Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 3034-38-6, name is 5-Nitro-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3034-38-6, Recommanded Product: 5-Nitro-1H-imidazole

Synthesis of LXX:To stirred solution of 4-nitro-1H-imidazole (LXIX, 5g: 44 mmol) in acetonitrile (20 mL) was added K2C03 (18.2 g, 137 mmol) at 0C, followed by addition of methyl iodide (8.9 mL, 57mmol). The reaction mixture was heated at 95C for 3h. The reaction mixture was concentrated, filtered through a celite bed and diluted with water. The aqueous layer was extracted with chloroform and the separated organic layer was washed with brine solution and dried over anhydrous Na2SO4 before being filtered and evaporated under reduced pressure to afford 1-methyl-4-nitro-1H-imidazole (LXX, 4g, 71%). ?H NMR (400 MHz, DMSO-d6) oe 8.35 (s, 1H), 7.8 (s, 1H), 3.74 (s, 3H). MS (M+1): 128.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitro-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole, molecular formula is C4H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Bromo-1-methyl-1H-imidazole

To a solution of 2-bromo-1-methyl-1H-imidazole (9) (0.10 g, 0.60 mmol) in dry toluene (6 mL), p-anisidine (0.15 g, 1.19mmol), Pd2(dba)3 (51.02 mg, 0.06 mmol), BINAP (0.11 g, 0.18 mmol) and Cs2CO3 (0.39 g, 1.19mmol) were added sequentially, and the resulting mixture was heated at 100 C for 21 h. Thereaction was quenched by the addition of saturated NaHCO3 (5 mL). The organic layer wasseparated and the aqueous phase was extracted with AcOEt (3 × 10 mL). The combined organicextracts were washed with brine (5 mL), dried (Na2SO4) and concentrated in vacuo, to obtain 10(0.11 g, 90 %) as an oil. This product was unstable and could not be further purified by columnchromatography: IR (film): numax 3343 cm-1; 1H NMR (300 MHz) delta 3.44 (broad s, 1H), 3.55 (s,3H), 3.70 (s, 3H), 6.67 (d, J 9.0 Hz, 2H), 6.72 (d, J 9.0 Hz, 2H), 6.92 (d, J 1.4 Hz, 1H), 6.97 (d, J1.4 Hz, 1H); 13C NMR (75.5 MHz) delta 34.3, 55.5, 114.6, 116.1, 119.8, 122.8, 129.5, 139.9, 152.5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16681-59-7, its application will become more common.

These common heterocyclic compound, 71759-89-2, name is 5-Iodo-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H3IN2

4-iodoimidazole (5.38g, 27.72mmol) was dissolved in THF (86ml_). Trityl chloride, (8.5g, 30.49mmol) and triethylamine (7.73ml_, 55.44mmol) were added and the reaction was heated at 70 C. After 3 h, TLC showed that the reaction had gone to completion. Therefore, the reaction mixture was allowed to cool to 45 C and filtered to remove the suspended white solid. The filtrate was concentrated, redissolved in DCM (300 mL) and washed with 5 wt% aq. sodium thiosulfate solution (300 mL), which was back-extracted with DCM (150 mL). The organics were combined, dried over sodium sulfate, filtered and concentrated to yield the crude product. The white solid was taken up in EtOAc (300ml) and heated to reflux for 30 minutes. The mixture was cooled and the solid was obtained by vacuum filtration. The white solid was dried in the vacuum oven for 3 hours affording 4- iodo-1 -trityl-imidazole (6.721 g, 15.40mmol, 55.57% yield). MS Method 2: RT 2.08 min, ES+ m/z 459 [M+Na]+ H NMR (400MHz, DMSO) delta/ppm: 7.35-7.40 (m, 10H), 7.06-7.1 1 (m, 7H).

The synthetic route of 5-Iodo-1H-imidazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C4H5BrN2

5-Bromo-1-methyl-1H-imidazole (0.5 M in DCM, 1.67 mL, 0.834 mmol) was treated with ethylmagnesium chloride (2.09 M in THF, 0.399 mL, 0.834 mmol) dropwise under argon with stirring at room temperature over 1 minute, and the resulting slurry was stirred at 40 C. for 20 minutes. This was treated rapidly dropwise over 1 minute with a solution of tert-butyl 4-(3-(piperidine-1-carbonyl)-2,4-bis(trifluoromethyl)quinoline-6-carbonyl)piperidine-1-carboxylate (196 mg, 0.334 mmol, Intermediate 3: step f) in THF (1.6 mL) with stirring at room temperature, and was then stirred at 40 C. for 2 hours. The reaction was then quenched at room temperature with 5 M aqueous NH4Cl (1 mL) and extracted with 1:1 THF/heptanes (2*3 mL), and the combined organic layers were dried (Na2SO4), filtered, and concentrated. The residue was purified by FCC (0-10% MeOH in DCM) to provide a ?1:1 mixture of the title compound and tert-butyl 4-(2-(1-methyl-1H-imidazol-5-yl)-3-(piperidine-1-carbonyl)-2,4-bis(trifluoromethyl)-1,2-dihydroquinoline-6-carbonyl)piperidine-1-carboxylate as a beige foam. MS m/e 670.3 [M+H]+.

The synthetic route of 5-Bromo-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Electric Literature of 33468-69-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of 0.8 g of the intermediate compound 2-3, 0.36 g of 4-(trifluoromethyl)imidazole and toluene were added 0.74 g of potassium carbonate, 0.26 mL of trans-N, N?-dimethylcyclohexane-1,2-diamine and 0.15 g of copper iodide. The reaction mixtures were stirred at 120 C. for 24 hours, and cooled to room temperature, and thereto was added water, and the mixtures were extracted with ethyl acetate. The obtained organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was subjected to a silica gel column chromatography (hexane:ethyl acetate=3:2) to obtain the compound A-12 of the present invention 0.32 g. (1689) Compound A-12 of the present invention: 1H-NMR (CDCl3) delta: 1.37 (3H, t), 3.41-3.49 (2H, m), 6.49 (1H, d), 6.66 (1H, s), 7.54 (1H, d), 7.70-7.76 (2H, m), 8.04 (1H, s), 8.50 (1H, d), 8.90 (1H, d).

The synthetic route of 4-(Trifluoromethyl)-1H-imidazole has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 41716-18-1

To a solution of intermediate 72-d.HCl (3.0 g, 4.61 mmol) in DMF cooled to 0° C. were sequentially added 1-N-methylimidazole carboxylic acid (988 mg, 7.83 mmol), HATU (2.98 g, 7.83 mmol) and DIPEA (3.22 mL, 18.43 mmol) and the reaction mixture was stirred at room temperature overnight. Saturated aqueous ammonium chloride and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 77-a as white foam.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

These common heterocyclic compound, 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2466-76-4

Nucleoside/nucleotide (2; 100 mM) and N-acetyl imidazole (1a;10 equiv) were dissolved in water (pH 8; adjusted with 4 MNaOH). The solution was incubated at r.t. for 4 h, and NMR spectra were periodically acquired. The product was purified byreverse-phase (C18) flash coumn chromatography (eluted at pH4 with 100 mM NH4HCO2/MeCN = 98:2 to 80:20). The fractions containing 5 were lyophilised to yield a white powder.Selected Data: 2?,3?-Di-O-acetyl-beta-cytidine-5?-phosphate (5a)Starting from 1a (160 mg, 0.50 mmol), 5a (172 mg, 85percent) wasobtained as a white powder. 1H NMR (600 MHz, D2O): delta = 8.08[d, J = 7.9 Hz, 1 H, H-(C6)], 6.22 [d, J = 7.9 Hz, 1 H, H-(C5)], 6.11[d, J = 5.1 Hz, 1 H, H-(C1?)], 5.41 [dd, J = 5.4, 5.1 Hz, 1 H, H-(C2?)],5.38 [dd, J = 5.4, 4.4 Hz, 1 H, H-(C3?)], 4.48 [ddd, J = 4.9, 4.4, 2.4Hz, 1 H, H-(C4?)], 4.13 [ABXY, J = 11.9, 4.4, 2.4 Hz, 1 H, H-(C5?)],4.02 [ABXY, J = 11.9, 4.9, 2.4 Hz, 1 H, H-(C5??)], 2.09 [s, 3 H, Ac-(C3?)], 2.05 [s, 3 H, Ac-(C2?)]. 13C NMR (151 MHz, D2O): delta = 173.4(3?-OAc), 173.1 (2?-OAc), 160.7 (C4), 150.1 (C2), 144.3 (C6), 96.5(C5), 88.2 (C1?), 82.5 (d, C4?), 74.5 (C2?), 71.5 (C3?), 64.4 (d, C5?),20.6 (3?-OAc), 20.5 (2?-OAc). 31P NMR (162 MHz, D2O, 1H-decoupled):delta = 0.30. IR (neat): 1746, 1660, 1489, 1462, 1429, 1375,1075 cm?1. ESI-HRMS: m/z [M + H+] calcd for C13H19N3O10P:408.0803; found: 408.0810.

The synthetic route of 1-(1H-Imidazol-1-yl)ethanone has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H7N3O

Preparation of 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea. Amine 2a (1.3 g, 5.9 mmol) was dissolved in 40 ml of AcOEt and at 0C triphosgene (1.75 g, 5.9 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1a (860 mg, 5.77 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 30 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 650mg of a yellow solid. Yield = 28% 1HNMR (DMSO, 200 MHz) delta 2.51 (6H, bs), 4.43 (2H, d, J = 5.6 Hz), 6.62 (1H, dd, J = 7.6 Hz, J’ = 1 Hz), 6.82 (2H, m), 6.97 (1H, dd, J = 8 Hz, J’ = 1 Hz), 7.32 (1H, s), 7.39 (1H, d), 7.49 (1H, d), 8.35 (1H, bs), 9.99 (1H, bs), 10.59 (1H, bs); [M+1] 394.1 (C18H18F3N5O2 requires 393.36).

According to the analysis of related databases, 75370-65-9, the application of this compound in the production field has become more and more popular.

Application of 312-73-2,Some common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A stirred mixture of 2-Trifluoromethyl-1 H-benzoimidazole (4.92g, 26.4 mmol), 4-fluorobenaldehyde (3.1 mL, 29.1 mmol), and K2CO3 (4.37g, 31.7 mmol) in DMF (50 mL) was heated to 150 0C for 16 h. After being cooled to room temperature, the reaction mixture was partitioned between H2O and EtOAC. After usual workup, the crude product was purified by silica gel chromatography (20% Hexane/EtOAc to 30% Hexane/EtOAc) to afford a yellow oil which was subjected to a second silica gel chromatography (DMC) to provide the aldehyde intermediate 4-(2-Trifluoromethyl-benzoimidazol-1-yl)- benzaldehyde as a white solid (4.0 g).To a solution of the above 4-(2-Trifluoromethyl-benzoimidazol-1-yl)- benzaldehyde (0.155g, 0.53 mmol) and (2,3-Difluoro-phenyl)-acetonttrile (83 mg, 0.54 mmol) in EtOH (5 mL) was added a solution of KOH (0.2g) in H2O (0.5 mL). The mixture was then stirred at rt for 1h, partitioned between EtOAc/H2theta. The organic layer was dried and concentrated followed by silica gel chromatography (20% Hexane/EtOAc) to afford the product Compound 47 as a colorless oil.To a stirred solution of 4-(2-Trifluoromethyl-benzoimidazol-1-yl)-benzaldehyde (0.58 g, 2 mmol) in acetone (25 mL) was added Jone’s reagent (1.0 mL, 2.0 M) at O0C. After stirring at room temperature for 2h, the mixture was partitioned between EtOAc and saturated NaHCO3 solution. After usual workup, the crude material was separated by silica gel chromatography (50% Hexane/EtOAc to EtOAc) to afford the intermediate acid 4-(2-Trifluoromethyl- benzoimidazol-1-yl)-benzoic acid as a while solid (490 mg).To a stirred solution of 4-(2-Trifluoromethyl-benzoirnidazol-1-yl)-benzoic acid (102 mg, 0.33 mmol) in dry CHCI3 (15 mL) was added oxalyl chloride (0.09 mL) followed by one drop of DMF at room temperature. After 1h, the reaction pot was concentrated and vacuum dried. Dry chloroform (15 mL) and pyridine (0.1 mL) was then added followed by the addition of 2,3-difluoroaniHine (36 mg, 0.28 mmol). The reaction was monitored by TLC, after completion, the mixture was partitioned between 1 N HCI and DCM. Organic layer was separated and dried (Na2SO4). Removal of solvents followed silica gel chromatography (20% hexane/EtOAc) afforded the product Compound 46 as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethyl)-1H-benzo[d]imidazole, its application will become more common.

Synthetic Route of 68282-47-3,Some common heterocyclic compound, 68282-47-3, name is 2-Phenyl-1H-imidazole-4-carbaldehyde, molecular formula is C10H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

COMPOUND 12.1. 8: 4-6. 7-DIMETHOXY-2-f (2-PHENYL-l-IMIDAZOL-5- YL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL}METHYL)-N,N- DIETHYLBENZAMIDE; INTERMEDIATE 5.1. 5 (15 mg, 0. 04 mmol) and 2-phenyl-4 (5) – imidazolecarbaldehyde (20 mg, 0.12 mmol) were dissolved in DCE (1.0 mL) and stirred for 15 min at room temperature. Sodium triacetoxyborohydride (34 mg, 0.16 mmol) was added and the reaction mixture was stirred for 18 h at room temperature. 1 M aqueous sodium hydroxide solution (15 mL) and DCM (15 mL) were added, the mixture stirred for 30 min and passed through a Whatman IPS silicon-treated filter paper. The organic layer was evaporated in vacuo and the crude product was purified by flash chromatography to give the product (12.5 mg, 0.025 mmol, 63%). 1H NMR (500 MHz, CDC13) : 15 1. 10,1. 27 (2 brs, 6H), 2.92-3. 12,3. 42-3. 64,3. 85-3.90 (3 m, 10H), 3.24 (brs, 2H), 3.73, 3. 88 (2 s, 6H), 3.95 (m, 1H), 6.28 (brs, 1H), 6.63 (s, 1H), 7.12, 7.24 (m, 4H), 7.29 (s, 1H), 7.34 (d, J 7.0 Hz, 1H), 7.43 (dd, J 7.0 Hz, 2H), 7.84 (d, J 7 Hz, 2H). 13C NMR (125 MHz, CDC13) : a 13. 1,14. 4,23. 3,39. 6,42. 3,43. 5, 56.1, 61.6, 111.4, 111. 8, 125.3, 126.5, 129.0, 129.9, 128.7, 130.1, 130.3, 135.4, 2 x 147.2, 147.9, 171.6. (+) LRESIMS m/z 539 [M+H] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenyl-1H-imidazole-4-carbaldehyde, its application will become more common.