Tag: M.W=0-100

Electric Literature of 3034-50-2, The chemical industry reduces the impact on the environment during synthesis 3034-50-2, name is Imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.

Example 10 : Ethyl 4-cyclohexyl-1-[(/?)-2-{3-[5-(1 H-imidazol-4-yl)pentyl]- ureido}-3-(4-methoxyphenyl)propionyl]piperidine-4-carboxylate10-1-1 1-Trityl- 1 H-imidazole-4-carbaldehyde:To a solution containing 1 g (10.4 mmol) of 1 H-imidazole-4-carbaldehyde and 3.18 g (11.4 mmol) of trityl chloride suspended in 28 ml of acetonitrile are added dropwise 2.5 ml (17.7 mmol) of triethylamine. After stirring for 2 hours at room temperature, 30 ml of water are added and the crude reaction product is filtered. 3.2 g in the form of a beige-coloured powder are obtained and used in the following step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 3034-50-2,Some common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[1815] To a stirred solution of 4(5)-imidazolecarboxaldehyde (20.0 g, 0.208 mmol) in CH2Cl2 (200 mL), was added Et3N (29.0 mL, 0.208 mmol). The solution was then cooled down at 0 C., followed by addition of triphenylmethylchloride (52.8 g, 0.18 mmol) at 0 C. The resulting solution was stirred at room temperature overnight and then washed it with brine, water and concentrated to dryness to give a white solid (63.0 g, 98% yield, MH+=339.1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Imidazole-4-carbaldehyde, its application will become more common.

Application of 3034-50-2, The chemical industry reduces the impact on the environment during synthesis 3034-50-2, name is Imidazole-4-carbaldehyde, I believe this compound will play a more active role in future production and life.

To a cooled (0 C) solution of NaH (60 % oil dispersion, 832 mg, 20.8 mmol) and 4-formylimidazole (2.0 g, 20.8 mmol) in dry DMF (30 mL) was added dropwise iodomethane (1.5 mL, 23.0 mmol). The reaction mixture was stirred at rt for 1.5 hr. After quenching the reaction with water, the solvent was removed by evaporation. The residue was dissolved in water and extracted with CHCl3. The extracts were dried over MgSO4 and concentrated by evaporation. The residue was purified by flash column chromatography on SiO2 (CHCl3 ? CHCl3 : MeOH = 100 : 1 ? 50 : 1 ? 10 : 1) to give 36 (1.2 g, 53 %) as a pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fuchida, Hirokazu; Tabata, Shigekazu; Shindo, Naoya; Takashima, Ippei; Leng, Qiao; Hatsuyama, Yuji; Hamachi, Itaru; Ojida, Akio; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 784 – 791;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 616-47-7 as follows. Quality Control of 1-Methyl-1H-imidazole

In a 100-mL round bottom flask, a mixture of 1-methyl imidazole (0.1 mol, 8.21 g) and 1,4-butane sultone (0.1 mol, 11 mL) in toluene (30 mL) was refluxed for 24 h. The obtained white solid was washed with toluene (2910 mL) and dried under reduced pressure. Then, a stoichiometric amount of concentrated sulfuric acid (98 %) was added to the solid and the mixture was stirred for 24 h at 70 C to form the DAIL. It was then washed with diethyl ether (2*10 mL) and dried under vacuum.

According to the analysis of related databases, 616-47-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rostamizadeh, Shahnaz; Zekri, Negar; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 2329 – 2341;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 31722-49-3, name is 1H-Imidazole-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Imidazole-2-carbonitrile

6.7. Synthesis of aR,2S,3R)-l-aH,l’H-2,2′-biimidazol-5-yl)butane-l,2,3,4- tetraolThe captioned compound was prepared by General Method B with the following alterations. To a solution of lH-imidazole-2-carbonitrile (0.39 g, 4.17 mmol) in methanol (4.8 ml) was added a solution of sodium methoxide in methanol (25 wt%, 0.54 g, 0.57 ml, 2.50 mmol), stirred for 16 h and compound 8 (0.964 g, 4.17 mmol) was added in 10 ml of MeOH. A precipitate formed and was filtered and washed with acetone (15 ml). The filtrate was concentrated to dryness, and was purified by preparative HPLC (10 mM aq ammonium acetate/acetonitrile) to give the title compound (0.0141 g, 0.0554 mmol) as an off-white solid. MS m/z Ci0Hi4N4O4 [M + H] + = 255; 1H NMR (400 MHz, CD3OD) delta 3.56-3.57 (m, 2H), 3.67-3.74 (m, 2H), 4.90 (s, IH), 7.04 (s, IH).

The synthetic route of 1H-Imidazole-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; WO2008/109314; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10111-08-7, name is Imidazole-2-carboxaldehyde, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H4N2O

An aqueous 30% H2O2 solution (10g) was added dropwise to a stirred solution of imidazole-2-carboxaldehyde (2.88g 0.030mol) in water (10ml). The reaction was allowed to proceed at room temperature for 72h, following which the water was removed in vacuo at room temperature to afford a white crystalline solid. This solid was washed with a stirred mixture of diethylether/water (4:1) to remove the excess peroxide. Note: heating causes decarboxylation. Yield: 97.5%. Mp=156-158C. deltaH (400MHz, D2O): 7.56 (2H, s, Im-H); deltaC (400MHz, D2O): 158.86, 141.02, 120.49ppm. IR nu (KBr): 3392(m), 3124(m), 2861(m), 1618(s), 1502(m), 1462(m), 1421(s), 1388(s), 1322(m), 1108(s), 925(s), 910(s), 819(m), 797(s), 774(m) cm-1. Anal. Calc. for C4H6N2O3 (130.11); C, 36.92; H, 4.65; N, 21.53%. Found: C, 37.18; H, 4.94; N, 21.47%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Gundhla, Isaac Z.; Walmsley, Ryan S.; Ugirinema, Vital; Mnonopi, Nandipha O.; Hosten, Eric; Betz, Richard; Frost, Carminita L.; Tshentu, Zenixole R.; Journal of Inorganic Biochemistry; vol. 145; (2015); p. 11 – 18;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H4N2

Reference Example 2 1.3 g of sodium hydride (60%) was added to 10 ml of tetrahydrofuran, and a solution of 2.0 g of imidazole in 10 ml of tetrahydrofuran was added dropwise to the resulting suspension. After 2 hours of stirring at 0 C., the solution was mixed with 1.86 ml of chloroacetonitrile and stirred at room temperature for 3 hours. To the reaction solution was added water and chloroform, and the organic layer was collected and dried over anhydrous sodium sulfate, followed by evaporation of the solvent. The residue was subjected to alumina column chromatography eluted with dichloromethane-methanol (200:1) to obtain 1.043 g of 1-cyanomethylimidazole. Mass spectrometry value (m/z): 107 (M+ +1) Nuclear magnetic resonance spectrum (CDCl 3, TMS internal standard) delta: 4.95 (2H, s), 7.06 (1H, d), 7.09 (1H, d), 7.57 (1H, s)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5565479; (1996); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 693-98-1, name is 2-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., COA of Formula: C4H6N2

General procedure: To a solution of N-heterocycle (1 equiv), bromobenzene (1.02 equiv) and tBuOK (2 equiv) in dry DMF, CuFe2O4 (10 mol percent) was added and heated at reflux for 24 h under N2 atmosphere. After cooling to room temperature, the mixture was diluted with ethyl acetate and the catalyst was separated by a magnetic separator. The catalyst was washed with ethyl acetate. The combined ethyl acetate layer was washed with water (twice), dried over anhydrous Na2SO4, and concentrated to yield the crude product, which was further purified by silica gel column chromatography using petroleum ether/ethyl acetate to yield N-arylated product.

The synthetic route of 693-98-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Panda, Niranjan; Jena, Ashis Kumar; Mohapatra, Sasmita; Rout, Smruti Ranjan; Tetrahedron Letters; vol. 52; 16; (2011); p. 1924 – 1927;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 822-55-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Petrov, Ognyan, introduce new discover of the category.

New Imidazole Derivatives of 2(3H)-Benzazolones as Potential Antifungal Agents

A series of new imidazole derivatives containing 2(3H)-benzoxazolone or 2(3H)-benzothiazolone ring were synthesized as analogues of the antifungal drug bifonazole. All compounds were tested in vitro against Candida albicans, Candida parapsilosis, and Candida krusli.

Reference of 822-55-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 822-55-9 is helpful to your research.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a document, author is Menegola, E, introduce the new discover, Formula: C4H6N2O.

Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro

Like triazole-derivatives, imidazole-derivatives exert their antifungal and toxicological properties by inhibiting P450 enzymes (Cyps). At the embryonic level, Cyp enzymes are involved also in the catabolism of the retinoic acid. Specific effects of triazole-derivatives have been reported on developing rodent embryos, and were correlated to an imbalance of the retinoid homeostasis. The aim of this work was to investigate if imidazole-derivatives are able to induce specific malformations similar to those observed after triazole-derivative exposure. Post implantation rat embryos were exposed in vitro to 1000 mu M Imidazole and to 5-100 mu M of the imidazole-derivatives Ketoconazole and Enilconazole. After 48 h in culture, the embryos exposed to the imidazole-derivatives showed specific malformations, quite similar to those observed after triazole-derivative exposure. The common dysmorphogenic effects of the azole-derivatives of the two classes could be due to the inhibition of retinoid catabolism. From this point of view, the contemporaneous exposure to these substances or their therapeutic use could be considered as potentially dangerous for human conceptuses. (c) 2005 Elsevier Inc. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 822-55-9 is helpful to your research. Formula: C4H6N2O.