Tag: M.W=100-200

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.Application In Synthesis of Bis(2-(Di(adamantan-1-yl)phosphino)ethyl)amine. The article 《Varying the metal to ethacrynic acid ratio in ruthenium(II)/osmium(II)-p-cymene conjugates》 in relation to this compound, is published in Journal of Inorganic Biochemistry. Let’s take a look at the latest research on this compound (cas:3724-19-4).

Following the identification of a ruthenium(II)-arene complex with an ethacrynic acid-modified imidazole ligand, which inhibits glutathione transferase (GST) and is cytotoxic to chemo-resistant cancer cells, a series of structurally related ruthenium(II)- and osmium(II)-p-cymene compounds have been prepared In these complexes the ethacrynic acid is linked to the metals via appropriately modified pyridine ligands. The influence of the metal center and the metal:ethacrynic acid ratio on the cytotoxicity of the compounds was evaluated with the derivatives with one metal center and two ethacrynic acid moieties being the most potent against chemo-resistant A2780cisR cells (human ovarian cancer cells with acquired resistance to cisplatin). Moreover, compared to a complex with an ethacrynic acid-modified imidazole ligand (RAIMID-EA), these complexes display a significant degree of cancer cell specificity.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)Formula: C8H9NO2, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about A Novel and Rapid Encoding Method Based on Mass Spectrometry for “”One-Bead-One-Compound”” Small Molecule Combinatorial Libraries.Computed Properties of C8H9NO2.

A method for the preparation and encoding of readily deconvoluted combinatorial libraries is discussed. Beads are prepared with topol. segregated regions – an inner region to which is bound coding tags and an outer segment to which the library compound is bound. Coding blocks are attached to the inner resin by a cleavable methionine-containing linker; the coding blocks are chosen to have similar reactivities to the building blocks incorporated in the synthesis of the combinatorial library. Synthesis of the library leads to the functionalization of the library-containing portion of the resin bead and the coding portion of the resin bead. Cleavage of the linkers for the coding blocks from the resin bead by Edman degradation with cyanogen bromide yields lactones whose mass is determined by FT-MALDI mass spectroscopy. Anal. of the lactones isolated from a given bead yields the mass of each of the fragments present; by careful choice of coding blocks and reactants, the identities of the building blocks incorporated into a library bead and of the library member attached to that bead can be readily derived from the fragment masses. A combinatorial library is prepared and tested for the binding of library members to streptavidin; seventeen of the compounds are found to bind strongly to streptavidin by a colorometric assay and identified unambiguously by the library encoding method described here.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)Computed Properties of C8H9NO2, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Khimiya Geterotsiklicheskikh Soedinenii called Reactions of aromatic and heteroaromatic compounds bearing electron-acceptor substituents. XX. Possible ways of forming chlorosubstituted compounds during bromination of complexes of some furan carbonyl compounds with aluminum halides, Author is Belen’kii, L. I.; Gromova, G. P.; Gol’dfarb, Ya. L., which mentions a compound: 58235-81-7, SMILESS is O=C(C1=CC=C(Cl)O1)OC, Molecular C6H5ClO3, Reference of Methyl 5-chlorofuran-2-carboxylate.

The conflict between the authors’ results and those of Chadwick et al. (1973) was explained by the different methods of product anal. NMR chem. shifts, in conjunction with gas chromatog., are most reliable for anal. of the halogenated furan products.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=C(Cl)O1)OC)Reference of Methyl 5-chlorofuran-2-carboxylate, and with the development of science, more effects of this compound(58235-81-7) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 3724-19-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Spacer-Directed Coordination Polymers-of-Oligomers (POLO) of Silver. Author is Teo, Peili; Koh, L. L.; Hor, T. S. Andy.

Ag(I) polymers-of-oligomers with pyridylcarboxylate spacers supported by a diphosphine [bis(diphenylphosphino)methane (dppm) or 1,1′-bis(diphenylphosphino)ferrocene (dppf)] were constructed and crystallog. established. The repeating oligomeric Ag5 block is invariably made up of five Ag(I) centers comprising Ag2 and Ag units with different metal geometries. Other related Ag5 and Ag4 assemblies also were isolated. The preparation of the [Ag2(isonic)(dppm)2]nn+ polymer (isonic = 4-pyridylformate, NC5H4CO2-) using a ligand transfer pathway from NiCl2(dppm) to AgOTf (OTf = CF3SO3-) was identified. The structural outcomes suggested that pyridylcarboxylates of different stereogeometrical and conformational properties can stabilize different oligomeric and topol. forms through adaptation to the contrasting demands of the diphosphine and metal.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)Product Details of 3724-19-4, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The synthesis of 1,6-naphthyridine》. Authors are Ferrier, B. M.; Campbell, Neil.The article about the compound:3-Pyridinepropionic acidcas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1).COA of Formula: C8H9NO2. Through the article, more information about this compound (cas:3724-19-4) is conveyed.

Reduction of 4.5 g. 3-pyridylacrylic acid (I) in 100 ml. water with 0.5 g. PtO2 by shaking in H 30 min., filtering, resuspending the insoluble portion in water and repeating the process until all insoluble I had disappeared, gave, on vacuum distillation of the combined water solutions, 2.92 g. 3-pyridylpropionic acid (II), cubes, m. 161-2° (EtOH). Under similar conditions reduction of I in one step until no more H was absorbed gave 3-piperidylpropionic acid, isolated as its hydrochloride (1.1 g.) from EtOH, prisms, m. 225°. II (1 g.) was heated 3 hrs. with 5 ml. 100-volume H2O2 and 25 ml. HOAc, the volume reduced to 10 ml. in vacuo, 25 ml. water added, and the process repeated until 0.8 g. 3-pyridylpropionic acid N-oxide (III) separated, prisms m. 144-53° (EtOH). III (0.5 g.), 10 ml. fuming HNO3, and 10 ml. H2SO4 were boiled 1 hr., poured on 50 ml. ice, the solution brought to pH 5 with NH4OH, and 0.36 g. 4-nitro-3-pyridylpropionic acid 1-oxide (IV), yellow plates, m. 169-71° (EtOH), extracted with EtOAc. IV (0.2 g.), 0.5 g. reduced Fe powder, and 6 ml. HOAc were heated 0.5 hr., poured into water, filtered, and the filtrate made alk. with NH4OH and extracted with EtOAc to give 0.05 g. 1,2,3,4-tetrahydro-2-oxo-1,6-naphthyridine, needles, m. 208° (C6H6). III (0.3 g.) in 5 ml. HCl was treated with 0.75 g. Zn dust until colorless, boiled with 0.25 g. more Zn for 2 min., made alk. with NH4OH, and the 1,2,3,4-tetrahydro-1,6-naphthyridine (V) which separated sublimed in vacuo and recrystallized to give 0.05 g. needles, m. 208°; picrate, orange-yellow prisms m. 175° (EtOH). Heating 0.03 g. V 2 hrs. at 220-30° with 0.025 g. 13.5% Pt/C gave, on EtOH extraction, an oil. The picrate of this oil (m. 211°) was dissolved in concentrated NH4OH, extracted with petr. ether, cooled, and after decanting an oil which separated, chilled in ice to give 3 mg. 1,6-naphthyridine, needles, m. 29-30°. 3-Ethylpyridine (3 g.) was oxidized and nitrated (as II above) to give 1.4 g. 3-ethyl-4-nitropyridine 1-oxide, yellow needles m. 63-4° (petr. ether), of which 0.38 g. was reduced (H, PtO2 in HOAc or Zn-HCl) to 4 mg. 4-amino-3-ethylpyridine, needles m. 42-3° (petr. ether); picrate m. 202-3°. Ultraviolet spectra were reported for the naphthyridines and compared with those of the corresponding pyridine derivatives

If you want to learn more about this compound(3-Pyridinepropionic acid)COA of Formula: C8H9NO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 3724-19-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Solid-phase photochemical decarboxylative hydroalkylation of peptides. Author is Elkhalifa, Mahmoud; Elbaum, Michael B.; Chenoweth, David M.; Molander, Gary A..

The compatibility of photochem. with solid-phase peptide synthesis is demonstrated via photochem. hydroalkylation to form C(sp3)-C(sp3) bonds between on-resin Giese acceptors and redox-active esters. Both iridium-based photocatalysts and Hantszch ester led to high yields, with final reaction conditions producing full conversions within 30 min under ambient conditions. The chem. is compatible with a broad range of peptide side chains, redox-active esters, and resin. These conditions represent the first example of photochem. peptide modifications on resin.

If you want to learn more about this compound(3-Pyridinepropionic acid)Application of 3724-19-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design and Synthesis of 56 Shape-Diverse 3D Fragments, published in 2020-07-25, which mentions a compound: 1116-98-9, mainly applied to alkyl piperidine pyrrolidine fragment diastereoselective preparation; 3D fragments; conformational diversity; fragment-based drug discovery; medicinal chemistry; synthesis design, Electric Literature of C7H11NO2.

Fragment screening collections were often predominantly populated with flat, 2D mols. A workflow for the design and synthesis of 56 3D disubstituted pyrrolidine and piperidine fragments that occupy under-represented areas of fragment space (as demonstrated by a principal moments of inertia (PMI) anal.) was described. A key, and unique, underpinning design feature of this fragment collection was that assessment of fragment shape and conformational diversity (by considering conformations up to 1.5 kcal mol-1 above the energy of the global min. energy conformer) was carried out prior to synthesis and was also used to select targets for synthesis. The 3D fragments were designed to contain suitable synthetic handles for future fragment elaboration. Finally, by comparing our 3D fragments with six com. libraries, it was clear that our collection was high three-dimensionality and shape diversity.

If you want to learn more about this compound(tert-Butyl 2-cyanoacetate)Electric Literature of C7H11NO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1116-98-9).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides.SDS of cas: 1116-98-9.

The development of efficient methods, particularly catalytic and enantioselective processes, for the construction of all-carbon quaternary stereocentres is an important (and difficult) challenge in organic synthesis due to the occurrence of this motif in a range of bioactive mols. One conceptually straightforward and potentially versatile approach is the catalytic enantioconvergent substitution reaction of a readily available racemic tertiary alkyl electrophile by an organometallic nucleophile; however, examples of such processes are rare. Here we demonstrate that a nickel-based chiral catalyst achieves enantioconvergent couplings of a variety of tertiary electrophiles (cyclic and acyclic α-halocarbonyl compounds) with alkenylmetal nucleophiles to form quaternary stereocentres with good yield and enantioselectivity under mild conditions in the presence of a range of functional groups. These couplings, which probably proceed via a radical pathway, provide access to an array of useful families of organic compounds, including intermediates in the total synthesis of two natural products, (-)-eburnamonine and madindoline A.

If you want to learn more about this compound(tert-Butyl 2-cyanoacetate)SDS of cas: 1116-98-9, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1116-98-9).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 3724-19-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity. Author is Reddy, K. Papi; Bid, Hemant K.; Nayak, V. Lakshma; Chaudhary, Preeti; Chaturvedi, J. P.; Arya, K. R.; Konwar, Rituraj; Narender, T..

The taxane diterpenoid 2-deacetoxytaxinine J (2-DAT-J; I) has been isolated from the bark of Himalayan yew, Taxus baccata L. spp. wallichiana in a reasonably good yield (0.1%) and its anticancer activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal human kidney epithelial cell line (HEK-293) has been studied. 2-DAT-J showed significant in vitro activity against breast cancer cell line at a concentration of 20 μM and 10 μM in MCF-7 and MDA-MB-231 resp. A few novel taxoids were derived from the naturally occurring 2-DAT-J and screened for their anticancer activity. The structure-activity relationship studies indicated that the cinnamoyl group on C-5 and acetyl group on C-10 are essential for the anticancer activity. 2-DAT-J was also tested for its in vivo activity on DMBA-induced mammary tumors in virgin female Sprague Dawley rats at a dose of 10 mg/kg body weight orally for 30 days and showed significant regression in mammary tumors as compared to vehicle treated group (p < 0.05). Here is a brief introduction to this compound(3724-19-4)Related Products of 3724-19-4, if you want to know about other compounds related to this compound(3724-19-4), you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Studies of furan derivatives. I. Synthesis of chlorofuran derivatives, published in 1958, which mentions a compound: 58235-81-7, Name is Methyl 5-chlorofuran-2-carboxylate, Molecular C6H5ClO3, HPLC of Formula: 58235-81-7.

Tetrachloro-2-furoic acid (I) dissolved in methanol, dropped into methanolic NaOH solution, previously chilled below 0°, with stirring, the mixture kept 24 hrs., and methanol removed under reduced pressure, gave 3,4-dichloro-2-furoic acid (II), m. 167-8° (dilute EtOH). II (8 g.) heated in 50 cc. water at 100°, 20 g. 1% Na-Hg added gradually, and the mixture kept at 100° for 1 hr. with stirring, cooled, and acidified deposited 3.8 g. 3-chloro-2-furoic acid (III), m. 148-9° (water). III yielded a chloride (IV) with SOCl2. IV added 1 mole Cl; the mixture was distilled at room pressure, the fraction b. 180-20° gradually added to a cold ethanolic solution of NaOH with stirring, the deposit filtered off, and dissolved in water, and the solution acidified with HCl to give 5-chloro-2-furoic acid (V), yield 4%, m. 176-7° (dilute MeOH). A similar run with Me 5-chloro-2-furoate (VI), which was prepared from 30 g. V, 60 cc. ethanol, and 15 g. concentrated H2SO4, gave 3,5-dichloro-2-furancarboxylic acid (VII) in 22% yield, m. 155-6° (dilute methanol). The acid chloride of II (8 g.), heated with 0.8 g. Pd-BaSO4 (5%) and 75 cc. dry xylene in 140-5° oil bath while passing H with stirring, gave 3,4-dichlorofurfural in 83% yield, m. 52-3°. A similar run with the chlorides of III, VI, and VII gave 3-chlorofurfural (VIII), 60%, m. 28°, 5-chlorofurfural, 7%, m. 31-3%, and 3,5-chlorofurfural, 59%, m. 11-13°, b4 59-61°, resp.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem