Tag: 300-400

On March 10, 2017, Shen, Chao; Qiao, Jun; Zhao, Linwei; Zheng, Kai; Jin, Jianzhong; Zhang, Pengfei published an article.Related Products of 73590-85-9 The title of the article was An efficient silica supported Chitosan@vanadium catalyst for asymmetric sulfoxidation and its application in the synthesis of esomeprazole. And the article contained the following:

A new type of silica supported chitosan@vanadium complex was used as a highly active heterogeneous catalyst for asym. oxidation of aryl alkyl sulfides. With the economic aqueous H2O2 (30%) as the oxidant, the oxidation products were obtained in high yields (up to 95%) with good enantioselectivities (up to 68% ee). It was noted that the marketed drug Nexium (first proton-pump inhibitor, esomeprazole) was synthesized easily by the newly developed asym. sulfoxidation reaction. In addition, the highly active catalyst was reused five times without losing its catalytic activity. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to reusable slica support chitosan vanadium complex catalyst preparation, aryl alkyl sulfide chitosan vanadium complex catalyst sulfoxidation, sulfoxide aryl alkyl enantioselective preparation and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 18, 2008, Sun, Jiangtao; Yang, Minghua; Dai, Zhenya; Zhu, Chengjian; Hu, Hongwen published an article.Electric Literature of 73590-85-9 The title of the article was Synthesis of optically active 2,5-dialkylcyclohexane-1,4-diols and their application in the asymmetric oxidation of sulfides. And the article contained the following:

A simple and efficient approach to obtain optically pure 1,4-diols was established. The asym. oxidation of sulfides to sulfoxides with cumyl hydroperoxide in moderate yields and moderate to high enantioselectivities (≤84%) catalyzed by chiral Ti/1,4-diols complexes was achieved. An ee of 76% was obtained in the asym. synthesis of esomeprazole. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9

The Article related to alkylcyclohexanediol resolution chiral ligand titanium catalyzed asym oxidation, sulfide asym oxidation titanium catalyst, thioether asym oxidation titanium catalyst, sulfoxide asym synthesis, esomeprazole asym synthesis and other aspects.Electric Literature of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 31, 2009, Jiang, Biao; Zhao, Xiao-Long; Dong, Jia-Jia; Wang, Wan-Jun published an article.Formula: C17H19N3O2S The title of the article was Catalytic asymmetric oxidation of heteroaromatic sulfides with tert-butyl hydroperoxide catalyzed by a titanium complex with a new chiral 1,2-diphenylethane-1,2-diol ligand. And the article contained the following:

Heteroaromatic sulfoxides, especially 1H-benzimidazolyl pyridinylmethyl sulfoxides, usually used as the blockbuster gastric proton pump inhibitors (PPIs), have been prepared highly enantioselectivity by catalytic asym. oxidation of sulfides attached to nitrogen-containing heterocycles with tert-Bu hydroperoxide in the presence of a chiral titanium complex, formed in situ from Ti(iPrO)4, chiral 1,2-diphenylethane-1,2-diol and water. The chiral sulfoxides were obtained in high yield (97%) with excellent enantiomeric excess (up to 98%). The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S

The Article related to benzimidazolyl pyridinylmethyl benzyl sulfide tertbutyl hydroperoxide titanium, chiral diphenylethane diol asym oxidation sulfoxide stereoselective preparation, asym oxidation catalyst titanium chiral diphenylethane diol and other aspects.Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 1, 2017, Talsi, Evgenii P.; Bryliakov, Konstantin P. published an article.Category: imidazoles-derivatives The title of the article was Ti-Salan catalyzed asymmetric sulfoxidation of pyridylmethylthiobenzimidazoles to optically pure proton pump inhibitors. And the article contained the following:

The asym. sulfoxidation of two pyridylmethylthiobenzimidazoles to anti-ulcer drugs of the PPI family (S)-omeprazole and (R)-lansoprazole with hydrogen peroxide, mediated by a series of chiral titanium(IV) salan complexes was reported. High sulfoxide yields (up to >95%) and enantioselectivities (up to 94% ee) were achieved. The introduction of electron-withdrawing substituents leaded to less active and less enantioselective catalysts. Like for the previously reported Ti-salalen catalyzed sulfoxidations, the temperature dependence of the sulfoxidation enantioselectivity in the presence of Ti-salan complexes was nonmonotonic, demonstrating isoinversion behavior with decreasing temperature The oxidation was likely rate-limited by the formation of the active (presumably peroxotitanium(IV)) species, followed by a faster oxygen transfer to the substrate. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Category: imidazoles-derivatives

The Article related to titanium salan complex catalyst preparation, pyridylmethylthiobenzimidazole titanium salan complex catalyst sulfoxidation, pyridylmethyl benzimidazolyl sulfoxide preparation chemoselective enantioselective green chem and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 2017, Jang, Hyun-Hee; Ryu, Sang-Hoon; Le, Thien-Kim; Doan, Tiep Thi My; Nguyen, Thi Huong Ha; Park, Ki Deok; Yim, Da-Eun; Kim, Dong-Hyun; Kang, Choong-Kyung; Ahn, Taeho; Kang, Hyung-Sik; Yun, Chul-Ho published an article.Synthetic Route of 73590-85-9 The title of the article was Regioselective C-H hydroxylation of omeprazole sulfide by Bacillus megaterium CYP102A1 to produce a human metabolite. And the article contained the following:

Objectives: To find a simple enzymic strategy for the efficient synthesis of the expensive 5′-hydroxyomeprazole sulfide, a recently identified minor human metabolite, from omeprazole sulfide, which is an inexpensive substrate. Results: The practical synthetic strategy for the 5′-OH omeprazole sulfide was accomplished with a set of highly active CYP102A1 mutants, which were obtained by blue colony screening from CYP102A1 libraries with a high conversion yield. The mutant and even the wild-type enzyme of CYP102A1 catalyzed the high regioselective (98 %) C-H hydroxylation of omeprazole sulfide to 5′-OH omeprazole sulfide with a high conversion yield (85-90 %). Conclusions: A highly efficient synthesis of 5′-OH omeprazole sulfide was developed using CYP102A1 from Bacillus megaterium as a biocatalyst. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Synthetic Route of 73590-85-9

The Article related to regioselective carbon hydrogen hydroxylation omeprazole sulfide bacillus megaterium cyp102a1, 5-hydroxyomeprazole sulphide, cyp102a1 mutant, human metabolite, hydroxylation, omeprazole sulfide, regioselectivity and other aspects.Synthetic Route of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ding, Fangwei; Jiang, Yanqiu; Gan, Shaoyan; Bao, Robert Li-Yuan; Lin, Kaifeng; Shi, Lei published an article in 2017, the title of the article was B(C6F5)3-Catalyzed Deoxygenation of Sulfoxides and Amine N-Oxides with Hydrosilanes.Synthetic Route of 73590-85-9 And the article contains the following content:

An efficient strategy for the deoxygenation of sulfoxides and amine N-oxides by using B(C6F5)3 and hydrosilanes was developed. This method provided the corresponding aromatic and aliphatic sulfides/amines in good to high yields and showed good functional-group tolerance under mild conditions. This protocol should be very useful in the future because of its ease of operation, the environmentally friendly reaction conditions and wide scope. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Synthetic Route of 73590-85-9

The Article related to sulfide green preparation, sulfoxide deoxygenation phenylsilane tris pentafluorophenyl borane catalyst, amine green preparation, deoxygenation amine oxide phenylsilane tris pentafluorophenyl borane catalyst and other aspects.Synthetic Route of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gaudencio, Susana P.; Pereira, Florbela published an article in 2020, the title of the article was A computer-aided drug design approach to predict marine drug-like leads for SARS-CoV-2 main protease inhibition.Recommanded Product: 73590-85-9 And the article contains the following content:

The investigation of marine natural products (MNPs) as key resources for the discovery of drugs to mitigate the COVID-19 pandemic is a developing field. In this work, computer-aided drug design (CADD) approaches comprising ligand- and structure-based methods were explored for predicting SARS-CoV-2 main protease (Mpro) inhibitors. The CADD ligand-based method used a quant. structure-activity relationship (QSAR) classification model that was built using 5276 organic mols. extracted from the ChEMBL database with SARS-CoV-2 screening data. The best model achieved an overall predictive accuracy of up to 67% for an external and internal validation using test and training sets. Moreover, based on the best QSAR model, a virtual screening campaign was carried out using 11,162 MNPs retrieved from the Reaxys database, 7 inhouse MNPs obtained from marine-derived actinomycetes by the team, and 14 MNPs that are currently in the clin. pipeline. All the MNPs from the virtual screening libraries that were predicted as belonging to class A were selected for the CADD structure-based method. In the CADD structure-based approach, the 494 MNPs selected by the QSAR approach were screened by mol. docking against Mpro enzyme. A list of virtual screening hits comprising fifteen MNPs was assented by establishing several limits in this CADD approach, and five MNPs were proposed as the most promising marine drug-like leads as SARS-CoV-2 Mpro inhibitors, a benzo[f]pyrano[4,3-b]chromene, notoamide I, emindole SB beta-mannoside, and two bromoindole derivatives The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to computer aided drug sars cov protease inhibition, actinomycetes, drug discovery, machine learning (ml) techniques, main protease enzyme (mpro), marine natural products (mnps), molecular docking, quantitative structure–activity relationship (qsar), severe acute respiratory syndrome coronavirus 2 (sars-cov-2), virtual screening and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boix, C.; Ibanez, M.; Sancho, J. V.; Niessen, W. M. A.; Hernandez, F. published an article in 2013, the title of the article was Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry: degradation experiments.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Omeprazole is one of the most consumed pharmaceuticals around the world. However, this compound is scarcely detected in urban wastewater and surface water. The absence of this pharmaceutical in the aquatic ecosystem might be due to its degradation in wastewater treatment plants, as well as in receiving water. Different laboratory-controlled degradation experiments were carried out on surface water to elucidate omeprazole transformation products (TPs). Surface water spiked with omeprazole was subjected to hydrolysis, photo-degradation under both sunlight and UV radiation and chlorination. Analyses by liquid chromatog. coupled to quadrupole time-of-flight mass spectrometry (LC-QTOF MS) permitted identification of ≤17 omeprazole TPs. In a subsequent step, the TPs identified were sought in surface water and urban wastewater by LC-QTOF MS and by LC coupled to tandem mass spectrometry with triple quadrupole. The parent omeprazole was not detected in any of the samples, but 4 TPs were found in several water samples. The most frequently detected compound was OTP 5 (omeprazole sulfide), which might be a reasonable candidate to be included in monitoring programs rather than the parent omeprazole. Copyright pr 2013 John Wiley & Sons, Ltd. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole water liquid chromatog mass spectrometry degradation, omeprazole, surface water, time-of-flight mass spectrometry, transformation/degradation products, triple quadrupole mass spectrometry, ultra-high-performance liquid chromatography, urban wastewater and other aspects.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chesnokov, V. V.; Shevchenko, M. A.; Soliev, S. B.; Tafeenko, V. A.; Chernyshev, V. M. published their research in Russian Chemical Bulletin in 2021. The article was titled 《Complexes LNi(Cp)X with alkylamino-substituted N-heterocyclic carbene ligands (L) and their catalytic activity in the Suzuki-Miyaura reaction》.SDS of cas: 141556-45-8 The article contains the following contents:

New nickel(II) complexes of the general formula LNi(Cp)X (L is an N-heterocyclic carbene (NHC) ligand of the 1,2,4-triazole or imidazole series; Cp is the cyclopentadienyl anion; X = Cl, I) are reported. In these complexes, the NHC ligands (L) contain an alkylamino group at the 3 or 4 position of the heterocycle. The synthesized complexes and structurally similar complexes without an alkylamino group were tested for catalytic activity in the Suzuki-Miyaura reaction. The introduction of an alkylamino group into the NHC ligand leads to the enhancement of the catalytic activity of complexes with N,N’-diaryl-substituted NHC ligands of the imidazole series and a decrease in the activity of the complexes with N,N’-dialkyl-substituted NHC ligands of the 1,2,4-triazole series. In the experimental materials used by the author, we found 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8SDS of cas: 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.SDS of cas: 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Wei-Ze; Wang, Zhong-Xia published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Nickel-catalyzed coupling of R2P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols》.Application of 141556-45-8 The article contains the following contents:

α-Alkylation of methyldiarylphosphine oxides with (hetero)arylmethyl alcs. was performed under nickel catalysis. Various arylmethyl and heteroarylmethyl alcs. can be used in this transformation. A series of methyldiarylphosphine oxides were alkylated with 30-90% yields. Functional groups on the aromatic rings of methyldiarylphosphine oxides or arylmethyl alcs. including OMe, NMe2, SMe, CF3, Cl, and F groups can be tolerated. The conditions are also suitable for the α-alkylation reaction of dialkyl methylphosphonates. After reading the article, we found that the author used 1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8Application of 141556-45-8)

1,3-Dimesityl-1H-imidazol-3-ium chloride(cas: 141556-45-8) is a ligand for arylation of aldehydes and for carbene catalyzed intermolecular arylation of C-H bonds. It is used as a phosphine-free ligand in various metal-catalyzed coupling reactions, often with advantageous results in difficult cases.Application of 141556-45-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem