Tag: M.W=100-200

Synthetic Route of 53981-69-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

alpha-Mangostin (1, 205 mg, 0.5 mmol) was dissolved in dichloromethane (10 mL) and acetylimidazole (55 mg, 0.5 mmol) was added at room temperature. After 6 hours, additional acetylimidazole (55 mg, 0.5 mmol) was added and the reaction was allowed to proceed overnight. The mixture was then diluted with ethyl acetate (15 mL) and washed in succession with 1M HCl (2 × 10 mL), saturated sodium hydrogen carbonate (2 × 10 mL) and saturated sodium chloride (2 × 10 mL). The organic layer was dried (sodium sulfate) and the solvent was evaporated under reduced pressure to give a yellow, oily solid (210 mg). Flash-column chromatography of the residue (silica gel, ethyl acetate/hexane 15 : 85) afforded three fractions: 3,6-O-diacetyl–mangostin (4, yellow solid, 20 mg, 8% yield); 3-O-acetyl–mangostin (6, yellow solid, 100 mg, 44% yield); unreacted -mangostin (1, yellow solid, 40 mg, 20 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 7189-69-7, The chemical industry reduces the impact on the environment during synthesis 7189-69-7, name is 1,1′-Sulfonyldiimidazole, I believe this compound will play a more active role in future production and life.

0.25 g (1.39 mmol) of 2-ethoxy-6-hydroxybenzenecarboximidamide is stirred without solvent with 0.65 g (3.28 mmol) of 1,1′-sulphonyldiimidazole at 130 C. for 18 hours. Cooling is followed by stirring the mixture with water and removing with dichloromethane. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. This gives 0.2 g of a pale yellow, crystalline material.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1′-Sulfonyldiimidazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 22884-10-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows.

3.8 mmol (1 equiv) of the respective carboxylic acid (658 mg 3-pyridylacetic acid hydrochloride for 1, 478 mg imidazol-1-yl-acetic acid for 2, 339 mg beta-alanine for 3, 392 mg gamma-aminobutyric acid for 4, 499 mg 6-aminohexanoic acid for 5) were added to 11.4 mmol (3 equiv) H3PO3 in a dry flask. 1.6 mL of distilled sulfolane was added and the contents were heated briefly to dissolve the solids. The solution was cooled down to approximately 25-35 C, and 11.4 mmol (3 equiv) of PCl3 were immediately added. The flask was then placed in a Milestone Ethos Synth Microwave Synthesis Labstation and fitted with a condenser through which cold water was passed. The following microwave programs were applied:For synthesis of 1: 3 min ramp to 65 C, followed by 15 s at 65 C. For synthesis of 2: 3 min ramp to 65 C, followed by 45 s at 65 C.For synthesis of 3: 3 min ramp to 65 C, followed by 15 s at 65 C.For synthesis of 4: 3 min ramp to 65 C, followed by 4 min at 65 C.For synthesis of 5: 3 min ramp to 65 C, followed by 4 min at 65 C.The power was automatically adjusted to reach and maintain the temperature designated by the program, which is determined by a built-in IR sensor in the microwave reactor. For the synthesis of intermediates 1 and 2, the power fluctuated between 0 and a max of 300-400 W, while for 3, 4, and 5, the max power was typically 200-300 W.The solid mixture after microwave irradiation consists of intermediate phosphorus compound together with a yellow-orange unwanted side product which can be removed by centrifugation before or after hydrolysis. The reaction mixture was quenched with 6 mL of H2O, yielding a clear solution that was then transferred to a 50 mL sealed quartz reaction vessel and was hydrolyzed to the bisphosphonic acid in the microwave reactor with a 6 min ramp to 150 C, followed by 4 min at 150 C. The power applied fluctuated between 0 and a max of 450-500 W. The pH of the hydrolysis mixtures for acids 1, 3, 4, and 5 was adjusted15 with NaOH and the mixture then aged at 0-5 C until crystallization of the products was complete. Acids 4 and 5 were precipitated as monosodium salts by stirring with 2-5 mL ethanol for 1-2 h at room temperature. Acid 2 was precipitated by the addition of 9 mL acetone to the acidic hydrolysis mixture and stirring for 3-4 h at room temperature. The white crystalline products were then filtered and washed with cold H2O and acetone or ethanol and then dried under vacuum at 45 C to constant weight.15 with NaOH and the mixture then aged at 0-5 C until crystallization of the products was complete. Acids 4 and 5 were precipitated as monosodium salts by stirring with 2-5 mL ethanol for 1-2 h at room temperature. Acid 2 was precipitated by the addition of 9 mL acetone to the acidic hydrolysis mixture and stirring for 3-4 h at room temperature. The white crystalline products were then filtered and washed with cold H2O and acetone or ethanol and then dried under vacuum at 45 C to constant weight.

The chemical industry reduces the impact on the environment during synthesis 2-(1H-Imidazol-1-yl)acetic acid. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 1072-84-0, name is 1H-Imidazole-4-carboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1072-84-0

For synthesis of methyl imidazole-4-carboxylate (5), conc. H2SO4(1.5 mL) was added to a suspension of Im-CO2H (1.00 g, 8.92 mmol)in MeOH (20 mL), and themixture was refluxed for 24 h to give a solutionthat was then cooled to 0 C and neutralized to pH 8 using 5 MNaOH. Evaporation in vacuo left a white residue that was re-dissolvedin a minimal volume of boiling water; cooling the solution depositedwhite crystals of the ester that were collected, washed with cold H2O(1 × 5 mL), and dried in vacuo at r.t. for 24 h. Yield: 0.87 g (77%). 1HNMR (DMSO-d6): delta 7.74 (s, 1H, H5-Im), 7.65 (s, 1H, H2-Im), 2.51 (s,3H, CH3-Im). IR: 3105 (N-H, s), 2976, 2846 (C-H, m), 1619 (C=O,m), 1363 (s), 1156 (m), 864 (m). ESI-MS: 127 (M+). Anal. Calcd. forC5H6N2O2: C, 47.62; H, 4.80; N, 22.21. Found: C, 47.5; H, 4.85; N, 21.7.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1072-84-0, its application will become more common.

Electric Literature of 4887-88-1, The chemical industry reduces the impact on the environment during synthesis 4887-88-1, name is 5-Bromo-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.

To a solution of (4,4-dimethylcyclohexyl)({3-[1-(triphenylmethyl)-1H-benzimidazol-6-yl]phenyl}methyl)amine and (4,4-dimethylcyclohexyl)({3-[1-(triphenylmethyl)-1H-benzimidazol-5-yl]phenyl}methyl)amine (0.18 g, 0.31 mmol) in tetrahydrofuran (3 mL) were added water (3 mL) and acetic acid (3 mL). The reaction mixture was heated at reflux for 1 h, then was allowed to cool to room temperature and was treated with 10% HCl (aq) until pH 2. The mixture was washed 2× EtOAc, then the aqueous phase was treated with solid K2CO3 until it reached pH 10, at which point it was extracted 3× CHCl3. The combined CHCl3 extracts were dried (Na2SO4) and concentrated in vacuo. The residue was taken up in Et2O and enough acetone to dissolve completely, then 4M HCl in dioxane was added until no more solid crashed out. The white solid was collected by filtration and dried under vacuum, providing the product {[3-(1H-benzimidazol-5-yl)phenyl]methyl}(4,4-dimethylcyclohexyl)amine hydrochloride (M+1) 334.2 ES, 1.30 min (LC/MS Method A).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 30148-21-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30148-21-1, name is Ethyl 1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(S)-[2-(hydroxydim-tolylmethyl)pyrrolidin-1-yl](1-methyl-imidazol-2-yl)methanone was first prepared by dissolving (S)-a,a-Di(3-methylphenyl)prolinol (prepared as described above, 0.8 g, 2.85 mmol) in toluene (10 mL) and NaH (60 % dispersion in mineral oil, 148 mg,3.7 mmol) added at room temperature. After stirring for 30 mins, ethyl-1-methylimidazole-2-carboxylate (527 mg, 3.4 mmol) was added. The resulting reaction mixture was slowly warm to 70 C and stirred for 24 h at the same temperature. The reaction was cooled to room temperature, quenched by addition of saturated aqueous NH4CI (20 mL) and extracted with dichloromethane (3 x 20 mL). The combined organic extracts were washed with brine (20 mL) and dried over magnesium sulfate. After filtration, the filtrate was evaporated and purified by chromatography on silica gel (10% to 50% ethyl acetate in petroleum ether) to yield the product (0.53 g, 48 %) as white solid; m.p. 162-164C;[a]D-95.5 (c1 .1 in CHCI3);vmax (thin film, cm -1) 2952, 1615, 1456, 1282; deltaEta (500 MHz, d6-DMSO, 100 C) 1 .66-1 .75 (m, 1 H, 1 xCH2), 1 .78-1 .86 (m, 1 H, 1 chi CH2), 1 .93-1 .97 (m, 1 H, 1 chi CH2), 2.05-2.12 (m, 1 H, 1 chi CH2), 2.14 (s, 3H, CH3), 2.29(s, 3H, CH3), 3.36 (s, 3H, NCH3), 3.47-3.52 (m, 1 H, 1 chi CH2), 3.87- 3.92 (m, 1 H, 1 x CH2), 5.68 (s, 1 H, NCH), 6.14 (br, s, 1 H, OH), 6.85-6.87 (m, 2H, ArH), 6.91 – 6.98 (m, 4H, ArH), 7.04 (app. d, 1 H, J 7.7, ArH), 7.18-7.24 (m, 2H, ArH), 7.28 (s, 1 H, ArH); deltaC (126 MHz, d6-DMSO, 100C) 20.6(2 x CH3), 22.2(CH2),27.2 (CH2), 33.6 (CH3),47.4(NCH2), 63.5(NCH), 80.1 (COH), 123.2, 123.3, 123.6, 125.3, 125.9, 126.2, 126.6, 126.9, 127.2, 135.2, 136.1 , 140.2, 145.3, 145.4, 158.9 ( CO) ;mlz (TOF ES+) 390.2188 (100%, MH+, C24H28N3O2 requires 390.2182), 372.2092 (20).

The synthetic route of Ethyl 1-methyl-1H-imidazole-2-carboxylate has been constantly updated, and we look forward to future research findings.

Related Products of 20485-43-2,Some common heterocyclic compound, 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Reaction monitoring. To check the progress of the reaction, some resin beadswere taken, mixed with 30 muL of 95% TFA solution and shaken for a fewseconds, while the beads turn red. The supernatant solution was removed andmixed 1:1 with H2O. 1 muL of the aqueous solution was mixed with 1 muL of DHBmatrix on the target, dried and the mass spectrum was measured by MALDI-ToF-MS. If necessary, the deprotection was repeated.Fmoc deprotection. The amino protecting group Fmoc was cleaved after eachcoupling step to allow the coupling of the next amino acid. For this, the resinwas swollen in DMF and then suspended three times for 15 minutes in a 20%piperidine solution in DMF. The resin was filtered off and washed twice withCH2Cl2, DMF and again CH2Cl2.Coupling reactions. The resin was swollen in DMF. The amino acid (3 equiv)was dissolved in DMF containing DIPEA (9 equiv) and the coupling reagent(HBTU or PyBOP, 3 equiv) was added for pre-activation. After 5 minutes thesolution was added to the resin, and the suspension was mixed for 1.5 hours byshaking. The resin was then filtered off with suction and washed twice withCH2Cl2, DMF and again CH2Cl2. The completeness of the reaction was checkedwith MALDI-ToF-MS. If necessary, the coupling reaction was repeated.Cleavage from the resin. After swelling in CH2Cl2, the acid-labile 2 chlorotritylresin containing the polyamide was mixed with a 2.5% solution ofS7CH2Cl2/TFA/TIS 95:2.5:2.5 (v/v/v), mixed for 5 minutes and filtered off. This wasrepeated until the discoloration of the filtrate was complete. The combinedfiltrates were evaporated and the oily residue was treated with a mixtureH2O:MeCN and lyophilized.

The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.

Electric Literature of 615-16-7,Some common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, molecular formula is C7H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a three flask equipped with a thermometer dichloroethane solvent 1000ml, added slowly with stirring 268gBenzimidazolone. Meanwhile weighed 305g of fuming nitric acid (concentration ?95%), and slowly poured three bottles, while down while stirring. Then added phosphorus pentoxide 20g. Reflux, the reaction temperature is 85 , TLC tracking dinitro compound detected is generated to stop the reaction. While recovering the solvent was concentrated under reduced pressure, water was added, extraction dichloroethane, and the solvent was evaporated to dryness to give the product recovered organic phase was dried over anhydrous sodium sulfate. 381g dried to give a solid, a yield of 85.1%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Hydroxybenzimidazole, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 78162-58-0, name is N,N-Dimethyl-1H-imidazole-1-sulfonamide, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78162-58-0, Product Details of 78162-58-0

EXAMPLE H Procedure for Preparation of 4(5)-phenylsulfanyl-1H-imidazole: Procedure 1-(N,N-dimethylsulfamoyl)imidazole (1.5g, 8.6 mmol) was taken up in 28mL of THF. The solution was cooled to -78 C. and n-BuLi (5.4mL, 8.6 mmol) added dropwise via syringe. After stirring at -78 C. for 1h TBSCl (1.3g, 8.56 mmol) in 10mL of THF was added. The bath was removed and the reaction allowed to warm-up to rt. The reaction mixture was stirred overnight. The reaction mixture was cooled to -20 C. and n-BuLi (5.4 mL, 8.6 mmol) added. After 45 min phenyldisulfide (1.9g, 8.6 mmol) in 8mL of THF was added. The reaction mixture was stirred at rt for 48h. The reaction mixture was quenched with saturated ammonium chloride and extracted with ethyl acetate. The organic layer was collected and washed with water and then brine. The solution was dried over sodium sulfate and the solvent removed under reduced pressure. Flash chromatography (2.5% EtOAc/hexane) afforded 2.8g (7.0 mmol) of 2-(t-butyldimethylsilyl)-5-phenylsulfanylimidazole-1-sulfonic acid dimethylamide (1) as a yellow color oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethyl-1H-imidazole-1-sulfonamide, other downstream synthetic routes, hurry up and to see.

Application of 5805-57-2, The chemical industry reduces the impact on the environment during synthesis 5805-57-2, name is (1H-Benzo[d]imidazol-2-yl)methanamine, I believe this compound will play a more active role in future production and life.

The residue was dissolved in DMF and EDC (0.15 rnmol), HOBt (0.1 rnmol), DIPEA (0.25 rnmol), ( lH-benzo[d]imidazol-2- yl)methanamine (0.1 rnmol) were added. The solution was stirred at room temperature overnight and then removed under vacuum. ‘T’he residue was dissolved in EtOAc (25 mL). The organic layer was washed with water, brine (25 mL), dried and concentrated under vacuum. The residue was chromatographed to give N-((lH-benzo[d]iniidazoi-2-yl)ineihyi)-2- (5,7-dichloro- 1 H-benzo[d]imidazol-2-yl)acetamide (1764). LC/MS: (EST) (M +H)+= 375.6.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Benzo[d]imidazol-2-yl)methanamine, other downstream synthetic routes, hurry up and to see.