Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Application In Synthesis of 5-Amino-1H-imidazole-4-carbonitrile

Example 19: General procedure for the preparation of (thiophene-2- carbonyl)-imidazo[1 ,5-a]pyrimidines of general formula (I) following Scheme 1. N-[3-[8-(thiophene-2-carbonyl)-imidazo[1 ,5-a]pyrimidin-4-yl]-phenyl]-N- methyl-methanesulfonamidePart A A solution of thiophen-2-yl magnesium bromide was prepared from 1.0 g ( 42 mmol) of magnesium and 6.94 g (42 mmol) of 2-bromo-thiophene in 40 ml of dry tetrahydrofuran.To the solution of the Grignard reagent, cooled by an ice-salt bath, a mixture of 1 g (9.3 mmol)of 5-amino-1 H-imidazole-4-carbonitrile and 20 ml of dry tetrahydrofuran was slowly added with stirring. After standing at room temperature for 2 hours, the mixture was cooled and decomposed by adding, with stirring, 40 ml of 3M hydrochloric acid. When the decomposition was completed (1 hour at a temperature between 90-950C), the reaction mixture EPO was basified to ph 10 with 25% ammonium hydroxide and was extracted with methylene chloride. The solution was dried with anhydrous sodium sulfate and the methylene chloride was distilled under diminished pressure to yield an oil which was chromatographied (silica gel) using ethyl acetate/methanol as eluent to produce 0.28 g (yield 16%) of (5-amino-1 H-imidazol-4-yl)- thiophen-2-yl-methanone. MS (ES) m/z = 194 (MH+)

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Adding a certain compound to certain chemical reactions, such as: 108035-45-6, name is 4-(1H-Imidazol-2-yl)benzoic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108035-45-6, category: imidazoles-derivatives

A. (4-(lH-Imidazol-2-yl)phenyI)methanol.; 4-(lH-Imidazol-2-yl)benzoic acid (2.05 g, 10.9 mmol) was suspended in anhydrous tetrahydrofuran (60 mL) and cooled to -78 0C. A solution of lithium aluminum hydride (2.0M, 21.8 mL, 43.6 mmol) was added and the reaction was allowed to slowly warm to room temperature with stirring overnight. The reaction was quenched with methanol and the crude product adsorbed onto silica gel. Flash Chromatography (20% MeOH in EtOAc) afforded the title compound (1.6 g, 9.19 mmol, 84%) as a white solid. MS (ESI) m/z 175.1 [M+ 1]+.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol

A mixture of m-1 (0.0273 mol) and m-2 (0.1095 mol) was stirred at 125C for 5 hours and then poured into a 10% solution OfK2CO3. The solution was saturated with K2CO3 (powder) and extracted with CH2CyCH3OH. The organic layer was separated, dried (over MgSO4), filtered and the solvent was evaporated. The residue (16 g) was purified by column chromatography over silica gel (eluent: CH2C12/CH3OH/NH4OH 88/12/0.5; 20-45 mum). The pure fractions were collected and the solvent was evaporated, yielding 5.4 g of intermediate m-3 (71%, melting point: 173C).

The synthetic route of 857070-66-7 has been constantly updated, and we look forward to future research findings.

26530-93-8, name is 1-Methyl-1H-benzo[d]imidazol-6-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H9N3

General procedure: Procedure A: The isothiocyanate compound (1 equiv) was added to the solution of amine (1 equiv) in 5 ml of a mixture of dichloromethane and acetonitrile (1:1, v/v). The mixture was cooled to 0°C. Then, triethylamine (2 equiv) was added gradually. The mixture was stirred at 0°C for 15 min, after which stirring was continued at room temperature for 2?10 h. The reaction mixture was concentrated, extracted with dichloromethane, and washed with brine.The organic layer was dried over MgSO4 and purified by column chromatography (MeOH/CH2Cl2) or by preparative TLC (MeOH/CH2Cl2) to afford the desired product.

The synthetic route of 26530-93-8 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 38585-62-5, name is (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride

EXAMPLE 26 6-Fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one A solution of 6-fluoro-2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (100 mg) in N-methylpyrrolidinone (10 ml) was treated with 4-toluenesulphonic acid monohydrate (17 mg) and 4-hydroxymethyl-5-methylimidazole hydrochloride (37 mg). The mixture was then heated to 125 for 18 h during which time three further portions of 4-hydroxymethyl-5-methylimidazole hydrochloride (37 mg) were added at 1,2 and 3 h respective. The solution was then poured into 8% sodium bicarbonate solution (100 ml) and extracted with dichloromethane (3*100 ml). The combined extracts were concentrated in vacuo and the N-methylpyrrolidinone was distilled at 100. The residue was purified by FCC eluding with System A (200:8:1) to give the title compound (100 mg), t.l.c. (System A, 100:8:1) Rf 0.3.

The synthetic route of (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride has been constantly updated, and we look forward to future research findings.

6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H6N4O2

A mixture of 4-bromo-1H-imidazole (1.0 g, 6.80 mmol) in dimethylformamide (5 mL) was stirred at 0C, to which was added sodium hydride, 60% suspension in oil, (326 mg, 8.20 mmol). The reaction mixture was warmed to room temperature and stirred for 30 minutes, followed by dropwise addition of 2-bromopropane (0.70 mL, 7.48 mmol). The reaction mixture was stirred at room temperature for 15 hours under nitrogen, then quenched with water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic extracts were washed with water (20 mL) and extracted with 1M hydrochloric acid (3 x 20 mL). The combined acidic extracts were washed with ethyl acetate (20 mL), then basified with ammonium hydroxide (pH 12), and extracted with ethyl acetate (3 x 20 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated. Preparative HPLC, eluting with an ethyl acetate- isohexane gradient, gave the product as a pale brown oil (380 mg, 30%) 8 (1H, 400MHz, CDCl3) 1.47 (6H, d, J = 6.8Hz), 4.28-4. 32 (1H, m), 6.92 (1H, d, J = 1.5 Hz), 7.40 (1H, d, J = 1.5 Hz). MS (ES+) 189,191 ([MH]+).

The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Quality Control of 5-Amino-1H-imidazole-4-carbonitrile

General procedure: Na3PSO3·xH2O (?90% purity, 0.320 mmol, 64 mg) was dissolvedin degassed 10% D2O in H2O (0.5 mL) in an Eppendorf tube andthe pH was lowered to 6.5 (5.0 in the case of 26) using degassedHCl. The nitrile was added (0.080 mmol), and the volume madeup to 1 mL with degassed 10% D2O. The reaction was sealed andheated at 50 C for 24 h taking time points at 8 and 24 h.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89088-69-7, name is 1-Methyl-1H-imidazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., SDS of cas: 89088-69-7

Intermediate 19; 1 -Ethyl-iV-d -methyl- lH-imidazol-4-yl)-6-(methylsulfonyl)- lH-pyrazolo[3 ,4-

Synthetic Route of 17289-26-8,Some common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The L-Proline or L-tert-Leucine-based amine was dissolved in DCM (2 M), followed by the additionof the imidazole based aldehyde (1-1.3 equiv.) and MgSO4H2O (1 g/5 mL solvent). The mixture wasstirred overnight at room temperature. Afterwards, solids were removed by filtration and the resultingsolution was concentrated in vacuo. The residue was dissolved in MeOH (2 M) and the solution wascooled to 0 C. NaBH4 (3 equiv.) and a catalytic amount of conc. HCl were added to this solution. Themixture was stirred for 30 min at 0 C, and 1 h at room temperature; after this period, an equal volumeof saturated NaHCO3 solution was added to quench the reaction. After washing with DCM and brine,the organic phase was separated, dried over anhydrous Na2SO4 and concentrated in vacuo to afford theraw product. Purification of the resulting raw material was carried out via column chromatography usingDCM and MeOH, eluted compound might be subsequently recrystallized from DCM and pentane.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-4-carbaldehyde, its application will become more common.

Related Products of 17289-26-8, These common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Synthesis of 4-ethynyl-1-methyl-1H-imidazole A solution of l-methyl-1H-imidazole-4-carbaldehyde (2 g, 1 eq) in MeOH (180 ml) was cooled at 0 C. K2CO3(5.02 g, 2 eq) and dimethyl (1-diazo-2-oxopropyl)phosphonate (7.7 g, 2.2 eq) was added. The mixture was stirred for 4 hr at 0 C., and extracted with dichloromethane and water. The organic layer was washed with sat. aq. NH4Cl, dried over anhydrous MgSO4 and concentrated in vacuo. The residue was purified with column chromatography to prepare the title compound (1.2 g, 62%). 1H NMR (600 MHz, CDCl3-d1); delta7.60 (s, 1H), 7.32 (m, 1H), 3.37 (s, 3H), 3.48 (s, 1H). MS (ESI, m/z): 107.1 [M+H]+.

Statistics shows that 1-Methyl-1H-imidazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 17289-26-8.