Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 98873-55-3, name is 2-(1H-Imidazol-1-yl)acetonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98873-55-3, Formula: C5H5N3

A 10 mL flask is charged with powdered KOH (159 mg, 2.43 mmol), DMSO (3 mL), purged with Argon and is cooled at 10CC with a water bath. A solution of 2-imidazol-1-ylacetonitrile (125 mg,1.17 mmol) and carbon disulfide (0.147 mL, 2.5 mmol) in DMSO (3 mL) is then added slowly to givean orange mixture. The cooling bath is removed and the reaction is stirred at room temperature for 30minutes. A solution of [2-bromo-1-(3-bromopyrazin-2-yl)ethyl] methanesulfonate (350 mg, 0.97 mmol)in DMSO (2 mL) is then added dropwise. After two hours, the reaction mixture is poured into H20 (15mL). The aqueous phase is extracted with dichloromethane, the combined organic phases are washedwith brine, dried with Na2504, filtered and evaporated to give a crude pale yellow residue. Purificationby chromatography on silica gel (heptanes I EtOAc, 5:1-*1:1-*1:3) afford (2E)-2-[4-(3-bromopyrazin-2-yl)-1 ,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile (Compound l.ao.25) as a yellow gum. 1HNMR(400 MHz, CDCI3): oe = 8.55 (d, J = 2.2 Hz, 1H), 8.41 (d, J = 2.2 Hz, 1H), 7.61 (s, 1H), 7.16 (s, 1H),7.03 (s, 1H), 5.67 (t, J= 5.5 Hz, 1H), 4.14 (dd, J= 5.5, 11.8 Hz, 1H), 3.91 (dd, J= 5.5, 11.8 Hz, 1H).MS (ESI): m/z= 366, 368 (M+1).

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Related Products of 4857-06-1,Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of ethyl 8-oxo-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]auinoline-3-carboxylate (I) A1. 2-Chloro-1-(tetrahydro-pyran-2-yl)-1H-benzimidazole (CAS No. 208398-29-2) A 10 l reactor is charged, under argon and with stirring, with 2.5 l of THF, 180 g of 2-chlorobenzimidazole (1.18 mol) and 325 ml of 3,4-dihydro-2H-pyran (6.56 mol, 3 eq.). The reactor is heated until dissolution occurs (temperature of the mixture: 40 C.). Then 6.3 g of para-toluenesulphonic acid (0.033 mol, 0.028 eq.) are introduced. The temperature is held at between 49 and 52 C. for 2.5 h. Cooling takes place at 12 C. and 7.65 g of sodium methoxide (0.142 mol, 0.12 eq.) are added, with stirring maintained for a total time of 15 min. The temperature is then taken to 18 C., 5 l of n-heptane are added, and the whole mixture is filtered on 300 g of Clarcel FLO-M, the retentate being washed with 5 l of n-heptane. The filtrate is concentrated to dryness under reduced pressure to give 292.6 g of 2-chloro-1-(tetrahydro-pyran-2-yl)-1H-benzimidazole in the form of a slightly yellow oil (quantitative yield). 1H NMR (400 MHz, DMSO-d6): 1.42 to 2.01 (m, 5H); 2.21 to 2.34 (m, 1H); 3.69 to 3.78 (m, 1H); 4.12 (d, J=11.4 Hz, 1H); 5.72 (dd, J=2.4 and 11.2 Hz, 1H); 7.22 to 7.34 (m, 2H); 7.82 (d. J=72 Hz, 1H); 7.78 (d, J=7.2 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-benzo[d]imidazole, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C10H8N2O

a 4-Aminomethyl-2-phenylimidazole dihydrochloride Hydroxylamine hydrochloride (229 mg, 3.3 mmol) was added to a suspension of 2-phenylimidazole4-carboxaldehyde (516 mg, 3 mmol; prepared according to J. Chem. Soc. Perkin Trans. I 1974, 1527) and sodium acetate (541 mg, 6.6 mmol) in absolute EtOH (5 mL) and H2 O (5 mL) at RT. A yellow, homogeneous solution was produced. After 15 min, the reaction was concentrated on the rotavap to remove the EtOH, and the oily, aqueous mixture was extracted with 20% MeOH/CHCl3 (10 mL) then with CHCl3 (10 mL). The combined organic layers were dried (MgSO4) and concentrated to leave a yellow foam. The yellow foam was dissolved in absolute EtOH (9 mL), and 1.0 N HCl (6 mL, 6 mmol) and 10% Pd/C (0.32 g, 0.3 mmol) were added. The mixture was shaken on a Parr apparatus at RT under H2 (50 psi) for 4 h, then was filtered through Celite. The filtrate was concentrated on the rotavap to leave a light yellow solid. Recrystallization fron absolute EtOH/H2 O gave the title compound as a light pink solid (465 mg, 63%): mp 273-275 C. (dec.); 1 H NMR (250 MHz, CD3 OD) delta 7.93-8.12 (m, 2H), 7.80 (s, 1H), 7.50-7.76 (m, 3H), 4.40 (s, 2H); MS (ES) m/e 347.2 (2M+H)+, 174.0 (M+H)+, 157.0 (M+H–NH3)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68282-47-3.

Application of 17325-26-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1H-Imidazole-4-carboxylic acid methyl ester (1.8 g, 14 mmol, Aldrich) reacted with bromine (1.6 mL, 29.8 mmol, Adrich) in acetic acid (20 mL) was stirred at RT for 12 h. The reaction mixture was filtered from the yellow precipitate, and the filter cake was washed with DCM (2*20 mL). The cake was mixed with sat. aqueous solution of NaHCO3 (100 mL) and EtOAc (200 mL), and the mixture was stirred for 1 h at RT. The organic layer was separated and the aqueous phase was extracted with EtOAc (2*200 mL). The organic extracts were combined, dried over MgSO4 and filtered. The filtrate was concentrated and the residue was purified by preparative HPLC [gradient 10-85% MeCN (0.1% TFA)/H2O (0.1% TFA)] to give the title compound as light-yellow solid. MS (ESI, positive ion) m/z: 282, 284 (M+I).

The synthetic route of Methyl 1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Electric Literature of 104619-51-4,Some common heterocyclic compound, 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, molecular formula is C7H7N5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

An oven-dried, round-bottomed flask was chargedwith di(lH-imidazoI-I-yl)methanimine (1.40 g, 8.69 mmol),2-amino-5-methylphenol (713 mg, 5.79 mmol) and anhydrous THF (20 ml) at ambient temperature. The resulting suspension was refluxed underN2 (g) for 2 h. The solvent wasremoved in vacuo and the residue was purified by silica gelchromatography (0-30% 9: I methanol:annnonium hydroxide-chloroform) to afford benzo[d]oxazol-2-amine (792 mg,5.35 mmol, 92% yield), as a grey solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Di(1H-imidazol-1-yl)methanimine, its application will become more common.

Application of 60-56-0, A common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A vial charged with 1 (0.25 g, 0.753 mmol), KF/Al2O3 (0.7 g) thiol (1.1 mmol), and 18-crown-6 (0.05 g, 0.225 mmol) in 5 mL of acetonitrile was heated for 20 h at 80 C. Then solvent was evaporated under reduced pressure and crude product was purified by flash chromatography on silica gel using the mixture petroleum ether – ethylacetate as eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 17325-26-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of (S)-2-((4-iodopyridin-2-yl)amino)butan-1-ol (0.8 g, 1.71 mmol), in DMF (5 mL) was added potassium phosphate (0.32 g, 2.57 mmol), methyl 1H-imidazole-4-carboxylate (0.323 g, 2.57 mmol), and L-proline (0.039 g, 0.34 mmol). The mixture was degassed with argon gas for 20 min, then copper(I) iodide (0.065 g, 0.34 mmol) was added, and then the mixture was stirred for 12 h at 150 C. in a sealed glass tube. Then the reaction mixture was cooled and quenched with water (35 mL), and extracted with ethyl acetate (3×60 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated under reduced pressure, and the residue was purified by gradient column chromatography eluting with 80% ethyl acetate in n-hexane to give (S)-methyl 1-(2-((1-hydroxybutan-2-yl)amino)pyridin-4-yl)-1H-imidazole-4-carboxylate as an off-white semi-solid, (0.25 g, 32% yield). 1HNMR (400 MHz, DMSO-d6): delta 8.42 (s, 1H), 8.38 (s, 1H), 8.02 (d, J=6 Hz, 1H,), 7.67 (m, 1H), 6.85 (m, 1H), 6.75 (s, 1H), 6.36 (d, J=8.4 Hz, 1H), 5.72 (s, 1H), 4.61 (s, 1H), 4.12 (m, 1H), 3.81 (d, J=4 Hz, 1H), 3.78 (s, 3H), 3.46 (t, J=5.6 Hz, 1H), 3.34 (t, J=5.6 Hz, 2H), 1.60-1.44 (m, 1H), 1.33-1.24 (m, 1H), 0.89-0.83 (m, 3H). LC-MS calcd exact mass 290.14, found m/z 291.2 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 3304-70-9, name is Dimethyl 4,5-imidazoledicarboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3304-70-9, Quality Control of Dimethyl 4,5-imidazoledicarboxylate

At ambient temperature 9.50 g (59.45 mmol) bromine were added dropwise to a solution of 9.90 g (53.76 mmol) dimethyl imidazole-4,5-dicarboxylate in 300 ml dichloromethane and 80 ml acetonitrile. 7.46 g (54.00 mmol) potassium carbonate was added, and the reaction mixture was stirred for 2 hours at ambient temperature. Then the dichloromethane was eliminated using the rotary evaporator and the residue was combined with a saturated solution of sodium chloride and sodium thiosulphate. It was extracted ten times with ethyl acetate, the organic extracts were dried over sodium sulphate and then the solvent was eliminated. Yield: 12.31 g (87% of theory) C7H7BrN2O4 (263.05) Mass spectrum: (M+H)+=263/265 (bromine)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 4,5-imidazoledicarboxylate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 39021-62-0,Some common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 54-(2-Chloro-11 -fhvdroxy-(3-methyl-3H-imidazol-4-yl)-methvn-dibenzofa,d1cvclohepten- 5-ylidene)-piperidine-1 -carboxylic acid tert-butyl ester 4-(11 -Bromo-2-chloro-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine-1 – carboxylic acid tert-butyl ester (2.5 gm, 5.1 mmol) was dissolved in dry tetrahydrofuran. Cooled to -78 C under a nitrogen atmosphere. Driped in a solution of 2.5M nBuLi in hexanes (3.25 ml) and stir 15 minutes. Added a tetrahydrofuran solution of 3-Methyl-3H-imidazo.e-4-carbaldehyde (0.56 gm, 5.1 mmol) quickly and stirred at -78 C. Let warm up to room temperature slowly and stired 20 tirs. Added to brine and extracted with 3X 100 ml of ethylacetate. Combined the ethylacetate extracts, dried over magnesium sulfate, filtered and evaporateed to a solid. Chromatographed on silica gel using 3%-5% methanol/dichloromethane to obtain 1.09 gm of pure title product. ESI M+1= 519

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-5-carbaldehyde, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Nitro-1H-benzo[d]imidazol-2(3H)-one

Intermediate 301 was prepared from 5-nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one 10 (CAS: 984-5) and bromoacetamide (CAS: 683-57-8) by the method indicated in the scheme below:

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93-84-5.