Tag: M.W=150-200

Petrenko, Viktor I. published the artcileStructural organization of ionic liquids embedded in fluorinated polymers, COA of Formula: C8H15ClN2, the publication is Journal of Molecular Liquids (2022), 119385, database is CAplus.

Hybrid materials based on ionic liquids (ILs) and polymers are increasingly being used for the development of smart and multifunctional materials, allowing to tune polymer properties or introduce new ones. Nonetheless, the structural organization of ILs within the polymer matrix is not properly understood. This work reports on the structural organization of different ILs incorporated into polyvinylidene fluoride (PVDF) films. The effect of IL type ([Pmim][TFSI], [Pmpip][TFSI], [Bmim]₂[NiCl₄] and [Bmim][FeCl₄]) incorporated into the PVDF matrix on the structural organization was evaluated and correlated to the observed variations in the morphol. and phys.-chem. properties. [Bmim][FeCl₄] and [Bmim]₂[NiCl₄] leads to highly porous structures and the incorporation of ILs into the polymer matrix increases the electroactive β phase content of PVDF. Different structural organization of the hybrid materials at nanoscale has been found by small-angle neutron scattering experiments Whereas just single polydisperse objects with average size of about 5 nm have been found in PVDF/[Pmim][TFSI] and PVDF/[Pmpip][TFSI] samples, more complex fractal-like organization of pores are present in PVDF/[Bmim][FeCl₄] and PVDF/[Bmim]₂[NiCl₄]. Thus, IL type influences both the morphol. and the electroactive phase of the polymer. Complex fractal-like organization observed for [Bmim][FeCl₄] and [Bmim]₂[NiCl₄] into the PVDF matrix allows a porous morphol., while single polydispersed [Pmpip][TFSI] or [Pmpip][TFSI] into PVDF favors strong ion-dipole interactions between the IL and the polymer matrix, resulting in higher electroactive β phase contents.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, COA of Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kido, H. published the artcileCoördination compounds. XVIII. Formation constants of some metal salts of hydroxyquinones, Application In Synthesis of 7467-35-8, the publication is Analytica Chimica Acta (1960), 116-23, database is CAplus.

cf. CA 53, 17875c. Dissociation constants of numerous hydroquinones determined in 75 volume % dioxane-H₂O solutions at 30° (CA 51, 7112f), formation constants of the UO₂⁺⁺, Cu⁺⁺, Be⁺⁺, Ni⁺⁺, Co⁺⁺, Zn⁺⁺, Cd⁺⁺, and Mn⁺⁺ complexes of four hydronaphthoquinones, two hydroanthraquinones, and three hydroxy-γ-pyrones measured in 75 volume % dioxane, and significant peaks in the infrared spectra of the hydroxyquinones, hydroxy-γ-pyrones, and various hydroxyanthraquinones are tabulated. The dissociation constants, pK₁, of 2-n-hydroxy-1,4-naphthoquinone and 5-hydroxy-1,4-naph thoquinone are 8.05 ± 0.03, and 13.29 ± 0.03, resp. The difference probably is due to the difference in the strength of H bonding in a 6-vs. a 5-membered ring. The formation constants of the metal complexes allow 2 generalizations: for a common metal ion the weaker the acid, the more stable the complex; for a given chelating group the order of stability of metal ion complexes is UO₂ > Cu > Zn > Be > Ni > Co > Mn, Cd.

Analytica Chimica Acta published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Srinivas, K. published the artcileZinc-mediated tandem-one-pot facile synthesis of 1-(arylsulfonyl) aryl/hetaryl methanes: A case of C-S bond formation, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Synthetic Communications (2011), 41(11), 1584-1592, database is CAplus.

Reaction of (arylmethyl)/(hetarylmethyl)zinc chloride, generated in situ from arylmethyl- and hetarylmethyl chloride., resp., and Zn, with arylsulfonyl chlorides in THF under mild conditions (i.e., at room temperature) furnished the corresponding 1-(arylsulfonyl)aryl/hetarylmethanes in good yields.

Synthetic Communications published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H10N2O2, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Srinivas, K. published the artcilePEG-600: a facile, eco-friendly, reaction medium for synthesis of 1-(arylsulfonyl) aryl/heteroarylmethanes, Synthetic Route of 4760-35-4, the publication is Chemica Sinica (2013), 4(3), 36-40, 5 pp., database is CAplus.

Reaction of arylmethyl/heteroaryl Me chlorides 1 with aryl sulfinate sodium salts 2 yields the corresponding sulfone derivatives promoted by polyethylene glycol-600 at room temperature

Chemica Sinica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H9NO5S, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Carini, David J. published the artcilePart VI. Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives, Application of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, the publication is Journal of Medicinal Chemistry (1990), 33(5), 1330-6, database is CAplus and MEDLINE.

A series of title compounds (I, R¹ = Bu, SEt, SPr; R² = H, Cl, CH₂OH, CH₂OAc; R³ = CH₂OH, Cl, CH₂OAc, CH₂NHCO₂Me; R⁴ = CO₂H, NHSO₂CF₃; X = NHCO, CO, O, S, OCH₂ etc.; n = 0-1) was synthesized and demonstrated to be antagonists of the angiotensin II (AII) receptor. I are structurally related to the N-(benzamidobenzyl)imidazoles and extend the scope of this new class of nonpeptide AII antagonists. The amide linkage (X = NHCO) in the N-(benzamidobenzyl)imidazoles can be replaced successfully by a variety of groups (X = O, S, CO, OCH₂, CH:CH, NHCONH; n = 0-1); linkers of 0-1 atoms in length are most effective. When administered i.v. to awake renal hypertensive rats, these compounds exhibited potent antihypertensive activity.

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Application of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Carini, David J. published the artcileNonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives, Formula: C8H13ClN2O, the publication is Journal of Medicinal Chemistry (1991), 34(8), 2525-47, database is CAplus and MEDLINE.

Nonpeptide angiotensin II receptor antagonists I (R = CH₂OH, CH₂OMe, CHO; R¹ = tetrazolyl, (un)substituted triazolyl, CO₂H, CONHR², R² = OH, OMe, OCH₂Ph, SO₂Ph, NHSO₂CF₃, COCF₃, SO₂CF₃) were prepared and produced a potent antihypertensive effect upon oral administration. The acidic group at the 2′-position of the biphenyl is essential. Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency. The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring was the most effective.

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Algul, Oztekin published the artcileSynthesis and evaluation of antimicrobial activity of some 1,5(6)-H/or -methyl-2-substituted benzimidazole derivatives, COA of Formula: C9H10N2O, the publication is Asian Journal of Chemistry (2007), 19(4), 3085-3092, database is CAplus.

Benzimidazoles I (R = CH₂OH, CH₂NH₂, Me, Et, CH₂SH; R¹, R² = H, Me) were prepared by cyclocondensation of 1,2-benzenediamines with RCO₂H, followed, in some cases, by methylation with MeI. These compounds were tested in vitro against three Gram pos. (Enterococcus faecalis, Staphyloccus aureus and Staphyloccus epidermidis) and two Gram neg. bacteria (Escherichia coli, Pseudomonas aeruginosa). In addition, they were screened in vitro for their antifungal activities. All these compounds inhibited the growth of Gram pos. and Gram neg. bacteria at MIC values between 12.5 and 200 μg/mL and had MIC values between 50 and 200 μg/mL for the following fungi (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis and Candida parapsilosis).

Asian Journal of Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, COA of Formula: C9H10N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

White, Gemma V. published the artcileKallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome, Product Details of C9H10N2O, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(6), 821-825, database is CAplus and MEDLINE.

Netherton syndrome (NS) is a rare and debilitating severe autosomal recessive genetic skin disease with high mortality rates particularly in neonates. NS is caused by loss-of-function SPINK5 mutations leading to unregulated kallikrein 5 (KLK5) and kallikrein 7 (KLK7) activity. Furthermore, KLK5 inhibition has been proposed as a potential therapeutic treatment for NS. Identification of potent and selective KLK5 inhibitors would enable further exploration of the disease biol. and could ultimately lead to a treatment for NS. This publication describes how fragmentation of known trypsin-like serine protease (TLSP) inhibitors resulted in the identification of a series of phenolic amidine-based KLK5 inhibitors 1. X-ray crystallog. was used to find alternatives to the phenol interaction leading to identification of carbonyl analogs such as lactam 13 and benzimidazole 15. These reversible inhibitors, with selectivity over KLK1 (10-100 fold), provided novel starting points for the guided growth towards suitable tool mols. for the exploration of KLK5 biol.

Bioorganic & Medicinal Chemistry Letters published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C7H11N3O2, Product Details of C9H10N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mowat, Jeffrey published the artcileIdentification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is ACS Medicinal Chemistry Letters (2022), 13(3), 348-357, database is CAplus and MEDLINE.

Mitochondria are key regulators of energy supply and cell death. Generation of ATP within mitochondria occurs through oxidative phosphorylation (OXPHOS), a process which utilizes the four complexes (complex I-IV) of the electron transport chain and ATP synthase. Certain oncogenic mutations (e.g., LKB1 or mIDH) can further enhance the reliance of cancer cells on OXPHOS for their energetic requirements, rendering cells sensitive to complex I inhibition and highlighting the potential value of complex I as a therapeutic target. Herein, we describe the discovery of a potent, selective, and species cross-reactive complex I inhibitor. A high-throughput screen of the Bayer compound library followed by hit triaging and initial hit-to-lead activities led to a lead structure which was further optimized in a comprehensive lead optimization campaign. Focusing on balancing potency and metabolic stability, this program resulted in the identification of BAY-179, an excellent in vivo suitable tool with which to probe the biol. relevance of complex I inhibition in cancer indications.

ACS Medicinal Chemistry Letters published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Abdellatif, Khaled R. A. published the artcileSynthesis and antimicrobial activity of novel 2-substituted-1H-benzimidazole derivatives, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Organic Chemistry: An Indian Journal (2013), 9(3), 115-120, database is CAplus.

The reaction of chloromethyl-1-methyl-1H-benzimidazole with ethyl-4-aminobenzoate yielded the ester 2 which upon hydrazinolysis resulted in [(1-methyl-1H-benzimidazol-2-ylmethyl)amino]benzohydrazide. Condensation of [(1-methyl-1H-benzimidazol-2-ylmethyl)amino]benzohydrazide with 2-nitrobenzaldehyde afforded the arylidene derivative which was cyclized to thiazolidinone derivative Substituted benzamide and oxadiazole derivative were prepared via reacting [(1-methyl-1H-benzimidazol-2-ylmethyl)amino]benzohydrazide with phthalic anhydride and benzoic acid, resp. Reaction of [(1-methyl-1H-benzimidazol-2-ylmethyl)amino]benzohydrazide with 4-chlorophenyl isocyanate and Et isothiocyanate gave the corresponding semicarbazide and thiosemicarbazide. The thiosemicarbazide was cyclized to triazole and thiadiazole derivatives Also, reacting thiosemicarbazide with both chloroacetic acid and maleic anhydride afforded thiazolidinone derivatives The prepared compounds were evaluated for in vitro antimicrobial activity using ciprofloxacin and triflucan as standard references

Organic Chemistry: An Indian Journal published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem