Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2080-75-3, name is 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: 2080-75-3

Obtained through a method the N- acetyl benzylamine piperazine (II) intermediate (19. 6mmol), an alcoholic solution of formaldehyde (16. 3mmol), 5_ methoxy-1,3-dihydro-benzimidazol-2 – one (16. 3mmol) into 30ml of absolute ethanol, at room temperature for 15h. The reaction was concentrated under reduced pressure to give a crude oil. The crude product was purified by silica gel column chromatography to obtain the free base of N- benzyl-2- {4 – [(5-methoxy-2-oxo-2,3-dihydro-benzo -111- [(1] imidazole – 1- yl) methyl] piperazin-1-yl} -acetamide (V-18), 4. 44g, 66.6% yield.

The synthetic route of 2080-75-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Pharmaceutical Industry Research Academy; China State Institute of Pharmaceutical Industry; Li, Jiangqi; Weng, Zhije; Cui, Ning; Jie, Peng; Ma, Xiao; (25 pag.)CN105418506; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Safety of 5-Amino-1H-imidazole-4-carbonitrile

4-amino-5-imidazolecarboxamide hydrochloride was heated to reflux in phosphorus oxychloride for 3.5 hs and after purification gave 4-amino-5-nitrile imidazole. This was resuspended in ethanol saturated with HCl overnight and purification gave 4-amino-5-ethylimino ester imidazole hydrochloride. This was combined with diphenylborinic acid ethanolamine ester in tetrahydrofuran (THF) overnight to yield the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1H-imidazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Benkovic, Stephen J.; Shapiro, Lucy; Wright, Rachel; Stephens, Craig; Kahng, Lyn Sue; Berdis, Anthony; Lee, Irene; US2005/227933; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39811-07-9, name is (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 39811-07-9

5-Fluoro-1H-benzimidazole-2-carboxylic acid 45 was synthesised using 5-fluoro-1H-benzimidazole-2-yl)methanol 29 (0.10 g, 0.60 mmol) dissolved in acetone (20 mL) and potassium permanganate (0.10 g, 0.63 mmol) dissolved in water (10 mL). 5-Fluoro-1H-benzimidazole-2-carboxylic acid 45 was recovered as bright white crystals in Yield 38%. mp 166-168 C.

According to the analysis of related databases, 39811-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6953-65-7, name is (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., category: imidazoles-derivatives

General procedure: Solution ofbenzimidazole (0.1 mmol) in TfOH (1 mL) and arene (0.1 mL) was magnetically stirred at 140 Cin glass high pressure tube for 2.5 h, then poured into water (50 mL). After extraction with CH2Cl2(3 × 30 mL), the combined extracts were consequently washed with water (50 mL), saturatedaqueous solution of Na2CO3 (30 mL), water (50 mL), dried with anhydrous Na2SO4 and evaporatedin vacuo to give crude products, which were subjected to chromatographic separation on silica gelusing petroleum ether/diethyl ether as an eluent.

According to the analysis of related databases, 6953-65-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ryabukhin, Dmitry S.; Turdakov, Alexey N.; Soldatova, Natalia S.; Kompanets, Mikhail O.; Ivanov, Alexander Yu.; Boyarskaya, Irina A.; Vasilyev, Aleksander V.; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1962 – 1973;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 931-36-2,Some common heterocyclic compound, 931-36-2, name is 2-Ethyl-5-methyl-1H-imidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: alpha,beta-unsaturated compound (4.8 mmol) was added dropwise to a well stirred mixture of N-heterocycle substrate (4.0 mmol) in [n-butyl urotropinium]OH (0.108 g, 0.25 mmol) and the reaction mixture was stirred for required time until completion of reaction (TLC). The product was then directly distilled out from the reaction mixture to provide pure Michael adducts (3a-3f and 4a-4f) in high yields.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethyl-5-methyl-1H-imidazole, its application will become more common.

Reference:
Article; Kumar, Sitanshu; Kaur, Amanpreet; Singh, Vasundhara; Synthetic Communications; vol. 49; 2; (2019); p. 193 – 201;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

15965-57-8, name is 2-Chloro-7-methyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 15965-57-8

Step B: (8-Methyl-3H-l ‘-azaspiro[benzo[4,5]imidazo[2, l-b]oxazole-2,3 ‘- bicyclo[2.2.2]octan]-l ‘-yl-8-ium)trihydroborate To 2-chloro-7-methyl-lH-benzo[d]imidazole (0.65 g, 3.9 mmol) from example 10, step A, in THF (35 mL) was added n-butyllithium (1.6 mL, 3.9 mmol) dropwise at – 78C. After 45 minutes, a solution of racemic (l’-azaspiro[oxirane-2,3′- bicyclo[2.2.2]octan]-l’-yl-4-ium)trihydroborate (0.66 g, 4.29 mmol) from the reference example, in THF (10 mL) was added dropwise at -78C. The cooling bath ws removed and the reaction mixture warmed to room temperature. After 15 minutes, the mixture was heated to 75C for 2 hours and then cooled to room temperature. The reaction was quenched with water and the product was extracted with ethyl acetate (100 mL). The organics were dried with MgS04, filtered and the solvent was removed to yield the crude product. The crude material was purified by chromatography (Biotage) to yield racemic (8-methyl-3H-l’-azaspiro[benzo[4,5]imidazo[2, l-b]oxazole-2,3′-bicyclo[2.2.2]octan]-r- yl-10-ium)trihydroborate (0.40 g, 1.4 mmol, 52%). The 5-methyl regioisomer product was not observed. MS (LC/MS) R.T. = 1.90; [M+1-BH3]+ = 270.07.

The synthetic route of 15965-57-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; ZUSI, F. Christopher; HILL, Matthew D.; (87 pag.)WO2016/73407; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Formula: C4H4N4

4-amino-5-imidazolecarboxamide hydrochloride was heated to reflux in phosphorus oxychloride for 3.5hs and after purification gave 4-amino-5-nitrile imidazole. This was resuspended in ethanol saturated with HCl overnight and purification gave 4-amino-5-ethylimino ester imidazole hydrochloride. This was combined with diphenylborinic acid ethanolamine ester in tetrahydrofuran (THF) overnight to yield the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1H-imidazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Penn State Research Foundation; EP1420021; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 83279-44-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83279-44-1, name is 1H-Imidazol-1-amine hydrochloride belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(d) 0.48 g of 1-aminoimidazole hydrochloride are suspended in 30 ml of ethanol, whereupon 0.93 g of 4-hydroxy-3,5-di-tert.-butylbenzaldehyde is added. The suspension is stirred at room temperature for 3 hours, whereby there results a clear solution which is evaporated in a vacuum. The residue is taken up in 15 ml of water, neutralized (pH=7) with ice-cold saturated sodium bicarbonate solution and extracted rapidly three times with 30 ml of methylene chloride each time. The combined organic phases are dried over sodium sulfate, filtered and evaporated in a vacuum. By sublimation of the residue (160/12 Torr), there is obtained 1-(4-hydroxy-3,5-di-tert.-butylbenzylideneamino)imidazole of m.p. 171-174.

The synthetic route of 1H-Imidazol-1-amine hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US4908363; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 253453-91-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 253453-91-7 name is 2-Chloro-1-methyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: (3-Fluoro-phenyl)-(2-chloro-3-methyl-3H-imidazol-4-yl)-methanol. To a 1-L, three-necked, round-bottomed flask equipped with a magnetic stirrer, nitrogen inlet and an addition funnel is added 2-chloro-1-methyl-1H-imidazole (1 equiv.) and THF (0.5 M). The reaction mixture is cooled to -78 C. and n-BuLi (2.5 M in hexanes, 1.05 equiv.) is added. The resulting mixture is stirred for 1 h and a solution of 3-fluorobenzaldehyde (1.05 eq) in THF (2.5 M) is then added dropwise. After the addition is complete, the cooling bath is removed and the reaction is allowed to warm to rt. The reaction mixture is quenched with satd. aq. NH4Cl, transferred to a separatory funnel, and extracted with EtOAc. The organic layer is washed with water, brine and dried over anhydrous Na2SO4. After filtration, the solvents are evaporated under reduced pressure to yield the product. The material is purified by recrystallization or column chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-1-methyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Jones, Todd K.; Mani, Neelakandha; US2005/250948; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6953-65-7, name is (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 6953-65-7

Step 2: synthesis of 4-(5-chloro-2-(hydroxymethyl)-1H-benzo[djimidazol-1- yl)butanenitrile (intermediate 21b) and 4-(6-chloro-2-(hydroxymethyl)-1H- benzo [dj imidazol-1-yl)butanenitrile (intermediate 21c)A mixture of (5 -chloro- 1 H-benzo [d]imidazo l-2-yl)methano 1 21 a (500 mg, 2.738 mmoles, 1 eq.), 4-bromobutyronitrile (466 mg, 1.15 eq.), cesium carbonate (1.338 g,1.5 eq.) and potassium iodide (45 mg, 0.1 eq.) in acetonitrile (5 mL) was refluxed overnight. The mixture was then cooled and filtered. The filtrate was evaporated under vacuum and the residue was treated with ethyl acetate (30 ml) and brine (20 ml). The separated organic layer was dried (Na2SO4), filtered and the solvent was evaporated under vacuum. The residue was purified by column chromatography (eluent: CH2C12:methanol from 1:0 to 15:1) to yield 732mg (54%) of a mixture containing the two regio-isomers 21b and 21c in a 1/1 ratio. This mixture was further separated by SFC to provide the pure regio-isomer 21b.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6953-65-7.

Reference:
Patent; JANSSEN R&D IRELAND; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; HU, Lili; DEMIN, Samuel Dominique; COOYMANS, Ludwig Paul; WO2014/60411; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem