Tag: M.W=0-100

Synthetic Route of 616-47-7, A common heterocyclic compound, 616-47-7, name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Triethyl amine (5OmL) is added to a solution of methyl imidazol (16.3g, 199mmol) in acetonitrile (10OmL), then it is cooled to -300C. A solution of ethyl chloroformate (3ImL, 328mmol) in acetonitrile (5OmL) is added slowly keeping the temperature bellow 100C. The reaction mixture is concentrated and diluted in water and extracted with chloroform, dried with MgSO4 anh, filtered and evaporated. Recrystallisation from ether yields l-Methyl-lH-imidazole-2- carboxylic acid ethyl ester as an orange oil (15.5g, 51%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BIOFOCUS DPI LIMITED; WO2009/24585; (2009); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., name: 2-Ethyl-1H-imidazole

The after-dihydro-furo indanol (6,1.76g, 10mmol) was dissolved in toluene (in 80 ml of), was added thionyl chloride (4.91ml, 30.4mmol), for 2 hours at 55 was heated with stirring, and concentrated under reduced pressure , was prepared chloro; which was dissolved in toluene or acetonitrile solvent (in 80 ml of), was added 2-ethyl imidazole (2.88g, 30mmol), the reaction was stirred at reflux for 24-48 hours. after the solvent was concentrated under reduced pressure, purified by silica gel column chromatography chromatography (100-200 mesh), petroleum ether – ethyl acetate (3:1 ? 1:1) as eluent, to give preparation of 1- (furo-dihydro-inden-alkoxy) -2-ethyl imidazole (8c, 1.52 g), yield 60%;

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Yunnan University; Yang Xiaodong; Zhang Hongbin; Chen Wen; Wang Xuequan; Yang Lijuan; Li Liang; (38 pag.)CN102766135; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7098-07-9, name is 1-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., Product Details of 7098-07-9

1,4-butane sultone(14. 98 g, 0.1 mol) was slowly added to a solution of N-ethylimidazole (9. 61 g,0. 1 mol) for 28 h stirring, temperature control 30 ° C, the reactants into solid,Washed thoroughly with ether and dried in an infrared oven. Take the above solid 7. 88g in a three-necked flask,The aqueous solution of periodic acid (9.12 g, 0.04 mol) was slowly added and stirred at 90 ° C for 18 h,Vacuum steam separation to obtain [HSO3-BEIM] IO4 | ionic liquid oxidant.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; China Petroleum and Chemical Corporation; China Petroleum and Chemical Corporation,Petrochemical Research Institute; ZHAO, JUNQI; CHENG, SHIBIAO; MU, XUHONG; ZONG, BAONING; DING, JING; DAI, WEILIN; (17 pag.)CN106279035; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-47-7, name is 1-Methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H6N2

General procedure: N-methyl imidazole (17.53 ml, 0.22 mol) and 1,4-butane sultone (20.5 ml, 0.20mol) were dissolved in toluene (60 ml) and stirred for 8h at 60ºC under nitrogen atmosphere. The white zwitter ion solid so formed was filtered and washed repeatedly with diethyl ether (3 × 40 ml) to remove non-ionic residues.The resulting solid (MIM-BS) was dried in vacuum for 8h. The MIM-BS (10.0 gm,0.0463 mol) was dissolved in water (2 ml) with constant stirring.Methanesulfonic acid (3 ml, 0.0463 mol) was taken in water (1 ml) and added to the reaction contents dropwise. The mixture was stirred for 6h at 85ºC. After completion of the reaction, water was removed and contents were dried for 24h under reduced pressure. The resulting colorless viscous liquid was stored in dry box for further use.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 616-47-7.

Reference:
Article; Garg, Bhaskar; Ling, Yong-Chien; Tetrahedron Letters; vol. 53; 42; (2012); p. 5674 – 5677;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7098-07-9, name is 1-Ethyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H8N2

(1) in the equipped with a stirrer,thermometer,Calcium chloride drying tube and dropping funnel500 ml four-necked flask6.10 g (0.05 mol) of 1,3-propanesultone and150 mL of ethyl acetate was added and the mixture was stirred1,3-propane sultone dissolved,The flask was heated in an oil bath equipped with methyl silicone oil70 ° C,Slowly drop dissolved(0.065 mol) of N-ethylimidazole50 mL of ethyl acetate was added dropwise(Dropwise addition time: 30 min)Insulation reaction 2h,Pressure filtration,The residue was washed with ethyl acetate,Vacuum drying,To give 1- (3-sulfopropyl) -3-ethylimidazolium salt (EIm-PS)10.20 g,The yield was 93.6percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7098-07-9.

Reference:
Patent; Guangxi Kemao Forest Chemical Co., Ltd.; Jiangxi Jinan Forest Products Industrial Co., Ltd.; Guangdong Komo Co., Ltd.; Weng, Liang; Xu, Sheyang; Chen, Jiuji; (16 pag.)CN104926664; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 616-47-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 616-47-7 as follows.

To a solution of N-methylimidazole (1.64 g, 19.97 mmol) and sodium acetate (25 g, 300 mmol) in acetic acid (180 mL) at room temperature was added bromine (9.6 g, 60.07 mmol) dropwise as a solution in 20 mL acetic acid. The resulting mixture was stirred for 2.5 h at room temperature. Acetic acid was removed in vacuo, the residue was suspended in 500 mL water and stirred at room temperature for 10 minutes. The resultant precipitate was filtered, washed with water and dried under high vacuum to give 2,4,5-tribromo-l-methyl- lH-imidazole (1.82 g, 29% – some product remained in the mother liquor) as a light yellow powder. Used without further characterization. To a suspension of the tribromide (1.82 g, 5.71 mmol) in 45 mL water was added sodium sulfite (13 g, 103 mmol) and the resulting mixture was stirred at rapid reflux for 24 h. After cooling to room temperature, organics were extracted with ether (3 chi 75 mL), dried over magnesium sulfate, filtered and concentrated to give 1.61 g of a mixture of tri-, di- and monobromoimidazoles. This mixture was re-subjected to the reduction conditions (same quantity of sodium sulfite) using 15 mL of 3: 1 water/acetic acid as solvent and heating in a sealed vessel at 130 C for 60 h. After cooling to room temperature, the pH of the reaction mixture was adjusted to 9-10 by addition of 2 N sodium hydroxide. Organics were extracted with ether (3 chi 50 mL), dried over magnesium sulfate, filtered and concentrated to give crude 4-bromo-l -methyl- lH-imidazole (571 mg, ca. 62%). Used without further characterization.. 4-Butyl-l -methyl- lH-imidazole (95 mg, 22 %) was synthesized as in Example 3.1 using 4-bromo-l -methyl- lH-imidazole (571 mg, ca. 3.53 mmol) in place of 5-bromo-2- formylfuran and propylboronic acid (372 mg, 4.24 mmol) in place of hexylboronic acid. Used without further characterization. To a solution of diisopropylamine (0.13 mL, 0.918 mmol) in 2 mL anhydrous tetrahydrofuran at – 0C was added -butyllithium (0.34 mL, 2.5 M in hexanes) dropwise. The solution was stirred while warming to -20 C over 20 minutes. After cooling to -78 C, 4-butyl-l -methyl- lH-imidazole (95 mg, 0.765 mmol) was added dropwise as a solution in 2 mL anhydrous tetrahydrofuran. The resulting solution was stirred for 40 minutes at -78 C. Dimethylformamide (0.24 mL, 3.06 mmol) was added and the solution stirred while warming to room temperature. The reaction mixture was poured into 15 mL of 1 N hydrochloric acid and stirred for 5 minutes. The pH of the reaction mixture was adjusted to 7-8 by careful addition of saturated sodium bicarbonate solution. Organics were extracted with dichloromethane (3 chi 20 mL), dried over magnesium sulfate, filtered and concentrated. The crude residue was subjected to chromatography on silica gel with gradient elution (5-50% ethyl acetate in hexanes) to give l -methyl-4-propyl-lH-imidazole-2-carbaldehyde (9 mg, 8%) as an off-white solid. Used without further characterization

According to the analysis of related databases, 616-47-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; PROVID PHARMACEUTICALS INC.; EBRIGHT, Richard H.; EBRIGHT, Yon W.; SHEN, Juan; BACCI, James; HIEBEL, Anne-Cecile; SOLVIBILE, William; SELF, Christopher; OLSON, Gary; WO2013/192352; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of imidazole 5 (20.4 g, 0.3 mol) in 95% sulfuric acid(60 mL), was heated up to 70 C and 60 mL of 65% nitric acid wasadded dropwise thereto. The temperature of the resulting mixturewas then elevated to 100 C and refluxed for 5 h. The reaction solutionwaspoured onto 100 g crushed ice and neutralized with 25%ammonia solution. Filtration, washing and drying were furtherperformed to give 6 as a white solid (23 g, 67% yield); mp:311-312 C (lit. mp 310-311 C) [40].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.

Reference:
Article; Shirvani, Pouria; Fassihi, Afshin; Saghaie, Lotfollah; Van Belle, Siska; Debyser, Zeger; Christ, Frauke; Journal of Molecular Structure; vol. 1202; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 288-32-4, These common heterocyclic compound, 288-32-4, name is 1H-Imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Cetyl chloride (1.26 mL, 17.4 mmol) was slowly added to a stirred solution of the imidazole 1.0g, 14.5 mmol in anhydrous tetrahydrofuran 20 mL under ice, under N2. The suspension wasstirred for 30 minutes and triethylamine (2.4 mL, 17.4 mmol) was added. The reaction mixture was stirred at 0 °C for 12 hours. Then the reaction mixture was filtered, and the solvent was evaporated under reduced pressure to give 1-acetylimidazole 1.53g, 13.9mmol, 94.5 as a white solid.

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tian, Qingqiang; Gan, Zongjie; Wang, Xuetong; Li, Dan; Luo, Wen; Wang, Huajun; Dai, Zeshu; Yuan, Jianyong; Molecules; vol. 23; 9; (2018);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 822-36-6, name is 4-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C4H6N2

A. 4-Methylimidazole (10 g, 0.12 moles), was cooled in a flask, and fuming nitric acid (11 ml, 0.24 moles) was added dropwise. This was followed by the addition of sulfuric acid (11 ml). The reaction was then heated with stirring at 100 C. for 21/2 hours. The cooled reaction mixture was then added to 500 ml of ice water, and the precipitate was filtered off. The filtrate was neutralized with ammonium hydroxide, and filtered again. The combined precipitates were then recrystallized from water to give 6.35 g of 4-methyl-5-nitroimidazole.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Merck & Co., Inc.; US4678799; (1987); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2

General procedure: A mixture of CuatCu2O NPs nanocomposite (5 mol% ofCu), Cs2CO3(1.5 mmol), N-heterocycle (1.0 mmol), aryl halide(1.0 mmol), and DMSO (2 mL) under air was stirred for 1 h at 110 C.After completion of the reaction as indicated by TLC, the heterogeneous mixture was cooled to room temperature and diluted with ethyl acetate (10 mL). The mixture was filtered through a pad of celite. The filtrate was concentrated and then residue was purified by column chromatography (SiO2, ethyl acetate and n-hexane) to yield pure product. The catalysts were recovered by simple filtration and washed extensively with acetone and deionized water and then drying in the air.

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Movahed, Siyavash Kazemi; Dabiri, Minoo; Bazgir, Ayoob; Applied Catalysis A: General; vol. 481; (2014); p. 79 – 88;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem