Tag: 200-300

Biginelli reaction starting directly from alcohols was written by Garima;Srivastava, Vishnu P.;Yadav, Lal Dhar S.. And the article was included in Tetrahedron Letters in 2010.Computed Properties of C10H20N2O4S The following contents are mentioned in the article:

An efficient of one-pot oxidative access to 3,4-dihydropyrimidin-2-(1H)-ones directly from aromatic alcs. under mild conditions is reported. The protocol involves 1-methylimidazolium hydrogen sulfate [Hmim]HSO₄ catalyzed oxidation of aromatic alcs. to aromatic aldehydes with NaNO₃ followed by their cyclocondensation with 1,3-dicarbonyl compounds and urea in the same reaction vessel at 80 °C within 2-4 h to afford 3,4-dihydropyrimidin-2-(1H)-ones in 55-97% overall yields. Thus, the present work utilizing alcs. instead of aldehyde in Biginelli reaction is a valid and green alternative to the classical synthesis of 3,4-dihydropyrimidin-2-(1H)-ones. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Computed Properties of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Computed Properties of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of aethylparabenum catalyzed by task-specific acidic ionic liquid was written by Tan, Feng;Hu, Rong;Yang, Xue-jun;Li, Jun-yang. And the article was included in Xinan Minzu Daxue Xuebao, Ziran Kexueban in 2008.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

P-hydroxybenzoic acid and anhydrous ethanol are used to synthesize aethylparabenum with novel Bronsted activated [Hmim]HSO₄ as the catalyst. The influences of the reaction period, the mole ratio between alc. and acid, and the amount of ionic fluid on the ester yield were investigated. The optimized reaction condition is confirmed, according to which the reaction period should be 2.5 h, the mole ratio between alc. and acid should be 1:1.5, and the amount of ionic fluid should be 3 mL. Under this optimized condition, the ester yield could achieve 81.5%, and the ionic fluid could be used for 5 times repeatedly without any change of its catalytic efficiency. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrothermal synthesis, crystal structures, and photoluminescent properties of two cadmium(II) coordination polymers derived from dicarboxylates and N-donor ligands was written by Xu, Jiakun;Sun, Xiaochun;Ju, Caixia;Yang, Lirong;Bi, Caifeng;Sun, Mi. And the article was included in Journal of Coordination Chemistry in 2013.Product Details of 1374155-84-6 The following contents are mentioned in the article:

Two metal coordination polymers, [Cd(ipa)(L₁)(H₂O)]_n (1) and [Cd(ipa)(L₂)]_n (2) [H₂ipa = isophthalic acid, L₁ = 3,5-bis(imidazol-1-yl)pyridine and L₂ = 3,5-bis(benzoimidazol-1-yl)pyridine], were synthesized and structurally characterized by IR, elemental anal., XRD, and x-ray single-crystal diffraction. Complex 1 shows a 2-fold cds topol. net and 2 features a 3-dimensional pcu topol. net. Luminescent properties of 1 and 2 were studied in the solid state at room temperature This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Product Details of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Indirect electrochemistry oxidation of alcohol to aldehyde in ionic liquid was written by Zhao, Xin-hua;Jiang, Xiao-min;Xie, Jiao. And the article was included in Guangzhou Huagong in 2013.Name: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

The indirect electrochem. oxidation of alc. could be carried out in the protonic ionic liquid methylimidazolium hydrogen sulfate with high selectivity-and current efficiency. The reaction consumed alc. and produced the corresponding aldehyde with the co-product of hydrogen gas in the electrochem. oxidation of alc. Further more, the corresponding carbonyl products could be separated from the electrolyte solution by the refluxing method, and the electrolyte solution could be recycled without apparent decrease in activity. Thus, this approach avoided the problematic by products and separation difficulty in the preparation of the short chain aliphatic aldehydes. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Name: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014 was written by Brodney, Michael A.;Auperin, David D.;Becker, Stacey L.;Bronk, Brian S.;Brown, Tracy M.;Coffman, Karen J.;Finley, James E.;Hicks, Carol D.;Karmilowicz, Michael J.;Lanz, Thomas A.;Liston, Dane;Liu, Xingrong;Martin, Barbara-Anne;Nelson, Robert B.;Nolan, Charles E.;Oborski, Christine E.;Parker, Christine P.;Richter, Karl E. G.;Pozdnyakov, Nikolay;Sahagan, Barbara G.;Schachter, Joel B.;Sokolowski, Sharon A.;Tate, Barbara;Wood, Douglas E.;Wood, Kathleen M.;Van Deusen, Jeffrey W.;Zhang, Lei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate The following contents are mentioned in the article:

A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding Ph acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with robust central efficacy. The reduction of brain Aβ in guinea pigs in the absence of changes in B-cells suggested a potential therapeutic index with respect to APP processing compared with biomarkers of notch related toxicity. Optimization of the FTOC to plasma concentrations at the brain Aβ EC₅₀ lead to the identification of compound I (PF-3084014) which was selected for clin. development. This study involved multiple reactions and reactants, such as Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate).

Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of imidazolium ionic liquids and their catalytic activity in the synthesis of β-enaminones was written by Yin, Wanxiang;Li, Runsheng;Long, Yulin;Li, Ming;Yang, Jun. And the article was included in Jinan Daxue Xuebao, Ziran Kexue Yu Yixueban in 2010.Recommanded Product: 478935-29-4 The following contents are mentioned in the article:

A series of imidazolium ionic liquids ([Hmim]⁺) with different anions were prepared and the catalytic performance of these catalysts for the synthesis of β-enaminones were investigated. The results showed that these [Hmim]⁺-type ionic liquids exhibited excellent activity; [Hmim]BF₄ had the best catalytic performance and had a yield of 96% after 10 min. [Hmim]BF₄ as a catalyst has been used for the synthesis of different β-enaminones and most of the reactions can proceed smoothly. [Hmim]BF₄ was reused five times without considerable loss of activity and had a yield of 89% after 10 min reaction. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Recommanded Product: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clean synthesis of adipic acid by catalytic oxidation of cyclohexene in acidic ionic liquid was written by Wang, Xiaodan;Cui, Tianfang;Yu, Xiulan. And the article was included in Shenyang Huagong Daxue Xuebao in 2012.Related Products of 478935-29-4 The following contents are mentioned in the article:

Without any organic solvent and halide, oxidation of cyclohexene to adipic acid with aqueous 30% hydrogen peroxide catalyzed by tungstic acid/acidic ionic liquids was carried out. When the molar ratio of cyclohexene, tungstic acid, N-methylimidazolium hydrosulfate ([HMM]HSO₄) and hydrogen peroxide was 50:1:5:220 ([HMM]HSO₄, 10 mmol), the isolated yield of adipic acid could reach 90.5% for 7.5 h under reflux temperature Such yield was the same or better than that obtained from the present research. The catalyst was cheap, easily prepared and environment friendly, and it could be recycled easily with no loss of the activity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators was written by Bischoff, Francois;Berthelot, Didier;De Cleyn, Michel;MacDonald, Gregor;Minne, Garrett;Oehlrich, Daniel;Pieters, Serge;Surkyn, Michel;Trabanco, Andres A.;Tresadern, Gary;Van Brandt, Sven;Velter, Ingrid;Zaja, Mirko;Borghys, Herman;Masungi, Chantal;Mercken, Marc;Gijsen, Harrie J. M.. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 1194374-75-8 The following contents are mentioned in the article:

The design and the synthesis of several chem. subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of an aminopyridone into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo potency. This has resulted in the identification of benzimidazole I as a GSM with low nanomolar potency in vitro. In mouse, rat, and dog, this compound displayed the typical γ-secretase modulatory profile by lowering Aβ42 and Aβ40 levels combined with an especially pronounced increase in Aβ38 and Aβ37 levels while leaving the total levels of amyloid peptides unchanged. This study involved multiple reactions and reactants, such as 8-Bromo-2-methylimidazo[1,2-a]pyridine (cas: 1194374-75-8Recommanded Product: 1194374-75-8).

8-Bromo-2-methylimidazo[1,2-a]pyridine (cas: 1194374-75-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1194374-75-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

ESR and polarography of nitro azoles. 4. Polarographic study of nitrobenzimidazoles was written by Lopyrev, V. A.;Larina, L. I.;Baumane, L.;Shibanova, E. F.;Gavars, R.;Ponomareva, S. M.;Vakul’skaya, T. I.;Stradins, J.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1984.Product Details of 93521-65-4 The following contents are mentioned in the article:

The 1st and 2nd polarog. half-wave potentials (E) of benzimidazoles I (R = NMe₂, NH₂, OMe, OEt, Me, H, Cl, etc.) were subjected to correlation anal. The effect of R on the 1st E values was exerted via the inductive and resonance mechanisms to approx. equal degrees; the effect of R on the 2nd E values was exerted primarily via the resonance mechanism. The calculation of a radical-stabilizing factor was discussed. The pK₂ values of I in MeCN range from 16.63 for I (R = cyano) to 23.40 for I (R = Me). This study involved multiple reactions and reactants, such as Methyl 5-Nitro-1H-benzimidazole-2-carboxylate (cas: 93521-65-4Product Details of 93521-65-4).

Methyl 5-Nitro-1H-benzimidazole-2-carboxylate (cas: 93521-65-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 93521-65-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 1,5-benzodiazepine derivatives catalyzed by acidic ionic liquid was written by Xu, Qiu-yan;Ji, Shun-jun;Gu, Da-gong. And the article was included in Hecheng Huaxue in 2005.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

A novel method was reported that 1,5-benzodiazepine derivatives were synthesized via the condensation of o-phenylenediamines with ketones using acidic ionic liquid and alc. as a catalyst system. Target compounds thus prepared included 2,3-Dihydro-2,2,4-trimethyl-1H-1,5-benzodiazepine, 2-ethyl-2,3-dihydro-2,3,4-trimethyl-1H-1,5-benzodiazepine, 2,3,9,10a-tetrahydrospiro[benzo[b]cyclopenta[e][1,4]diazepine-10(1H),1′-cyclopentane], etc. The ionic liquid used in this study was 1-he;yl-3-methyl-1H-imidazolium hydrogen sulfate. This catalyst system can be reused three times. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem