Tag: M.W=100-200

Related Products of 71759-89-2, The chemical industry reduces the impact on the environment during synthesis 71759-89-2, name is 5-Iodo-1H-imidazole, I believe this compound will play a more active role in future production and life.

4-lodo-1H-imidazole (194mg, LOmmol), phenylboronic acid (158.5 mg, 1.3mmol), potassium carbonate (345mg, 2.5mmol) and Pd (PPh3)2Cl2 (42 mg, 6%) were taken up in a degassed mixture of 1 ,4-dioxane (5mL) and water (0.8mL) under an atmosphere of nitrogen. The resulting mixture was heated at 901C for 3 hours. The reaction mixture was cooled to room temperature, and taken up in ethyl acetate and water. The organic phase was separated and the aqueous layer further extracted with 3×20 ml portions of ethyl acetate. The combined ethyl acetate layers were washed with water, brine, dried over magnesium sulfate, filtered, and concentrated under vacuum. The residue was purified by flash chromatography to give the product (112 mg) with a yield of 78%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Iodo-1H-imidazole, other downstream synthetic routes, hurry up and to see.

17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: imidazoles-derivatives

To a solution of methyl 1H-imidazole-4-carboxylate (14.0 g) in acetonitrile (200 mL) were added potassium carbonate (19.9 g) and potassium iodide (0.092 g), 3,4,5-trifluorobenzyl bromide (14.6 mL) was added dropwise thereto at room temperature, and then the mixture was stirred at 70C for 6 hours. The mixture was cooled to room temperature, and to the reaction mixture was added water, and then the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtrated, and then concentrated in vacuo. The resulting crude product was washed with hexane/ethyl acetate (1/2, 60 mL) to give the title compound (14.0 g). LC-MS, condition B ([M+H]+/Rt (min)): 271.4/0.725

The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1632-83-3, name is 1-Methylbenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1632-83-3, Quality Control of 1-Methylbenzimidazole

Under argon atmosphere, the catalyst (66 mg, 0.05 mmol, 10 mol%) and magnesium turnings (12.0 mg, 0.5 mmol) were successively added to the reaction flask.N-methylbenzimidazole (66 mg, 0.5 mmol), styrene (86 mul, 0.75 mmol), tetrahydrofuran (1.5 ml) as a solvent, reacted at 80C for 60 hours, and quenched with water, the reaction product Extract with ethyl acetate,Purification by column chromatography (developing solvent in a mixed solvent of ethyl acetate/petroleum ether at a volume ratio of 1:20) gave a yield of 87%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylbenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference of 10040-98-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10040-98-9 as follows.

The compound of formula 6-3 (methyl4-((5-(piperidin-4-yl)- I H-pyrrolo[2,3-b]pyridin- I -yl)methyl)benzoate) (0.100 g, 0.286 mmol), 4-(1H-imidazol-1-yl)benzaldehyde (0.074 g, 0.429 mmol), and sodium triacetoxyborohydride (0.09 1 g, 0.429 mmol) were dissolved in methylene chloride (3 mL) at room temperature, and the solution was stirred at the same temperature for 3 hours. Water was added to the reaction mixture, followed by extraction with methylene chloride. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, filtered, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (SiO 2, 12 g cartridge; methanol I methylene chloride = from 0% to 10%) to afford the desired compound of formula 12-2 (0.077 g, 52.9%) as a yellow liquid.

According to the analysis of related databases, 10040-98-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75370-65-9, Safety of 4-Amino-1H-benzo[d]imidazol-2(3H)-one

Example 55: 2-(4-(trifluoromethyl)phenyl)-N-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)acetamide (scheme 10) Preparation of 2-(4-(trifluoromethyl)phenyl)-N-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)acetamide 4-trifluoromethylphenylacetic acid (300 mg, 1.47 mmol) was dissolved in 20 ml of THF and at 0C DEPC (0.28 ml, 1.3equiv) and amine 1a (260 mg, 1.2equiv.) were added to the solution. The mixture was warmed at 80C overnight, then evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column using AcOEt as eluant gave 150 mg of a white solid. Yield = 30% 1HNMR (DMSO, 400 MHz) delta 3.78 (2H, s), 6.75 (1H, d), 6.84 (1H, t), 7.05 (1H, d), 7.56 (2H, d, J = 8 Hz), 7.70 (2H, d, J = 8 Hz), 9.80 (1H, bs), 10.18 (1H, bs), 10.64 (1H, bs); [M+1] 336.1 (C16H12F3N3O2 requires 335.3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1H-benzo[d]imidazol-2(3H)-one, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1848-84-6, name is 2-Ethyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H10N2

General procedure: To a stirred solution of 10.0 mmol of compound 1a?1i in 10 mL of conc. H2SO4 we added dropwise 10 mL (0.11 mmol) of 33percent aqueous hydrogen peroxide at 100?105°C. The mixture was stirred for 0.5 h at 120°C, let to cool down, and poured in water. The pH of the solution was adjusted to ~2 with sodium carbonate, and the precipitate of 2-alkylimidazole-4,5-dicarboxylic acid 2a?2i was filtered off and recrystallized from water.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1848-84-6.

Synthetic Route of 53710-78-4,Some common heterocyclic compound, 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, molecular formula is C6H9ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Chloropropyl)-1H-imidazole, its application will become more common.

Application of 4857-06-1,Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 2 (2-chloro-1H-benzimidazole; 1 g) inMeOH (30 mL), a solution of Br2/MeOH (1.5 mL/15 mL) was addeddrop wise. The resulting suspension was stirred at room temperature for6 h, added H2O (30 mL) and stirring continued at room temperature for18-20 h. The reaction mixture was filtered and the precipitate waswashed thoroughly with cold H2O until the washing was neutral. Thewhite coloured solid was air dried and crystallized from MeOH. Whitesolid, yield (72%); mp 227-228 C; Rf – 0.52 (EtOAc:Hexane:: 3:7); 1HNMR (400 MHz, DMSO-d6) deltappm: 7.95 (s, 2H), 13.79 (br, s, 1H, eNH);13C NMR (100 MHz, DMSO-d6) deltappm: 120.9, 121.5, 138.7, 140.2; HRMSm/z Calcd. for C7H3Br2ClN2 (M+H)+: 308.8430, Found: 308.8434;Anal. Calcd. For C7H3Br2ClN2: C, 27.05; H, 0.95; Br, 51.45; Cl, 11.42; N,9.01% Found: C, 27.07; H, 0.96; Br, 51.48; Cl, 11.44; N, 9.05%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-1H-benzo[d]imidazole, its application will become more common.

Reference of 85692-37-1, A common heterocyclic compound, 85692-37-1, name is 1-(1-Methyl-1H-imidazol-2-yl)ethanone, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 45 (1-Methyl-2-imidazolyl)glyoxal By the method of Preparation 41, 1-methyl-2-acetylimidazole was converted to present title product. The hydrate (200 mg.) was sublimed from a bath at 100-110 C. at 0.2 mm to yield 97 mg. of title product; 1 H-nmr 4.03 (s, 3H), 7.32 (s, 1H), 7.63 (s, 1H), 10.33 (s, 1H),; tlc Rf 0.16 (2:1 hexane:ethyl acetate).

The synthetic route of 85692-37-1 has been constantly updated, and we look forward to future research findings.

Reference of 16681-59-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16681-59-7 name is 2-Bromo-1-methyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0461] 2-(2-chlorophenyl)-4-(piperazine-l-yl)quinazoline (91 mg, 0.281 mmol) was dissolved in NMP (3 mL) in a microwave reactor vial. Then 2-bromo-l- methylimidazole (0.05 mL, 0.561 mmol) was added and the mixture heated at 200 0C for 10 minutes in a microwave reactor. The mixture was poured into H2O, extracted with CH2Cl2, dried over Na2SO4, filtered, and concentrated in vacuo. The crude material was then purified by reverse phase HPLC (10% – 90% MeCNZH2O) to give the title compound. 1U NMR (400 MHz, CDCl3) delta 8.23 (m, IH), 8.13 (m, IH), 8.02 (m, IH), 7.92 (m, 2H), 7.67 (m, IH), 7.46 (m, 2H), 7.16 (d, IH), 6.83 (d, IH), 4.32 (m, 4H), 3.69 (m, 5H), 3.39 (m, 2H). MS (M/z, M+l), 405.5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-methyl-1H-imidazole, and friends who are interested can also refer to it.