Tag: M.W=100-200

Synthetic Route of 872-82-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 872-82-2, name is 2-(1H-Imidazol-5-yl)ethanol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

0.291 g (1 mmol) of cobalt(II) nitrate hexahydrate was dissolvedin 5 mL of methanol. In a separate flask 0.224 g (2 mmol) 4(5)-(bhydroxyethyl)imidazole was dissolved in 5 mL of methanol. Bothsolutions were mixed and refluxed for 60 min. The resulting solutionwas left to evaporate in room temperature. After severalmonths reddish crystals of 1 were formed in the initially obtainedpink oil. Anal. calcd. for CoC10H20N6O10 (442.03 g/mol): C 27.10; H4.55; N 18.96, found: C 27.11; H 4.26; N 19.78. M.p. 355 K. FT-IR(solid): t = 3224 (vs), 2929 (s), 1655 (w), 1591 (w), 1575 (w),1501 (w), 1474 (w), 1331 (vs), 1269 (s), 1188 (m), 1105 (m),1090 (w), 1064 (w), 1044 (w), 1022 (s), 964 (w), 946 (w), 857(w), 821 (m), 771 (w), 657 (w), 637 (w), 621 (m), 501 (w) cm1.Vis spectra of aqueous solutions are presented in Supplementarycontent (Fig. 1S).

The synthetic route of 2-(1H-Imidazol-5-yl)ethanol has been constantly updated, and we look forward to future research findings.

Application of 54624-57-6, These common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 2-bromo-1H-benzo[d]imidazole (0.75 g, 3.8 mmol) in THF (25 mL) was added n-butyllithium (1.5 mL, 3.8 mmol) dropwise at -78°C. After 45 minutes, a solution of racemic (1′-azaspiro[oxirane-2,3′-bicyclo[2.2.2]octan]-1′-yl-4-ium)trihydroborate (0.7 g, 4.6 mmol) from the reference example, in THF (15 mL) was added dropwise at -78°C. The cooling bath was removed and the reaction mixture warmed to room temperature. After 15 minutes, the mixture was heated to 75°C for 2 hours and then cooled to room temperature. The reaction was quenched with water and the product was extracted with ethyl acetate (100 mL). The organics were dried with MgSO4, filtered and the solvent was removed to yield the crude product. The crude material was purified by chromatography (Biotage) to yield racemic (3H-1′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,3′-bicyclo[2.2.2]octan]-1′-yl-10-ium)trihydroborate (0.66 g, 2.5 mmol, 64.4 percent yield) as a white powder. 1H NMR (500MHz, DMSO-d6) d 7.44 – 7.34 (m, 1H), 7.31 – 7.19 (m, 1H), 7.18 – 6.97 (m, 2H), 4.53 (d, J=9.8 Hz, 1H), 4.31 (d, J=9.8 Hz, 1H), 3.45 (dd, J=15.3, 2.5 Hz, 1H), 3.36 – 3.29 (m, 1H), 3.09 – 3.01 (m, 1H), 2.99 – 2.83 (m, 3H), 2.43 (br. s., 1H), 2.15 – 2.04 (m, 1H), 1.92 – 1.75 (m, 3H), 1.69 – 1.20 (m, 3H). MS (LC/MS) R.T. = 2.09; [M+1-BH3]+ = 256.12.

Statistics shows that 2-Bromobenzimidazole is playing an increasingly important role. we look forward to future research findings about 54624-57-6.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Formula: C7H5ClN2

To a solution of 2-chloro-1H-benzimidazole (3.8 g) in DMF (25 ml) was added sodium hydride (60% in oil, 1.1 g) at 0 C. in several portions. The reaction mixture was stirred at 0 C. for 30 min, 2-(trimethylsilyl)ethoxymethyl chloride (4.7 ml) was added dropwise, and the mixture was stirred at room temperature overnight. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by basic silica gel column chromatography (hexane/ethyl acetate) to give the title compound (6.3 g). [0427] 1H NMR (300 MHz, CDCl3) 5-0.05 (9H, s), 0.87-0.95 (2H, m), 3.55-3.61 (2H, m), 5.57 (2H, s), 7.27-7.36 (2H, m), 7.42-7.50 (1H, m), 7.66-7.74 (1H, m).

The synthetic route of 4857-06-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 17228-38-5, These common heterocyclic compound, 17228-38-5, name is N-Methyl-1H-benzo[d]imidazol-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2.03 AND EXAMPLE 2.04 N-Methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazol-2-amine and N-Methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazol-2-amine; Cesium carbonate (942 mg, 2.89 mmol) was added to (3R)-4-(2-chloro-6-(1-(S-methylsulfonimidoyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine (319 mg, 0.96 mmol) and N-methyl-1H-benzo[d]imidazol-2-amine (284 mg, 1.93 mmol) in DMA (10 ml). The resulting suspension was stirred at 80 C. for 45 hours. A further portion of N-methyl-1H-benzo[d]imidazol-2-amine (284 mg, 1.93 mmol), cesium carbonate (942 mg, 2.89 mmol) and sodium methanesulfinate (98 mg, 0.96 mmol) were added and the suspension was stirred at 80 C. for 70 hours. The reaction mixture was filtered and then evaporated. The residue was dissolved in EtOAc (250 ml), and washed sequentially with water (250 ml) and saturated brine (75 ml). The organic layer was dried over MgSO4, filtered and evaporated onto silica gel (5 g). The resulting powder was purified by flash chromatography on silica, eluting with a gradient of 0 to 5% MeOH in DCM. Pure fractions were evaporated and the residue was purified by preparative chiral chromatography on a Merck 50 mm, 20 mum Chiralpak AS column, eluting isocratically with 70% isohexane in IPA (modified with Et3N) as eluent. The fractions containing the desired compound were evaporated to afford the title compound: N-Methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazol-2-amine (166 mg, 39%) as the first eluting compound; 1H NMR (400 MHz, DMSO-d6) 1.29 (3H, d), 1.47 (2H, dq), 1.55-1.66 (1H, m), 1.69-1.89 (1H, m), 3.01 (3H, s), 3.04 (3H, d), 3.30-3.39 (1H, m), 3.52 (1H, td), 3.66 (1H, dd), 3.80 (1H, d), 3.95 (1H, s), 4.01 (1H, dd), 4.09 (1H, d), 4.51 (1H, s), 6.77 (1H, s), 6.97 (1H, t), 7.08 (1H, t), 7.25 (1H, d), 8.08 (1H, d), 8.67 (1H, d); m/z: (ES+) MH-, 442.09. Chiral HPLC: (HP1100 System 4, 20 mum Chiralpak AS (250 mm×4.6 mm) column eluting with iso-Hexane/IPA/TEA 70/30/0.1) Rf, 12.219 >99%.and the title compound: N-Methyl-1-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-benzimidazol-2-amine (123 mg, 29%) as the second eluting compound; 1H NMR (400 MHz, DMSO-d6) 1.33 (3H, t), 1.45-1.61 (2H, m), 1.61-1.68 (1H, m), 1.80-1.89 (1H, m), 3.07 (3H, s), 3.09 (3H, d), 3.39 (1H, dd), 3.58 (1H, td), 3.72 (1H, dd), 3.86 (1H, d), 4.01 (1H, s), 4.06 (1H, dd), 4.15 (1H, d), 4.55 (1H, s), 6.82 (1H, s), 7.03 (1H, t), 7.14 (1H, t), 7.31 (1H, d), 8.14 (1H, d), 8.73 (1H, d); m/z: (ES+) MH+, 442.09. Chiral HPLC: (HP1100 System 4, 20 mum Chiralpak AS (250 mm×4.6 mm) column eluting with iso-Hexane/IPA/TEA 70/30/0.1) Rf, 25.093 >99%.

Statistics shows that N-Methyl-1H-benzo[d]imidazol-2-amine is playing an increasingly important role. we look forward to future research findings about 17228-38-5.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-56-4, name is 2-Bromo-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 16681-56-4

A solution of 5,7-dimethyl-N-(4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl)pyrazolo[l,5-a]pyrimidine-3-carboxamide 6 (440 mg, 1.12 mmol) in DMF (5 mL) was charged with 2-bromo-lH- imidazole (150 mg, 1.02 mmol), potassium carbonate (422 mg, 3.06 mmol) and the mixture was degassed with argon for 15 min. To the resulting solution was added Pd(PPh3)4(1 17 mg, 0.10 mmol) and the reaction mixture was degassed for another 10 min and heated at 100C for 15h. Then, the reaction mixture was diluted with water (10 mL), extracted with ethyl acetate (3 X 10 mL) and the combined organic layer was dried over sodium sulphate and concentrated in vacuo to obtain crude compound. The crude compound was purified by FCC (eluent, 1-3% methanol in DCM) to afford the title compound as a white solid (40 mg, 12%). NMR (400 MHz, DMSO-i) delta 12.48 (br s, 1H), 10.27 (s, 1H), 8.65 (s, 1H), 7.93 (d, J=8.87 Hz, 2H), 7.82 (d, J=8.87 Hz, 2H), 7.07-7.24 (m, 3H), 2.78 (s, 3H), 2.73 (s, 3H). ES-MS m/z 333.35 (M+H)+. HPLC purity 98.3%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16681-56-4.

Related Products of 13750-62-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 6; Tetra(1-benzyl-2-methylimidazolium) salt; To a solution of hydroxy gallium(III) naphthalocyaninetetrasulfonic acid (2.60 g, 2.33 mmol) in water (5 mL) and methanol (100 mL) was added 1-benzyl-2-methylimidazole (2.0 mL, 2.16 g, 0.013 mol) and then the reaction mixture was evaporated to dryness with heating and stirring under a stream of nitrogen. The residue was suspended in water (200 mL) and filtered, washed with water (2×200 mL) and air-dried. The solid was then washed with diethyl ether (2×200 mL) and dried to give the product as a green powder (2.95 g, 70%).1H NMR (d6-DMSO) 2.57 (12H, s); 5.37 (8H, s); 7.30-7.45 (20H, m); 7.55 (4H, d, J=2.1 Hz); 7.63 (4H, d, J=2.1 Hz); 8.0-11.5 (20H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-2-methyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Application of 1849-01-0,Some common heterocyclic compound, 1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Take 10 ml sealed,Weigh 50 mg 1f,139 mg 2b,154 mg of cesium fluoride,Add 2 ml of acetonitrile, pump for nitrogen, 90 reaction 12h.The solvent was then removed by distillation under reduced pressure to give petroleum ether and ethyl acetate as eluant,The residue was purified by silica gel column chromatography to give 3 fb as a white solid in 53% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H6N2O2

Given that A’l4-mcthyl substituted tubulysins (such as A14-desacetoxytubulysin H, (Nicolaou, et al., 2016; Wipf & Wang, 2007) Tbl) have been proven more potent than their L’|4-H and A14-acetoxytubulysin (such as tubulysin H) coimterparts, considerable efforts were focused on designing and synthesizing a number of A’l4-mcthyl substituted tubulysins. Scheme 4 summarizes the synthesis of A’l4-mcthyl substituted tubulysins Tb50 and Tb51, in which the pipecolic acid residue of the molecule is replaced with pyrrole and A-Me substituted imidazole structural motifs, respectively. Thus, cleavage of the Fmoc protecting group from previously synthesized intermediate 22 through the action of | A’, A’-b i s(2-am i nocthy 1 )- 1.2- ethanediamine] followed by coupling of the so generated amine with 1 -methyl- lA-pyrrole-2 -carboxylic acid (23) and 1 -methyl- lA-imidazole-2-carboxy lie acid (24) provided Al4-dcsacctoxy tubulysin analogues Tb50 and Tb51, in 74% and 76% yields, respectively, as summarized in Scheme 4.

The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.

Related Products of 1457-58-5,Some common heterocyclic compound, 1457-58-5, name is 2-Methyl-1H-imidazole-5-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 371.1. N,2-Dimethyl-lH-imidazole-4-carboxamide. 2-Methyl-lH- imidazole-4-carboxylic acid (378 mg, 3 mmol), EDCI (745 mg, 3.9 mmol), HOBt (253 mg, 1.5 mmol), DIEA (1.6 mL, 9 mmol) and methyl amine (2M in THF) (3.6 mL, 7.2 mmol) were dissolved in DMF (10 mL) and stirred at room temperature for 16 hours. After removal of DMF, the residue was dry loaded and purified by flash chromatography (SiC^; 0-10 % methanol in DCM and 1% NH4OH) to give 280 mg (67%) of the title compound, m/z (ES+) 140 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-1H-imidazole-5-carboxylic acid, its application will become more common.

Electric Literature of 3314-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3314-30-5, name is 1H-Benzo[d]imidazole-2-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The equimolar aldehyde 3a?3d (1 mmol) and substituted phenylhydrazine 5a?5s (1 mmol) weremixed in CH3OH (10 mL) and stirred at room temperature [18]. After about 2 h, the reaction wascompleted (monitored by TLC). The residual crude was purified via silica gel column chromatogramusing a gradient mixture of petroleum ether and ethyl acetate to obtain the pure target compounds6a?6ai (in 45?80percent yield).

The synthetic route of 1H-Benzo[d]imidazole-2-carbaldehyde has been constantly updated, and we look forward to future research findings.