Tag: M.W=100-200

In an article, author is MAURICE, M, once mentioned the application of 23996-25-0, Application In Synthesis of 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, Name is 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, molecular formula is C9H13N3, molecular weight is 163.22, MDL number is MFCD00051492, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

EFFECTS OF IMIDAZOLE DERIVATIVES ON CYTOCHROMES-P450 FROM HUMAN HEPATOCYTES IN PRIMARY CULTURE

The expression of several forms of cytochrome P450 including P450 1A2, 2D6, 2E1 and 3A was investigated in human hepatocytes maintained in primary culture for 96 h in the absence or presence of 50-mu-M of various imidazole derivatives. These included ketoconazole, clotrimazole, miconazole, fluconazole, secnidazole and metronidazole. In addition, the typical inducers rifampicin and beta-naphthoflavone were used for comparison. Western and Northern blot analysis of microsomes and RNA prepared from these cultures as well as de novo synthesis experiments revealed that, among the imidazole derivatives tested, only clotrimazole was a strong rifampicin-like inducer of P450 3A. The expression of the other forms of P450 tested was not affected by the treatments. Analysis of the inhibition of 13 monoxygenase activities, including ethoxyresorufin and phenacetin O-deethylases, coumarin 7-alpha-, lauric acid 11- and 12-, mephenytoin 4-, debrisoquin 4-, and aniline hydroxylases, benzphetamine, aminopyrine, mephenytoin and erythromycin demethylases, and cyclosporin oxidase (representative of 10 different forms of P450 in human liver microsomes) revealed that ketoconazole was a strong and selective in vitro inhibitor of P450 3A (cyclosporin oxidase) with a K(i) < 1-mu-M. Clotrimazole and miconazole were also strong inhibitors of P450 3A-mediated activities in contrast to the other imidazole derivatives. If you are interested in 23996-25-0, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, HPLC of Formula: C13H10N2716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, SMILES is C1(C2=CC=CC=C2)=NC3=CC=CC=C3N1, belongs to imidazoles-derivatives compound. In a article, author is Li, Qing, introduce new discover of the category.

Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents

A novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 5 with good anti-inflammatory activity was identified from our in-house library. Based on hit compound 5, two series of 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 6a-g and 7a-h were designed and synthesized as novel anti-inflammatory agents. Most of synthesized compounds exhibited good inhibitory activity on NO and TNF- production in LPS-stimulated RAW 264.7 macrophages, in which the compound 6e showed most potent inhibitory activity on NO (IC50=0.86m) and TNF- (IC50=1.87m) production. Further evaluation revealed that compound 6e displayed more potent in vivo anti-inflammatory activity than ibuprofen did on xylene-induced ear oedema in mice. Additionally, Western blot analysis revealed that compound 6e could restore phosphorylation level of IB and protein expression of p65 NF-B in LPS-stimulated RAW 264.7 macrophages.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 716-79-0. HPLC of Formula: C13H10N2.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 23996-25-0, Name is 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, SMILES is CCC1=NC(C)=CN1CCC#N, in an article , author is Rossi, Renzo, once mentioned of 23996-25-0, COA of Formula: C9H13N3.

Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives

In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-111-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial and antiulcer activities. The present review with 411 references, in which we focused on the literature data published mainly from 2011 to 2017, aims to update the readers on the recent developments on the synthesis and biological evaluation of pharmacologically relevant 1,2,4,5-tetrasubstituted-lff-imidazole derivatives with an emphasis on their different molecular targets and their potential use as drugs to treat various types of diseases. Reference was also made to substantial literature data acquired before 2011 in this burgeoning research area.

Interested yet? Read on for other articles about 23996-25-0, you can contact me at any time and look forward to more communication. COA of Formula: C9H13N3.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, 23996-25-0, Name is 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, SMILES is CCC1=NC(C)=CN1CCC#N, belongs to imidazoles-derivatives compound. In a document, author is Cammers, A, introduce the new discover.

Solid state hydrogen bonding in imidazole derivatives: a persistent tape motif

The Cambridge Structural Database was mined for non N-substituted, neutral imidazole derivatives. Solid states with metal centres bound to the imidazole nitrogen atoms and ionic species were not included. The N-N, hydrogen-bound, tape motif was found to be a structural trend in the solid-state of neutral imidazole derivatives in the presence of possible competing hydrogen bonds and in highly steric environments. A chemically intuitive set of parameters was chosen to characterize the relationships between imidazole rings in the solid states. The choice of structural parameters and the values these parameters take as a function of substitution patterns of imidazole derivatives was discussed. The complexities that can arise in the crude extraction of hydrogen bond strength from solid state data was discussed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 23996-25-0. Name: 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 583-39-1, Name is 2-Mercaptobenzimidazole, molecular formula is C7H6N2S. In an article, author is Bansal, Ravi,once mentioned of 583-39-1, Quality Control of 2-Mercaptobenzimidazole.

Green Synthesis of 1,2,4,5-Tetrasubstituted and 2,4,5-Trisubstituted Imidazole Derivatives Involving One-pot Multicomponent Reaction

Sodium lauryl sulfate has been found convenient, versatile, and eco-friendly catalyst for the synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazole derivatives by one-pot multicomponent reactions at 80 degrees C using water as solvent. This protocol afforded advantages, that is, the metal-free reaction, purification of products by non-chromatographic method, and excellent yields.

Interested yet? Keep reading other articles of 583-39-1, you can contact me at any time and look forward to more communication. Quality Control of 2-Mercaptobenzimidazole.

Related Products of 10045-45-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 10045-45-1, Name is 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one, SMILES is O=C1N(CC)C2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a article, author is Safa, Kazem D., introduce new discover of the category.

Synthesis of 2-aryl-1,1-bis(silyl)alkenes-containing tetrasubstituted imidazoles catalysed by M-Cu/ZSM-5 (M: Cr, Mn, Co, Ni, V, Zn and Fe) zeolites-supported bimetallic nanostructures

The one-pot synthesis of tetrasubstituted imidazoles by using a series of M-Cu/ZSM-5 (M: Cr, Mn, Co, Ni, V, Zn and Fe) zeolites-supported bimetallic catalysts was studied. Fe-Cu/ZSM-5 bimetallic oxide catalyst had the highest activity in improving the efficiency of the heterogeneous cyclo-condensation reaction. Some imidazole derivatives terminated by vinylbis(silanes) have been synthesised using (Me3Si)(3)CLi through the Peterson olefination reaction.

Related Products of 10045-45-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 10045-45-1 is helpful to your research.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 10045-45-1, Name is 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one, SMILES is O=C1N(CC)C2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a document, author is Wong, Fung Fuh, introduce the new discover, Safety of 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one.

New investigation of 1-substituted imidazole derivatives as thermal latent catalysts for epoxy-phenolic resins

Novel 1-substituted imidazole derivatives (4-10) were synthesized by imidazole and the corresponding substituted reagents (chloromethylpivalate, diphenylphosphinicchloride, di-tert-butyldicarbonate, 1,1′-oxalylchloride, pyrazine, phneylisocyanat, and p-toluensulfonylchloride). Polymerization of diglycidyl ether of bisphenol A (DGEBA) with 1-substituted imidazole derivatives, two commercial available catalysts (imidazole and 1-cyanoethyl-2-ethyl-4-methylimidazole) and N-benzylpyrazinium hexafluoroantimonate were investigated as model reactions of epoxy resin systems with respect to the thermal latency and storage stability of the catalysts. The catalytic activity of I-substituted imidazole derivatives 4-10 depended on the steric and withdrawing electronic effect of the substitution groups. To characterize the cure activation energy and the viscosity-storage time, the order of thermally latent activity is 1-tosylimidazole (6) > 1,1′-oxalyldiimidazole (8) > N-benzylpyrazinium hexafluoroantimonate (BPH, 3) > 1-tritylimidazole (9) > N-phenyl-imidazole-1-carboxamide (5) > 3-(diphenylphosphinoyl)imidazole (7) > tert-butyl-1H-imidazole-1-carboxylate (4) > 1-cyanoethyl-2-ethyl-4-methylimidazole (2E4MZ, 2) > 1-[(pivalyloxy)methyl]imidazol (10) > imidazole (1). In comparison with commercially available catalysts imidazole (1) and 1-cyanoethyl-2-ethyl-4-methylimidazole (2) and a cationic latent catalyst N-benzylpyrazinium hexafluoroantimonate (BPH, 3) as the standard compounds, in addition to 1-[(pivalyloxy)methyl]imidazole (10), the I-substituted imidazole derivatives (4-9) revealed better thermal latency. (c) 2007 Wiley Periodicals, Inc.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10045-45-1 is helpful to your research. Safety of 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 10045-45-1, Name is 1-Ethyl-1H-benzo[d]imidazol-2(3H)-one, SMILES is O=C1N(CC)C2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a document, author is Jadhav, Ganesh R., introduce the new discover, COA of Formula: C9H10N2O.

Synthesis and characterization of some novel 2-{2-[1-(3-substituted-phenyl)-1H-1,2,3-triazol-4-yl-] ethyl}-1-substituted-1H-benzo [d] imidazole derivatives

Synthesis of some novel 2-{2-[1-(3 -substitutedphenyl)-1H-1,2,3-triazol-4-yl -]ethyl)-1H-benzo [d] imidazole derivatives, by the condensation of o-phenylenediamine with 3-(1-(3-substituted-phenyl)-1H-1,2,3-triazol-4-yl) propanoic acid and then subsequent reactions with different substituted alkyl halides as electrophiles are mentioned. The synthesized compounds were characterized by H-1 NMR, EI-MS and IR spectroscopic techniques.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 10045-45-1 is helpful to your research. COA of Formula: C9H10N2O.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 25676-75-9, Name is 4-Bromo-1-methylimidazole, SMILES is CN1C=NC(Br)=C1, belongs to imidazoles-derivatives compound. In a document, author is Belhassan, Assia, introduce the new discover, Product Details of 25676-75-9.

Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach

Because of the fast increase in deaths due to Corona Viral Infection in majority region in the world, the detection of drugs potent of this infection is a major need. With this idea, docking study was executed on eighteen imidazole derivatives based on 7-chloro-4-aminoquinoline against novel Coronavirus (SARS-CoV-2). In this study, we carried out a docking study of these molecules in the active site of SARS-CoV-2 main protease. The result indicate that Molecules No 3, 7 and 14 have more binding energy with SARS-CoV-2 main protease recently crystallized (pdb code 6LU7) in comparison with the other imidazole derivatives and the two drug; Chloroquine and hydroxychloroquine. Because of the best energy of interaction, these three molecules could have the most potential antiviral treatment of COVID-19 than the other studied compounds. The structures with best affinity in the binding site of the protease have more than 3 cycles and electronegative atoms in the structure. This may increase the binding affinity of these molecules because of formation of p-bonds, halogen interactions and/or Hydrogen bond interactions between compounds and the enzyme. So, compounds with more cycles and electronegative atoms could have a potent inhibition of SARS-CoV-2 main protease.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 25676-75-9 is helpful to your research. Product Details of 25676-75-9.

In an article, author is Shoaib, Mahbubul Alam, once mentioned the application of 25676-75-9, Recommanded Product: 4-Bromo-1-methylimidazole, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, molecular weight is 161, MDL number is MFCD01320501, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

Fast and accurate predictions of heat of formation by G4MP2-SFM parameterization scheme: An application to imidazole derivatives

We proposed a new parameterization scheme, G4MP2-SFM, for the prediction of heat of formation by combining SFM (Systematic Fragmentation Method) and high accuracy G4MP2 theories. In an application to imidazole derivatives, we found that the overall MAD and RMSD of the particular G4MP2-SFM(opt) are 1.9 and 2.2 kcal/mol, respectively, demonstrating its high prediction accuracy. In addition, our parameterization scheme replaces the ab initio computations with a set of simple arithmetic, allowing fast predictions. Our new computational scheme can be of practical use in high throughput search for new high energy materials. (C) 2014 Elsevier B. V. All rights reserved.

If you are interested in 25676-75-9, you can contact me at any time and look forward to more communication. Recommanded Product: 4-Bromo-1-methylimidazole.