Tag: M.W=100-200

Application of 6-Nitroindoline

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Adding a certain compound to certain chemical reactions, such as: 19727-83-4, name is 6-Nitroindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19727-83-4, Recommanded Product: 6-Nitroindoline

At room temperature, 6-nitroindoline (99 mg, 0.6 mmol) was added to the reaction tube containing p-methylthiophenol (62 mg, 0.5 mmol) and dimethyl sulfoxide (1.0 mL). After stirring uniformly at room temperature, riboflavin 1 (0.025 mmol, 8 mg) and elemental iodine (0.05 mmol, 13 mg) were added in sequence, and then vacuum oxygen protection was applied. After the reaction tube was reacted at 60C for 24 hours, it was cooled to room temperature, and saturated sodium thiosulfate solution was added to quench the reaction. Then, the reaction solution was extracted with ethyl acetate, and then washed with saturated sodium chloride solution, and the organic layers were combined and dried with anhydrous sodium sulfate, and the organic layer was concentrated by rotary evaporation.Finally, it was purified by column chromatography (n-hexane: ethyl acetate = 30: 1) to obtain a yellow solid 6-nitro-3-(4-methylphenylthio)indole 106 mg, yield 75%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Zhejiang University of Technology; Jiang Xinpeng; Zhao Zongchen; Yu Chuanming; (8 pag.)CN111100056; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Continuously updated synthesis method about 6-Fluoroindoline-2,3-dione

The synthetic route of 324-03-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 324-03-8, name is 6-Fluoroindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 324-03-8

General procedure: A 25-mL flask, equipped with a magnetic stirring bar, was charged with 2-(1,3-dithiolan-2- ylidene)acetonitrile 1a (143 mg, 1.0 mmol), isatin 2a (74 mg, 0.5 mmol), and MeCN (3.0 mL), followed by addition of a solution of I2 (25 mg, 0.1 mmol) in MeCN (1.0 mL). The reaction mixture was stirred at 80 C for 12 h. After 1a was consumed, as indicated by TLC, the reaction mixture was quenched with saturated aqueous Na2S2O3 (1.0 mL) and water (20.0 mL), and stirred for another 10 min. The fully precipitated solid was filtered and washed with water (20.0 mL). Then it was further washed with petroleum ether-ethyl acetate (1/1, V/V, 20.0 mL) and dried under vacuum to afford 3a.

The synthetic route of 324-03-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liang, Deqiang; Li, Xiangguang; Yang, Juan; Li, Yanni; Wang, Baoling; Cheng, Ping; Synthetic Communications; vol. 46; 23; (2016); p. 1924 – 1931;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

A new synthetic route of 7-Chloroisatin

According to the analysis of related databases, 7477-63-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7477-63-6 as follows. COA of Formula: C8H4ClNO2

General procedure: A mixture of isatins 1 (1 mmol), substituted 1H-pyrazol-5-amine 2 (1 mmol), 6-aminopyrimidine-2,4(1H,3H)-dione 3 or 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 5 (1 mmol), H2O(6 mL), and HOAc (2 mL) was placed in a 25-mL flask andstirred at 90 ¡ãC (monitored by thin layer chromatography (TLC)) for about 7 h. Afterreaction completion, the mixture was cooled to room temperature and the precipitateobtained by filtration. Compounds 4 or 6 were further purified by recrystallizationfrom DMF.

According to the analysis of related databases, 7477-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dai, Lei; Mao, Kaimin; Pan, Zhengbing; Rong, Liangce; Research on Chemical Intermediates; vol. 45; 2; (2019); p. 769 – 788;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Extended knowledge of 5-Nitroindoline-2,3-dione

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 611-09-6, name is 5-Nitroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 611-09-6, COA of Formula: C8H4N2O4

A mixture of 5-nitroisatin 22a (5.0 g, 26.0 mmol), 2, 2′-dimethylpropane-1, 3-diol (2.69 g, 25.9 mmol) and a catalytic amount ofp-TSA was suspended in cyclohexane (35 mL) and refluxed with azeotropic removal of water using Dean-Stark apparatus, overnight. The reaction mixture was cooled to room temperature and the solid that separeted was filtered, washed with dilute aqueous sodium bicarbonate, water and then air dried to give 22b. Yield 6. 5g, 90%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE ROCKEFELLER UNIVERSITY; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WO2005/41954; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

Extended knowledge of 583-39-1

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 583-39-1. The above is the message from the blog manager. Quality Control of 2-Mercaptobenzimidazole.

583-39-1, Name is 2-Mercaptobenzimidazole, molecular formula is C7H6N2S, Quality Control of 2-Mercaptobenzimidazole, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Alloui, Mebarka, once mentioned the new application about 583-39-1.

Imidazole derivatives as angiotensin II AT1 receptor blockers: Benchmarks, drug-like calculations and quantitative structure-activity relationships modeling

We performed benchmark studies on the molecular geometry, electron properties and vibrational analysis of imidazole using semi-empirical, density functional theory and post Hartree-Fock methods. These studies validated the use of AM1 for the treatment of larger systems. Then, we treated the structural, physical and chemical relationships for a series of imidazole derivatives acting as angiotensin II AT1 receptor blockers using AM1. QSAR studies were done for these imidazole derivatives using a combination of various physicochemical descriptors. A multiple linear regression procedure was used to design the relationships between molecular descriptor and the activity of imidazole derivatives. Results validate the derived QSAR model. (C) 2018 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 583-39-1. The above is the message from the blog manager. Quality Control of 2-Mercaptobenzimidazole.

Discovery of 2-Phenyl-1H-benzo[d]imidazole

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 716-79-0. The above is the message from the blog manager. Quality Control of 2-Phenyl-1H-benzo[d]imidazole.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, molecular formula is C13H10N2, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Komori, K, once mentioned the new application about 716-79-0, Quality Control of 2-Phenyl-1H-benzo[d]imidazole.

Toward selectivity control of a heme peptide electrode by modification with a phase-transition polymer

Reduction currents for H2O2 at a heme peptide (HP)-modified electrodes are suppressed by inhibitors, such as imidazole derivatives. Although this inhibition effect allows determinations of the total inhibition ability of imidazole derivatives, it has no selectivity. In this study the selectivity control of HP-modified electrodes for imidazole derivatives was performed utilizing the thermoresponsive phase transition of poly(N-isopropylacrylamide), which was chemically immobilized on HP-modified electrodes. The inhibition ratios for imidazole derivatives appeared to be small at temperatures below the lower critical solution temperature (LCST), and to be large above the LCST. This change was ascribed to a steric hindrance caused by a phase transition of the polymer. On the other hand, the inhibition ratio for histamine, which has a larger molecular size relative to imidazole, was not significantly changed by the phase transition. Thus, the selectivity of the HP-modified electrode was found to be controllable using an immobilized phase-transition polymer.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 716-79-0. The above is the message from the blog manager. Quality Control of 2-Phenyl-1H-benzo[d]imidazole.

The Absolute Best Science Experiment for 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10045-45-1 help many people in the next few years. Name: 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 10045-45-1, Name is 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one. In a document, author is Perevalov, Valery P., introducing its new discovery. Name: 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one.

Synthesis of highly functional imidazole derivatives via assembly of 2-unsubstituted imidazole N-oxides with CH-acids and arylglyoxals

A novel and convenient method for the synthesis of a wide range of polyfunctional imidazole derivatives based on the three-component condensation of imidazole N-oxides with CH-acids and arylglyoxals has been developed. This reaction proceeds smoothly in moderate-to-good yields with a wide range of starting materials. (C) 2020 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 10045-45-1 help many people in the next few years. Name: 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one.

Some scientific research about 1H-Benzo[d]imidazole

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 51-17-2, Name is 1H-Benzo[d]imidazole, molecular formula is C7H6N2. In an article, author is Rieder, JM,once mentioned of 51-17-2, Application In Synthesis of 1H-Benzo[d]imidazole.

Synthesis of visoltricin and fungerin: imidazole derivatives of Fusarium sp.

The synthesis of two imidazole derivatives of Fusarium sp. is described. 3-[1-Methyl-4-(3-methyl-2-butenyl)-1H-imidazol-5-yl]-2(E)-propenoic acid methylester was synthesized for the first time and spectroscopic data showed differences to the reported data. Naturally occurring visoltricin proved to be identical to fungerin and the structure of visoltricin is revised. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Extended knowledge of 4-Bromo-1-methylimidazole

If you are interested in 25676-75-9, you can contact me at any time and look forward to more communication. Computed Properties of C4H5BrN2.

In an article, author is Veeraragavan, Vijayakumar, once mentioned the application of 25676-75-9, Computed Properties of C4H5BrN2, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, molecular weight is 161, MDL number is MFCD01320501, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

Molecular Docking Analysis of Imidazole Derivatives and Polybenzimidazole Analogs as Inhibitors of Superoxide Dismutase (SOD) and Xanthine Oxidase (XO)

The present study describes, molecular docking analysis of Imidazole derivatives and Polybenzimidazole (PBI) analogs as inhibitors of Superoxide dismutase (SOD) and Xanthine oxidase (XO). Twelve imidazole derivatives and twelve PBI analogs were evaluated on the docking behaviour of SOD and XO using PatchDock. Docking studies revealed that 1-Ethylimidazole and pyridine-PBI (1 Unit) showed the least atomic contact energy (-15.60 & -200.60 kcal/mol) with that of SOD. Similarly 1-Imidazole and pyridine-PBI (1 Unit) showed the least atomic contact energy (-68.01 & -80.88 kcal/mol) with that of XO. Hence, the results of this present study exhibited the potential of these Imidazole derivatives and Polybenzimidazole (PBI) analogs as SOD and XO inhibitory agents.

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A new application about 716-79-0

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, molecular formula is C13H10N2. In an article, author is Singh, Gajendera,once mentioned of 716-79-0, Recommanded Product: 716-79-0.

STRUCTURE AND SYNTHESIS OF SOME IMIDAZOLE DERIVATIVES CONTAINING 2-(4-CHLOROPHENYL)-4, 5-DIPHENYL IMIDAZOLE MOIETY AS ANTI-INFLAMMATORY AND ANTIMICROBIAL AGENTS

A series of imidazole derivatives (4a-e) have been synthesized from2-(4-chlorophenyl)-4, 5-diphenyl-1H-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, (HNMR)-H-1 and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized imidazole derivatives have been investigated for their anti-inflammatory, anti-bacterial and antifungal effect and showed moderate to good activity.

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