Tag: M.W=100-200

Reference of 137049-00-4, The chemical industry reduces the impact on the environment during synthesis 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, I believe this compound will play a more active role in future production and life.

Intermediate 27 (40 mg, 79 mumol) was dissolved in 1 mL of pyridine and flushed with nitrogen, It was cold to 0 C. and added 1-methyl-1 H-imidazole-4-sulfonyl chloride (43,mg, 240 mumol). The mixture was allowed to warm to room temperature and stirred for 20 h under nitrogen. The reaction was diluted with 10 mL of EtOAc, washed with brine, dried over Na2SO4 and concentrated in vacuum to give crude product which was then purified by flash chromatography on silica gel (20% to 50% ethyl acetate in hexane, then 5/5/1 of EtOAc/hexane/MeOH) to provide 55 (24 mg, 47%). m/z=648 (M+1). The deprotection of the DPM group at C8-OH was carried out as in the conversion of 28 to 29. The resulting residue was then purified by reverse-phase prep HPLC to provide 13 mg (59% in yield) of 56 as a TFA salt. 300 MHz 1H NMR (CDCl3) delta (ppm): 9.0 (d, 1H); 8.4 (d, 1H); 7.5 (m, 1H); 7.4 (s, 1H); 7.3 (m, 2H); 7.2 (s, 1H); 7.0 (t, 2H); 4.8 (s, 2H); 4.3-4.5 (m, 2H); 3.6 (s, 3H); 3.4 (s, 3H). m/z=482 (M +1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Application of 21252-69-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21252-69-7, name is 1-Octyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 1,2-Dimethyl imidazole (9.61 g; 0.10 mol) and trimethylphosphate (14.01 g; 0.10 mol) were mixed at room temperature under argon and vigorous stirring, then heated to 80°C and stirred at this temperature for 1h. Acetonitrile (20 mL) was added and the mixture was stirred at 80°C for 23h. The mixture was left at room temperature, the precipitate was separated,washed twice with acetonitrile and dried under vacuum (2 Torr) for 4 h at 80°C.

The synthetic route of 1-Octyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934-32-7, Recommanded Product: 934-32-7

General procedure: A mixture of aromaticaldehyde (1.0 mmol) and dimedone(1.0 mmol) with 2-aminobenzimidazole or 3-amino-1,2,4-triazole (1.0 mmol) was stirred in acetic acid (5 mL) at 60 Cfor the appropriate time (Tables 3, 4). The progress of thereaction was monitored by TLC. After completion of thereaction, a thick precipitate was obtained. The solid productwas filtered off and washed with acetic acid (3 × 2 mL) togive the pure products 4 and 6, and subsequently dried in air.The pure products were characterized by conventional spectroscopicmethods. Physical and spectral data for the compounds,4b, 4c, 4h, 4j, 6a, 6c, and 6h are represented below:

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89830-98-8, name is 5-Cyclopropyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Cyclopropyl-1H-imidazole

A solution of methyl 2,5- dioxo-2,3,4,5,7,8-hexahydro-[1,4]diazepino[7,1-a]isoquinoline-9-carboxylate (225 mg, 0.79 mmol) in DCE (20 mL) was treated with POCI3 (0.37 mL, 3.93 mmol) and the mixture was heated to 100 °C for 1 h. The mixture was then allowed to cool to RT, and then concentrated in vacuo, and dried azeotropically with toluene. The residue obtained was taken up in DCE (40 mL) and 4-cyclopropyl-1H-imidazole (261 mg, 2.41 mmol) were added. The mixture was heated to to 100 °C for 1h and then allowed to cool to RT, diluted with DCM and washed with a saturated aq, solution of NaHC03. The org. layer was dried over Na2S04, filtered and concentrated in vacuo. Purification by flash chromatography (Si02, AcOEt MeOH 100. to 90: 10) and crystallization in Et20/petroleum ether gave the title compound (116 mg). UPLC- MS: MS 377.2 (M+H+); UPLC rt 0.88 min. 1H NMR (600 MHz, DMSO-c/6): delta ppm 0.54-0.73 (m, 2H); 0.73-0.88 (m, 2H); 1.74-1.89 (m, 1 H); 3.25 (br s, 2H); 3.67-3.82 (m, 2H); 3.88 (s, 3H); 4.25 (br s, 2H); 7.13 (s, 1H); 7.44 (s, 1H); 7.48-7.57 (m, 1H); 7.96 (d, J=7.65 Hz, 1H); 8.09 (s, 1H); 8.19 (d, J=7.91 , 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 54624-57-6, name is 2-Bromobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54624-57-6, name: 2-Bromobenzimidazole

To a stirred solution of Intermediate 13 (0.25 g, 0.92 mmol) in dry DMF (3 mL), TEA (0.5 mL, 3.71 mmol) and 2-bromo-1H-benzoimidazole (0.18 g, 0.92 mmol, Arbor chemicals) were added at rt and the reaction mixture was stirred at 100 °C overnight. It was cooled to rt and concentrated. This crude product was purified by flash column chromatography to afford the title compound (brown solid). 1H NMR (400 MHz, CDCl3): delta 7.33 (m, 2H), 7.07-7.06 (m, 2H), 6.86 (d, J=1.2 Hz, 1H), 6.76-6.74(m, 2H), 5.97-5.96 (m, 2H), 3.59-3.58 (m, 4H), 3.35-3.34 (m, 1H), 2.60-2.59 (m, 2H), 2.52-2.51 (m, 2H), 1.35 (d, J=8.0 Hz, 3H). LCMS: (Method A) 351.2 (M+H), Rt. 2.29min, 95.81 percent (Max). HPLC: (Method A) Rt. 2.19 min, 96.33percent (Max).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-imidazole-5-carbaldehyde

Example 3: : (2,4-Dichloro-3-(2-chlorophenyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)n-BuLi (2,5 M in hexanes, 0,52 mL, 1.3 mmol) was added dropwise to a solution ofn 6-bromo-2,4-dichloro-3-(2-chlorophenyl)quinoline (387.5 mg, 1 mmol, Intermediate 2: step c) in dry THF (10 mL) in a 500 mL three necked round bottomed flask at -78 C under N2. Stirring was continued for 30 minutes then a solution of 1-methyl-1H-imidazole-5-carbaldehyde (550 mg, 1 mmol) in dry THF (50 mL) was added at -78 C. The cooling bath was removed and the mixture was gradually warmed to room temperature and stirred for 2 hours. The mixture was quenched by adding H2O (10 mL) and then extracted with CH2Cl2 (2 x 50 mL). The combined organic phase was dried over Na2SO4, concentrated to dryness and purified by prep-TLC (developed by CH3OH/CH2Cl2 1:40) to afford the title compound as a white solid. MS (ESI): 418.1 [M+H]+. 1H NMR (300 MHz, CD3OD) delta ppm 8.47 (s, 1H), 8.06 (d, J = 8.6 Hz, 1H), 7.98-7.84 (m, 1H), 7.68- 7.34 (m, 5H), 6.57 (d, 3.3 Hz, 1H), 6.17 (s, 1H), 3.71 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 2849-93-6, A common heterocyclic compound, 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of tert-butyl-piperazine-1-carboxylate (1.75 g), benzimidazole-2-carboxylic acid (1.69 g), HOBt (1.52 g), WSC (1.75 g), and DMF (35 ml) was stirred at room temperature overnight. To the reaction liquid was added a saturated aqueous sodium hydrogen carbonate solution, followed by extraction with EtOAc. The organic layer was washed with saturated brine, then dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent; Hex_EtOAc=2:1 (V/V)) to obtain tert-butyl-4-(benzimidazol-2-ylcarbonyl)piperazine-1-carboxylate (2.4 g) as a white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 17289-26-8, A common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

14.1 Methyl (E) -3- (l-methyl-lH-imidazol-4-yl) acrylate1 ml (5.5 mmol) of methyl diethylphosphonoacetate are added to a suspension of 220 mg (5.5 mmol) of sodium hydride at 60% in 5 ml of tetrahydrofuran cooled to 00C. After stirring for 1 h, 500 mg (4.5 mmol) of 1- methyl-lH-imidazole-4-carbaldehyde are added and the mixture is stirred for 4 hours at ambient temperature and then hydrolysed with water and extracted with ethyl acetate. The organic phase is washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over magnesium sulphate, filtered and evaporated. The product obtained is precipitated from heptane and filtered. 430 mg of methyl (E) -3- (1-methyl-lH-imidazol- 4-yl) acrylate are obtained in the form of a yellow powder with a yield of 57%.

The synthetic route of 17289-26-8 has been constantly updated, and we look forward to future research findings.

Application of 384821-19-6, A common heterocyclic compound, 384821-19-6, name is N-Methyl-1-(1-methyl-1H-imidazol-5-yl)methanamine, molecular formula is C6H11N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 3-{3-[2,2,2-Trifluoro-ethyl)-ureido]-imidazo[1 ,2-a]pyridine-7- carboxylic acid (600 mg, 1.45 mmol), HBTU (823 mg, 2.17 mmol), triethylamine (402 mul_, 2.9 mmol) in a 10/1 mixture of THF/DMF (15 ml_) was added, under an atmosphere of N2, (1-lambda/-methyl-imidazol-5-yl)methylamine (322 mg, 2.89 mmol). The reaction mixture was stirred at room temperature for 18 hours then quenched with water. The aqueous layer was extracted with AcOEt. The organic layer was allowed to stand overnight. The precipitate was filtered off to afford 3-{3-[2,2,2-Trifluoro-ethyl)-ureido]-imidazo[1 ,2-a]pyridine-7-[5-(1-lambda/- methyl-imidazole)]-methylamide (454 mg, 66%).1H NMR (500 MHz, DMSO-d6): 9.15 (br. s., 1 H), 9.07 (br. s., 1 H), 8.61 (d, J = 7.25 Hz, 1 H), 8.25 (s, 1 H), 7.89 (s, 1 H), 7.77 (s, 1 H), 7.56 (s, 1 H), 7.39 – 7.52 (m, 3 H), 7.26 (d, J = 7.25 Hz, 1 H), 7.11 (br. s., 1 H), 6.87 (s, 1 H), 4.51 (s, 2 H), 3.93 (q, J = 9.77 Hz, 2 H), 3.64 (s, 3 H). MS: [M+H] +: 472.2 Melting point > 2600C

The synthetic route of 384821-19-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5805-57-2, name is (1H-Benzo[d]imidazol-2-yl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5805-57-2

General procedure: 9-Chloroacridine or its derivatives (1.0 mmol) and phenol (10.0 mmol) were added into a 100 ml round-bottom flask and the mixture was stirred for 1 h at 60 C under argon atmosphere. Then benzimidazole derivatives (8a-8n, 8p-8q, 1.2 mmol) were added. The mixture was stirred under 120 C for 2 h. Then the mixture was poured into a mixture of ethyl acetate (50 mL) and N-methyl morpholine (1 ml) to get the crude product as yellow precipitation. The crude product was recrystallized from ethylacetate.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5805-57-2.