Tag: M.W=150-200

Kowalska, Dorota published the artcileInteraction of ionic liquids with human serum albumin in the view of bioconcentration: a preliminary study, Formula: C8H15ClN2, the publication is Chemical Papers (2022), 76(4), 2405-2417, database is CAplus.

Bioaccumulation potential is critical in PBT and risk assessment of chems. However, for ionic liquids (ILs), this aspect remains neglected. It is especially important to fill this gap, because for this group of compounds, existing data confirm their risk of being environmentally persistent and toxicity. Moreover, considering preliminary reports on the interactions of ILs with lipids, it may be assumed that ILs have a higher potential for bioaccumulation than indicated by previous estimations built upon octanol-water partition coefficients Moreover, the bioconcentration of ionizable chem. compounds may also be strongly related to plasma protein contents. Therefore, in this work, the affinity of a set of imidazolium cations and organic anions, and their combination to human serum albumin (HSA) was determined The obtained results reveal that both cations and anions can be strongly bound to HSA, and blood proteins might play an important role in overall bioaccumulation. Furthermore, it was observed that HSA binding properties towards IL cations depend on the hydrophobicity of cations. The obtained data also provide indication that cation-anion interaction may affect ILs ions affinity to HSA.

Chemical Papers published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shreenivas, M. T. published the artcileSynthesis and antibacterial evaluation of some novel aminothiazole derivatives, Application In Synthesis of 79047-41-9, the publication is Pharma Chemica (2011), 3(2), 156-161, database is CAplus.

A series of N-(4-arylthiazol-2-yl)-4′-{[2-butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl}biphenyl-2-carboxamides was prepared The newly synthesized title compounds were screened for in-vitro antibacterial activity. Some of the compounds exhibited encouraging results.

Pharma Chemica published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C24H20Ge, Application In Synthesis of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ang, Chee Wei published the artcileAntitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (2020), 63(24), 15726-15751, database is CAplus and MEDLINE.

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting addnl. efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal Ph group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Elterman, V. A. published the artcileFeatures of aluminum electrodeposition from 1,3-dialkylimidazolium chloride chloroaluminate ionic liquids, Formula: C8H15ClN2, the publication is Journal of Molecular Liquids (2022), 118693, database is CAplus.

The mechanism of aluminum electrodeposition from acidic 1-butyl-3-methylimidazolium chloride chloroaluminate ionic liquids ([BMIm]Cl ILs) is studied over a wide range of the molar ratio of AlCl₃ to [BMIm]Cl (N) at 30°C. The findings for AlCl₃-[BMIm]Cl and AlCl₃-1-ethyl-3-methylimidazolium chloride ([EMIm]Cl) are analyzed and compared in order to identify dependences common for 1,3-dialkylimidazolium chloride ILs. Limiting currents were detected on the cathodic polarization curves at the aluminum | ionic liquid interface. Limiting currents are caused by the Al₂Cl^–₇ anions diffusion to the electrode surface. The limiting c.d. values for AlCl₃-[BMIm]Cl are lower (i_lim, 1.1 ≤ N leq 2.0 = 1.17 – 12.36 mA•cm^-2) than for AlCl₃-[EMIm]Cl (i_lim, 1.1 ≤ N leq 2.0 = 1.81 – 25.37 mA·cm^-2). It is shown that anion AlCl-4 can be reduced to metallic aluminum at cathodic overpotentials above 1.5 V. The diffusion coefficient of Al₂Cl-7 in AlCl₃-[BMIm]Cl (7.4•10-7 cm²•s^-1) is lower than in AlCl₃-[EMIm]Cl (9.3•10-7 cm²•s^-1) and is unaffected by aluminum chloride concentration in either system.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Singh, Gagandeep published the artcileSynthesis, molecular docking, α-glucosidase inhibition, and antioxidant activity studies of novel benzimidazole derivatives, SDS of cas: 4760-35-4, the publication is Medicinal Chemistry Research (2020), 29(10), 1846-1866, database is CAplus.

A novel series of N-methyl/benzyl-substituted benzimidazolyl-linked para-substituted benzyl-based compounds containing 2,4-thiazolidinediones, di-Me malonate (DMM) and di-Et malonate (DEM) were designed, docked, synthesized, and evaluated for their antidiabetic activity studies. Four targeted compounds I (R = Me, Bn) and II showed good inhibitory potential in the range of 4.10 +/- 0.01 to 9.12 +/- 0.06μM. Furthermore, synthesized compounds were evaluated for their antioxidant potential and compared with standard ascorbic acid and results showed that compound I (R = Bn) (EC₅₀ = 0.176 +/- 0.002 mM) being the most active. Compounds I and II exhibited prominent antidiabetic as well as antioxidant activity. Compound I (R = Bn) was considered a promising candidate for this series. The designed mols. were docked into α-glucosidase protein (PDB Code. 3TOP) to develop a correlation with the α-glucosidase inhibition studies and were also addnl. docked into PPARγ proteins (PDB ID: 2PRG) with rosiglitazone (standard drug) to study their PPARγ binding affinity in comparison with rosiglitazone and to classify these compounds for their PPARγ agonistic behavior.

Medicinal Chemistry Research published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C25H29N9O3, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pathak, Devender published the artcileSynthesis, characterization and antimicrobial evaluation of some newer substituted benzimidazole derivatives, SDS of cas: 4760-35-4, the publication is Journal of Chemical and Pharmaceutical Sciences (2011), 4(1), 26-29, database is CAplus.

1,2-Benzenediamine dihydrochloride when reacted with different carboxylic acid derivatives yielded 2-substituted benzimidazole derivatives [no data] which on methylation afforded 1-methyl-2-substituted benzimidazole derivatives, and on acetylation yielded 1-acetyl-2-substituted benzimidazole derivatives The synthesized compounds were elucidated by phys. and spectral data and screened for in vitro antibacterial activity against two gram pos. (Staphylococcus aureus, Bacillus subtilis) and two gram neg. bacterial strains (Pseudomonas aeruginosa, Escherichia coli) and in vitro antifungal activity against Candida albicans, Aspergillus niger.

Journal of Chemical and Pharmaceutical Sciences published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Artemenko, M. V. published the artcileComplexes of copper salts with 2-(hydroxymethyl)benzimidazole and 1-methyl-2-(hydroxymethyl)benzimidazole, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1966), 32(6), 560-6, database is CAplus.

2-(Hydroxymethyl)benzimidazole (ROH) and 1-methyl-2-(hydroxymethyl)benzimidazole (R’OH) react with Cu salts and an equimolar amount of PhNMe₂ in MeOH to form the following compounds (formula and m.p. given): ROCuCl, 216°; ROCuBr, 196°; R’OCuCl, 224°; R’ OCuBr, 223°; R’ OCuONO₂, 231°. The following were prepared by grinding together and adding MeOH or by mixing solutions of the components in MeOH solution: ROCuOAc, over 300°; R’ OCuOAe, 219°; 2ROH.Cu(NO₃)₂. MeOH (heating to 80° forms 2ROH. Cu(NO₃)₂, m. 203°); 2ROH.CuSO₄, over 250°; 3ROH.CuSO₄, over 250°; R’ OH.R’ OCuCl, 178°; R’ OH.R’ OCuBr, 196°; R’ OH.R’ OCuONO₂, 218°; 2R’ OH.Cu(NO₃)₂, 172°; 3R’OH.CuSO₄, 154°. ROH and CuSO₄ form ROH.CuSO₄4H₂O, m. 234°, in H₂O solution Dehydration yields ROH.-CuSO₄, m. 234°. Salts of ROH and R’ OH after grinding with Cu salts, solution in MeOH, and precipitation with Et₂O, form (ROH₂)₂(CuBr₄), m. 126°; (R’ OH₂)₂(CuCl₄), m. 166°; and (R’ OH₂)₂(CuBr₄), m. 158°. R’OH and Cu(OCH₂CH₂NH₂)₂ (CA 59, 8340h) in MeOH form R’ OCuOH, m. 142°.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Artemenko, M. V. published the artcileComplex formation in the cupric nitrate-1-methyl-2-(hydroxymethyl)benzimidazole-methanol system, Synthetic Route of 7467-35-8, the publication is Zhurnal Neorganicheskoi Khimii (1967), 12(11), 3055-61, database is CAplus.

The complex formation of Cu(NO3)2 with 1-methyl-2-(hydroxymethyl)benzimidazole (I) in MeOH was studied by means of various optical methods. Four complex compounds, 2 addition products with the molar ratio of Cu:I = 1:1 and 1:3 and the other 2 mixed chelate alcoholates with 1:1 and 1:2 composition, were found. On the basis of the anal. the absorption spectra of the isomolar series of the solutions were decomposed into sep. Gaussian components. The application of crystal field theory established that these complex compounds have a tetragonal bipyramidal configuration. The optical characteristics for the detected bands of these complex compounds are given. The Me group in the 1 position in the I mol. has no influence on the composition and optical characteristics of the complex compounds

Zhurnal Neorganicheskoi Khimii published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Synthetic Route of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Alasmary, Fatmah A. S. published the artcileSynthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents, Quality Control of 7467-35-8, the publication is Molecules (2015), 20(8), 15206-15223, database is CAplus and MEDLINE.

A library of 53 benzimidazole derivatives, with substituents at positions 1, 2 and 5, were synthesized and screened against a series of reference strains of bacteria and fungi of medical relevance. The SAR analyses of the most promising results showed that the antimicrobial activity of the compounds depended on the substituents attached to the bicyclic heterocycle. In particular, some compounds displayed antibacterial activity against two methicillin-resistant Staphylococcus aureus (MRSA) strains with min. inhibitory concentrations (MICs) comparable to the widely-used drug ciprofloxacin. The compounds had some common features; three possess 5-halo substituents; two were derivatives of (S)-2-ethanaminebenzimidazole; and the others were derivatives of one 2-(chloromethyl)-1H-benzo[d]imidazole and (1H-benzo[d]imidazol-2-yl)methanethiol. The results from the antifungal screening were also very interesting: 23 compounds exhibited potent fungicidal activity against the selected fungal strains. They displayed equivalent or greater potency in their MIC values than amphotericin B. The 5-halobenzimidazole derivatives were considered as promising broad-spectrum antimicrobial candidates that deserve further study for potential therapeutic applications.

Molecules published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Quality Control of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Butera, John A. published the artcileSynthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (1991), 34(11), 3212-28, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of a series of novel 1-(aryloxy)-2-propranolamines and several related deshydroxy analogs are described. The compounds were prepared and investigated for their class III electrophysiol. activity in isolated canine Purkinje fibers and in anesthetized open-chest dogs. None of these compounds showed any class I activity. On the basis of the in vitro data, structure-activity relations for the series are discussed. Two compounds, WAY-123,223 (I) and WAY-125,971 (II) were identified and characterized as potent and specific class III antiarrhythmic agents in vitro and in vivo. I was orally bioavailable, to produce large increases of ventricular fibrillation threshold (VFT), and, in some instances, to restore sinus rhythm from ventricular fibrillation in anesthetized open-chest dogs at a dose of 5 mg/kg (i.v.). The enantiomers of I were synthesized and found to exhibit similar electrophysiol. effects in the Purkinje fiber screen. II, a propylamine analog with potency and efficacy comparable to those of UK-68798 and E-4031, was studied in voltage-clamp experiments (isolated cat myocytes) and found to be a potent and specific blocker of the delayed rectifier potassium current (I_K).

Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem