Tag: 300-400

Spectroscopic, quantum mechanical, electronic excitation properties (Ethanol solvent), DFT investigations and molecular docking analysis of an anti-cancer drug Bendamustine was written by Ramana, P. Venkata;Sundius, Tom;Muthu, S.;Mouli, K. Chandra;Krishna, Y. Rama;Prasad, K. Venkata;Devi, R. Niranjana;Irfan, Ahmad;Santhamma, C.. And the article was included in Journal of Molecular Structure in 2022.HPLC of Formula: 16506-27-7 The following contents are mentioned in the article:

In this investigation, optimization geometry of the mol., FT-IR, FT-Raman, and UV-Vis spectra, vibrational frequencies, assigning of suitable vibrational modes of Bendamustine (an anti-cancer drug) were summarised on the grounds of distribution of potential energy. Spectroscopic investigations are attempted by employing DFT/B3LYP with 6-311++G (d, p) level. The output of the computations was implemented to model the spectra of the Bendamustine, which agrees well with the recorded spectra. The TDFT had been utilized to compute the strengths of oscillators. To ascertain the transfer of charge inside the mol. HOMO and LUMO analytics have been utilized. The NBO investigation has been employed to verify the stability of the mol. by observing internal charge transfer, hyperconjugation, and energy of stabilization. Mol. electrostatic potential and Mulliken’s charges were thoroughly studied by using DFT methods. The NLO characteristics of the title drug mol. were investigated with B3LYP and HF basis functionals. The reactive sites and reactivity of the title drug mol. have been extensively studied with help of condensed Fukui functions and global descriptors. The mol. docking investigations of the title drug mol. were executed with the DNA binding protein of Cellular Tumor Antigen P53. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7HPLC of Formula: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clinical characteristics of hospitalized patients with drug-induced acute kidney injury and associated risk factors: a case-control study was written by Yu, Chengxuan;Guo, Daihong;Yao, Chong;Yang, Hongyi;Liu, Siyuan;Zhu, Yu;Kong, Xianghao. And the article was included in BioMed Research International in 2020.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clin. characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alc. abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). The occurrence of D-AKI in hospitalized patients had significant associations with alc. abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reappraisal of the prognostic value of Epstein-Barr virus status in monomorphic post-transplantation lymphoproliferative disorders-diffuse large B-cell lymphoma was written by Kim, Jwa Hoon;Cho, Hyungwoo;Sung, Heungsup;Jung, Ah Ra;Lee, Yoon Sei;Lee, Sang-wook;Ryu, Jin-Sook;Chae, Eun Jin;Kim, Kyoung Won;Huh, Jooryung;Park, Chan-Sik;Yoon, Dok Hyun;Suh, Cheolwon. And the article was included in Scientific Reports in 2021.Category: imidazoles-derivatives The following contents are mentioned in the article:

Abstract: The role of the Epstein-Barr virus (EBV) status in the blood for predicting survival in post-transplantation lymphoproliferative disorders-diffuse large B-cell lymphoma (PTLD-DLBCL) is unknown. We evaluated the prognostic values of pre-treatment EBV-encoded small RNA (EBER) detected with in situ hybridization in tissues and EBV DNA in the whole blood (WB) and plasma in 58 patients with monomorphic PTLD-DLBCL after solid organ transplantation. There were no significant differences in the rates of overall response, complete response, and survival according to EBER EBV and WB EBV status. In contrast, patients with pos. plasma EBV DNA had significantly lower rates of overall response (60.0% vs. 94.4%, P = 0.043) and complete response (40.0% vs. 88.9%, P = 0.019) as well as worse progression-free survival (PFS) (P = 0.035) and overall survival (OS) (P = 0.039) compared with patients with neg. plasma EBV DNA. In multivariate anal., plasma EBV DNA positivity was a significantly unfavorable prognostic factor for PFS [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.22-19.86, P = 0.025] and OS (HR 4.48, 95% CI 1.14-17.63, P = 0.032). Despite small number of 6 patients with plasma EBV positivity, plasma EBV DNA positivity might be more prognostic for survival than EBER or WB EBV DNA positivity in patients with monomorphic PTLD-DLBCL. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Category: imidazoles-derivatives).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Impact of rabeprazole sodium on pharmacokinetics of nimesulide in healthy volunteers: a prospective study from Pakistan was written by Munir, Iqra;Aslam, Bilal;Naseer, Rana Dawood;Mahmood, Asif;Saleem, Uzma;Sultana, Aisha;Muneer, Saiqa;Abrar, Muhammad Asad;Ashraf, Mudassar. And the article was included in Acta Poloniae Pharmaceutica in 2018.COA of Formula: C18H20N3NaO3S The following contents are mentioned in the article:

Nimesulide is mostly being prescribed along proton pump inhibitors such as rabeprazole sodium to reduce gastric irritation and damage. Therefore, present study was aimed to evaluate the effect of rabeprazole sodium on the pharmacokinetics of nimesulide in healthy adult male volunteers. Healthy volunteers (n = 30) participated in this study. After overnight fasting, blood samples (5 mL) were withdrawn at predetermined time intervals i.e. 0, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12 h. After washout period of 15 days, Nimesulide was co-administered with rabeprazole sodium to the same volunteers and blood samples were taken again. Plasma concentration of nimesulide was determined by using HPLC technique. Pharmacokinetic parameters were determined by using pharmacokinetic software APO, MW/PHRAM version 3.02. Results showed that rabeprazole sodium increased the Cmax of nimesulide from 1.21 卤 0.27 mg/L to 1.79 卤 0.18 mg/L and AUC was increased from 12.96 卤 1.34 mg/L.h to 17.46 卤 1.54 mg/L.h. Clearance and Vd of nimesulide were decreased. Elevated plasma levels of nimsulide were observed due to enzymic inhibition effect of rabeprazole sodium. Impact of nimsulide on pharmacokinetics of rabeprazole was successfully determined The knowledge regarding drug – drug interaction would be beneficial for the researchers, health care professionals and patients. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6COA of Formula: C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia was written by Bodaar, Kimberly;Yamagata, Natsuko;Barthe, Anais;Landrigan, Jack;Chonghaile, Triona Ni;Burns, Melissa;Stevenson, Kristen E.;Devidas, Meenakshi;Loh, Mignon L.;Hunger, Stephen P.;Wood, Brent;Silverman, Lewis B.;Teachey, David T.;Meijerink, Jules P.;Letai, Anthony;Gutierrez, Alejandro. And the article was included in Leukemia in 2022.Reference of 16506-27-7 The following contents are mentioned in the article:

Resistance to mitochondrial apoptosis predicts inferior treatment outcomes in patients with diverse tumor types, including T-cell acute lymphoblastic leukemia (T-ALL). However, the genetic basis for variability in this mitochondrial apoptotic phenotype is poorly understood, preventing its rational therapeutic targeting. Using BH3 profiling and exon sequencing anal. of childhood T-ALL clin. specimens, we found that mitochondrial apoptosis resistance was most strongly associated with activating mutations of JAK3. Mutant JAK3 directly repressed apoptosis in leukemia cells, because its inhibition with mechanistically distinct pharmacol. inhibitors resulted in reversal of mitochondrial apoptotic blockade. Inhibition of JAK3 led to loss of MEK, ERK and BCL2 phosphorylation, and BH3 profiling revealed that JAK3-mutant primary T-ALL patient samples were characterized by a dependence on BCL2. Treatment of JAK3-mutant T-ALL cells with the JAK3 inhibitor tofacitinib in combination with a spectrum of conventional chemotherapeutics revealed synergy with glucocorticoids, in vitro and in vivo. These findings thus provide key insights into the mol. genetics of mitochondrial apoptosis resistance in childhood T-ALL, and a compelling rationale for a clin. trial of JAK3 inhibitors in combination with glucocorticoids for patients with JAK3-mutant T-ALL. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Reference of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Validated liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of bendamustine and copanlisib in mouse plasma: Application to a pharmacokinetic study in mice was written by Tripathy, Harsha K.;Manju, S. V. Nair;Bestha, Rama Murthy;Kiran, Vinay;Dittakavi, Sreekanth;Mullangi, Ramesh. And the article was included in Biomedical Chromatography in 2022.Reference of 16506-27-7 The following contents are mentioned in the article:

In this study, we report the development and validation of an LC-tandem mass spectrometry method for the simultaneous quantitation of bendamustine and copanlisib in mouse plasma as per the US FDA regulatory guidelines. The sample processing involves extraction of bendamustine and copanlisib along with internal standard (IS; warfarin) from 50渭L mouse plasma using a liquid-liquid extraction method. The chromatog. separation of bendamustine, copanlisib and the IS was achieved on an Atlantis dC18 column using an isocratic mobile phase (5 mM ammonium acetate:methanol, 20:80 volume/volume). Bendamustine, copanlisib and the IS eluted at 0.88, 1.39 and 0.74 min, resp., with a total run time of 2.5 min. The calibration curve ranged from 3.99-2996 and 4.33-3248 ng/mL for bendamustine and copanlisib, resp. Inter- and intra-day precision and accuracy, stability in processed samples and upon storage, dilution integrity and incurred sample reanal. were investigated for both the analytes. The intra- and inter-day precisions were in the ranges of 2.01%-5.05% and 2.74%-6.13% and 1.98%-7.64 and 8.62%-9.04% for bendamustine and copanlisib, resp. Stability studies showed that both analytes were stable on bench top for 6 h, in auto-sampler for 24 and at -80掳C for 30 days. The validated method was successfully applied to a pharmacokinetic study in mice. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Reference of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Solvent-dependent carbon dots for multifunctional sensing of temperature, pH, and proton pump inhibitors was written by Chen, Piao;Peng, Jingdong;Zhang, Zilong;Wang, Xiang;Zhu, Xiaolan;Fan, Kun;Luo, Pan. And the article was included in Analytica Chimica Acta in 2022.Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Multifunctional sensing, a strategy to improve the efficiency of anal. and detection, has attracted much attention. In this study, a multifunction sensing platform was developed for temperature, pH, and proton pump inhibitors (PPI) with fluorescence carbon dots. Solvent-dependent carbon dots (PG-CDs) were synthesized through a one-step solvothermal method from phloroglucinol with the assistance of HCl. Base on the effect of functional groups on the surface, solvent-dependent behavior, temperature and pH responsive fluorescence can be observed The PG-CDs display a reversible temperature-sensitive fluorescent behavior within 15-65 掳C in N, N-dimethylacetamide. The fluorescence intensity of PG-CDs also responded to pH in a range of 3.0-7.0 with good reversibility and anti-interference. Therefore, the platform for temperature and pH sensing was proposed. In addition, since the synergistic effect of dynamic and static quenching, proton pump inhibitors (PPI) can be detected sensitively, including esomeprazole (EPZ), omeprazole (OPZ), and rabeprazole (RPZ). The linear range of detection for EPZ, OPZ, and RPZ is 2.0-80.0, 2.0-75.0, and 10.0-200.0 渭M and the limits of detection is 0.29, 0.55, and 2.99 渭M, sep. The recoveries for real samples were between 91.83 and 102.3%, which indicated that the platform for PPI sensing had good accuracy. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Identification and verification of m7G modification patterns and characterization of tumor microenvironment infiltration via multi-omics analysis in clear cell renal cell carcinoma was written by Dong, Kai;Gu, Di;Shi, Jiazi;Bao, Yewei;Fu, Zhibin;Fang, Yu;Qu, Le;Zhu, Wentong;Jiang, Aimin;Wang, Linhui. And the article was included in Frontiers in Immunology in 2022.Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

The epigenetic modification of tumorigenesis and progression in neoplasm has been demonstrated in recent studies. Nevertheless, the underlying association of N7- methylguanosine (m⁷ G) regulation with mol. heterogeneity and tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remains unknown. Author explored the expression profiles and genetic variation features of m⁷ G regulators and identified their correlations with patient outcomes in pan-cancer. Three distinct m⁷ G modification patterns, including MGCS1, MGCS2, and MGCS3, were further determined and systematically characterized via multi-omics data in ccRCC. Compared with the other two subtypes, patients in MGCS3 exhibited a lower clin. stage/grade and better prognosis. MGCS1 showed the lowest enrichment of metabolic activities. MGCS2 was characterized by the suppression of immunity. Author then established and validated a scoring tool named m7Sig, which could predict the prognosis of ccRCC patients. This study revealed that m⁷ G modification played a vital role in the formation of the tumor microenvironment in ccRCC. Evaluating the m⁷ G modification landscape helps us to raise awareness and strengthen the understanding of ccRCC’s characterization and, furthermore, to guide future clin. decision making. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Frequency and component analysis of contaminants generated in preparation of anticancer agents using closed system drug transfer devices (CSTDs) was written by Sumikawa, Satomi;Yakushijin, Yoshihiro;Aogi, Kenjiro;Yano, Takuya;Hiroki;Hashimoto;Tsukui, Chiyuki;Noguchi, Tadashi;Shiraishi, Taro;Horikawa, Yasuhiro;Yasuoka, Yasuo;Tanaka, Akihiro;Hidaka, Noriaki;Tanaka, Mamoru. And the article was included in Scientific Reports.COA of Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Occupational exposure of anticancer agents during their preparation has been recognized as a serious hazard. Closed system drug transfer devices (CSTDs) enable “safe” preparation of agents for medical personnel and ensure a safe hospital environment. However, artificial particles of infusion materials have been reported during CSTD use. Here, the incidence of insoluble fine particles during preparation of anticancer agents using CSTDs was examined Visible insoluble fine particles were found in 465 (9.4%) of 4948 treatment cases at Ehime University Hospital with CSTD use. Contaminants occurred more frequently during preparation of monoclonal antibodies than cytotoxic anticancer agents (19.4% vs. 4.1%, resp., P < 0.01). A similar survey was conducted at nine hospitals to investigate the incidence of insoluble fine particles with or without CSTDs. Insoluble fine particles were detected in 113 (15.4%) of 732 treatment cases during preparation of monoclonal antibodies with CSTD use. In contrast, the occurrence of insoluble fine particles without CSTDs was found in only 3 (0.073%) of 4113 treatment cases. Contamination with CSTDs might cause harmful effects on patients during cancer therapy. We strongly recommend the use of in-line filters combined with infusion routes after CSTD use to avoid contamination-associated adverse events. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7COA of Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A comparative study of chiral separation of proton pump inhibitors by supercritical fluid chromatography and high-performance liquid chromatography was written by Raja, Rupak;Alam, Syed Dilshad;Srisath, Vikas;Jain, Arvind Kumar;ALOthman, Zeid A.;Mohammed, Abdallah A. A.;Islam, Mohammad Ataul;Bhatt, Tahir;Ali, Imran. And the article was included in Journal of Separation Science in 2022.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

A comparative study of chiral separation of pantoprazole and rabeprazole is carried out using supercritical fluid chromatog. and high-performance liquid chromatog. The columns used were Chiralpak IA and Chiralpak IE. The best mobile phase in supercritical fluid chromatog. was carbon dioxide-0.2% triethylamine in methanol (60:40) and 0.1% triethylamine in n-hexane-ethanol (50:50) in high-performance liquid chromatog. For supercritical fluid chromatog., values of the retention factor of pantoprazole enantiomers were 3.97 and 4.88. These values for rabeprazole enantiomers were 6.10 and 7.52. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.23 and 1.23 and 2.20 and 3.36, resp. Similarly, for high-performance liquid chromatog., the values of retention factor for enantiomers of pantoprazole were 4.02 and 7.32. These values for rabeprazole enantiomers were 5.32 and 7.88, resp. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.82 and 1.48 and 9.22 and 6.58, resp. A comparison was carried out, which confirmed supercritical fluid chromatog. as the best method due to its fastness, eco-friendly, and inexpensiveness. The reported methods are effective, efficient, and reproducible and may be used to sep. and identify pantoprazole and rabeprazole in any unknown samples. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem