptl. results. Motivated from the good agreement between experiments and simulations, we applied the same method to estimate the gas adsorption in two new IL/CuBTC composites which have been synthesized and characterized for the first time in this work. Mol. simulations accurately predicted the exptl. gas uptakes of newly synthesized IL/CuBTC composites, validating the transferability of our approach to different types of IL-incorporated CuBTC samples. We also provided a detailed anal. of binary gas mixture separation performances of IL/CuBTC composites and self-diffusion coefficients of gases in the composites performing GCMC and mol. dynamics simulations, resp. Results showed that IL/CuBTC composites have higher CO2/CH4, CO2/N2, and CH4/N2 selectivities than those of CuBTC, demonstrating a broad potential of these composites for CO2 separation from natural gas and flue gas mixtures The combination of experiments and mol. simulations that we described in this study will be useful to efficiently screen various IL/MOF composites to unlock their full potential for gas separation applications. The experimental part of the paper was very detailed, including the reaction process of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6Application In Synthesis of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate)

3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate(cas: 174501-65-6) is a member of lonic liquids. A multidisciplinary study on lonic liquids is emerging, including chemistry, materials science, chemical engineering, and environmental science. More specifically, some important fundamental viewpoints are now different from the original concepts, as insights into the nature of lonic liquids become deeper. For example, the physicochemical properties of lonic liquids are now recognized as ranging broadly from the oft quoted “nonvolatile, non-flammable, and air and water stable” to those that are distinctly volatile, flammable, and unstable. Application In Synthesis of 3-Butyl-1-methyl-1H-imidazol-3-ium tetrafluoroborate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Cellular and molecular gastroenterology and hepatology included an article by Skupsky, Jonathan; Sabui, Subrata; Hwang, Michael; Nakasaki, Manando; Cahalan, Michael D; Said, Hamid M. COA of Formula: C10H16N2O3S. The article was titled 《Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation.》. The information in the text is summarized as follows:

BACKGROUND & AIMS: Biotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis. We previously reported that biotin deficiency also can lead to severe colitis in mice, which is completely reversed with supplementation. Our aim in this study was to determine if high-dose biotin supplementation can provide a therapeutic benefit in a preclinical model for inflammatory bowel disease (IBD) and to identify the molecular mechanism by which this occurs. METHODS: Mice were challenged with dextran sodium sulfate to induce colitis and were treated with 1 mmol/L biotin to induce or maintain remission. Clinical response was monitored by the Disease Activity Index and fecal calprotectin levels. The colon tissue was investigated for histology, length, as well as expression of inflammatory cytokines (interleukin 6, tumor necrosis factor-α, interleukin 1β), intestinal permeability, tight junctions (zonula occludens-1 and claudin-2), and the transcription factor nuclear factor-κB (NF-κB). RESULTS: Biotin therapy led to delayed onset and severity of colitis as well as accelerated healing. There was improvement in the Disease Activity Index, fecal calprotectin levels, colon length, and histology. In addition, biotin-treated mice had reduced expression of inflammatory cytokines, reduced intestinal permeability, and reduced activation of NF-κB. CONCLUSIONS: Oral supplementation with biotin provides benefit for maintenance and induction of remission in the dextran sodium sulfate preclinical model for IBD. Biotin does this by reducing the activation of NF-κB, which prevents the production of inflammatory cytokines and helps maintain the integrity of the intestinal barrier. Clinically, the NF-κB pathway is important in the development of IBD and this finding suggests that biotin may have therapeutic potential for patients with IBD. The results came from multiple reactions, including the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5COA of Formula: C10H16N2O3S)

5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.COA of Formula: C10H16N2O3S And it has been used for blocking endogenous biotin during immunohistology procedures.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem