Tag: M.W=150-200

Leigh, Vivienne published the artcileSynthesis of pincer-type N-heterocyclic carbene palladium complexes with a hemilabile ligand and their application in cross-coupling catalysis, Category: imidazoles-derivatives, the publication is Journal of Organometallic Chemistry (2014), 33-39, database is CAplus.

Benzimidazolium salts containing both a neutral imine and a masked carboxylate functional group for potential metal chelation were prepared Palladation of the ester-protected ligand afforded a N,C-bidentate carbene complex I [X = Cl, Br]. Subsequent ester hydrolysis preserved the bidentate coordination mode and yielded complex II [X = Cl, CF₃CO₂] with a pending COOH group exclusively. However, when ester deprotection was carried out prior to metalation, the N,C,O-tridentate pincer-type coordinated palladium complex III was obtained. Proton-abstraction of the dangling COOH group in the bidentate ligand of complex II by treatment with a base led to the formation of the N,C,O-tridentate coordinated Pd system III, and inversely, exposure of the tridentate bound Pd complex III with acid afforded the N,C-bidentate ligand coordination mode in complex II, demonstrating hemilability of the oxygen donor site in the pincer ligand. All three palladium(II) complexes I, II and III were evaluated in cross-coupling catalysis and revealed distinct activity differences that are dependent on the type of coupling. These differences suggest that judicious choice of donor groups in pincer-type complexes is a viable strategy for catalyst optimization.

Journal of Organometallic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verma, Raman K. published the artcileDesign, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPARγ partial agonists, HPLC of Formula: 7467-35-8, the publication is Journal of Chemical Sciences (Bangalore, India) (2013), 125(6), 1555-1571, database is CAplus.

The design and synthesis of benzimidazolyl and indolyl linked α-alkoxy phenylpropanoic acid derivatives and the β-keto ester analogs in an effort to develop novel peroxisome proliferator activated receptors ligands expected to exhibit PPARα and PPARγ partial agonism in the management of hyperglycemia and hyperlipidemia for the treatment of type 2 diabetes is reported. Computational validation of the designed mols. through activity prediction and docking studies showed expected results.

Journal of Chemical Sciences (Bangalore, India) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H17NO, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileDesign, synthesis and antifungal evaluation of novel benzimidazole tertiary amine type of fluconazole analogues, COA of Formula: C9H9ClN2, the publication is Arabian Journal of Chemistry (2019), 12(8), 2224-2235, database is CAplus.

A novel series of compounds containing tertiary amine moiety, substituted benzimidazole and triazole ring I (X = Cl; R¹ = Me, Et; R² = Me, Ph) based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of lanosterol 14α-demethylase (homol. modeled of C. albicans) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro (turbidimetric method) and in vivo (kidney burden test) antifungal activity against C. albicans revealed activity for many compounds as comparable to that of fluconazole.

Arabian Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, COA of Formula: C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileSynthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives, Computed Properties of 4760-35-4, the publication is Oriental Journal of Chemistry (2014), 30(4), 1855-1863, database is CAplus.

A series of [(benzimidazolylalkyl)piperazinyl]phenylmethanone derivatives I [R¹ = H, Cl, R² = H, Me, Et, R³ = H, Me, Ph] was synthesized by microwave irradiation and evaluated for in vitro antifungal activity using ketoconazole as the standard Among the tested compounds, benzimidazole derivatives with an N-1 Me, a C2 asym. center and C5 chlorine substitution showed good antifungal activity against the C. albicans strain using the turbidimetric method.

Oriental Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileMicrowave assisted synthesis, antifungal evaluation and molecular docking of benzimidazole derivatives, Related Products of imidazoles-derivatives, the publication is Pharma Chemica (2014), 6(6), 396-405/1-396-405/10, 10 pp., database is CAplus.

A novel series of benzimidazole derivatives, carrying biphenyl carbonyl piperazine moiety based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14 α-demethylase (CYP51) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro antifungal activity against Candida albicans revealed activity for many compounds as comparable to that of ketoconazole.

Pharma Chemica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileSynthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives, HPLC of Formula: 7467-35-8, the publication is Oriental Journal of Chemistry (2014), 30(4), 1855-1863, database is CAplus.

A series of [(benzimidazolylalkyl)piperazinyl]phenylmethanone derivatives I [R¹ = H, Cl, R² = H, Me, Et, R³ = H, Me, Ph] was synthesized by microwave irradiation and evaluated for in vitro antifungal activity using ketoconazole as the standard Among the tested compounds, benzimidazole derivatives with an N-1 Me, a C2 asym. center and C5 chlorine substitution showed good antifungal activity against the C. albicans strain using the turbidimetric method.

Oriental Journal of Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileMicrowave assisted synthesis, antifungal evaluation and molecular docking of benzimidazole derivatives, Application In Synthesis of 7467-35-8, the publication is Pharma Chemica (2014), 6(6), 396-405/1-396-405/10, 10 pp., database is CAplus.

A novel series of benzimidazole derivatives, carrying biphenyl carbonyl piperazine moiety based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14 α-demethylase (CYP51) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro antifungal activity against Candida albicans revealed activity for many compounds as comparable to that of ketoconazole.

Pharma Chemica published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Yoa Jun published the artcileA practical synthesis of 2-butyl-4(5)-chloro-5(4)-hydroxymethyl-1H-imidazole, COA of Formula: C8H13ClN2O, the publication is Synthetic Communications (1993), 23(18), 2623-30, database is CAplus.

A practical process for the synthesis of 2-butyl-4-hydroxymethylimidazole (I, R = H) followed by silylation-chlorination-desilylation to provide chloroimidazole I (R = Cl) in an overall 71% yield has been developed.

Synthetic Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C5H10O2S, COA of Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia-Alvarez, Ana C. published the artcileSelf-assembled nickel cubanes as oxygen evolution catalysts, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(69), 8608-8611, database is CAplus and MEDLINE.

Ni₄O₄ cubanes [(μ₃-L¹O)NiCl(MeOH)]₄ and [(μ₃-L²O)NiCl(H₂O)]₄ (L¹OH = 1-H-2-benzimidazolylmethanol, L²OH = 1-methyl-2-benzimidazolylmethanol) self-assemble from com. available 1-H- and 1-methyl-2-benzimidazolylmethanol and NiCl₂·6H₂O in high yields under mild conditions. Both complexes were characterised spectroscopically and by X-ray crystallog. The cubanes oxidise water electrocatalytically to dioxygen at neutral pH in aqueous potassium phosphate buffer solutions

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hosadurga, K. Keerthy published the artcileSynthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines, SDS of cas: 79047-41-9, the publication is PLoS One (2014), 9(9), e107118/1-e107118/11, 11 pp., database is CAplus and MEDLINE.

The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles I (R¹ = 3-O₂NC₆H₄, 4-BrC₆H₄, 1H-indol-3-yl, etc.) from alcs., malanonitrile and 2-naphthalenol is reported. Addnl. chromenecarbonitriles from resorcinol and 4-hydroxy-2-chromenones were also reported. These novel 2-amino-chromene-3-carbonitriles showed cytotoxicity in human acute myeloid leukemia (AML) cell lines. Compound I (R¹ = 2,6-Cl₂C₆H₃) was found to be the most bioactive, decreasing growth and increasing apoptosis of AML cells and moreover, it (at a concentration of 5 μM) increased the G2/M and sub-G1 (apoptosis) phases of AML cells and when the AML cells were treated with this compound it exhibited decreased levels of Bcl-2 and increased levels of caspase-9. In silico mol. interaction anal. showed that this compound shared a similar global binding motif with navitoclax (another small mol. that binds Bcl-2), however it occupies a smaller volume within the P2 hot spot of Bcl-2. The intermol. π-stacking interaction, direct electrostatic interactions, and docking energy predicted for I (R¹ = 2,6-Cl₂C₆H₃) in complex with Bcl-2 suggest a strong affinity of the complex, rendering it as a promising Bcl-2 inhibitor for evaluation as a new anticancer agent.

PLoS One published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, SDS of cas: 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem