Tag: M.W=100-200

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33468-67-6 as follows. SDS of cas: 33468-67-6

A solution of ethyl 2-bromopropionate (3.98 g, 22 mmol), 4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazole (3.00 g, 20 mmol), and K2CO3 (5.53 g, 40 mmol) in THF/DMF (2:1, 39 mL) was allowed to stir at 45 C. for 16 h. The mixture was then concentrated in vacuo and diluted with EtOAc (70 mL). The organic layer was washed with water and brine, dried over MgSO4, filtered, and concentrated in vacuo to give the product (5.3 g) as a colorless oil that was used without further purification.

According to the analysis of related databases, 33468-67-6, the application of this compound in the production field has become more and more popular.

Related Products of 57667-50-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57667-50-2 name is 1-Propyl-1H-benzo[d]imidazol-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Bromo-N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide 13. A mixture of 5-bromoisophthalic acid (100 mg, 4.1 mumol), N-propylaminobenzamidazole (72 mg, 4.1 mumol), N-hydroxysuccinimide (56 mg, 4.9 mumol), DMAP (5 mg, 0.4 mumol) and EDC (234 mg, 1.2 mmol) were dissolved in methylene chloride (5 mL), treated with Hunig’s base (53 mg, 4.1 mumol) and stirred for 1 d to give 12. The reaction mixture was then treated with 9/1 MeOH/NH4OH (5 mL) and stirred for 2 h. The mixture was concentrated to a solid, dissolved in DMSO, added to a column and chromatographed (50 g isco C18, 0 to 100% MeOH with 0.2% formic acid) to give 13 (71 mg, 43%) as a white powder. LC/MS gave a single peak with m/z=401.1 [M+1]+ and 823.1 [2M+Na]+. 1H-NMR (dmso-d6) delta 12.77 (br s, 1H), 8.65 (br s, 1H), 8.45 (br s, 1H), 8.22 (br s, 1H), 8.17 (br s, 1H), 7.54-7.60 (m, 3H), 7.28 (t, J=8 Hz, 1H), 7.24 (t, J=8 Hz, 1H), 4.27 (t, J=7 Hz, 2H), 1.85 (h, J=7 Hz, 2H), 0.92 (t, J=7 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Propyl-1H-benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.

Electric Literature of 614-97-1,Some common heterocyclic compound, 614-97-1, name is 5-Methyl-1H-benzo[d]imidazole, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Charged benzimidazole (III) (5.115 mmoles), 2-bromo-thiophene-2-carboxamide (VIII) (3.938 mmoles), cesium carbonate (7.161 mmoles), cuprous oxide (0.307 mmoles), 4,7- dimethoxy-l,10-phenathroline (0.716 mmoles), PEG (5.115 mmoles) and DMSO to the RB flask fitted with thermo well and condenser. The reaction was heated to 110-1150C under magnetic stirring for 24 hours. After completion of reaction cooled to room temperature, dichloromethane (500 ml) added and filtered through a celite bed, washed the bed with dichloromethane (100 ml X 2), distilled off the solvent completely under reduced pressure. Aq. ammonia (10 ml) was added to the residue and extracted with ethyl acetate (250 ml X 3).Dry the ethyl acetate layer with sodium sulfate, distilled completely to get the crude compound. The crude compound is then purified by using silica gel 60-120 mesh column chromatography and DCM: MeOH 100-5 % as mobile phase to get the pure compound. (Some compounds are isolated by preparative HPLC purification method.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-benzo[d]imidazole, its application will become more common.

Electric Literature of 66121-69-5, These common heterocyclic compound, 66121-69-5, name is 1-Methyl-1H-imidazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4.1.3 Compounds with formula 3 according to Scheme 1a: Synthesis of 1-(1-Methyl-1H-imidazol-4-yl)-ethanone (3.3) for Example 2-16, 18, 19, 22, 26-28, 32-101, 103-175 43.4 ml 1.4M methylmagnesiumbromide in toluene were added dropwise to a mixture of 5.0 g 1-methyl-1H-imidazole-carbonitrile in 70 ml diethylether at 0 C. After 30 min, the mixture was warmed up to ambient temperature. After 1 h the reaction was quenched with 1M aqueous HCl solution and neutralised with saturated sodium bicarbonate solution. The reaction mixture was extracted with dichloromethane. The combined organic extracts were dried with magnesium sulfate and concentrated under reduced pressure. The crude material was purified by flash chromatography (dichloromethane/methanol=98/2) to give the intermediate 3.3. Yield: 4.8 g of 3.3 (75% content; 62% of theory); Analysis: [M+H]+=125

Statistics shows that 1-Methyl-1H-imidazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 66121-69-5.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1546-79-8, name is 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone

Step 4 Preparation of 6-chloro-5,6-dihydro-3-trifluoroacetyl-4H-thieno[2,3-b]thiopyran-4-one The compound from Step 3 (1.03 g, 5.0 mmol) was dissolved in tetrahydrofuran (50 mL) and cooled to -78 C. A solution of sodium bistrimethylsilylamide (5.0 mL of a 1.0M tetrahydrofuran solution) was added and the reaction stirred for 0.75 hours at -78 C. Trifluoroacetyl imidazole (0.68 mL, 6.0 mmol) was added and the reaction was warmed to room temperature and stirred under a nitrogen atmosphere for 16 hours. At this time, 1N hydrochloric acid (300 mL) was added to the reaction followed by extraction with ether (350 mL). The organics were washed with brine (200 mL), dried over MgSO4 and concentrated in vacuo. The resulting yellow oil was used without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1546-79-8.

Adding a certain compound to certain chemical reactions, such as: 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60-56-0, Application In Synthesis of 1-Methyl-1H-imidazole-2(3H)-thione

Aroyl chloride (1 mmol) was added to a stirred solution of ammonium thiocyanate (1 mmol) in 10 mL MeCN. The mixture was stirred at room temperature (r.t.) for 30 min. Then, 2-mercapto-1-methylimidazole (1 mmol) was added and the reaction mixture was stirred for 2 h at r.t. The solvent was removed under reduced pressure and the resulting precipitate was collected and washed with 10 mL ofcold diethyl ether to afford the pure title compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 39021-62-0

Methyl magnesium bromide (100 ml of a 3M solution in diethyl ether, 0.30 mol) was added dropwise to a solution of 5-formyl-1-methylimidazole (14.5 g, 0.13 mol) in THF (750 ml) cooled to -20 C. such that the reaction temperature was kept below 3 C. The mixture was allowed to warm to ambient temperature and water (150 ml) was carefully added. The aqueous mixture was continuously extracted with EtOAc. The EtOAc extract was dried, and the volatiles removed by evaporation to give the title compound 14.4 g, (88%) as a solid product. NMR: 1.41 (d, 3H), 4.65-4.77 (m, 1H), 4.96-5.11 (m, 1H), 6.72 (s, 1H), 7.47 (s, 1H).

The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-38-6, name is 5-Nitro-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3N3O2

A solution of LiOH.H2O (0.84 g, 20 mmol) in MeOH (10 mL) was added dropwise to a stirred mixture of 4-nitroimidazole (2.26 g, 20 mmol) and MeOH (20 mL) at rt. After stirring (30min) the clear dark orange solution was evaporated under reduced pressure to give a solid that was dried under high vacuum to give compound 12 (2.33 g, 98%) as an orange/brown solid. mp >300 C. 1H NMR (DMSOd6,250.1 MHz): d 7.34 (s, 1H, CH), 7.89 (s, 1H, CH). 13C NMR (62.9 MHz, DMSO-d6): d 127.4 (CH), 142.7 (CH),not observed (CNO2). MS (CI) m/z (%) 112 (M-, 100).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23328-88-3, name is 2-Bromo-4-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 23328-88-3

To a stirred solution of 2-bromo-4-methyl-1H-imidazole (240 mg, 1.49 mmol) and cyclopropyl{4-[(2-{[6-(4,4, 5, 5-tetramethyl- 1, 3,2-dioxaborolan-2-yl )- 1 H-benzim idazol-2- yl]am ino}pyridin-4-yl)methyl]piperazin-1 -yl}methanone (150 mg, 299 iJmol) in dioxane (2.0 m L) and water (0.5 mL) was added sodium carbonate (130 mg, 1.22 mmol) and Pd(dppf)C12CHCl2 (48.8 mg, 59.7 pmol) and Tetrakis(triphenylphosphin)palladium (69.0 mg, 59.7 pmol). The mixture was heated to reflux for 24 h. Methanol was added, the mixture was filtered and the solvent was removed in vacuum. Silicagel chromatography gave 19.0 mg (13 % yield) of the title compound.LC-MS (Method 5): R1 = 2.31 mm; MS (ESIpos): m/z = 457 [M+H]1H-NMR (400 MHz, DMSO-d6) [ppm]: 0.691 (1.89), 0.711 (2.62), 0.718 (2.69), 0.731 (2.52),1.234 (0.47), 1.952 (0.59), 1.964 (0.84), 2.341 (6.66), 2.395 (0.88), 2.495 (10.55), 2.500(13.36), 2.504 (11.34), 3.169 (0.43), 3.309 (16.00), 3.565 (1.65), 3.718 (0.95), 6.986 (1.09),6.999 (1.14), 7.227 (1.50), 7.408 (1.77), 7.639 (1.33), 7.997 (2.12), 8.299 (1.25), 8.312 (1.25).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 21252-69-7, The chemical industry reduces the impact on the environment during synthesis 21252-69-7, name is 1-Octyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

1,6-Dibromohexane (10.00 g, 42 mmol) was dissolved in anhydrous acetonitrile (10 mL) and introduced into a three-neck round-bottom flask. After the solution was heated gently to reflux, a solution of 1 (0.50 g, 2.80 mmol) in anhydrous acetonitrile (5 mL) was added dropwise under N2 atmosphere. The reaction mixture was stirred for 24 h at reflux and then cooled to room temperature. The solvent was removed to give a residue, which was purified by washing with anhydrous diethyl ether (35 mL), and concentrated under reduced pressure. The residue was dried under vacuum to afford 2 as a puce oil (1.01 g,85 percent). deltaH (CDCl3, 400 MHz) 10.32 (1H, s), 7.62 (1H, s), 7.50 (1H, s), 4.40 (2H, t, J 7.2), 4.34 (2H, t, J 7.6), 3.43?3.40 (4H, m), 2.03?1.84 (6H, m), 1.51?1.23 (12H, m), 0.87 (3H, t, J 6.8). deltaC (CDCl3, 100 MHz) 136.3, 122.1, 121.8, 49.9, 49.6, 33.7, 32.3,32.1, 31.5, 30.1, 30.0, 28.9, 27.2, 26.1, 25.1, 22.4, 14.0. m/z (ESI) 345 ([M]+). m/z 345.1733. HRMS (ESI) Anal. Calc. for C17H32BrN2 ([M]+) 345.1728.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Octyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.