Tag: M.W=0-100

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2

Imidazole (10 g, 0.150 mol) and sodium hydroxide (29.4 g, 0.74 mol) were charged to the reaction flask containing water (250 mL) and stirred vigorously for 15 min at ambient temperature. Cooled the reaction mass to 10 C and charged sodium hypochlorite (16.7 g, 0.225 mol) to the reaction mixture, during the addition temperature was maintained at 10 C. Stirred the reaction mass for 6 h at ambient temperature, the reaction completion was monitored by TLC. After the completion of the reaction cooled the reaction mass to 10 C and slowly charged concentrated HCl solution to bring the reaction pH to 6 to 7. Charged dichloromethane (2 * 200 mL) and stirred for 10 min, separated the organic layer and was washed with saturated brine solution. The organic layer was dried over sodium sulfate and concentrated the dichloromethane and the crude obtained was purified by column chromatography on a silica gel (230-400 mesh) using ethyl acetate (10-35%) in petroleum ether as eluant to afford 4-chloroimidazole. Appearance: Pale yellow solid; Yield = 52%; M.P. = 118-119 C; 1H NMR (400 MHz, DMSO-d6) delta ppm = 7.09 (s, 1H, ArH), 7.39 (s, 1H, ArH), 12.42 (s, 1H, NH); 13C NMR (300 MHz, DMSO-d6) delta ppm = 126.7, 128.2, 140.2; LC/MS (ESI-MS) m/z = 103.6 (M + 1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 822-36-6, name is 4-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Product Details of 822-36-6

4-Methylimidazole (249 mg, 3.03 mmol), 4-fluoro-3-methoxybenzonitrile (417 mg, 2.76 mmol), and cesium carbonate (1.89 g, 5.80 mmol) were placed in a reaction vessel in a nitrogen gas atmosphere, N,N-dimethylformamide (5.0 mL) was added to the vessel and the resultant mixture was stirred at room temperature for 96 hours. To the reaction mixture were successively added water (2 mL) and ethyl acetate (6 mL) to perform an extraction, and the aqueous layer was separated and then, the organic layer was washed with water (5 mL). To the organic layer were added ethyl acetate (5 mL) and water (5 mL) to perform an extraction, and the aqueous layer was separated and then, the organic layer was washed with water (5 mL) and concentrated under a reduced pressure to obtain 499 mg of a crude product. To the crude product was added tert-butyl methyl ether (2.5 mL) to obtain a suspension, and the solids collected by filtration of the suspension were washed with tert-butyl methyl ether/heptane (2.5 ml; 1 :3) three times to obtain 431 mg of a crude product. To the obtained crude product was added tert-butyl methyl ether (4.3 mL) in a nitrogen gas atmosphere, and the resultant mixture was stirred at 50C for 30 minutes and then naturally cooled to room temperature, and the solids collected by filtration were washed with tert-butyl methyl ether/heptane (2.1 mL; 1 :3) twice and dried under a reduced pressure to obtain 310 mg of a title compound. Yield: 53%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 3034-50-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-50-2, name is Imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of acetophenone 7 (0.56g, 3.0mmol) and imidazole-4-carbaldehyde (0.29g, 3.0mmol) in ethanol (25mL) was added 10% sodium hydrate aqueous (5mL), the mixture was stirred for 24h at room temperature [17]. The solution was acidified with 1N HCl and filtered, and the filter cake was recrystallized from ethanol got 8 as white power (0.60g). Yield: 87.4%; mp: 185-186C; IR (KBr, cm-1) nu: 3443 (OH), 3063 (Ar-H), 1719 (C=O), 1617, 1571 (aromatic frame); 1H NMR (400MHz, DMSO-d6) delta: 11.44 (s, 1H, OH), 7.91 (s, 1H, imidazole-2-H), 7.79 (s, 1H, imidazole-5-H), 7.59 (d, J=8.4Hz, 1H, flavone-5-H), 6.85 (d, J=1.8Hz, 1H, flavone-3-H), 6.77-6.72 (m, 2H, flavone-6-H, flavone-8-H) ppm; 13C NMR (101MHz, DMSO-d6) delta: 181.2, 167.7, 166.9, 146.0, 138.0, 130.6, 126.0, 113.9, 113.3, 104.1, 99.0ppm; MS (m/z): 229 [M+H]+; HRMS (TOF) calcd for C12H8N2O3: [M+H]+, 229.0613; found, 229.0617.

The chemical industry reduces the impact on the environment during synthesis Imidazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

General procedure: To a solution of 1 (0.02 mmol) in H2O/MeCN (v/v=2/1, 4 mL) was added 1H-imidazole (1.0 mmol) and arylboronic acid (2 mmol)under O2 atmosphere. The mixture was stirred at 60 C for 24 h. After cooling to ambient temperature, the mixture was partitioned between water and CH2Cl2. The organic layer was separated, and the aqueous layer was extracted with CH2Cl2. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Adding a certain compound to certain chemical reactions, such as: 616-47-7, name is 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-47-7, name: 1-Methyl-1H-imidazole

(Comparative Examples 1 to 4) 1-methyl-1H-imidazole 3.3 g scaleAfter replacing the inside of a 100 mL three-necked flask with an argon atmosphere, 22 mL of acetonitrile, 3.3 g of 1-methyl-1H-imidazole and triethylamine in the amounts shown in Table 1 were added and cooled to -20 C. To this solution, a solution of ethyl chloroformate in the amount shown in Table 1 in 8 mL of acetonitrile was added at the addition time shown in Table 1. Thereafter, the mixture was stirred at room temperature for the reaction time shown in Table 1. To the reaction solution were added 20 mL of ethanol and 10 mL of water to dissolve the precipitate, and 1 mL was collected from the homogenized solution. The collected solution was diluted 1000-fold with acetonitrile and subjected to HPLC analysis, and the yield was calculated. The results are shown in Table 2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-50-2, name is Imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Imidazole-4-carbaldehyde

General procedure: To a mixture of 2-aminopyridines (1 mmol), aromatic aldehydes (1 mmol) and isocyanides in EtOH (or MeCN) was added beta-cyclodextrin-SO3H (10 mol%). The reaction mixture was then allowed to stir for 1 h under 80 C.After complication of this reaction, the resulting mixture was cooled and the beta-cyclodextrin-SO3H was removed by filtration, the organic phase was concentrated under reduced pressure. Afterwards the residue were washed with EtOAc and cyclohexane (1:3) and dried to give the product

According to the analysis of related databases, 3034-50-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1H-Imidazole

General procedure: A solution of imidazole 3 (30 mmol) in THF (60 mL) was treated with NaOH (25 mL, 40% aq) and the alkyl bromide (30 mmol), and the reaction was refluxed overnight. The solvent was evaporated and the crude reaction mixture was extracted with CH2Cl2 against water. The organic layer was washed with water, dried over MgSO4 and concentrated. The final product was distilled under vacuum (~5 mbar) to provide 4 as yellow oily liquid in 80-85% yield.

According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 930-62-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 930-62-1 as follows.

1H-NMR(CDCl3,delta):1.47(3H,t,J=7.3 Hz),1.53(3H,t,J=7.3 Hz), 2.24(6H,s),4.23(3H,s),4.56(2H,q,J=7.3 Hz),4.66(2H,q,J=7.3 Hz), 6.66(1H,s),8.10(1H,s),8.44(1H,s).

According to the analysis of related databases, 930-62-1, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H8N2

NaH (0.13 g; 3.3 mmol) was added portionwise to 2,4-dimethylimidazole (0.3 g; 3 mmol) in /V,/V-dimethylformamide (25 mL) at 5C under N2 flow. The reaction mixture was stirred at 5C for 30 minutes, then compound 236 (1 g; 2.4 mmol) was added at 5C under N2 flow. The reaction mixture was allowed to warm to room temperature and stirred for 18 hours. The reaction was poured out into ice water. The organic layer was separated and washed with water, dried (MgS04), filtered and the solvent was evaporated. The residue (1 .8 g) was purified by chromatography over silica gel (SiOH, 15-40mueta, 300 g; mobile phase 0.5% NH4OH, 95% DCM, 5% MeOH). The pure fractions were collected and concentrated. The residue (1 g) was purified by achiral super critical fluid chromatography (Amino thetamuetaiota; mobile phase 0.3% isopropylamine, 15% MeOH, 85% C02). The pure fractions were collected and the solvent was evaporated till dryness. The first fraction (0.44 g) was further purified by chromatography over silica gel (SiOH, 5mu?iota; mobile phase gradient from 0.4% NH4OH, 96% DCM, 4% MeOH to 1.5% NH4OH, 85% DCM, 15% MeOH). The pure fractions were collected and concentrated. The residue (0.38 g) was dissolved in acetone, then HCI 4N in dioxane was added dropwise. Diethyl ether was added and the precipitate was filtered and dried to afford 0.39 g (27%) of compound 692 . MP: 157C (DSC).The second fraction was dissolved in CH3CN, then HCI 4N in dioxane was added dropwise. The precipitate was filtered and dried to afford 0.1 1 g (8%) of compound 563 . MP: 201 C (DSC).

The synthetic route of 2,4-Dimethylimidazole has been constantly updated, and we look forward to future research findings.

616-47-7, name is 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-1H-imidazole

After replacing the inside of a 100 mL three-necked flask with an argon atmosphere, 22 mL of acetonitrile and 6.3 mL of methyl chloroformate were added and the mixture was cooled to -20 C. To this solution, a solution of 3.3 g of 1-methyl-1H-imidazole and 6.8 mL of triethylamine in 8 mL of acetonitrile was added in 30 minutes, followed by stirring at room temperature for 12 hours. After adding 50 mL of ethyl acetate to the reaction solution, insoluble matter was filtered off, and the residue was washed with 50 mL of ethyl acetate. The filtrate and the washing solution were combined, concentrated under reduced pressure,the concentrated residue was purified by column chromatography(Silica gel, hexane / ethyl acetate) to obtain 4.2 g (yield: 73%) of methyl 1-methyl-1H-imidazole-2-carboxylate.

The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.