Sharma, Pankaj’s team published research in European Journal of Medicinal Chemistry in 124 | CAS: 7467-35-8

European Journal of Medicinal Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H21NO3, HPLC of Formula: 7467-35-8.

Sharma, Pankaj published the artcileSynthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents, HPLC of Formula: 7467-35-8, the publication is European Journal of Medicinal Chemistry (2016), 608-621, database is CAplus and MEDLINE.

A series of new benzimidazole-thiazolidinedione hybrids was synthesized and evaluated for their cytotoxic potential against a selected human cancer cell lines of prostate (PC-3 and DU-145), breast (MDA-MB-231), lung (A549) and a normal breast epithelial cells (MCF10A). Among the tested compounds, I exhibited promising cytotoxicity with IC50 value of 11.46 ± 1.46 μM on A549 lung cancer cell line and did not show significant toxicity on normal MCF10A cells. Lung cancer cells (A549) was used to know the mechanism of cell growth inhibition and apoptosis inducing effect with compound I. The treatment of A549 cells with I showed typical apoptotic morphol. like cell shrinkage, chromatin condensation and horseshoe shaped nuclei formation. Flow-cytometry anal. revealed the G2/M phase of cell cycle arrest in a dose dependent manner. Preliminary mechanistic studies suggested that the cell migration was inhibited through the disruption of F-actin protein. Acridine orange-ethidium bromide (AO-EB), DAPI, annexin V-FITC/propidium iodide, rhodamine-123 and MitoSOX assays suggested the induction of apoptosis in A549 cells by compound I.

European Journal of Medicinal Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H21NO3, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wolf, Silke’s team published research in Inorganic Chemistry in 61 | CAS: 79917-90-1

Inorganic Chemistry published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C3H9ClOS, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Wolf, Silke published the artcileRoom-Temperature Synthesis of [BMIm][Sn5O2Cl7] with 1(Sn2OCl2) Strands in a Saline [BMIm][SnCl3] Matrix, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Inorganic Chemistry (2022), 61(9), 4018-4023, database is CAplus and MEDLINE.

The novel tin(II) oxychloride [BMIm][Sn5O2Cl7] (BMIm: 1-butyl-3-methylimidazolium) is obtained by room-temperature reaction (25°C) of black SnO and SnCl2 in [BMIm]Cl/SnCl2 as ionic liquid The title compound can be described to be composed of noncharged, infinite inf1(Sn2OCl2) strands, which are embedded in a saline matrix of [BMIm]+ and [SnCl3]. The inf1(Sn2OCl2) strands consist of a backbone of edge-sharing OSn4/2 tetrahedra, which represent one-dimensional strands cut out of the layer-type structure of SnO. In [BMIm][Sn5O2Cl7] the inf1(Sn2OCl2) strands, which mimic a 1D semiconductor, are terminated by chlorine atoms, whereas they are interconnected by oxygen in the 2D semiconductor SnO. The view of the noncharged inf1(Sn2OCl2) strands in a saline [BMIm][SnCl3] matrix is validated by dissolution experiments Thus, electron microscopy and Raman spectroscopy show a deconstruction of [BMIm][Sn5O2Cl7] single crystals after treatment with CHCl3 with a dissolution of [BMIm][SnCl3], the formation of SnCl2 needles, and tin oxide as a solid remain.

Inorganic Chemistry published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C3H9ClOS, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kumar, Akhilesh’s team published research in Polyhedron in 172 | CAS: 4760-35-4

Polyhedron published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application In Synthesis of 4760-35-4.

Kumar, Akhilesh published the artcileStructure, magnetism and reactivity of a {MnIII(μ-O)2MnIV}3+ core towards oxidation of phenols, Application In Synthesis of 4760-35-4, the publication is Polyhedron (2019), 226-235, database is CAplus.

Two complexes [(L)2MnII(OClO3)(MeCN)](ClO4)·CH3CN (1) and [(L)4MnIII/IV2(μ-O)2](ClO4)3·2CH3CN·Et2O (2), where L is 2-((1H-pyrazol-1-yl)methyl)-1-methyl-1H-benzimidazole, were synthesized, structurally characterized, UV-visible and EPR spectral properties, variable-temperature (2-300 K) magnetic susceptibility and redox behavior studied. Structural anal. reveals that the {MnIII(μ-O)2MnIV}3+ core in 2 is an example of delocalized class III system. Complex 1 has S = 5/2 ground-state. The MnIII and MnIV centers in 2 are antiferromagnetically coupled (J = -192 cm-1) and has S = 1/2 ground-state. Complex 2 exhibits characteristic 16-line EPR spectrum (120 K) centered at g ≈ 2. Reactivity of 2 towards p-X-2-tert-butylphenols (X = H, Me, OMe, tBu) was studied. The oxidation of phenols generate phenoxyl radical (2,4,6-tri-tert-butylphenol exhibits EPR signal due to radical)/radical-coupled bis-phenol product (in the case of 2,4-di-tert-butylphenol, DTBP). Kinetic experiments have allowed the authors to evaluate second-order rate constant values for the faster initial step (k2 × 10-2 M-1s-1) for p-X-2-tert-butylphenols: 0.6 (X = H), 1.95 (Me), 3.0 (OMe), 1.85 (tBu) and for the slower second step (k2 × 10-3 M-1s-1) for p-X-2-tert-butylphenols: 0.9 (X = H), 2.5 (Me), 4.0 (OMe). Reaction between {MnIII(μ-O)2MnIV}3+ of 2 and phenols proceeds via hydrogen atom transfer mechanism to produce oxidation products. Initial reaction supposedly generates {MnIII(O)(OH)MnIII}3+ species, which finally ends up as (L)-coordinated MnII species (ESI-MS spectrum for the reaction between 2 and DTBP).

Polyhedron published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application In Synthesis of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Azadfar, Roohollah’s team published research in International Journal of Thermophysics in 43 | CAS: 79917-90-1

International Journal of Thermophysics published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Azadfar, Roohollah published the artcileEstimation of Heat Capacity of 143 Pure Ionic Liquids Using Artificial Neural Network, HPLC of Formula: 79917-90-1, the publication is International Journal of Thermophysics (2022), 43(6), 81, database is CAplus.

Based on artificial neural network (ANN), a new model is presented to estimate the heat capacity of pure ionic liquids A database for the heat capacity of ionic liquids created by extracting exptl. data from literature covering the period from 1971 to 2021 is reported. With the presented approach, heat capacity is calculated and evaluated by source data bank for 7059 data points of 143 ionic liquids The accuracies of new ANN model are evaluated by comparing with the most commonly used correlations in the literatures, and the results reveal that the proposed network provides more accurate results than other literature correlations considered in this work. The average absolute percentage deviation from the new model is only 1.14%.

International Journal of Thermophysics published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Guo, Tao’s team published research in Bioorganic & Medicinal Chemistry Letters in 15 | CAS: 4760-35-4

Bioorganic & Medicinal Chemistry Letters published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Guo, Tao published the artcileDiscovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(16), 3696-3700, database is CAplus and MEDLINE.

An encoded combinatorial library based on aryl- and biarylpiperidine scaffolds was designed and synthesized. Screening of this library resulted in the discovery of high-nanomolar biarylpiperidine-based MCH1 receptor antagonists. Follow-up optimization using a parallel synthesis provided potent, single digit nanomolar antagonists.

Bioorganic & Medicinal Chemistry Letters published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ganguli, Kasturi’s team published research in Dalton Transactions in 48 | CAS: 4760-35-4

Dalton Transactions published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Product Details of C9H9ClN2.

Ganguli, Kasturi published the artcileCooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines, Product Details of C9H9ClN2, the publication is Dalton Transactions (2019), 48(21), 7358-7366, database is CAplus and MEDLINE.

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism.

Dalton Transactions published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Product Details of C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ye, Chen-Xi’s team published research in Nature Chemistry in 14 | CAS: 4760-35-4

Nature Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H7BrFN, COA of Formula: C9H9ClN2.

Ye, Chen-Xi published the artcileStereocontrolled 1,3-nitrogen migration to access chiral α-amino acids, COA of Formula: C9H9ClN2, the publication is Nature Chemistry (2022), 14(5), 566-573, database is CAplus and MEDLINE.

Here a protocol for the economical and practical synthesis of optically active α-amino acids RNHC(R1)(R2)C(O)OH (R = Ts, Ms, C(O)OMe, (2,2,2-trichloroethoxy)carbonyl; R1 = H, Me; R2 = pent-2-yn-1-yl, 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, etc.) based on an unprecedented stereocontrolled 1,3-nitrogen shift was reported. The method employs abundant and easily accessible carboxylic acids R1CH(R2)C(O)OH as starting materials, which are first connected to a nitrogenation reagent, followed by a highly regio- and enantioselective ruthenium- or iron-catalyzed C(sp3)-H amination. This straightforward method displays a very broad scope, providing rapid access to optically active α-amino acids with aryl, allyl, propargyl and alkyl side chains, and also permits stereocontrolled late-stage amination of carboxylic-acid-containing drugs and natural products.

Nature Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H7BrFN, COA of Formula: C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Martinez-Alanis, Paulina R.’s team published research in Chemistry – A European Journal in 19 | CAS: 4760-35-4

Chemistry – A European Journal published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Martinez-Alanis, Paulina R. published the artcileCopper Versus Thioether-Centered Oxidation: Mechanistic Insights into the Non-Innocent Redox Behavior of Tripodal Benzimidazolylaminothioether Ligands, SDS of cas: 4760-35-4, the publication is Chemistry – A European Journal (2013), 19(19), 6067-6079, database is CAplus and MEDLINE.

A series of Cu+ complexes with ligands that feature varying numbers of benzimidazole/thioether donors and methylene or ethylene linkers between the central nitrogen atom and the thioether sulfur atoms have been spectroscopically and electrochem. characterized. Cyclic voltammetry measurements indicated that the highest Cu2+/Cu+ redox potentials correspond to sulfur-rich coordination environments, with values decreasing as the thioether donors are replaced by nitrogen-donating benzimidazoles. Both Cu2+ and Cu+ complexes were studied by DFT. Their electronic properties were determined by analyzing their frontier orbitals, relative energies, and the contributions to the orbitals involved in redox processes, which revealed that the HOMOs of the more sulfur-rich copper complexes, particularly those with methylene linkers (-N-CH2-S-), show significant aromatic thioether character. Thus, the theor. predicted initial oxidation at the sulfur atom of the methylene-bridged ligands agrees with the exptl. determined oxidation waves in the voltammograms of the NS3– and N2S2-type ligands as being ligand-based, as opposed to the copper-based processes of the ethylene-bridged Cu+ complexes. The electrochem. and theor. results are consistent with our previously reported mechanistic proposal for Cu2+-promoted oxidative C-S bond cleavage, which in this work resulted in the isolation and complete characterization (including by X-ray crystallog.) of the decomposition products of two ligands employed, further supporting the novel reactivity pathway invoked. The combined results raise the possibility that the reactions of copper-thioether complexes in chem. and biochem. systems occur with redox participation of the sulfur atom.

Chemistry – A European Journal published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Castillo, Ivan’s team published research in Polyhedron in 85 | CAS: 4760-35-4

Polyhedron published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Castillo, Ivan published the artcileSynthesis, spectroscopic, and structural characterization of mixed thioether-benzimidazole copper complexes, Computed Properties of 4760-35-4, the publication is Polyhedron (2015), 824-829, database is CAplus.

Mixed N,S tripodal ligands bis(2,4-dimethylphenylthioethyl)(2-methylbenzimidazolyl)amine L1, bis(2,4-dimethylphenylthioethyl)(1-methyl-2-methylbenzimidazolyl)amine L2, and bis(1-methyl-2-methylbenzimidazolyl)(2-methylthioethyl)amine L3 were employed to prepare the corresponding copper complexes. L1 and L2 associate weakly with Cu2+, while the reaction of CuI with L1 affords [L1CuI]. This was characterized in the solid state by the chelating tridentate coordination mode of L1, with a free thioether, and a terminal iodide, in contrast with the commonly observed Cu-I-Cu bridges. For L3, Cu+ and Cu2+ complexes are accessible as [L3Cu]PF6, and the crystallog. characterized [L3CuCl]Cl. The latter has a square pyramidal coordination around the Cu2+ ion, with the thioether as an axial ligand that remains coordinated in solution, as evidenced by UV-visible spectroscopy.

Polyhedron published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Munoz-Patino, Natalia’s team published research in Journal of Inorganic Biochemistry in 211 | CAS: 4760-35-4

Journal of Inorganic Biochemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Munoz-Patino, Natalia published the artcileSynthesis, structure, and biological activity of bis(benzimidazole)amino thio- and selenoether nickel complexes, SDS of cas: 4760-35-4, the publication is Journal of Inorganic Biochemistry (2020), 111198, database is CAplus and MEDLINE.

Four new nickel(II) complexes with bis(benzimidazole)thio- and selenoether-based ligands were synthesized and characterized in the solid state by elemental anal., IR, magnetic susceptibility and x-ray crystallog., and in solution by FAB+ mass spectrometry, UV-visible spectroscopy and cyclic voltammetry. Single-crystal x-ray diffraction anal. of the compounds revealed octahedral geometries for all nickel centers. Three of the four complexes are dimers with chloride bridges between the two Ni(II) ions. However, in solution all complexes have a monomeric formulation, based on mass spectrometry and osmometry measurements. The complexes were also screened for their cytotoxic activity on human cell lines (HeLa, SK-LU-1 and HEK-<293≥), and compared with a related Cu(II) complex.

Journal of Inorganic Biochemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem