Tag: 300-400

Li, Yiming; Rizvi, S. Aal-e-Ali; Hu, Deqing; Sun, Danwen; Gao, Anhui; Zhou, Yubo; Li, Jia; Jiang, Xuefeng published an article in 2019, the title of the article was Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex mols. with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O::U::O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogs by late-stage oxygenation in an atom- and step-efficient manner. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to photooxidation catalyst uranyl sulfide sulfoxide sulfone, oxygen, oxygenation, photocatalysis, sulfides, uranyl catalysis, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acosta-Guzman, Paola; Mahecha-Mahecha, Camilo; Gamba-Sanchez, Diego published an article in 2020, the title of the article was Electrophilic Chlorine from Chlorosulfonium Salts: A Highly Chemoselective Reduction of Sulfoxides.COA of Formula: C17H19N3O2S And the article contains the following content:

A selective late-stage deoxygenation of sulfoxides based on a novel application of chlorosulfonium salts RS+(Cl)R1 (R = Ph, benzyl, benzamidazol-2-yl, pyridin-2-yl, etc.; R1 = Me, Pr, allyl, vinyl, etc.; RR1 = -CH2S(CH2)3-) demonstrates a new process using these species generated in situ from sulfoxides RS(O)R1 as the source of electrophilic chlorine. The use of highly nucleophilic 1,3,5-trimethoxybenzene (TMB) as the reducing agent is described for the first time and applied in the deoxygenation of simple and functionalized sulfoxides. The method is easy to handle, economic, suitable for gram-scale operations, and readily applied for poly-functionalized mols., as demonstrated with more than 45 examples, including com. medicines and analogs. Also results of competition experiments that define the more reactive sulfoxide, and a mechanistic proposal based on substrate and product observations was reported. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to sulfide preparation chemoselective, sulfoxide deoxidation, chemoselectivity, deoxygenation, sulfides, sulfonium salts, sulfoxides, synthetic methods, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Dong; Liu, Zhenlin; Wang, Zhentao; Ma, Xinyue; Yu, Peng published an article in 2019, the title of the article was Metal- and base-free regioselective thiolation of the methyl C(sp3)-H bond in 2-picoline N-oxides.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

A one-pot, two-step synthesis of pyridine-2-ylmethyl thioethers is developed through a TFAA-mediated [3,3]-sigmatropic rearrangement of pyridine N-oxides and TBAB-catalyzed direct conversion of trifluoroacetates into thioethers under metal- and base-free conditions. This methodol. enables thiolation of the unactivated Me C(sp3)-H bond in 2-picolines with thiols. Remarkable features of the method include high regioselectivity, step- and atom-economy, mild conditions, simple operation, wide substrate scope and scalability. Furthermore, the method has been successfully applied to the synthesis of omeprazole sulfide and rabeprazole sulfide without the need for TBAB catalysis. A comprehensive green chem. metrics anal. indicated that this method is much more efficient and greener than the reported synthesis of rabeprazole sulfide. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to aryl pyridylmethyl sulfide preparation, picoline thiophenol regioselective thiolation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 9, 2009, Sousa, Sara C. A.; Fernandes, Ana C. published an article.Formula: C17H19N3O2S The title of the article was Highly efficient and chemoselective reduction of sulfoxides using the system silane/oxo-rhenium complexes. And the article contained the following:

This work reports a novel method for the reduction of sulfoxides with silanes catalyzed by high valent oxo-rhenium(V) and (VII) complexes. The catalytic system PhSiH3/ReIO2(PPh3)2 (1 mol %) proved to be highly efficient for the reduction of a wide range of sulfoxides in excellent yields under mild conditions. This novel methodol. is also highly chemoselective, tolerating several functional groups such as -CHO, -CO2R, -Cl, -NO2, and double or triple bonds. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S

The Article related to chemoselective reduction sulfoxide silane rhenium catalyst, thio ether preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 30, 2014, Baddam, Sudhakar Reddy; Neelam, Uday Kumar; Manne, Naga Raju; Adulla, Panasa Reddy; Bandichhor, Rakeshwar published an article.Application of 73590-85-9 The title of the article was Zinc triflate catalyzed synthesis of thioethers. And the article contained the following:

Zinc triflate-catalyzed aralkylation of thiols using various substituted benzylic alcs. was developed for the synthesis of thioether (sulfide) derivatives This procedure presents a greener approach for the synthesis of sulfides. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to alc thiol thioetherification zinc triflate catalyst green chem, thioether preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 15, 2014, Boix, C.; Ibanez, M.; Zamora, T.; Sancho, J. V.; Niessen, W. M. A.; Hernandez, F. published an article.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Identification of new omeprazole metabolites in wastewaters and surface waters. And the article contained the following:

Omeprazole is 1 of the world-wide most consumed pharmaceuticals for treatment of gastric diseases. As opposed to other frequently used pharmaceuticals, omeprazole is scarcely detected in urban wastewaters and environmental waters. This was corroborated in a previous research, where parent omeprazole was not detected while 4 transformation products (TPs), mainly resulting from hydrolysis, were found in effluent wastewaters and surface waters. However, the low abundance of omeprazole TPs in the H2O samples together with the fact that omeprazole suffers an extensive metabolism, with a wide range of excretion rates (between 0.01 and 30)̂, suggests that human urinary metabolites should be studied in the H2O environment. The results obtained in excretion tests after administration of a 40 mg omeprazole dose in 3 healthy volunteers are reported. Anal. by liquid chromatog. coupled to hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF MS) reported low concentrations of omeprazole in urine. Up to 20-four omeprazole metabolites (OMs) were detected and tentatively elucidated. The most relevant OM was an omeprazole isomer, which obviously presented the same exact mass (m/z 346.1225), but also shared a major common fragment at m/z 198.0589. Subsequent analyses of surface H2O and effluent wastewater samples by both LC-QTOF MS and LC-MS/MS with triple quadrupole revealed that this metabolite (named as OM10) was the compound most frequently detected in H2O samples, followed by OM14a and OM14b. Up to the knowledge, OM10 had not been used before as urinary biomarker of omeprazole in waters. On the contrary, parent omeprazole was never detected in any of the H2O samples. After this research, it seems clear that monitoring the presence of omeprazole in the aquatic environment should be focused on the OMs suggested in this article instead of the parent compound The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole metabolite wastewater surface water urine analysis sample pollution, metabolites, omeprazole, time-of-flight mass spectrometry, triple quadrupole mass spectrometry, urine, water samples and other aspects.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 15, 2014, Nevado, Juan Jose Berzas; Penalvo, Gregorio Castaneda; Dorado, Rosa Maria Rodriguez; Robledo, Virginia Rodriguez published an article.COA of Formula: C17H19N3O2S The title of the article was Simultaneous determination of omeprazole and their main metabolites in human urine samples by capillary electrophoresis using electrospray ionization-mass spectrometry detection. And the article contained the following:

The authors report a novel method for the simultaneous determination of omeprazole and their main metabolites (omeprazole sulfide, omeprazole sulfone and 5-hydroxy omeprazole) in human urine samples. For this purpose, two new capillary electrophoresis (CE) methods were developed for the simultaneous determination of target compounds, using initially diode-array for optical detection and electrospray ionization-mass spectrometry (ESI-MS) for metabolites identification and identity confirmation. A new metabolite (5-hydroxysulfide omeprazole) was identified by electrospray ionization multi-stage mass spectrometry (ESI-MS2) fragment which was then used to support the proposed chem. structure. Pharmacokinetic results using CE method were compared with those obtained when a HPLC method was used. Equivalent pharmacokinetics profiles resulted when any anal. methods were carried out. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to omeprazole metabolite capillary electrophoresis electrospray ionization mass spectrometry, capillary electrophoresis-mass spectrometry, human urine, metabolites, omeprazole, pharmacokinetics and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 10, 2017, Shen, Chao; Qiao, Jun; Zhao, Linwei; Zheng, Kai; Jin, Jianzhong; Zhang, Pengfei published an article.Related Products of 73590-85-9 The title of the article was An efficient silica supported Chitosan@vanadium catalyst for asymmetric sulfoxidation and its application in the synthesis of esomeprazole. And the article contained the following:

A new type of silica supported chitosan@vanadium complex was used as a highly active heterogeneous catalyst for asym. oxidation of aryl alkyl sulfides. With the economic aqueous H2O2 (30%) as the oxidant, the oxidation products were obtained in high yields (up to 95%) with good enantioselectivities (up to 68% ee). It was noted that the marketed drug Nexium (first proton-pump inhibitor, esomeprazole) was synthesized easily by the newly developed asym. sulfoxidation reaction. In addition, the highly active catalyst was reused five times without losing its catalytic activity. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to reusable slica support chitosan vanadium complex catalyst preparation, aryl alkyl sulfide chitosan vanadium complex catalyst sulfoxidation, sulfoxide aryl alkyl enantioselective preparation and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 15, 2014, Boix, C.; Ibanez, M.; Zamora, T.; Sancho, J. V.; Niessen, W. M. A.; Hernandez, F. published an article.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Identification of new omeprazole metabolites in wastewaters and surface waters. And the article contained the following:

Omeprazole is 1 of the world-wide most consumed pharmaceuticals for treatment of gastric diseases. As opposed to other frequently used pharmaceuticals, omeprazole is scarcely detected in urban wastewaters and environmental waters. This was corroborated in a previous research, where parent omeprazole was not detected while 4 transformation products (TPs), mainly resulting from hydrolysis, were found in effluent wastewaters and surface waters. However, the low abundance of omeprazole TPs in the H2O samples together with the fact that omeprazole suffers an extensive metabolism, with a wide range of excretion rates (between 0.01 and 30)̂, suggests that human urinary metabolites should be studied in the H2O environment. The results obtained in excretion tests after administration of a 40 mg omeprazole dose in 3 healthy volunteers are reported. Anal. by liquid chromatog. coupled to hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF MS) reported low concentrations of omeprazole in urine. Up to 20-four omeprazole metabolites (OMs) were detected and tentatively elucidated. The most relevant OM was an omeprazole isomer, which obviously presented the same exact mass (m/z 346.1225), but also shared a major common fragment at m/z 198.0589. Subsequent analyses of surface H2O and effluent wastewater samples by both LC-QTOF MS and LC-MS/MS with triple quadrupole revealed that this metabolite (named as OM10) was the compound most frequently detected in H2O samples, followed by OM14a and OM14b. Up to the knowledge, OM10 had not been used before as urinary biomarker of omeprazole in waters. On the contrary, parent omeprazole was never detected in any of the H2O samples. After this research, it seems clear that monitoring the presence of omeprazole in the aquatic environment should be focused on the OMs suggested in this article instead of the parent compound The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole metabolite wastewater surface water urine analysis sample pollution, metabolites, omeprazole, time-of-flight mass spectrometry, triple quadrupole mass spectrometry, urine, water samples and other aspects.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 15, 2014, Nevado, Juan Jose Berzas; Penalvo, Gregorio Castaneda; Dorado, Rosa Maria Rodriguez; Robledo, Virginia Rodriguez published an article.COA of Formula: C17H19N3O2S The title of the article was Simultaneous determination of omeprazole and their main metabolites in human urine samples by capillary electrophoresis using electrospray ionization-mass spectrometry detection. And the article contained the following:

The authors report a novel method for the simultaneous determination of omeprazole and their main metabolites (omeprazole sulfide, omeprazole sulfone and 5-hydroxy omeprazole) in human urine samples. For this purpose, two new capillary electrophoresis (CE) methods were developed for the simultaneous determination of target compounds, using initially diode-array for optical detection and electrospray ionization-mass spectrometry (ESI-MS) for metabolites identification and identity confirmation. A new metabolite (5-hydroxysulfide omeprazole) was identified by electrospray ionization multi-stage mass spectrometry (ESI-MS2) fragment which was then used to support the proposed chem. structure. Pharmacokinetic results using CE method were compared with those obtained when a HPLC method was used. Equivalent pharmacokinetics profiles resulted when any anal. methods were carried out. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to omeprazole metabolite capillary electrophoresis electrospray ionization mass spectrometry, capillary electrophoresis-mass spectrometry, human urine, metabolites, omeprazole, pharmacokinetics and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem