Tag: M.W=100-200

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Name: 1H-Benzo[d]imidazole, 51-17-2, Name is 1H-Benzo[d]imidazole, SMILES is C12=CC=CC=C1N=CN2, belongs to imidazoles-derivatives compound. In a document, author is Alloui, Mebarka, introduce the new discover.

Imidazole derivatives as angiotensin II AT1 receptor blockers: Benchmarks, drug-like calculations and quantitative structure-activity relationships modeling

We performed benchmark studies on the molecular geometry, electron properties and vibrational analysis of imidazole using semi-empirical, density functional theory and post Hartree-Fock methods. These studies validated the use of AM1 for the treatment of larger systems. Then, we treated the structural, physical and chemical relationships for a series of imidazole derivatives acting as angiotensin II AT1 receptor blockers using AM1. QSAR studies were done for these imidazole derivatives using a combination of various physicochemical descriptors. A multiple linear regression procedure was used to design the relationships between molecular descriptor and the activity of imidazole derivatives. Results validate the derived QSAR model. (C) 2018 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 51-17-2. Name: 1H-Benzo[d]imidazole.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, SMILES is NC1=NC2=CC=CC=C2N1, in an article , author is PARLIER, D, once mentioned of 934-32-7, Application In Synthesis of 1H-Benzo[d]imidazol-2-amine.

SUPERCRITICAL FLUID CHROMATOGRAPHY OF IMIDAZOLE DERIVATIVES

The aim of this work was to use SFC to separate simple, slightly basic, imidazole derivatives which are used for the synthesis of more complex molecules with therapeutic properties. Control of their purity utilizes separation techniques and this paper shows that SFC can do in comparison with LC which requires derivatization before detection and with GC where peak tailing can be a problem. Our results concern the use of sub-critical mixtures of CO2 and polar modifiers because imidazole derivatives react with neat CO2, thus failing to elute from packed columns, and are only partially resolved on capillary columns with neat N2O. Therefore, separations with CO2-alcohol-amine-water mixtures on aminopropyl-bonded silica with UV detection are discussed. The resolution and sensitivity limits allow real sample analysis within a very short time.

Interested yet? Read on for other articles about 934-32-7, you can contact me at any time and look forward to more communication. Application In Synthesis of 1H-Benzo[d]imidazol-2-amine.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, SMILES is NC1=NC2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a document, author is Eshghi, Hossein, introduce the new discover, Product Details of 934-32-7.

A novel imidazolium-based acidic ionic liquid as an efficient and reusable catalyst for the synthesis of 2-aryl-1H-phenanthro[9,10-d]imidazoles

A novel acidic ionic liquid based on imidazoliumcation is designed, synthesized, and successfully used as a catalyst for the one-pot synthesis of 2-aryl-1H-phenanthro[9,10-d]imidazole derivatives. The remarkable feature of this new catalyst is its ethyleneoxy bridge which participates in dissolving organic compounds in ionic liquids. The application of this acidic ionic liquid is studied in a new one-pot method for the synthesis of imidazole derivatives under solvent-free conditions. The advantages of this method are the reusability of the catalyst, high conversion, short reaction time, and simple experimental procedure.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 934-32-7 is helpful to your research. Product Details of 934-32-7.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 25676-75-9, Name is 4-Bromo-1-methylimidazole. In a document, author is Adeyemi, Oluyomi Stephen, introducing its new discovery. Formula: C4H5BrN2.

Imidazole derivatives as antiparasitic agents and use of molecular modeling to investigate the structure-activity relationship

Toxoplasmosis is a common parasitic disease caused by Toxoplasma gondii. Limitations of available treatments motivate the search for better therapies for toxoplasmosis. In this study, we synthesized a series of new imidazole derivatives: bis-imidazoles (compounds 1-8), phenyl-substituted 1H-imidazoles (compounds 9-19), and thiopene-imidazoles (compounds 20-26). All these compounds were assessed for in vitro potential to restrict the growth of T. gondii. To explore the structure-activity relationships, molecular analyses and bioactivity prediction studies were performed using a standard molecular model. The in vitro results, in combination with the predictive model, revealed that the imidazole derivatives have excellent selectivity activity against T. gondii versus the host cells. Of the 26 compounds screened, five imidazole derivatives (compounds 10, 11, 18, 20, and 21) shared a specific structural moiety and exhibited significantly high selectivity (> 1176 to > 27,666) towards the parasite versus the host cells. These imidazole derivatives are potential candidates for further studies. We show evidence that supports the antiparasitic action of the imidazole derivatives. The findings are promising in that they reinforce the prospects of imidazole derivatives as alternative and effective antiparasitic therapy as well as providing evidence for a probable biological mechanism.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 25676-75-9 help many people in the next few years. Formula: C4H5BrN2.

Application of 23996-25-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 23996-25-0, Name is 2-Ethyl-4-methyl-1H-imidazole-1-propanenitrile, SMILES is CCC1=NC(C)=CN1CCC#N, belongs to imidazoles-derivatives compound. In a article, author is Bucinski, A, introduce new discover of the category.

Artificial neural networks for prediction of antibacterial activity in series of imidazole derivatives

Artificial neural networks (ANNs) have been applied for the quantitative structure-activity relationships (QSAR) studies of antibacterial activity against Escherichia coli, Serratia marcescens, Proteus vulgaris, Klebsiella pneumoniae and Pseudomonas aeruginosa of a large series of new imidazole derivatives. Antibacterial activity against individual bacteria, expressed as logarithm of reciprocal of the minimal inhibitory concentrations, log 1/MIC, has been related to a number of physicochemical and structural parameters of the imidazole derivatives investigated. Molecular descriptors of agents were obtained by quantum-chemical calculations combined with molecular modelling and from respective structure fragment reference data (e.g., log P). A high correlation resulted between the predicted from ANN model antibacterial activity, log 1/MICANN, and that from biological experiments, log 1/MICexp, both for the data used in learning and in the testing sets of imidazoles. Correlation coefficient, R, depending oil the type of bacteria and Structural subset of analysed imidazole compounds, varies front 0.875 to 0.969. The applicability of ANNs has been demonstrated for the prediction of pharmacological potency of new imidazole derivatives based on their structural descriptors generated exclusively by calculation chemistry.

Application of 23996-25-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 23996-25-0 is helpful to your research.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, SMILES is NC1=NC2=CC=CC=C2N1, in an article , author is Trofimov, Boris A., once mentioned of 934-32-7, Category: imidazoles-derivatives.

Reaction of imidazole derivatives with trifluoromethylated arylacetylenes

The nucleophilic addition of imidazole derivatives to trifluoromethylated acetylenes was studied. Unpredictable regioselectivity of the reaction was observed to yield both beta- and alpha-addition products. The reaction is 100% stereoselective to give the corresponding adducts as a Z-isomers only. The observed regioselectivity is discussed in terms of polarization of triple bond using experimental and calculated data. (C) 2016 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 934-32-7, you can contact me at any time and look forward to more communication. Category: imidazoles-derivatives.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 1H-Benzo[d]imidazol-2-amine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3. In an article, author is CONSONNI, R,once mentioned of 934-32-7.

A NEW APPROACH TO IMIDAZOLE DERIVATIVES

Cycloaddition reactions of mesoionic 1,3-oxazolium-5-olates with N-(phenylmethylene)benzenesulphonamides give substituted imidazoles via elimination of carbon dioxide and benzenesulphinic acid; structural assignments were confirmed by 2D NOESY experiments.

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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 25676-75-9, Name is 4-Bromo-1-methylimidazole, molecular formula is C4H5BrN2, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Jamaledini, Azar, once mentioned the new application about 25676-75-9, Product Details of 25676-75-9.

A practical one-pot three-component procedure for preparation of 3a,8a-dihydroxyindeno[1,2-d]imidazole derivatives in aqueous ethanol

The results of our investigations on the preparation of 3a,8a-dihydroxyindeno[1,2-d]imidazole derivatives via reaction of thiourea, ninhydrin, and alkyl/benzyl chlorides in aqueous ethanol and under convenient conditions is reported. On the other hand, when guanidinium chloride was used instead of thiourea, the reaction mixtures reached with unexpected products; 2,2-dialkoxy-1H-indene-1,3(2H)-diones.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 25676-75-9. The above is the message from the blog manager. Product Details of 25676-75-9.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, SMILES is NC1=NC2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a document, author is Nakamura, T, introduce the new discover, Name: 1H-Benzo[d]imidazol-2-amine.

Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors

In a previous paper, we reported that an imidazole derivative I exhibited a potent inhibitory activity of 20-HETE synthase (1; IC50 value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs). We examined some derivatives of imidazole I which had an amino group on the side chain, and found that a dimethylaminohexyloxy derivative (3g ;IC50 value of 8.8 nM) showed potent and selective inhibitory activity. (C) 2003 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 934-32-7 is helpful to your research. Name: 1H-Benzo[d]imidazol-2-amine.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of 1H-Benzo[d]imidazol-2-amine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3. In an article, author is Song, Zhegang,once mentioned of 934-32-7.

Synthesis of Imidazole-Based AIEgens with Wide Color Tunability and Exploration of their Biological Applications

Research on aggregation-induced emission (AIE) has become increasingly popular recently and various AIE luminogens (AIEgens) have been developed based on tetraphenylethene, hexaphenylsilole, distyrylanthracene, tetraphenylpyrazine, etc. However, facile tuning of the AIEgen emissions in a wide range remains challenging. Herein, a novel series of AIEgens is reported, based on imidazole-cored molecular rotors, with facile synthesis and emission colors covering the whole visible spectrum. Moreover, these imidazole derivatives exhibit biological functions unique among the AIEgens, including mitochondria-specific imaging and antifungal activity. Benefiting from the easy preparation and the tunable emission, the imidazole derivatives are expected to not only diversify the family of AIEgens but also enrich their biological applications.

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