Tag: 300-400

Mohan, T. S. S. Jagan; Varma, Datla Peda; Bhavyasri, Khagga; Prasad, Kancherla; Mukkanti, Khagga; Jogia, Hitesh A. published an article in 2017, the title of the article was HPLC method for determining esomeprazole and its related substances in pharmaceutical formulations.Application of 73590-85-9 And the article contains the following content:

A green, novel, selective, rapid, precise, accurate and simple isocratic reverse phase stability indicating RP-HPLC method has been developed and validated as per ICH guidelines for estimation of esomeprazole and its impurities in pharmaceutical formulations. Inertsil ODS (150 × 4.6 mm, 5 μ) stationary phase by using mobile phase 0.05 % glacial acetic acid and isopropanol in the ratio of 85:15 volume/volume at flow rate of 1.0 mL/min and column temperature of 50 °C. Esomeprazole was detected at 280 nm. The proposed method was validated as per ICH guidelines for precision, accuracy, specificity, robustness and sensitivity. The proposed method proves its stability by resolving esomeprazole peak from its degradation products in forced degradation study. The proposed method is not only eco-friendly but faster than the official method in EP 8.0 by meeting resolution criteria as per the monograph. The proposed method was capable to determine assay of esomeprazole in the presence of its related substances within the same run. The proposed method can be used for routine anal. in quality control laboratories for its pharmaceutical formulations. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to esomeprazole impurity tablet formulation hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Hong; Li, Yuan; Chen, Yan; Zhao, Haipeng published an article in 2015, the title of the article was Main component self-comparison with calibration factor method for determination of related substances in Omeprazole Enteric Capsules.Product Details of 73590-85-9 And the article contains the following content:

Objective: To establish the main component self-comparison with calibration factor method to determine the contents of related substances in Omeprazole Enteric Capsules. Methods: An Agilent HC-C8 column (4.6 mm × 250 mm, 5 μm) was adopted with the mobile phase composed of 0.01 mol·L-1 disodium hydrogen phosphate (adjusted to pH 7.6 with phosphoric acid) and acetonitrile in the ratio of 75:25 pumped at a flow rate of 1.0 mL·min-1. The detection was carried out at 280 nm and a column temperature of 35°C. The injection volume was 20 μL. The slope of linear equation was used to determine the correction factor between impurities A, B, C, D and omeprazole. The relative retention time was used to determine the position of impurities. Results: The relative retention time between impurities A, B, C, D and omeprazole was 0.27, 0.31, 0.41 and 0.79, resp. The correction factor of impurities A, B, C, D was 1.20, 0.58, 0.57 and 1.04, resp. The content of impurity D was 0.022% in three batches of samples. Other impurities were not detected. Conclusion: The method is simple, efficient and accurate for analyzing the related substances in Omeprazole Enteric Capsules. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9

The Article related to omeprazole enteric capsule related substance, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 30, 2016, Koppala, Srinivasarao; Ranga Reddy, V.; Anireddy, Jaya Shree published an article.Electric Literature of 73590-85-9 The title of the article was Development and validation of a novel stability-indicating RP-HPLC method for the simultaneous determination of related substances of ketoprofen and omeprazole in combined capsule dosage form. And the article contained the following:

A novel, simple, sensitive, selective and reproducible stability-indicating high performance liquid chromatog. method was developed for the quant. determination of degradation products and process-related impurities of ketoprofen (KET) and omeprazole (OMZ) in combined oral solid dosage form. Chromatog. separation was achieved on a Phenomenex Luna C18 (2) column (150 × 4.6 mm, 5 μm) under gradient elution by using a binary mixture of potassium dihydrogen phosphate buffer and acetonitrile at a flow rate of 0.8 mL/min. Chromatogram was monitored at 233 nm for KET impurities and at 305 nm for OMZ impurities using a dual wavelength UV detector. Resolution for KET and OMZ and 14 impurities was found to be >1.5 for any pair of components. Typical retention behaviors of impurities at various pH values were depicted graphically. To prove the stability-indicating power of the method, the drug product was subjected to hydrolytic, oxidative, photolytic, humidity and thermal stress conditions as per ICH. The developed method was validated according to the current ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, ruggedness and robustness. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9

The Article related to ketoprofen omeprazole capsule rp hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Electric Literature of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2009, Yang, Chuanbo; Jin, Qingping; Zhang, Hua; Liao, Jian; Zhu, Jin; Yu, Bin; Deng, Jingen published an article.Product Details of 73590-85-9 The title of the article was Tetra(tetraalkylammonium)octamolybdate catalysts for selective oxidation of sulfides to sulfoxides with hydrogen peroxide. And the article contained the following:

A method for the synthesis of the title compounds [i.e., tetrabutylammonium octamolybdate and tetrakis(1-butylpyridinium) octamolybdate] is reported here. Tetra(tetraalkylammonium)octamolybdate catalysts are successfully applied in the selective oxidation of various sulfides to sulfoxides with 30% aqueous hydrogen peroxide as oxidant under mild reaction conditions in 94-100% yield and 95-100% selectivity. The octamolybdate catalysts show high catalytic activity in a high ratio of substrate to catalyst (up to 10000:1) and are recyclable, with actively functional groups, including hydroxyl group and C:C bonds, tolerated in the oxidation The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9

The Article related to octamolybdate ammonium preparation oxidation sulfoxidation catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 2, 2009, Li, Xie; Du, Youguo; Zong, Zaiwei; Chen, Xiangfeng published an article.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Research on synthesis of S-(-)-omeprazole sodium. And the article contained the following:

A method for the synthesis of the title compound [i.e., 6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt (1:1)] is reported here. (-)-Omeprazole was prepared from 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylthio]benzimidazole (i.e., a sulfide derivative) and cumene hydroperoxide by an asym. oxidation method. The product was treated with sodium hydroxide to give S-(-)-omeprazole sodium. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to proton pump inhibitor s omeprazole sodium asym oxidation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 20, 2018, Bong, Yong Koy; Song, Shiwei; Nazor, Jovana; Vogel, Michael; Widegren, Magnus; Smith, Derek; Collier, Steven J.; Wilson, Rob; Palanivel, S. M.; Narayanaswamy, Karthik; Mijts, Ben; Clay, Michael D.; Fong, Ryan; Colbeck, Jeff; Appaswami, Amritha; Muley, Sheela; Zhu, Jun; Zhang, Xiyun; Liang, Jack; Entwistle, David published an article.Electric Literature of 73590-85-9 The title of the article was Baeyer-Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation. And the article contained the following:

A wild-type Baeyer-Villiger monooxygenase was engineered to overcome numerous liabilities to mediate a com. oxidation of pyrmetazole to esomeprazole, using air as the terminal oxidant in an almost exclusively aqueous reaction matrix. The developed enzyme and process compares favorably to the incumbent Kagan inspired chemocatalytic oxidation, as esomeprazole was isolated in 87% yield, in >99% purity, with an enantiomeric excess of >99%. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9

The Article related to baeyer villiger monooxygenase esomeprazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 31, 2008, Koneva, E. A.; Khomenko, T. M.; Kurbakova, S. Yu.; Komarova, N. I.; Korchagina, D. V.; Volcho, K. P.; Salakhutdinov, N. F.; Tolstikov, A. G.; Tolstikov, G. A. published an article.Recommanded Product: 73590-85-9 The title of the article was Synthesis of optically active omeprazole by catalysis with vanadyl complexes with chiral Schiff bases. And the article contained the following:

A new method for the preparation of optically active omeprazole I via asym. oxidation of the corresponding sulfide with the use of vanadyl complexes with chiral Schiff bases as the catalysts has been elaborated. The best yields and enantioselectivity of the oxidation were achieved using the complex of VO(acac)2 with ligand II. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to enantioselective omeprazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 10, 2009, Wan, Huan; Fang, Feng; Duan, Mei-Li; Xu, Xu; Ji, Ya-Fei published an article.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Synthesis of 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (omeprazole). And the article contained the following:

A method for the synthesis of the title compound [i.e., 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, omeprazole] is reported here. Omeprazole is a proton pump inhibitor. A one-pot method was performed for the oxidation and nitration of of 2,3,5-trimethylpyridine to provide 2,3,5-dimethylpyridine N-oxide. The chlorination of that intermediate gave 2-(chloromethyl)-3,5-dimethyl-4-nitropyridine 1-oxide. A reaction of this chloromethyl compound with 2-mercapto-5-methoxybenzimidazole in the presence of excess sodium methoxide simultaneously achieved a condensation and methoxylation to give 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-1-oxido-2-pyridinyl)methyl]thio]-1H-benzimidazole. The target compound was formed by deoxidation with phosphorus trichloride and the oxidation with sodium perborate in an overall yield of 48.7%. The structures of the intermediates and omeprazole were confirmed by 1H NMR and MS. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Song, Weiguo; Dong, Liangjun; Zhou, Yuhan; Fu, Yongqiang; Xu, Wenfang published an article in 2015, the title of the article was Catalytic Asymmetric Synthesis of Esomeprazole by a Titanium Complex with a Hexa-aza-triphenolic Macrocycle Ligand.Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

An efficient synthesis of esomeprazole I via catalytic asym. oxidation of 1H-benzimidazolyl pyridinylmethyl sulfide by a titanium complex with a hexa-aza-triphenolic macrocycle ligand is described. Esomeprazole was prepared with 99.6% ee, which meets the high requirement of the European Pharmacopeia on enantiomeric purity. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to esomeprazole enantioselective synthesis, benzimidazolyl pyridinylmethyl sulfide oxidation titanium complex hexaazatriphenolic macrocycle ligand, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Zhicheng; Kong, Xiaobo; Mai, Wenpeng; Sun, Gangchun; Zhao, Shizhao published an article in 2014, the title of the article was Synthesis of esomeprazole through asymmetric oxidation.Related Products of 73590-85-9 And the article contains the following content:

N,N’-dicyclohexyl-d-tartaric diamide 2a and N,N’-di-[(R)-indan]-d-tartaric diamide 2b were prepared through the reaction of diethyl-d-tartrate with cyclohexylamine and (R)-(-)-1-aminoindan, resp. The two compounds coordinated with iso-Pr titanate (Ti(O-iPr)4), were used as catalyst in the asym. oxidation of pyrmetazol 3 with cumene hydroperoxide (CHP) as oxidant. The results revealed that both the catalytic systems derived from ligand 2a and 2b with Ti(O-iPr)4 showed good catalytic activity and enantioselectivity in the synthesis of esomeprazole. Under the optimized conditions, the yield reached 91%, 91% and the enantio excess (ee) was up to 87%, 89%. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to asym oxidation esomeprazole synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem