Tag: M.W=0-100

Application of 1072-62-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-62-4 name is 2-Ethyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of the appropriate bromoacetophenone 1 or 2 (0.500mmol), appropriate benzimidazole or imidazole (0.750 mmol), andsodium acetate (49.2 mg, 0.600 mmol) in tetrahydrofuran (3 ml)was stirred at room temperature for 24 h. The reaction mixturewas poured into water. The precipitate was filtered off, washedwith water, and then with diethyl ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethyl-1H-imidazole, and friends who are interested can also refer to it.

Synthetic Route of 10111-08-7, These common heterocyclic compound, 10111-08-7, name is Imidazole-2-carboxaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In DMF (15 ml), 2-imidazole carboxaldehyde (500 mg) was dissolved. Then, the solution was added with iodoethane (1.25 ml) and sodium hydride (208 mg), followed by stirring at room temperature for 5 days. After completion of the reaction, the solvent was distilled off and the residue was then added with chloroform, followed by washing with water and saturated saline solution. The resultant was dried with anhydrous sodium sulfate, and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (280 mg) as a yellow oily substance. 1H-NMR(500MHz,DMSO-d6):delta=1.44(3H,t,J=7.3Hz),4.44 (2H,q,J=7.3Hz),7.18(1H,s),7.29(1 H,s),9.82(1H,s).

The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.

Reference of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution ofnitrogen-containing nucleophile (1 eq.) and cesium carbonate (3.0 eq.) in N,N-dimethylformamide (2 mL/mmol) was added 2-haloheterocycle (1.1 eq.). Thereaction was heated to 100 C. and stirred at this temperature for 2 hours. Thereaction was then cooled to room temperature and acidified to pH=1 with 10%aqueous HCl solution if product contains a carboxylic acid, or diluted withwater if neutral. The solution was extracted with twice with dichloromethane.The organic layers were combined, dried with sodium sulfate and concentratedunder vacuum. The crude material was either used directly in subsequentreactions or purified by flash chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.

Application of 822-36-6,Some common heterocyclic compound, 822-36-6, name is 4-Methyl-1H-imidazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 9 5-(4-Methyl-1 H-imidazol-1 -yl)-3-trifluoromethyl-phenylamine (I) EPO To a single neck flask fitted with a condenser are added CuI (89.5 mg, 0.47 mmol), cyclohexanediamine (107.3 mg, 0.94 mmol) and diglyme (10 ml_). The mixture is stirred for 10 minutes at ambient temperature. To the purple heterogeneous mixture, 3-bromo-5- trifluoromethyl-phenylamine (XVI) (1.13 g, 4.7 mmol), 4-methyl-1 /-/-imidazole (0.77 g, 9.4 mmol) and Cs2CO3 (1.53 g, 4.7 mmol) are added. The mixture is heated at 1500C and stirred for an additional 24 hours. The mixture is cooled to 250C and purified by column chromatography (silica gel; EtOAc/MeOH 95:5) to afford (I) as the major product (840 mg).

The synthetic route of 822-36-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-50-2, name is Imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Safety of Imidazole-4-carbaldehyde

A) 1-trityl-1H-imidazol-4-carbaldehyde A mixture of 1H-imidazol-4-carbaldehyde (3.00 g), triethylamine (7.00 g) and N,N-dimethylformamide (40 mL) was cooled to 0C, trityl chloride (10.5 g) was added thereto. The reaction mixture was stirred at room temperature for 18 hr, water was added thereto, and the solid was collected by filtration. The obtained solid was washed with water and diethyl ether to give the title compound (10.0 g). 1H NMR (400 MHz, DMSO-d6) delta 7.11-7.14 (6H, m), 7.40-7.48 (9H, m), 7.67 (1H, d, J = 0.8 Hz), 7.80 (1H, d, J = 1.2 Hz), 9.23 (1H, s).

According to the analysis of related databases, 3034-50-2, the application of this compound in the production field has become more and more popular.

288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C3H4N2

EXAMPLE 11 Preparation of 1-triphenylmethylimidazole A mixture of pyridine (15 ml), diphenyl phosphite (2.34 g, 10 mmole), imidazole (0.68 g, 10 mmole) and triphenylmethanol (2.08 g, 8 mmole) was refluxed for 3 hours. Pyridine was removed under reduced pressure, and the residue was extracted with dichloromethane. The extract was washed with a 5percent aqueous hydroxide solution and water in order, dried and evaporated. Recrystallization of the residue (2.23 g) from acetonitrile gave 2.05 g of 1-triphenylmethylimidazole as colorless needles. Yield, 82.7percent. M.P., 221°-223° C. Elementary analysis: Calcd. for C22 H18 N2: C, 85.13percent; H, 5.85percent; N, 9.03percent. Found: C, 85.20percent; H, 6.03percent; N, 9.21percent.

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-32-4, Recommanded Product: 288-32-4

Example L Procedure for the synthesis of [L-DIMETHYLSULFAMOYL-2-T-BUTYLDIMETHYLSILYL IMIDAZOLE] (Formula 13) N CISO2NMe2 N 1) n-BuLi.-78C N/ C Si – N”N’N H Et3N, benzene % 2) TBDMSCI S02NMe2 S02NMe2 Intermediate L1 Intermediate L2 Formula 13 Imidazole (Intermediate [LL,] available from Aldrich, 20.0 g, 0.29 mol), triethylamine [(41.] 0 mL, 0.29 mol) [AND N, N DIMETHYLSULFAMOYL] chloride (31.6 [ML,] 0.29 mol) were added to benzene (320 mL). The reaction was stirred for 48h at rt and then filtered. The filtrate was collected and concentrated under reduced pressure. Vacuum distillation of the crude produc (-0. 5 [MMHG,] [115-118 C)] afforded dimethylsulfamoyl) imidazole (Intermediate L2) 38.7 g (76%) as a clear and colorless oil. Upon cooling the product solidifies to give white crystals. 1- (Dimethylsulfamoyl) imidazole (Intermediate L2) (18.8 g, 0.11 mol) was added to THF (430 mL). The solution was cooled [TO-78 C.] A solution of n-BuLi (70.9 [ML,] 1.6 M in hexane) was added dropwise to the reaction mixture. Upon completion, the solution was stirred for lh [AT-78 C. T-BUTYLDIMETHYLSILYLCHLORIDE (TBSC1)] (17.8 g, [0. 12] mol) in THF (50 [ML)] was added via cannula to the mixture. After the addition was completed the reaction mixture was warmed slowly to rt and stirred for 24h. The mixture was diluted with water and the organic layer separated. The organic phase was washed with brine and then dried over [NA2S04.] The mixture was filtered and the filtrate concentrated under reduced pressure. Column chromatography on [SI02] with 20% ethyl acetate/hexane afforded [1-DIMETHYLSULFAMOYL-2-T-BUTYLDIMETHYLSILYL] imidazole (Formula 13) as a light yellow solid. Recrystallization from pentane gave 30 g (94%) of white crystals.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H8N2

Preparation of 2-(2,4-dimethyl-1H-1-yl)benzonitrile Sodium hydride (8.65 g 60%, 0.216 mol) were stirred in anhydrous dimethylformamide in 75 . Thus in the 100 2,4- dimethyl DMF was added dropwise to a solution of imidazole (20.75 g, 0.216 mol). After stirring for 1 hour at room temperature, it was added dropwise a solution of benzonitrile (23.0 , 0.216 mol) of 2-fluoro-75 of DMF. This was stirred for 2 hours at 50 , was stirred at room temperature for 16 hours. The mixture was poured into water and the product was extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate. The crude product was 19: 1 dichloromethane-methanol followed by 9: 1 dichloromethane-treated by chromatography (silica gel) eluting with methanol to give the product as a solid. LCMS data were confirmed the structure.

The synthetic route of 2,4-Dimethylimidazole has been constantly updated, and we look forward to future research findings.

Synthetic Route of 7098-07-9, A common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 750 mL three-necked flask, 1-ethyl-1H-imidazole (3 g, 3.13 ml, 31.2 mmol, Eq: 1.00) was combined with DCM (140 ml) to give a colorless solution. 1,3-Dibromo-5,5-dimethylimidazolidine-2,4-dione (4.55 g, 15.9 mmol, Eq: 0.51), dissolved in DCM (140 ml), was added dropwise at 0° C. during 20 min. to give a dark green solution. The reaction mixture was stirred at 0° C. for another 2 h. Work up: The reaction mixture was poured into 125 mL sat Na2SO3, extracted with DCM (2*100 mL) and washed with H2O/brine (20 ml). The organic layers were combined, washed with brine, dried over Na2SO4, and concentrated i. V. Purification: The crude product was purified by flash chromatography (silica gel, 400 g, 5percent MeOH in DCM) go give 1.66 g of pure title compound as yellow liquid. MS (ESI): 175.0, 177.0 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 3034-50-2, name is Imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3034-50-2, Recommanded Product: 3034-50-2

Preparation 5 1-Trityl-1H-imidazole-4-carboxaldehyde A solution of trityl chloride (9.5 g, 34.3 mmol) in N,N-dimethylformamide (50 ml) was added dropwise to an ice-cooled solution of imidazole-4-carboxaldehyde (3 g, 31.2 mmol) and triethylamine (17 ml, 125 mmol) in N,N-dimethylformamide (30 ml) and the solution was stirred for 2 hours. The reaction was then allowed to warm to room temperature, and was stirred for a further 18 hours. Water (200 ml) was added, and the resulting pink solid was collected and dried, then dissolved in dichloromethane (200 ml). The resulting solution was washed with water (2*100 ml), dried (MgSO4) and evaporated under reduced pressure. The product was recrystallized from ethanol to afford the title compound as a solid, 7.8 g. 1H-NMR (CDCl3, 400 MHz) delta: 7.06 (m, 6H), 7.32 (m, 9H), 7.48 (s, 1H), 7.58 (s, 1H), 9.82 (s, 1H). Microanalysis found: C, 81.54; H, 5.37; N, 8.24. C23H18N2O requires C, 81.63; H, 5.36; N, 8.28%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Imidazole-4-carbaldehyde, and friends who are interested can also refer to it.