Tag: M.W=100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 53710-78-4

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.

Electric Literature of 68282-53-1, These common heterocyclic compound, 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

COMPOUND 12.1. 57: NV-DIETHYL-4-f 5, 6, 7-TRIMETHOXY-2-r (4-METHYL- lH-IMIDAZOL-5-YL) METHYLl-1, 2 3, 4-TETRAHYDROISOQUINOLIN-1- YL}BENZAMIDE; 4-Methyl-imidazole-5-carboxyaldehyde (65.2 mg, 0.59 mmol) was added to a solution of INTERMEDIATE 5.1. 16 (117.9 mg, 0.30 mmol) in 1,2-dichloroethane (5 mL) and the reaction mixture stirred at room temperature for 10 min. Sodium triacetoxyborohydride (439 mg, 2.07 mmol) was added followed by N-methyl-2- pyrrolidinone (350, uL) and the reaction mixture stirred at RT for 16 h. 1 N NaOH (5 mL) was added and the organic solvent removed in vacuo. The residue was extracted with EtOAc (3 x 20 mL) and the organic layer washed with water (20 mL). The organic layer was concentrated in vacuo and the residue purified by flash chromatography on Si02 column (EtOAc: MeOH 95: 5) to afford COMPOUND 12.1. 57 as an oil (32.2 mg, 22%).’HNMR (500 MHz, CDCl3) : 8 1.11 (br s, 3H), 1.25 (br s, 3H), 2. 09 (s, 3H), 2.52 (m, 1H), 2.70 (dt, J6.5, 17 Hz, 1H), 2 : 81 (dt, J4. 5, 17 Hz, 1H), 3.05 (m, 1H), 3.27 (br s, 2H), 3.39 (m, 2H), 3.55 (br s, 1H), 3.59 (m, 1H), 3.60 (s, 3H), 3.85 (s, 3H), 3.89 (s, 3H), 4.56 (s, 1H), 6.00 (s, 1H), 7.28-7. 32 (m, 4H), 7.39 (s, 1H) ; 13C NMR (125 MHz, CDC13) : 6 11. 12, 13.11, 14.41, 22.43, 39.69, 43.65, 46.30, 49.22, 56.12, 60. 71, 61.03, 67.59, 107.92, 121. 56,126. 55,129. 87, 130. 31, 132.67, 133.31, 136.29, 140.75, 145.12, 150. 85, 151. 79,171. 51; (+) LRESIMS m/z 493.24 [M+H] +.

Statistics shows that 5-Methyl-1H-imidazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 68282-53-1.

Some common heterocyclic compound, 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Benzimidazole-7-carboxylic acid

Step 1: ethyl 1H-benzimidazole-4-carboxylate 2.50 g (15.4 mmol) 1H-benzimidazole-4-carboxylic acid in 100 mL ethanol are combined with 50 mL saturated ethanolic hydrochloric acid solution and refluxed for 15 hours. The reaction mixture is poured into saturated, aqueous potassium carbonate solution and extracted with ethyl acetate. The combined organic phases are dried on sodium sulphate and evaporated down to 50 mL using the rotary evaporator and filtered. 1.80 g (9.46 mmol, 61%) ethyl 1H-benzimidazole-4-carboxylate are obtained as a colourless solid. Rf=0.92 [silica gel, dichloromethane/methanol (80/20)] MS [ESI (M+H)+]]=191

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 46006-36-4, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17289-26-8, category: imidazoles-derivatives

To a solution of 15 (1.01 g, 9.18 mmol) in dry THF (10 mL) were added 5a (3.35 g. 10.1 mmol, 1.1 eq)and TMG (1.7 mL, 13.8 mmol, 1.5 eq) at 0 C, and the mixture was stirred for 24 h at rt. The reaction mixture was quenched with water and acidified with 1N aqueous HCl, and extracted with CH2Cl2. The aqueous layer was neutralized with sat. aqueous NaHCO3 and extracted with CH2Cl2. The combined organic extracts wered ried over anhydrous MgSO4, concentrated in vacuo to afford the crude product. The residue was purified by silica gel flash column chromatography (40:1 CHCl3 / MeOH). The obtained residue was washed with Et2O and the cake was dried in a house vacuum oven to afford 11a (1.90 g, 65%) as a white solid. IR (solid, cm-1) 1063, 1225, 1273, 1462, 1728, 2951, 32291H NMR (500 MHz, CDCl3) delta 3.68 (s, 3H), 3.79 (s, 3H), 5.18 (s, 2H), 6.56 (s, 1H), 6.95 (s, 1H), 7.31-7.43 (m,6H)13 C NMR (125 MHz, CDCl3) delta 33.5, 52.2, 67.1, 112.9, 121.4, 126.6, 128.0, 128.1, 128.4, 136.2, 137.7, 154.1,165.8FAB-MS : m/z 316 (M+H)+HRMS (ESI) Calculated for C16H18N3O4 316.1291 Found 316.1299

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 1072-84-0, These common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1H-Imidazole-4(5)-carboxylic acid (0.560 g, 5 mmol) was dissolved in DMF (20 mL) and a small amount of insoluble solid was filtered off. A cooled (0 C) solution of diazomethane in ether36 was added until no more bubbles were formed. After evaporation of the solvent under reduced pressure the residue was dissolved in ether and washed with water to neutral pH. Then the ethereal solution was dried and evaporated. The product was obtained as a white solid homogeneous by TLC in 40% yield (0.252 g); mp 144-147 C (mp.lit37 = 153-154 C).1H NMR (CD3OD) delta: 7.77(d, J = 4.5 Hz, 2H, NCHNHCH), 3.85(s, 3H, CH3).13C NMR delta: 164.2(COO), 138.6, 126.6, 123.4, 52.0(CH3).Anal. Calcd for C5H6N2O2: C, 47.62; H, 4.80; N, 22.21. Found: C, 47.58; H, 4.96; N, 22.12.

The synthetic route of 1072-84-0 has been constantly updated, and we look forward to future research findings.

Related Products of 27231-33-0, A common heterocyclic compound, 27231-33-0, name is 4-Methyl-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C8H8N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20 2,3-Dihydro-5-methyl-2-(2-pyridyl)thiazolo[3,2-a]benzimidazole 4-Methyl-2-mercaptobenzimidazole (13.32 g) was suspended in 2-methylpropan-2-ol (150 ml) and potassium tertbutoxide (9.04 g) added. The mixture was stirred for 2 hours and 2-(1,2-dibromoethyl)pyridine hydrobromide (27.68 g) added. The mixture was stirred at ambient temperature for 1 hour and then at reflux for 2 hours. The reaction mixture was filtered and the solid washed with ether. The filtrate was evaporated to dryness under reduced pressure and the residue combined with the first solid obtained. The combined material was dissolved in 2N HCl (100 ml). The aqueous solution was extracted with ethyl acetate, basified (Na2 CO3) and extracted with dichloromethane. The organic layer was dried (MgSO4) and the solvent removed under reduced pressure. The residue was purified on Florisil using chloroform as eluent and on silica using ethyl acetate as eluent to give the title compound (1.55 g) mp 128-130 C. Analysis: Found: C, 67.1; H, 5.0; N, 16.1. C15 H13 N3 S requires: C, 67.4; H, 4.9; N, 15.7%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 670-96-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 670-96-2, name is 2-Phenyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[0003081 To a stirred solution of compound 1 (2 g, 1 eq) in Conc. H2S04 (8 mL), nitrating mixture (0.88 mL Conc. HN03 + 2 mL Conc. H2S04) was added at 0 C and stirred at same temperature for 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured onto ice water and basified to pH 9 using 2N NaOH. The precipitated solid was filtered, washed with water and dried under reduced pressure to afford the title compound 2. LCMS (mlz): 190.00 (M + 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Phenyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 41806-40-0, The chemical industry reduces the impact on the environment during synthesis 41806-40-0, name is 1-Methylimidazole-5-carboxylic Acid, I believe this compound will play a more active role in future production and life.

To a solution of 1-methyl-1 H-imidazole-5-carboxylic acid (45 mg, 0.36 MMOL) in DICHLOROMETHANE (3.6 mL) was added 6-CHLORO-2, 3,4, 9-tetrahydro-1H-carbazol-1- amine (95 mg, 0.43 MMOL), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (83 mg, 0.43 MMOL), and 1-hydroxybenzotriazole (54 mg, 0. 40 MMOL). After 5 minutes, triethylamine (100 muL, 0.72 MMOL) was added and the reaction was stirred at room temperature for 15 hours. The reaction mixture was diluted with dichloromethane, washed with water, 1 N hydrochloric acid, 1 N sodium hydroxide, brine, dried with magnesium sulfate, filtered, and concentrated. The residue was purified by PREPARATIVE chromatography (10-90% acetonitrile-water (0. 1% trifluoroacetic acid) ) and then diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate, and dried with magnesium sulfate to give 43 mg (36% yield) of a white SOLID. H-NMR (CDCI3) : 8 9.21 (s, 1H), 7. 43 (M, 1H), 7. 32 (s, 1H), 7. 30 (s, 1H), 7. 20 (d, 1H), 7.07 (dd, 1H), 6. 60 (d, 1H), 5.25 (m, 1H), 3. 81 (s, 3H), 2.67 (m, 2H), 2. 21 (m, 1H), 1.90 (m, 3H) ; MiS m/z 327 (M-1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylimidazole-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 75370-65-9, These common heterocyclic compound, 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Commercially available p-chlorobenzylamine (846 mg, 6 mmol) was dissolved in 40 ml of AcOEt and at 0C triphosgene (1.78 g, lequiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 20 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound la (900 mg, 6 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 30 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 300 mg of a white solid. Yield = 16% ‘HNMR (DMSO, 200 MHz) delta 4.30 (2H, d, J = 6.2 Hz), 6.62 (1H, dd, J = 7.6 Hz, J’ = 1.2 Hz), 6.83 (2H, m), 6.96 (1H, dd, J = 8 Hz, J’ = 1 Hz), 7.35 (4H, m), 8.27 (1H, bs), 9.98 (1H, bs), 10.59 (1H, bs); [M+1] 317.1 (C15H13ClN4O2 requires 316.74).

The synthetic route of 75370-65-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 106429-57-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106429-57-6, name is Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate (1.3 g, 6.6 mmol), pyridine hydrobromide (1.0 g, 6.6 mmol) and phosphorous oxybromide (3.7 g, 13 mmol) were mixed in EtOAc (100 ml). The reaction mixture was stirred at reflux for 7 d. Water was added. The organic phase was washed with NaHC03 (sat., aq), dried over MgS04, filtered and concentrated. The intermediate methyl 2-bromo-1H-benzimidazole-6-carboxylate was obtained in 100% yield (1.6 g). MS (ESI+) m/z 255 [M+H]+. HPLC purity: 95%. 1H NMR (600 MHz, MeOD- ) delta ppm 8.21 (s, 1 H) 7.96 (dd, J=8.55, 1.53 Hz, 1 H) 7.58 (d, J=8.55 Hz, 1 H) 3.93 (s, 3 H)

The synthetic route of Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.