Tag: M.W=100-200

70631-93-5, name is 5-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5-Methyl-1H-imidazole-2-carboxylic acid

Example 527 2-(((3R,4S)-3-fluoro-1-(4-methyl-1H-imidazole-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile 3-Fluoro-2-(((3R,4S)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile (82 mg, 0.15 mmol), HATU (117 mg, 0.31 mmol), TEA (76 mg, 0.62 mmol) and 4-methyl-1H-imidazole-2-carboxylic acid (41 mg, 0.31 mmol) were dissolved in DMF (4 mL) and stirred at room temperature overnight. The mixture was concentrated and the residue was purified by silica gel column with 5-20% MeOH in CH2Cl2 to give the product. 1H NMR (400 MHz, DMSO-d6) delta 12.63 (m, 1H), 10.12 (d, 1H), 8.83-8.34 (m, 2H), 7.83-7.33 (m, 4H), 6.76 (d, 1H), 5.91-5.55 (m, 1H), 5.37 (s, 1H), 5.08 (m, 3H), 4.51 (m, 4H), 4.30 (d, 1H), 3.79 (m, 1H), 3.43 (m, 1H), 3.13 (s, 4H), 2.40 (t, 4H), 2.15 (s, 3H), 1.65-1.98 (m, 2H).

The synthetic route of 70631-93-5 has been constantly updated, and we look forward to future research findings.

Reference of 38585-62-5, A common heterocyclic compound, 38585-62-5, name is (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride, molecular formula is C5H9ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one. A mixture of 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (49.97 g), p-toluenusulphonic acid monohydrate (9.50 g) and 4-hydroxymethyl-5-methylimidazole hydrochloride (20.25 g) in N-methylpyrrolidinone (250 ml) was stirred and heated to 125 (over 1 h) The reaction was then heated at 125-130 for 4.5 h, during which time two further portions of 4-hydroxymethyl-5-methylimidazole hydrochloride (17.51 g and 6.88 g) were added. The reaction mixture was cooled, diluted with water (100 ml), and the stirred mixture was treated slowly with 8% aqueous sodium bicarbonate (750 ml). The resultant suspension was stirred in an ice bath for 1 h and then filtered to give a solid (57.64 g). A portion of this solid (11.09 g) was dissolved in dichloromethane (307 ml) and ethanol (166 ml), boiled with decolourising charcoal for 10 min and then filtered. The dichloromethane was distilled off at atmospheric pressure until the temperature of the mixture was at 65. The stirred mixture was cooled and the resulting precipitate was filtered off to give the title compound (9.28 g), t.l.c. (dichloromethane: ethanol: 0.88 ammonia, 50:8:1) Rf 0.55. 1 H-n.m.r (DMSO-d6): delta2.20(3H,s), 3.03(2H,t), 3.64(2H,m), 3.71(3H,s), 4.50(2H,s), 7.19(2H,m), 7.44(1H,s), 7.50(1H,d), 7.99(1H,d), 11.76(1H,s).

The synthetic route of 38585-62-5 has been constantly updated, and we look forward to future research findings.

6953-65-7, name is (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H7ClN2O

N-Methyl-2-methanol-5-chlorobenzimidazole 49 was prepared according to using the procedure by Harisha et al. [28] A solution of 5-chloro-(1H-benzimidazole-2-yl)-methanol 28 (1.50 g, 8.20 mmol), and sodium hydroxide (0.33 g, 8.2 mmol) were stirred in dry acetone (30 mL) for 30 min. Then, iodomethane (1.41 g, 8.20 mmol) was added and the mixture was stirred for 24 h. The reaction mixture was concentrated to a quarter and then poured into ice-cold water. The solid was filtered and washed with 50% HCl to neutralize the excess potassium carbonate. The solid was washed with cold water (100 mL) and aqueous ethanol. The product was purified by column chromatography (9:1 chloroform/ethanol) to give the desired product 38 as bright orange crystals Yield 9%.

The synthetic route of 6953-65-7 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14003-66-8 as follows. Formula: C4H5N3O2

EXAMPLE 4 127 parts of 4-methyl-5-nitroimidazole is heated under reflux with 350 parts of formic acid and 126 parts of dimethyl sulfate for 4 hours. The formic acid is distilled off in vacuo and the residue is dissolved in 500 parts of water and adjusted to pH 1.8 with aqueous ammonia solution. The mixture is cooled to 5 C. and the unreacted 4-methyl-5-nitroimidazole is suction filtered. The filtrate is adjusted to pH 10 with aqueous ammonia solution and is continuously exhaustively extracted with ethyl acetate. The extract is evaporated in vacuo. The oily residue crystallizes on standing. 47 parts of unreacted 4-methyl-5-nitroimidazole and 66 parts of 1,4-dimethyl-5-nitroimidazole melting at 45 C. are obtained; this is equivalent to a yield of 74% of theory.

According to the analysis of related databases, 14003-66-8, the application of this compound in the production field has become more and more popular.

Application of 64038-64-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64038-64-8, name is Ethyl 2-mercapto-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester (5.81 mmol) and chloroacetone (6.97 mmol) in EtOH (8.0 mL) is heated at reflux for 120 min. The solvents are removed in vacuo and POCl3 (87.1 mmol) is added. The mixture is stirred at RT for 16 h and at reflux for 4 h, concentrated in vacuo and diluted with chloroform. Ice water is added and the mixture is neutralized by addition of Na2CO3. The layers are separated and the aq. layer is extracted with chloroform. The combined organic layers are dried over Na2SO4 and concentrated in vacuo to give a crude product which is purified by CC (heptane/EtOAc 9/1 to heptane/EtOAc 3/7). LC-MS: tR=0.73 min; [M+H]+=211.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-mercapto-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 14840-18-7, These common heterocyclic compound, 14840-18-7, name is 3-(1H-Benzo[d]imidazol-1-yl)propanoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Oxalylchloride (2), (0.48 g, 3.52 mmol) was added to 2-benzimidazolepropionic acid (1), (0.5 g, 2.62 mmol) in a flask immersed in an ice bath, followed by the addition of few drops of DMF and 15 mL of DCM. The resulting reaction mixture was refluxed under magnetic stirring for 1 h. Then the solvent and the excess oxalyl chloride were removed by evaporation and the crude acyl derivative 3 was used immediately without further purification.

The synthetic route of 14840-18-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 6232-92-4, A common heterocyclic compound, 6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, molecular formula is C7H6N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Benzoyl chloride (0.51 mL, 4.4 mmol) was added to a solution of 2-amino-5-nitro-benzoimidazole (0.712 g, 4.00 mmol) in pyridine (15 mL) and the mixture was heated to 100°C for 0.5 h. Additional benzoyl chloride (0.19 mL, 1.6 mmol) was added and heating was continued for another 0.5 h. After removal of the solvent, the residue was treated with water (10 mL). The undissolved material was separated by filtration and washed with water (2 x 10 mL). After recrystallisation from pyridine (9 mL) / water (2 mL), N-(5-nitro-benzoimidazol-2-yl)benzamide (0.588 g, 2.08 mmol, 52 percent) was obtained. LC/ESI-MS: m/z = 283 [M+H]+; m/z = 281 [M-H]-; Rt =3.74 min.

The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.

Related Products of 50591-22-5, A common heterocyclic compound, 50591-22-5, name is 1-Methyl-1H-benzo[d]imidazol-5-ol, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-methyl-1H-benzo[d]imidazol-5-ol (296 mg), methyl 4-bromo-2-fluorobenzoate (311 mg) and potassium carbonate (553 mg) were combined in dimethylsulfoxide and heated to 90 C. overnight. The reaction mixture was diluted with ethyl acetate and washed thoroughly with water and with brine, dried over MgSO4, filtered and concentrated.

The synthetic route of 50591-22-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29518-68-1, Computed Properties of C9H11N3

Example 299 7-[2-(1H-Benzoimidazol-2-yl)-ethylcarbamoyl]-heptanoic acid methyl ester (3/90) Using an analogous method (J11A), the title compound was obtained from 2-(1H-benzoimidazol-2-yl)-ethylamine (1/90) and suberic acid monomethyl ester (6c). Yield 78% (white solid). TLC: single spot at Rf 0.66 (ethyl acetate-methanol, 13:1; detection-UV-254 nm).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 178388-79-9, name is 3-(1H-Imidazol-2-yl)propanoic acid, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(1H-Imidazol-2-yl)propanoic acid

4.2.1 Methyl 3-(1H-imidazol-2-yl) propanoate To a round bottom flask charged with 143 mL of methanol was added 1 g (g) (1 equiv, 7.15 mmol) of 3-(1H-imidazol-2-yl)propanoic acid (Astatech Inc.). This solution was cooled to 0 C, then 5.2 mL (10 equiv, 71.5 mmol) of thionyl chloride was added and the reaction stirred for 5 h. Upon completion, the reaction was reduced, diluted with dichloromethane, and washed three times with 0.1 M K2CO3. The organic portions were dried with sodium sulfate, filtered, and reduced to afford the HCl salt of methyl 3-(1H-imidazol-2-yl)propanoate as a white powder in quantitative yield (1.35 g, 99%). deltaH (500 MHz, DMSO-d6) 2.98 (s, 2H, CH2CH2Im), 3.16 (s, 2H, CH2CH2Im), 3.59 (s, 3H, CH3), 7.52 (s, 2H, Im), 14.58 (s, 1H, NH); deltaC (125 MHz, DMSO-d6) 20.44, 29.98, 51.45, 118.20, 145.76, 171.31; HRMS (ES+) calcd for [C7H10N2O2+H] 155.08205, found 155.08202.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 178388-79-9, its application will become more common.