Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 16042-25-4, name is 2-Imidazolecarboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16042-25-4, Product Details of 16042-25-4

General procedure: The syntheses of 1-5 followed a similar procedure. In thesynthesis of 1, CoCl2*2H2O (0.0129 g, 0.100 mmol) and 2-Htza(0.0129 g, 0.100 mmol) were dissolved in distilled water(5.0 ml). The solution was left undisturbed at room temperaturefor several days, from which 1 crystallized. The sameprocedure was adopted for the syntheses of 2 and 3, exceptthat NiCl2*2H2O (0.0129 g, 0.100 mmol) and Cd(NO3)2*4H2O(0.0129 g, 0.100 mmol), respectively, were used instead ofCoCl2*2H2O. The procedure was also applied for the preparationof 4 and 5, except that Co(NO3)2*6H2O (0.0290 g,0.100 mmol) was used as a metal salt, whereas 2-H2ima(0.0112 g, 0.100 mmol) and 4-Hoxa (0.0113 g, 0.100 mmol)were used as the ligands for the preparation of 4 and 5,respectively.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Synthetic Route of 4887-88-1,Some common heterocyclic compound, 4887-88-1, name is 5-Bromo-1H-benzo[d]imidazole, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 5-bromo-1 H- benzimidazole (43.78 g, 222.0 mmol) in chloroform (800 mL) was added N-methylimidazole (44.5 mL, 560.0 mmol), followed by methyl 2-chloro-3-oxo-2,3-dihydro-2-thiophenecarboxylate (44.8 g, 233.0 mmol). The reaction was stirred 20 h at room temperature, then N- methylimidazole (18.0 mL, 226.0 mmol) was added, followed by X- butyldimethylsilylchloride (36.8 g, 245.0 mmol). The reaction was stirred 1 hr, then quenched with MeOH and poured into DCM and water. The aqueous layer was extracted with DCM (3x). The combined organics were then dried over Na2SO4, concentrated and chromatographed on silica gel, eluting with a 50-to-75% gradient of 25% EtOAc in hexane/hexane to give 25.18 g (24%) of the title compound. MS (ESI): 467 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1H-benzo[d]imidazole, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6775-40-2, name is 5-Phenyl-1H-imidazol-2-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Phenyl-1H-imidazol-2-amine

General procedure: The mixture of corresponding 2-amino-4-arylimidazoles 1 (1.0 mmol), isatin 18 (1.0 mmol) andmalononitrile 12 (1.0 mmol) in 2 mL of 2-propanol was refluxed during 50-60 min. After cooling, the solid products 19 were filtered off and crystallized from iPrOH.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H4N2O4

The complex was synthesized by hydrothermal method. A mixture of Zn(NO3)2.6H2O (0.47 g; 1.6 mmol), H3idc (0.25 g, 1.6 mmol) and water (30 mL) was sealed in a 45 mL Parr brand teflon-linedacid digestion bomb and heated at 180 C for 5 days, and then cooled to room temperature at a rate of 5 C/h. Pale yellow crystals of 1 were obtained (yield: 0.195 g, 73% based on Zn(NO3)26H2O). Anal. Calc. for C10H2N4O8Zn3: C, 23.91; H, 0.40; N, 11.15. Found:C, 23.90; H, 0.52; N, 10.90%. IR data (KBr, cm1): 3531m, 3359m, 3120m, 1589s, 1544s, 1474s, 1477s, 1384s, 1296m, 1253s, 1205m, 1107s, 1020w, 871m, 835m, 792m, 661m, 540w.

The synthetic route of 1H-Imidazole-4,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Synthetic Route of 10394-38-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10394-38-4, name is 1-Methylbenzoimidazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.

10.2 N-(1-methyl-benzimidazol-5-yl)-5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide A solution of 0.32 g (0.95 mmol) of 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid, obtained in step 10.1, and 0.69 ml (9.49 mmol) of thionyl chloride in 25 ml of dichloromethane is refluxed for 2 hours. The mixture is concentrated under reduced pressure, the residue is taken up in 20 ml of diethyl ether, and 0.17 g (1.14 mmol) of 5-amino-1-methylbenzimidazole and a solution of 0.2 g (1.9 mmol) of sodium carbonate in 2 ml of water are added. The mixture is stirred for 24 hours at room temperature, the organic phase is evaporated under reduced pressure and the resulting phase is extracted with ethyl acetate and dichloromethane. The organic phases are washed with water and with saturated sodium chloride solution, dried over sodium sulfate and concentrated under reduced pressure. The residue is taken up in petroleum ether, collected by filtration, washed and dried under reduced pressure. It is then purified by chromatography on a column of silica gel, eluding with a mixture of dichloromethane and ethyl acetate. The residue is taken up in petroleum ether, collected by filtration, washed and dried under reduced pressure. 0.3 g of solid is obtained. Melting point: 223-224 C. 1H NMR (DMSO), delta (ppm): 5.9 (s, 2H); 7 (m, 3H); 7.3 (m, 1H); 7.55 (m, 4H); 7.8 (d, 1H); 8.05 (s, 1H); 8.1 (d, 2H); 10.5 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 1-Methylbenzoimidazol-5-amine. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 2302-25-2, name is 4-Bromo-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2302-25-2, Product Details of 2302-25-2

(iv) Production of (2,3-Dihydronaphtho[2,3-b]furan-6-yl)(1H-imidazol-4-yl)methanol A solution of 4-bromo-1H-imidazole (2.11 g) in THF (40 ml) was cooled to -78 C. A solution of tert-butyllithium in pentane (1.7 M; 13 ml) was added to the solution. The mixture was stirred at 5 C. for 2 h and then cooled to -78 C. 6-formyl-2,3-dihydronaphtho[2,3-b]furane (1.46 g) in THF (30 ml) was added to the mixture. The mixture was allowed to room temperature and was stirred for 20 h. Ammonium chloride solution was added to the mixture and extracted with mixed solution of THF and ethyl acetate. The organic layer was dried and concentrated. The residue was purified by silica gel chromatography to give the titled compound (1.01 g) as a colorless solid. 1H-NMR (DMSO-d6) delta: 3.33 (2H, t, J=8.2 Hz), 4.59 (2H, t, J=8.2 Hz), 5.79 (1H, s), 6.79 (1H, s), 7.07 (1H, s), 7.40 (1H, d, J=8.8 Hz), 7.57 (1H, s), 7.65 (1H, d, J=8.8 Hz), 7.70 (1H, s), 7.76 (1H, s). IR (KBr): 3069, 1460, 1229, 1028, 886, 839 cm-1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-imidazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20075-26-7, name is 1-(Methoxymethyl)-1H-imidazole, A new synthetic method of this compound is introduced below., name: 1-(Methoxymethyl)-1H-imidazole

Step B. N-Methyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(1-methoxymethyl-1H-imidazol-2-yl)-ethyl]-phenyl}-benzenesulfonamide To a solution of 55 mg (0.49 mmol) of 1-methoxymethyl-1H-imidazole in 5 ml of THF at -78 C. was added 0.20 ml (0.50 mmol) of a 2.5 M solution of n-butyllithium in hexanes and the resultant mixture was stirred at -78 C. for 30 mins.After this time, a solution of 160 mg (0.47 mmol) of N-methyl-N-(4-trifluoroacetyl-phenyl)-benzenesulfonamide (Example 22, Step A) in 2 ml of THF was added and the resultant mixture stirred at -78 C. for a further 2 h, and then at room temperature for 14 h.After this time the reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered and the filtrate was concentrated.The residue was purified by chromatography on silica gel (hexanes:EtOAc, 4:1) to give the title compound. 1H-NMR (CDCl3) delta 3.09 (s, 3H), 3.19 (s, 3H), 4.90 (s, 2H), 5.16 (brs, 1H), 7.07-7.16 (m, 4H), 7.42-7.62 (m, 7H).Mass Spectrum (CI+) m/e=456.1 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, molecular formula is C7H4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 6478-73-5

Step B: 2-[(S)-1-Phenylethylamino]-4-[5,6-dichlorobenzimidazol-1-yl]pyrimidine To a solution of 100 mg of 5,6-dichlorobenzimidazole in 3 mL of DMF was added 26 mg of NaH (60% dispersion in oil) and the resulting suspension was stirred at room temperature for 15 minutes. Then, 138 mg of 2-[(S)-1-phenethylamino]-4-chloropyrimidine (EXAMPLE 117) was added and the reaction was heated to 100 C. for 3 hours. After cooling to room temperature, the solution was then diluted with 10 mL of H2O and extracted with 2*10 mL EtOAc. The organic phases were then dried over MgSO4 and concentrated under reduced pressure. The residue was purified with preparatory thin-layer chromatography (SiO2, 5% MeOH in CH2Cl2) to yield 205 mg of the title compound as a yellow oil. RF: 0.63 (5% MeOH in CH2Cl2). 1H NMR (500 MHz, CD3OD): delta 8.89 (br S, 1H), 8.36 (s, 1H), 7.86 (s, 1H), 7.74-7.45 (m, 2H), 7.32-7.28 (m, 3H), 7.19 (t, 1H, J=7.0 Hz), 6.99 (d, 1H, J=5.5 Hz), 5.19 (q, 1H, J=7.0 Hz), 1.59 (d, 3H, J=7.0 Hz). Mass Spectrum (ESI) 384 (M+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6478-73-5, its application will become more common.

Application of 51605-32-4, The chemical industry reduces the impact on the environment during synthesis 51605-32-4, name is Ethyl 5-methyl-1H-imidazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

(1) Ethyl 4-methyl-1H-imidazole-5-carboxylate (7.5 g, 48.7mmol) was dissolved in acetonitrile (120 mE), N-bromosuccinimide (10.4 g, 58.4 mmol) was added thereto, and then themixture was stirred at room temperature for 3 hours. Afier thereaction, saturated aqueous sodium hydrogen carbonate wasadded and the mixture was extracted twice with ethyl acetate.Afier washing with saturated aqueous sodium chloride, theorganic layer was dried over anhydrous sodium sulfate. Afterconcentrating the organic layer, the residue was purified bycolunm chromatography to obtain ethyl 2-bromo-4-methyl-1 H-imidazole-5-carboxylate (3.6 g):(3H, s), 1.37 (3H, t, J=7.i Hz);j0127] iH.NMR (CDC13) oe: 4.35 (2H, q, J=7.i Hz), 2.51j0128] ESI-MS mlz=233 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-methyl-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 46006-36-4

To a solution of methyl 1H-benzo[d]imidazole-4-carboxylate (1.136 g, 7.02 mmol) in MeOH (115 mL) was added conc. H2SO4 (0.86 mL, 15.45 mmol). The reaction was heated at reflux temperature until TLC showed full conversion (24-36 hrs). The reaction was concentrated to a few mL and pH was adjusted to 8.5 with 1M K3PO3. The resulting precipitate was isolated by filtration and dried under reduced pressure to afford the title compound (0.940 g, 76%) as a white solid. mp. 211 – 213 C (Litt5. 204 C). 1H NMR (300 MHz, DMSO-d6) delta 8.31 (s, 1H), 7.95 (dd, J = 8.0, 0.9 Hz, 1H), 7.83 (dd, J = 7.6, 0.9 Hz, 1H), 7.29 (dd, J = 8.0, 7.6 Hz, 1H). 13C NMR (75 MHz, DMSO-d6) delta 165.5, 144.1, 143.6, 132.3, 124.7, 124.3, 121.0, 113.8

The synthetic route of 1H-Benzimidazole-7-carboxylic acid has been constantly updated, and we look forward to future research findings.