Tag: M.W=100-200

Related Products of 5805-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5805-57-2 name is (1H-Benzo[d]imidazol-2-yl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a round bottom flask a mixture of (1H-benzo[d]imidazol-2-yl)methanamine (58; 720 mg, 3.8 mmol), 4,7-dichloroquinoline (1.07 g, 5.39 mmol) and phenol (2.33 g, 24.74 mmol) was heated for 3.5 h at 130 C, stirring under N2. After cooling, the mixture was dissolved in a solution of CH2Cl2/MeOH (95:5) and surplus of phenol was extracted with 2 N NaOH. The organic layers were washed with water, brine, dried over anhydrous Na2SO4 and evaporated to dryness. The crude solid was purified by CC on silica gel (CH2Cl2/MeOH; 93:7). The resulting product was rinsed with diethyl ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Benzo[d]imidazol-2-yl)methanamine, and friends who are interested can also refer to it.

Synthetic Route of 2302-25-2,Some common heterocyclic compound, 2302-25-2, name is 4-Bromo-1H-imidazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1-propanol (7.5 mL) and water (2.5 mL) was purged with nitrogen for 5 minutes. To the solution were added 4-bromo-1H-imidazole (146.97 mg, 1 mmol), 2-(hydroxyl-methyl)phenylboronic acid (190 mg, 1.25 mmol), Pd(OAc)2 (11.2 mg, 0.05 mmol), PPh3 (39.3 mg, 0.15 mmol) and potassium carbonate (276 mg, 2.0 mmol). After stirring at 85 C. for 16 h, the mixture was allowed to cool to room temperature and was partitioned between EtOAc (30 mL) and water (15 mL). The aqueous layer was extracted with EtOAc (2×20 mL) and the combined organic layers were washed with water, brine, and dried over sodium sulfate. The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography on silica gel to afford the pure product (62 mg, 37% yield). 1H NMR: 4.48 (s, 2H), 6.25 (br s, 1H), 7.18-7.28 (m, 2H), 7.39-7.47 (m, 2H), 7.62 (d, 1H, J=7.0 Hz), 7.80 (d, 1H), 12.30 (br s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1H-imidazole, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Methyl 1H-imidazole-5-carboxylate

(1) To a solution of methyl 4-imidazole carboxylate (a-1) (1.2 g, 9.5 mmol) and (4-fluorophenyl)methanol (h-1) (1.2 mL, 11 mmol) in THF (12 mL), PPh3 (3.0 g, 11 mmol) and DIAD (2.2 mL, 11 mmol) were added and the resulting mixture was stirred overnight at room temperature. The solvent was distilled off under reduced pressure and ethyl acetate and n-hexane were added; the resulting solids were recovered by filtration. The solvents in the filtrate were distilled off under reduced pressure and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=90:1050:50) to give methyl 1-(4-fluorobenzyl)-1H-imidazole-5-carboxylate (h-2) (amount, 1.6 g; yield, 73%).

The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.

Related Products of 934-22-5, These common heterocyclic compound, 934-22-5, name is 6-Aminobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a vessel charged with N-(2-(1H-indol-3-yl)ethyl)-2-chloroquinazolin-4-amine (8a, 232 mg, 0.72 mmol)was added ethanol (5 mL), hydrochloric acid (10 mL), and 1Hindazol-5-amine (96 mg, 0.72 mmol). The vessel was sealed andstirred for 6 h at 120 C. The resulting mixture was dried underreduced pressure and subjected to silica gel column chromatographyusing dichloromethane/methanol (90:10) as the mobilephase to afford the desired compound 9a as a white solid (184 mg,0.87 mmol, 61% yield).

The synthetic route of 934-22-5 has been constantly updated, and we look forward to future research findings.

Application of 1848-84-6, The chemical industry reduces the impact on the environment during synthesis 1848-84-6, name is 2-Ethyl-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.

General procedure: Sodium hydride (0.53 g, 6.6 mmol, 60percent oil dispresion) was added to the stirred solution of the corresponding azole (3.3 mmol) in anhydrous THF (2 mL) at room temperature. After 15 min, freshly prepared 2-(chloromethyl)-4,5-dihydro-1H-imidazole 2 (0.47 g, 4.0 mmol) was added and the reaction mixture was stirred at ambient temperature for 6 h. The N-alkylation products 3, 5, 7 and 8 were isolated upon quenching the reaction mixture with water (5 mL) followed by extraction with dichloromethane (3 .x. 5 mL). The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The oily residue thus obtained was purified on silica with use of chromatotron (Et3N/MeOH/AcOEt 1:5:100). All products were very polar with Rf values close to 0.05.The N-alkylation reaction of indazoles (1) provided the desired N1 substituted products (3) along with the N2 substituted side product. The latter compounds demonstrated considerably lower Rf than 3 and were not isolated in pure form. The alkylation reactions of benzotriazoles 6a and 6c allowed the isolation of N1 substituted products 7a-b (higher Rf) and N2 isomer 8b (lower Rf). However, in the case of 4-methyl-benzotriazole 6b only the N2 substituted isomer 8a was isolated as a pure product.The products 3, 5, 7 and 8 were then converted into water-soluble hydrochloride salts suitable for biological tests with use of methanolic hydrochloric acid solution or by passing gaseous hydrogen chloride through dichloromethane solution of the corresponding free base.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 2849-93-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2849-93-6 name is 1H-Benzimidazole-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0401] To a 4 mL sample vial equipped with a magnetic stir bar was placed benzyl (7-amino-5-((2S,4S)-1-((R)-2-amino-3-cyclohexylpropanoyl)-4-(5-(2-hydroxypropan- 2-yl)-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxamido)-6,7-dioxoheptyl)carbamate (Intermediate L, 20 mg, 0.028 mmol, 1.0 equiv), 1H-benzo[d]imidazole-2-carboxylic acid (10 mg, 0.062 mmol, 2.2 equiv), HATU (12.7 mg, 0.033 mmol, 1.2 equiv) and DMF (400 muL). The solution was treated with EtN(iPr)2 (15 muL, 0.083 mmol, 3 equiv) and the mixture was stirred at room temperature for 18 h overnight. The reaction mixture was filtered through a 13 mm 0.45 muM PFTE syringe filter and the filtrate was collected. Purification of the filtrate by reverse-phase column chromatograph (Waters XSelect CSH Prep C18, 5 mum, 30 × 75 mm) using 60:40 to 35:65 H2O:MeCN + 0.1% HCO2H as a gradient over 10 minutes afforded the title compound. MS (ESI+) 826 (M+1) ^

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzimidazole-2-carboxylic acid, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3034-38-6, name is 5-Nitro-1H-imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Nitro-1H-imidazole

Reference example 1 Preparation of 2,5-dibromo-4-nitroimidazole To a suspension of water (100 ml), 4-nitroimidazole (25 g) and sodium hydrogencarbonate (40.87 g), was dropwisely added bromine (26.5 ml) at lower than 10C, the reaction mixture was stirred at 25 to 30C for 1 hour, and at 50 to 60C for 4 hours. Then concentrated hydrochloric acid was added to the reaction mixture at lower than 10C to adjust pH 1, the crystals separated were collected by filtration, and were washed thoroughly with water. The crystals were dried at 50C under a reduced pressure for 24 hours, there was obtained 51.01 g (85.2%) of 2,5-dibromo-4-nitroimidazole of pale yellow powdery product.

The synthetic route of 3034-38-6 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H3F3N2

NMP (1.5 ml) was added to a mixture of 4-trifluoromethyl-1H-imidazole (65.8 mg, 0.484 mmol), methyl 3-iodo-6-methyl-2-pyridinecarboxylate D44 (67 mg), 4,7-bis(methyloxy)-1,10-phenanthroline (8.72 mg, 0.036 mmol), bis(copper(I) trifluoromethanesulfonate), benzene complex (6.09 mg, 0.012 mmol) and cesium carbonate (126 mg, 0.387 mmol) in a screw-topped vial with septum and the mixture was rapidly degassed via three vacuum/nitrogen cycles. The reaction mixture was then shaken and heated to 90 C. for 2 hours. The reaction mixture was heated to 110 C. for 2 hours. Another quantity of bis(copper(I) trifluoromethanesulfonate), benzene complex (6.09 mg, 0.012 mmol) was added and the mixture was heated with shaking to 110 C. for 2 hours. UPLC check shows all the methyl 3-iodo-6-methyl-2-pyridinecarboxylate has reacted but there are still only traces of the expected product methyl 6-methyl-3-[4-(trifluoromethyl)-1H-imidazol-1-yl]-2-pyridinecarboxylate-closer scrutiny showed that signals in the mass spectrum corresponding to the acid 6-methyl-3-[4-(trifluoromethyl)-1H-imidazol-1-yl]-2-pyridinecarboxylic acid co-elute with 4,7-bis(methyloxy)-1,10-phenanthroline in the UPLC. UPLC in basic conditions showed a better separation confirming the formation of the acid 6-methyl-3-[4-(trifluoromethyl)-1H-imidazol-1-yl]-2-pyridinecarboxylic acid as well as de-iodinated product. The reaction mixture was cooled, diluted with water (15 ml) and loaded onto an ENV+ cartridge (1 g). The cartridge was eluted with water and then with MeOH. UPLC check of the water washes indicated they contain NMP as well as the deiodinated product and the excess 4-trifluoromethyl-1H-imidazole. UPLC check of the MeOH washes indicated they contained the acid 6-methyl-3-[4-(trifluoromethyl)-1H-imidazol-1-yl]-2-pyridinecarboxylic acid plus some impurities. The MeOH washes were combined and evaporated under reduced pressure to give a dark brown residue which was purified on the Biotage (mobile phase A was water made up with 0.1% formic acid, mobile phase B was acetonitrile made up with 0.1% formic acid. 12M C18 column was eluted with phase A for 2 column volumes then in gradient 0-50% A/B). The fractions containing the acid of the desired product were not pure by UPLC-they were combined and evaporated under reduced pressure to give 35 mg of a solid residue which was further purified by FractionLynx (Acid LC1, note a considerable quantity of the solid was insoluble in DMSO/MeOH). The fraction containing the desired product was evaporated under reduced pressure to give the title compound D121 (9 mg) of a pale orange glass. UPLC (Basic GEN_QC): rt=0.38 minutes, peak observed: 272 (M+1). C11H8F3N3O2 requires 271.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 33468-69-8, its application will become more common.

Some common heterocyclic compound, 2302-25-2, name is 4-Bromo-1H-imidazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C3H3BrN2

To a stirred solution of 4-bromo-1 /-/-imidazole (5.0 g; Aldrich Chemical Company,Inc., Milwaukee, Wl) in 100 ml_ anhydrous THF at -78C in an oven dried 500 ml_ 3 necked-round bottom flask was added t-butyl-lithium (48.0 ml_, 1.7 M in pentane) dropwise over 45 minutes with a dropping funnel. After complete addition, the mixture was warmed to about 100C to 15C for 2 hours and then it was cooled to -78C, and a cold (-780C) solution of diisopropyl disulfide (6.78 ml_) in 30 ml_ THF was added via cannula. The reaction was stirred for 16 hours allowing the bath to warm. The pale yellow solution was quenched with saturated NH4CI followed by neutralization with 10% HCI. The layers were separated and the aqueous extracted with THF three times. The combined organics were dried over MgSO4 and purified by flash chromatography (40+M, 100:0, 95:5, 90:10 ethyl acetate/methanol) to afford 3.3767 g of (l-6a); m/z 143.0 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2302-25-2, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Formula: C10H8N2O

EXAMPLE XVI To a solution of 220 mg of 2-phenyl-4-imidazole carboxaldehyde in 5 mL of tetrahydrofuran was added 6.4 mL of a 1L methyllithium solution in tetrahydrofuran. The reaction mixture was quenched with 50 mL of water and the mixture extracted with 2*50 mL aliquots of ethyl acetate. The combined ethyl acetate extracts were dried over anhydrous sodium sulfate, filtered and the solvent evaporated under reduced pressure to yield 250 mg of 2-phenyl-4(5)-(1-hydroxyethyl)imidazole which was used in the next step without further purification or characterization.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.