Tag: M.W=100-200

Related Products of 22884-10-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2.5 mL (0.029 mol) of phosphorus trichloride was added dropwise into the mixture of 1.6 g (0.013 mol) of 1H-imidazol-1-ylacetic acid (1), 2.2 g (0.027 mol) of phosphorous acid and 1.4 mL (0.008 mol) of [bmim][BF4] (A), or into the mixture of 5 mL of sulfolane and 1.4 mL (0.008 mol) of [bmim][BF4] (B) on stirring in ca. 30 min, and the contents of the flask were stirred at 75 C for 3 h. Further process including hydrolysis, pH adjustment, filtration and recrystallization was performed as described above to afford 2.9 g (75%, (A), Table 2, entry 3) and 3.6 g (93%, (B), Table 3, entry 1) of zoledronic acid dihydrate (2) in a purity of 99%. 31P NMR (D2O) delta: 17.6 and 17.3 respectively, delta[13]: 16.0.

The synthetic route of 2-(1H-Imidazol-1-yl)acetic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 1544-75-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1544-75-8 as follows.

[00312] lodomethane (0.82 mL, 13.15 mmol) was added to a mixture of 5-fluoro-1,3-dihydro-2H-benzimidazol-2-one (500. mg, 3.29 mmol) and potassium carbonate (1.81 g, 13.15mmol) in DMF (25 mL), and the reaction mixture stirred at ambient temperature for 16 h. DCM(30 mL) and water (60 mL) were added and the mixture stirred for 5 min. The DCM layer wasisolated by passing through a hydrophobic frit and the aqueous washed with DCM (2 x 50mL). The combined DCM extracts were concentrated under reduced pressure to yield 5-fluoro-1,3-dimethyl-benzimidazol-2-one (556 mg, 2.99 mmol, 91%).[00313] 1H NMR (300MHz, CDCI3) 5 = 6.91 – 6.71 (m, 3H), 3.42 (s, 3H), 3.41 (s, 3H)

According to the analysis of related databases, 1544-75-8, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23785-21-9, name is Ethyl 1H-imidazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 23785-21-9

Synthesis of Compound 8.1. Into a 100-mL 3-necked round-bottom flask, was placed ethyl lH-imidazole-5-carboxylate (1.4 g, 9.99 mmol, 1.00 equiv) and N,N- dimethylformamide (25 mL) was added. The reaction was cooled in an ice bath and then LiHMDS (IN in tetrahydrofuran) (11 mL, 1.10 equiv) was added. The reaction was stirred at R.T. Then amino diphenylphosphinate (2.8 g, 12.01 mmol, 1.20 equiv) was added at RT. The reaction was stirred for 2 h at 25 C. Then it was concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (100: 1). This provided 1.0 g (65%) of ethyl 1 -amino- lH-imidazole-5-carboxylate (8.1) as an off-white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 52099-72-6

Propargyl bromide(11.4 mmol) was added to a mixture of 1-isopropenyl-1H-1,3-benzimidazol-2(3H)-one 2 (5.7 mmol), potassium hydroxide(5.7 mmol) and tetra-n-butyl ammonium bromide (0.15 mmol) inCH2Cl2 (15 mL). Stirring was continued at room temperature for48 h. Salts were removed by filtration, and the filtrate wasconcentrated under reduced pressure. The residue obtained waspurified by recrystallization from ethanol to obtain colourlesscrystals in 91% yield.2.2.1.4. 1-(Prop-1-en-2-yl)-3-(prop-2-ynyl)-1H-benzimidazol-2(3H)-one: 3. Yield (%) 91;mp 331 K; 1H NMR (300 MHz, CDCl3): 2.22(d, 3H, 4JH-H 3 Hz, CH3), 2.30 (t, 3H, 3JH-H 3 Hz, CH), 4.69 (d, 2H,4JH-H 3 Hz, CH2C^CH), 5.20 (d, 1H, 4JH-H 3 Hz, CH2), 5.35 (d, 1H,4JH-H 3 Hz, CH2), 7.10e7.30 (m, 4H, CHarom). 13C NMR (75 MHz,CDCl3): 151.99 (C]O), 137.99 (Cq), 129.07 (Cq), 128.72 (Cq), 121.86(CHarom), 121.78 (CHarom), 113.32 (CH2), 109.20 (CHarom), 108.57(CHarom), 77.06(CH), 72.82 (C^CH), 30.40 (CH2), 20.22 (CH3).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52099-72-6.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23328-88-3 as follows. Computed Properties of C4H5BrN2

To a mixture of 5-(benzyloxy)-1,3-difluoro-2-nitrobenzene (2.65 g, 10 mmol) and potassium carbonate (2.76 g, 20 mmol) in 50 mL DMF was added 2-bromo-4-methylimidazole (1.46 g, 9.09 mmol) at RT. The resulting mixture was stirred at RT for 40 h. Majority of solvent was removed by rotavap. The residue was diluted with ethyl acetate and washed with water. Extraction with ethyl acetate, condensation on rotavap, followed by column chromatography using 20-40% ethyl acetate in hexane as eluent to provide 1.72 g (47% yield) product as a thick foam.

According to the analysis of related databases, 23328-88-3, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Methyl-1H-imidazole-2(3H)-thione

Reference Example 98 2-Cyano-6-(1-methyl-1H-imidazol-2-yl)thiopyridine 2-Mercapto-1-methyl-1H-imidazole (0.91 g, 7.94 mmol) and sodium hydride (60 % in oil, 0.35 g, 8.66 mmol) were dissolved in DMF (30 ml), and 2-chloro-6-cyanopyridine (1.05 g, 3.00 mmol) was added thereto.. The reaction mixture was stirred at 70 C for 18 hrs and combined with ethyl acetate and water.. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated, and the residue was recrystallized from n-hexane-ethyl acetate to give the titled compound (1.71 g, ca. 100 %) as pale yellow crystals.1H-NMR (CDCl3) delta: 3.79 (3H, s), 7.21-7.23 (1H, m), 7.63-7.66 (1H, m), 8.85 (1H, t, J = 4.8 Hz), 8.25 (1H, d, J = 7.6 Hz), 8.56 (1H, d, J = 4.8 Hz). IR(KBr): 2231, 1570, 1550, 1433, 1373, 1167, 1152, 1086, 983, 798 cm-1.

According to the analysis of related databases, 60-56-0, the application of this compound in the production field has become more and more popular.

Reference of 75370-65-9, A common heterocyclic compound, 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of 1-(4-chloro-2-(dimethylamino)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Amine 2af (1 g, 5.5 mmol) was dissolved in 20 ml of AcOEt and at 0C triphosgene (1.63 g, lequiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 10ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1a (820 mg, 5.5 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 550mg of a white solid. Yield = 28% 1HNMR (DMSO, 200 MHz) delta 2.64 (6H, s), 4.34 (2H, d, J = 5.8 Hz), 6.62 (1H, dd, J = 7.2 Hz, J’ = 1 Hz), 6.73 (1H, t), 6.83 (1H, t, J = 7.6 Hz), 6.90 (1H, dd, J = 8.2 Hz, J’ = 1Hz), 7.06 (2H, m), 7.31 (1H, d, J = 8.8 Hz), 8.33 (1H, bs), 9.98 (1H, bs), 10.59 (1H, bs); [M+1] 360.7 (C17H18ClN5O2 requires 359.81).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1849-01-0, A common heterocyclic compound, 1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Scheme 15: (1264) (1265) To a THF solution (2 mL) of 15-1 (100 mg, 674 mumol) was added NaH (13.4 mg, 337 mumol) under Nitrogen atmosphere. The resultant solution was heated at 60oC for 30 minutes. To the hot reaction mixture was added a THF solution (2 mL) of 2-1 (64.7 mg, 337 mumol) drop wise and the heating was continued for another 5 hours to produce Compound 176. It was then cooled to room temperature, diluted with 20% IPA-DCM solution, washed with water and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Crude mass was purified by column chromatography (silica, gradient: 0-3% MeOH in DCM) to afford Compound 176 (3.5 mg, 13 mumol, 5%). 1H NMR (400 MHz, DMSO-d6) delta 11.10 (s, 1H), 7.19 (d, J = 7.6 Hz, 1H), 7.15- 7.01 (m, 3H), 5.38 (s, 1H), 3.25 (s, 3H), 2.90-2.87 (m, 1H), 2.72-2.50 (m, 2H), 2.07-2.05 (m, 1H). LC MS: ES+ 260.3.

The synthetic route of 1849-01-0 has been constantly updated, and we look forward to future research findings.

4887-94-9, name is 2-Chloro-5-methyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Chloro-5-methyl-1H-benzo[d]imidazole

10 g of 2-chloro-5-methyl-1H-benzo[d]imidazole was added to 130 ml of N,N-dimethylformamide,Add 15g of anhydrous potassium carbonate and 9g of piperidine-4-carboxylic acid,Heated at reflux for 2 hours,cool down,Add water and ethyl acetate extractionLiquid separation,Collect the organic phase,concentrate,The residue was separated on a silica gel column to give 7 g of 1-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid.

The synthetic route of 4887-94-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 56248-10-3, A common heterocyclic compound, 56248-10-3, name is 5-Phenyl-1H-imidazole-2-carbaldehyde, molecular formula is C10H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of compound 3 (100mg, 0.40 mmol) in ethanol was added corresponding benzohydrazides (4a-m) (1.0 mmol) and refluxed for 1 h. The reaction mass was washed with pet ether, filtered and dried undervacuum to obtain the pure hydrazone compounds. Yields ofthe products varied between 78 and 88 %.

The synthetic route of 56248-10-3 has been constantly updated, and we look forward to future research findings.