Tag: M.W=100-200

Synthetic Route of 2302-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2302-25-2, name is 4-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General Procedure 48 A mixture of 4-bromo-imidazole (217 mg, 1.48 mmol) and cesium carbonate (875 mg, 2.69 mmol) in dimethylformamide (5 mL) was stirred for 30 minutes. 4-(2-Chloro-ethyl)-morpholine hydrochloride (250 mg, 1.34 mmol) was added and the mixture was heated to 50 C. After heating overnight the reaction was concentrated by rotary evaporation. The residue was suspended in a mixture of dichloromethane and methanol and filtered. The filtrate was concentrated by rotary evaporation. The residue was purified by silica gel chromatography using gradient elution of dichloromethane, methanol to afford 4-[2-(4-Bromo-imidazol-1-yl)-ethyl]-morpholine (148 mg, 42%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Application of 2302-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2302-25-2, name is 4-Bromo-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 1: To a stirred mixture of DMF (15 mL) and NaH (60% dispersion in mineral oil, 539 mg, 21 mmol) at 0C under argon was added 4-bromo-1H-imidazole (3 g, 20 mmol) in one portion. The mixture was stirred for 5 min at 0C. A solution of 2-(trimethylsilyl)ethoxymethyl chloride (4.3 mL, 24 mmol) in DMF (3 mL) was added dropwise. Afterstirring at 0 C for 1 h, the mixture was warmed slowly to rt and stirred for 6 h. The mixture was then partitioned betweenEtOAc (100 mL) and water (50 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4, filtered,and the filtrate was concentrated under reduced pressure. The residue was purified via silica gel flash chromatography(eluting with a gradient of 100% hexanes to 100% EtOAc) to afford a regioisomeric mixture of 4-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole and 5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole as an oil (2.9 g, 53%).LCMS (ESI) m/z 277 and 279 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Application of 75370-65-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation of 1-(4-(trifluoromethyl)-2-(1H-1,2,4-triazol-1-yl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Amine 2e (600 mg, 2.48 mmol) was dissolved in 20 ml of AcOEt and at 0C triphosgene (755 mg, lequiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 10ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1a (450 mg, 3 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 9.5 / MeOH 0.5). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 110 mg of an orange solid. Yield = 10% 1HNMR (DMSO, 200 MHz) delta 4.30 (2H, d, J = 6 Hz), 6.64 (1H, dd, J = 7.4 Hz, J’ = 1.2 Hz), 6.79 (2H, m), 6.91 (1H, dd), 7.83 (1H, d), 7.92 (2H, d), 8.33 (1H, bs), 8.42 (1H, bs), 9.07 (1H, bs), 9.94 (1H, bs), 10.59 (1H, bs); [M+1] 418.2 (C18H14F3N7O2 requires 417.34).

The synthetic route of 4-Amino-1H-benzo[d]imidazol-2(3H)-one has been constantly updated, and we look forward to future research findings.

Related Products of 68282-53-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68282-53-1 name is 5-Methyl-1H-imidazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Apim (2.81 g, 22.5 mmol) in dry methanol (17 mL) was added 4-methyl-5-imidazolecarboxaldehyde (2.17 g, 22.5 mmol). The resulting light-yellow suspension was heated to reflux for 3 h. The suspension was dissolved completely after 5 min. The solution was then stirred overnight at room temperature. After 0.5 h the solution turned orange in colour. The solvent was removed under reduced pressure to give an orange oil, which, on standing for 3 weeks, yielded the orange solid (5) (3.10 g, yield 76 %). M.p. 113-115C. C11H15N5 (217.27): Calc. C, 60.81; H, 6.96; N, 32.23. Found: C, 60.60; H, 6.72; N, 31.35%. 1H NMR (d6-DMSO): delta=8.23 (s, 1H), 7.64 (s, 1H), 7.61 (s, 1H), 7.18 (s, 1H), 6.91 (s, 1H), 4.04 (t, 2H, J=7.2Hz), 3.42 (t, 2H, J=6.6Hz), 2.32 (s, 3H), 2.03 (p, 2H, J=6.9, 6.6Hz) ppm. 13C NMR (d6-DMSO): delta=137.2, 128.3, 119.3, 57.3, 48.5, 43.9, 32.1ppm. IR (KBr): nu=3113, 1643, 1529, 1452, 1395, 1354, 1233, 1110, 1082, 826, 747cm-1. LC/TCOF-MS: Calc. for C10H14N5 [M+1]+ 218.3. Found 218.1%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-imidazole-4-carbaldehyde, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 360-97-4, name is 4-Amino-1H-imidazole-5-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Amino-1H-imidazole-5-carboxamide

A solution of delta-amino-I H-imidazole^-carboxamide (1.4 g, 11 mmol), toluene- 4-sulfonic acid 1 -(tert-butoxycarbonyl-isopropyl-amino)-propyl ester (5 g, 13 mmol) previously prepared (cf. Llauger et al., “Evaluation of 8-Arylsulfanyl, 8- Arylsulfoxyl, and 8-Arylsulfonyl Adenine Derivatives as Inhibitors of the Heat Shock Protein 90”, J. Med. Chem. 2005, vol. 48, p. 2892), and Cs2CO3 (3.6 g, 11 mmol) in 40 ml_ of DM F was stirred at 8O0C for 16 h. Removal of the solvent and purification by chromatography on silica (CHCI3/MeOH, 5%) yielded ^-(delta-Amino^-carbamoyl-imidazol-i-yO-propyll-isopropyl-carbamic acid tert-butyl ester (1.45 g, 40%) as a viscous oil . 1H-NMR [CDCI3, delta, ppm]: 7.12 (s, 1 H), 3.37 (m, 2H), 3.32 (m, 1 H), 3.07 (m, 2H), 1.92 (m, 2H), 1.40 (s, 9H), 1.07-1.06 (2s, 6H).

According to the analysis of related databases, 360-97-4, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H3F3N2

Production Example 58A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 0.18 g of 4-(trifluoromethyl)-1H-imidazole, 0.55 g of potassium carbonate and 2 ml of DMF was stirred while heating at 50 C. for 1.5 hours. Then, the reaction mixture was cooled to room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.40 g of 2-{3-[4-(trifluoromethyl)imidazole-1-yl]pyridin-4-yl}-5-(trifluoromethyl)benzoxazole (hereinafter, referred to as ?active compound 57?).Active Compound 571H-NMR (CDCl3) delta: 9.00 (d, J=5.2 Hz, 1H), 8.84 (s, 1H), 8.31 (d, J=5.1 Hz, 1H), 8.06-8.04 (m, 1H), 7.77-7.75 (m, 1H), 7.74-7.70 (m, 1H), 7.62 (d, J=8.6 Hz, 1H), 7.52-7.50 (m, 1H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33468-69-8.

Application of 104619-51-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 104619-51-4 as follows.

Example 27: r4-(5-Amino- H .3.41 oxadiazol-2-yl)-1-oxy-pyiotadin-3-v?-(2-fluoro-4- iodo-phenvh-amine; To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-1-oxy-isonicotinic acid hydrazide (150mg, 0.39mmol, 1eq) in DMSO (2mL) C- (Di-imidazol-i-yl)-methyleneamine (124mg, 0.78mmol, 2eq) was added. The reaction mixture was stirred at RT under argon overnight and then poured into water. The product was isolated by filtration (80 mg) . LC/MS (Method A) [4.68min; 414(M+1 )]

According to the analysis of related databases, 104619-51-4, the application of this compound in the production field has become more and more popular.

Related Products of 2466-76-4, A common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 10364-94-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10364-94-0 as follows.

General procedure: To a stirred solution of NaSH (9 mmol, 3 equiv.) in water (4 mL) was added N-acyl benzotriazole 1 (3 mmol, 1 equiv.). The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, HCl (2N) was added dropwise to acidify the solution. The precipitated solid was collected by vacuum filtration, washed with water (10 mL), and dried. In case of oily residue, the aqueous solution was decanted, and the residue was dissolved in EtOAc (15 mL). This solution was washed with 10% HCl (2 × 10 mL), brine (10 mL), dried over MgSO4, and concentrated under reduced pressure. These compounds are oils at room temperature but usually solidify after refrigeration.

According to the analysis of related databases, 10364-94-0, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 24134-09-6, name is 5-Bromo-1,2-dimethyl-1H-imidazole, molecular formula is C5H7BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives

General procedure: To a solution of 2-disubstituted 1-methyl-1H-imidazole 1 (1 mmol) in DMF (5 mL), NBS(169 mg, 0,95 mmol) was added and the resulting reaction mixture was stirred in the dark at room temperature for 3h. Then, Pd(PPh3)2Cl2 (14 mg, 0.02 mmol, 2 mol%), CuI (8 mg, 0.04mmol, 4 mol%), an alkyne 3 (1,1 mmol) and piperidine (300 muL, 255 mg, 3 mmol) were added and the resulting reaction mixture was stirred at 80C (when trimethylsilylacetylene was employed as the alkyne, the reaction was carried out at 50C) for 3 h. The reaction mixture was diluted with EtOAc (100 mL), then saturated aqueous NH4Cl (100 mL) was added. The resulting mixture was stirred for 30 minutes and extracted with EtOAc (3x 25mL). The organic extracts were washed with water (3 x 25 mL) and brine (1 x 25 mL), driedover anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatogaraphy on silica gel. This procedure was employed to prepare compounds 4a-l. GLC analysis showed that all these compounds had chemical purity higherthan 98%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 24134-09-6, its application will become more common.