Tag: M.W=100-200

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Nontoxic corrosion inhibitors for copper in sulphuric acid

The aim of this paper is to study influence of the molecular structure on the inhibiting properties of organic compounds in corrosion processes in acid media. The inhibiting efficiency of nontoxic imidazole derivatives on copper corrosion in sulphuric acid is investigated. The investigation is performed using electrochemical methods of potentiodynamic polarization as well as gravimetric measurements. The results of the investigation show that the inhibiting properties of substituted imidazoles depend on molecular structure. The best protection (93%) is obtained by adding a phenyl ring to the imidazole structure. The values of standard free energies of adsorption, as calculated from the Freundlich isotherm, indicate that in the presence of sulphuric acid imidazole derivatives adsorb on copper by a physisorption-based mechanism.

If you are hungry for even more, make sure to check my other article about 25676-75-9, SDS of cas: 25676-75-9.

Synthetic Route of 583-39-1, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 583-39-1, Name is 2-Mercaptobenzimidazole, SMILES is SC1=NC2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a article, author is Lue Shiming, introduce new discover of the category.

Synthesis and Calm Activity of Imidazole Derivatives of Helicid

A convenient approach for synthesis of the imidazole derivatives of helicid 4a similar to 4h is presented via condensation of helicid, 2-hydroxy-1,2-diarylethanone (2a similar to 2d), ammonium acetate and alkyl amine, using iodine as efficient catalyst. The structures of the target compounds 4a similar to 4h were characterized by (1)H NMR, (13)C NMR, IR and FIRMS techniques. Their calm activities were investigated in healthy mice, and compound 4e showed favorable calm activity compared with helicid.

Synthetic Route of 583-39-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 583-39-1 is helpful to your research.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 25676-75-9, Name is 4-Bromo-1-methylimidazole, formurla is C4H5BrN2. In a document, author is Nemati, Firouzeh, introducing its new discovery. Safety of 4-Bromo-1-methylimidazole.

Glycerol as a green solvent for efficient, one-pot and catalyst free synthesis of 2,4,5-triaryl and 1,2,4,5-tetraaryl imidazole derivatives

A simple, efficient and catalyst-free method has been developed for the synthesis of 2,4,5-triaryl and 1,2,4,5-tetraaryl imidazole derivatives in glycerol as green solvent at 90 degrees C. It is noteworthy that in this protocol the yields of products were comparable to or better than, those in conventional media. The use of green reaction media makes this methodology simple, safe and costeffective. (C) 2013 King Saud University. Production and hosting by Elsevier B.V.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 25676-75-9 help many people in the next few years. Safety of 4-Bromo-1-methylimidazole.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Chhetri, Abhijit, Quality Control of 1H-Benzo[d]imidazol-2-amine.

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (M-pro: 6LU7)

A series of six novel imidazole anchored azo-imidazole derivatives (L1-L6) have been prepared by the simple condensation reaction of azo-coupled ortho-vaniline precursor with amino functionalised imidazole derivative and the synthesized derivatives (L1-L6) have been characterized by different analytical and spectroscopic techniques. Molecular docking studies were carried out to ascertain the inhibitory action of studied ligands (L1-L6) against the Main Protease (6LU7) of novel coronavirus (COVID-19). The result of the docking of L1-L6 showed a significant inhibitory action against the Main protease (M-pro) of SARS-CoV2 and the binding energy (Delta G) values of the ligands (L1-L6) against the protein 6LU7 have found to be-7.7 Kcal/mole (L1),-7.4 Kcal/mole (L2),-6.7 Kcal/mole (L3),-7.9 Kcal/mole (L4),-8.1 Kcal/mole (L5) and-7.9 Kcal/mole (L6). Pharmacokinetic properties (ADME) of the ligands (L1-L6) have also been studied. (c) 2020 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 934-32-7, in my other articles. Quality Control of 1H-Benzo[d]imidazol-2-amine.

Related Products of 1003-21-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1,3-Benzenediboronic acid (300 mg, 1.8 mmol), 5-bromo-1-methylimidazole (291 mg, 1.8 mmol), potassium phosphate (1.15 g, 5.4 mmol), tris(dibenzylideneacetone)dipalladium(0) (164 mg, 0.18 mmol), and 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (142 mg, 0.36 mmol) were combined with DMA (3 mL) in a sealed tube purged with N2. The reaction was heated at 130 C. for 25 min in a microwave reactor. The solution was diluted with MeOH, filtered, and concentrated in vacuo. Purification by preparatory HPLC gave 166 mg (45%) of the title compound as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 9.12 (s, 1H), 7.91-7.98 (m, 2H), 7.83 (s, 1H), 7.63 (d, J=7.6 Hz, 1H), 7.52 (t, J=7.6 Hz, 1H), 3.83 (s, 3H). [M+H] calc’d for C10H11BN2O2, 202; found, 202

The synthetic route of 5-Bromo-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dong, Qing; Hosfield, David J.; Paraselli, Bheema R.; Scorah, Nicholas; Stafford, Jeffrey A.; Wallace, Michael B.; Zhang, Zhiyuan; US2006/84650; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 33543-78-1,Some common heterocyclic compound, 33543-78-1, name is Ethyl 1H-imidazole-2-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 1-(2-Trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylic acid ethyl ester A flask charged with 1H-imidazole-2-carboxylic acid ethyl ester (1.03 g, 7.36 mmol), K2CO3 (2.00 g, 14.5 mmol), SEM-Cl (1.56 mL, 8.89 mmol), and 20 mL of acetone was stirred for 10 h at RT. The reaction was diluted with EtOAc (100 mL), washed with NaHCO3 (2*100 mL), brine (100 mL), and the organic layer dried over Na2SO4 and concentrated. The title compound was eluted from a 20-g SPE with 50percent EtOAc/hexanes to give 1.50 g (76percent) of a colorless oil. Mass spectrum (ESI, m/z): Calcd. for C12H22N3O3Si, 271.1 (M+H), found 271.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1H-imidazole-2-carboxylate, its application will become more common.

Reference:
Patent; Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; DesJarlais, Renee Louise; Meegalla, Sanath K.; Wall, Mark; Wilson, Kenneth; US2007/249593; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 615-16-7, These common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 4a or 4b (1 equiv.) and K2CO3 (3 equiv.) in DMF was stirred at 90C for 1h, then the solution was allowed to cool to 60C and was added different substituted 2-chloro-1-phenylethan-1-one (3 equiv.). The mixture was stirred at 60C for another 3h and allowed to cool to room temperature. The saturated NH4Cl solution was added to quench the reaction. The mixture was diluted with water and was extracted with ethyl acetate to afford the crude product that was purified by flash column chromatography on silica gel to yield the target products

The synthetic route of 615-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zou, Yi; Wang, Yan; Wang, Fang; Luo, Minghao; Li, Yuezhen; Liu, Wen; Huang, Zhangjian; Zhang, Yihua; Guo, Wenjie; Xu, Qiang; Lai, Yisheng; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 199 – 211;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 496-46-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 496-46-8, name is Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 9; PREPARATION OF A CUCURBITURIL TRIMER HAVING A RIGID ASSMEBLING UNIT; An exemplary pathway for preparing a cucurbituril trimer having a rigid assembling unit, according to the present invention, is presented in Figure 25. Coronene-1,2, 5,6, 9, 10-HEXANE (Figure 25, Compound 41), a derivative of coronene, is reacted with urea, so as to afford an assembling unit which includes three glycolurils units fused therein. The assembling coronene unit is then reacted with glycoluril, Compound 2, in a 1: 15 ratio, and with formaldehyde, in the presence of concentrated sulfuric acid, to thereby obtain the rigid derivatized cucurbituril trimer (Figure 25, Compound 42).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.; WO2005/23816; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4857-06-1, Safety of 2-Chloro-1H-benzo[d]imidazole

[1372] mel (6.1 ml, 98.3 mmol) was added to a mixture of 2-chloro-1H-benzo[d]imidazole (5.0 g, 32.8 mmol) and K2CO3 (13.6 g, 98.3 mmol) in DMF(20 ml). The mixture was stirred at 25 C for lh. The insoluble substance was removed by filtration and the filtrate was treated with ea (50 ml), H2O (50 ml). The organic layer was separated and the aqueous layer was extracted with ea (35 ml x 3). The combined organic layer was washed with H2O (35 ml x 2), brine (35 ml x 2), dried over mgs04, filtered and concentrated. The residue was triturated with tbme/pe (v/v = 1/1, -20 ml) to afford compound 294a (3.3 g, yield 60.38%) as pale yellow solid. 1H NMR (DMSO-d6, 400 mhz) delta .60 – 7.56 (m, 2h), 7.31 – 7.24 (m, 2h), 3.80 (s, 3h). MS (ESI) m/z (M+H)+ 167.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89532-38-7, name is 2-Cyclopropyl-1H-imidazole, A new synthetic method of this compound is introduced below., Formula: C6H8N2

Compound 44.2. 2-Cyclopropyl-4,5-diiodo-lH-imidazole. Into a 100-mL round- bottom flask, was placed a solution of 2-cyclopropyl-lH-imidazole (compound 44.1, 1.8 g, 16.6 mmol) in sodium hydroxide (2 M, 40 mL). A solution of iodine (8.5 g, 33.5 mmol) in dichloromethane (40 mL) was added drop-wise and the resulting mixture was stirred overnight at room temperature. The aqueous layer was separated and neutralized with acetic acid and quenched by the addition of a2S203 (sat. aq.). The solids were collected by filtration to yield 3.8 g (63%) of the title compound as a brown solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; 3-V BIOSCIENCES, INC.; HEUER, Timothy Sean; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2015/95767; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem