Tag: M.W=150-200

Liu, Hui published the artcileLow-temperature Hg⁰ abatement by ionic liquid based on weak interaction, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Hazardous Materials (2022), 127836, database is CAplus and MEDLINE.

Low-temperature gaseous elemental mercury (Hg0) abatement is an objective demand in industrial flue gas treatment. In this work, we proposed a new approach for Hg⁰ capture via weak interaction of ionic liquids Ionic liquids with varied anions (1-butyl-3-methylimidazolium thioacetate ([Bmim][ThAc]), 1-butyl-3-methylimidazolium diethyldithiocarbamate ([Bmim][DTCR]), and 1-butyl-3-methylimidazolium ethylxanthate ([Bmim][EX])) were designed and synthesized. The interaction energies between ionic liquids and elemental mercury were proved to be pos. related to mercury removal efficiency, revealing that the electrostatic interaction derived phys. adsorption from anions is the dominant factor affecting mercury removal performance. [Bmim][ThAc] with the largest anionic electrostatic interaction energy showed the best mercury abatement performance, achieving a Hg0 removal efficiency of over 98% and an adsorption capacity of 10.66 mg/g at 50 °C. The influence of temperature and the results of mercury temperature-programmed desorption (Hg-TPD), XPS further confirmed that the ionic liquid combines with elemental mercury through phys. adsorption. The work provides a new perspective on designing high-efficiency sorbents for mercury removal at low temperature

Journal of Hazardous Materials published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Hao published the artcileAnti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation, Related Products of imidazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry (2019), 27(14), 3089-3096, database is CAplus and MEDLINE.

Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable mol. ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The mol. is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.

Bioorganic & Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Deng, Qian-Jun published the artcileTwo tetranuclear butterfly-shaped Co(II) complexes: structure, mass spectrometric, and magnetism, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Crystals (2019), 9(9), 477, database is CAplus.

The organic ligand (1-methyl-1H-benzo[d]imidazol-2-yl)methanol (HL) was used to react with CoX₂·6H₂O (X = Cl and Br) under solvothermal conditions to obtain the complex [Co₄(L)₆(X)₂] (1, X = Cl; 2, X = Br). The butterfly-shaped structure of complex 1 and 2 suggest that Co(II) ions have two different coordinated modes, which are five coordination with O₃NX environment and six coordination with O₄N₂ environment. In addition, the electrospray ionization mass spectrometry (ESI-MS) anal. indicated that the ion mol. fragment of highest intensity was [Co₄(L)₆]²⁺, and there existed a high nuclear fragment peak of [Co₇(L)₁₂] ²⁺. Interestingly, it was basically completely transformed into [Co₇(L)₁₂]²⁺ two days later, so those two complexes were relatively stable in CH₃OH. Magnetic characterization exhibited that complex 1 and 2 display field-induced single-mol. magnetic behavior, of which the energy hills Ueff/kB were 28 and 20 K under direct-current field of 0.1 T, resp.

Crystals published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Xing-Xing published the artcileMonitoring fragmentation and oligomerization of a di-μ-methoxo bridged copper(II) complex: structure, mass spectrometry, magnetism and DFT studies, Application In Synthesis of 7467-35-8, the publication is Dalton Transactions (2019), 48(34), 13094-13100, database is CAplus and MEDLINE.

Analyses of the structural information of mol. fragments from the mass spectra of the solid-state products and their reaction solutions allow for the understanding of their formation and of their diverse properties. The reaction of CuCl₂ and (1-methyl-1H-benzo[d]imidazole-2-yl)methanol (HL) led only to crystals containing mol. dimers of [Cu₂(L)₂Cl₂] (Cu2). The Cu^II-Cu^II distance and Cu-OR-Cu angle in the structure are 3.044 Å and 104.8°, resp. The magnetic susceptibility (3-400 K) was characterized by a very strong intradimer antiferromagnetic interaction of J = -465 and interdimer zj = -0.83 cm^-1. But mass spectrometry of a dissolved single crystal in different source energies identifies both its fragmentation and oligomerization to [Cu^II₃] and [Cu^II₄]. DFT calculations give the relative stabilization energies of the fragments observed in ESI-MS to provide a formation process.

Dalton Transactions published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C8H6F3NO, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Shu-kai published the artcileSynthesis of Carbophosphinocarbene and Their Donating Ability: Expansion of the Carbone Class, Computed Properties of 4760-35-4, the publication is Organometallics (2020), 39(23), 4395-4401, database is CAplus.

In recent years, carbones (CL₂) established themselves to be reliable ligands in organometallic and catalytic reactions. With its superb donating ability as well as a 2nd lone pair for extra coordination, it distinguishes itself from the widely used carbenes and phosphines. However, a lack of modular structural diversity in carbones has limited its use. A carbophosphinocarbene (CPC), a subclass of carbones containing a carbene and phosphine as flanking groups, offers an easy structural modification. The authors report a new modular synthetic procedure for CPCs by using readily available starting materials. The phosphine moiety can be easily exchanged and directly used out of the bottle. The resulting CPCs offer a strong donating ability. Their electronic properties were determined using Ga and Au complexes.

Organometallics published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Tong published the artcileDeep Oxidative Desulfurization of Model Fuels Catalyzed by Subnanosized Ti Oxoclusters, Application In Synthesis of 79917-90-1, the publication is Energy & Fuels (2022), 36(3), 1402-1416, database is CAplus.

Oxidative desulfurization is a highly effective approach to decrease the sulfur content in transportation fuel and has become an attractive research topic in recent years. Herewith, we have developed a new kind of carboxylic acid-functionalized imidazolium-based ionic liquid-stabilized Ti oxoclusters via a solvothermal method. The as-synthesized Ti oxoclusters were investigated by elemental anal., Fourier transform IR spectroscopy, diffuse reflectance UV-vis, X-ray diffraction, thermogravimetric anal., high-resolution transmission electron microscopy (HRTEM), and high-angle annular dark field-scanning TEM. Characterization indicated that Ti oxoclusters existed in the form of subnanosized structure and uniformly dispersed with an average particle size of ca. 1 nm due to the protection role of the ionic liquids (ILs). Especially, Ti oxo-HSO₄ afforded a superior catalytic activity in the extraction and catalytic oxidative desulfurization process with MeOH as an extractant and H₂O₂ as an oxidant. The full removal of dibenzothiophene in model fuels was achieved within 30 min at 60 °C. Besides, the Ti oxoclusters were robust and exhibited high stability in consecutive catalytic recycles. The parent Ti oxoclusters treated with H₂O₂ can afford Ti-OOH species, which was catalytically active species. The anion HSO₄^– in IL played a crucial role in the activation of Ti-hydroperoxo species by forming hydrogen bonds. This may provide a new insight into the construction of metal oxoclusters for oxidative desulfurization.

Energy & Fuels published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C10H10N2, Application In Synthesis of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pierce, Michael E. published the artcilePractical synthesis and regioselective alkylation of methyl 4(5)-(pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate to give DuP 532, a potent angiotensin II antagonist, Application of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, the publication is Journal of Organic Chemistry (1993), 58(17), 4642-5, database is CAplus.

(Hydroxymethyl)[(tetrazolylbiphenyl)methyl]imidazole, DuP 532 (I), which is a potent angiotensin II receptor antagonist, has been prepared by two different routes. One route, which is more practical for large-scale synthesis, required the preparation of Me 4(5)-(pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate (II, R = C₂F₅). This imidazole was synthesized in five steps from com. available 2-propyl-4(5)-(hydroxymethyl)imidazole in 32% overall yield. Alternate perfluoroalkylation methods of the iodoimidazole precursor II (R = iodo) are presented. II (R = C₂F₅) (III) is remarkably stable to basic conditions and is alkylated by 2-[N-(triphenylmethyl)tetrazol-5-yl]-4′-(bromomethyl)-1′,1′-biphenyl (IV), giving only the desired regioisomer. A comparison of the alkylation of the trisubstituted precursors and analogs to III with IV indicate that even under mildly basic conditions (K₂CO₃/DMF), the mechanism is S_E2cB (anionic), except for 2-propyl-4(5)-(hydroxymethyl)imidazole which alkylates as a neutral species (S_E2′).

Journal of Organic Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Application of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Casella, Luigi published the artcileHemocyanin and tyrosinase models. Synthesis, azide binding, and electrochemistry of dinuclear copper(II) complexes with poly(benzimidazole) ligands modeling the met forms of the proteins, Quality Control of 4760-35-4, the publication is Inorganic Chemistry (1993), 32(10), 2056-67, database is CAplus.

The new poly(benzimidazole) ligands α,α’-bis[[bis(1-methyl-2-benzimidazolyl)methyl]amino]-m-xylene (L-5,5) and α,α’-bis[bis[2-(1-methyl-2-benzimidazolyl)ethyl]amino]-m-xylene (L-6,6) and their dicopper(I) and bis(aqua)-dicopper(II) complexes are reported. The ligands provide 1 tertiary amino and 2 benzimidazole N donors to each metal center; each of the 2 arms of L-5,5 binds the metal with 2 adjacent 5-membered chelate rings, while with L-6,6 these chelate rings are 6-membered. The dicopper(I) complexes react with dioxygen to produce the bis(hydroxo)dicopper(II) complexes. The bis(aqua)- and bis(hydroxo)dicopper(II) complexes can be interconverted in a single step by addition of base and acid, resp. The electrochem. behavior of the bis(aqua)dicopper(II) complex of L-6,6 shows reversible reduction to the corresponding dicopper(I) complex whereas the analogous complex of L-5,5 is irreversibly reduced. The bis(hydroxo)dicopper(II) complexes of both ligands also undergo irreversible reduction Azide adducts of the dicopper(II) complexes were isolated; the anion bridges the 2 coppers in μ-1,1 fashion in the L-5,5 derivative and in μ-1,3 fashion in the L-6,6 derivative The spectral properties of the 2 complexes are significantly different. Binding studies performed in solution for the bis(aqua)- and bis(hydroxo)dicopper(II) complexes show that up to 4 azide mol. can bind to the complexes and the affinity of azide decreases with the charge of the complex. Electrochem. shows that, upon increasing the number of bound azide groups, the successive reductions of the 2 Cu(II) centers tend to coalesce, thus indicating progressive lowering of the electronic communication between the metal centers. The relevance of the spectroscopic and binding data of these azide complexes to hemocyanin and tyrosinase is discussed.

Inorganic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Quality Control of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Suwalsky, Mario published the artcileIn vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes, SDS of cas: 4760-35-4, the publication is Journal of Inorganic Biochemistry (2018), 87-93, database is CAplus and MEDLINE.

Two cytotoxic copper(II) complexes with N-H and N-methylated benzimidazole-derived ligands (Cu-L¹ and Cu-L^1Me; L¹ = bis(2-methylbenzimidazolyl)(2-methylthioethyl)amine, L^1Me = bis(1-methyl-2-methylbenzimidazolyl)(2-methylthioethyl)amine) were synthesized and exposed to human erythrocytes and mol. models of its membrane. The latter were bilayers built-up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), classes of lipids present in the external and internal moieties of the human red cell membrane, resp. SEM of erythrocytes incubated with solutions of both Cu(II) complexes showed that they induced morphol. changes to the normal cells to echinocytes, and hemolysis at higher concentrations Real-time observation of the dose-dependent effects of the complexes on live erythrocytes by defocusing microscopy (DM) confirmed SEM results. The formation of echinocytes implied that complex mols. inserted into the outer moiety of the red cell membrane. X-ray diffraction studies on DMPC and DMPE showed that none of these complexes interacted with DMPE and only Cu-L¹ interacted with DMPC. This difference was explained by the fact that Cu-L^1Me complex is more voluminous than Cu-L¹ because it has two addnl. Me groups; on the other hand, DMPC mol. has three Me groups in its bulky terminal amino end. Thus, by steric hindrance Cu-L^1Me mols. cannot intercalate into DMPC bilayer, which besides is present in the gel phase. These results, together with the increased antiproliferative capacity of the N-methylated complex Cu-L^1Me over that of Cu-L¹ are rationalized mainly based on its higher lipophilicity.

Journal of Inorganic Biochemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H13ClNNaO5S, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Andrade, U. M. S. published the artcileImidazolium-based ionic liquids binding to DNA: Mechanical effects and thermodynamics of the interactions, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is International Journal of Biological Macromolecules (2022), 500-511, database is CAplus and MEDLINE.

We performed a robust characterization of the mol. interactions between the DNA mol. and two imidazolium-based ionic liquids (ILs): 1-Butyl-3-methylimidazolium chloride ([bmim]Cl) and 1-Octyl-3-methylimidazolium chloride ([omim]Cl), using single mol. approaches (optical and magnetic tweezers) and bulk techniques (isothermal titration calorimetry and conductivity measurements). Optical and magnetic tweezers allowed us to obtain the changes on the mech. properties of the DNA complexes formed with both ILs, as well as the relevant physicochem. (binding) parameters of the interaction. Despite the weak binding measured between DNA and the two ILs, we identify a transition on the regime of polymer elasticity of the complexes formed, which results in a relevant DNA compaction for high IL concentrations In addition, isothermal titration calorimetry and conductivity complemented the single mol. investigation, giving a complete thermodn. characterization of the interactions and allowing the identification of the most relevant driving forces at various different concentration ranges of the ILs. Based on the results obtained with all the employed techniques, we propose a model for the binding schemes involving DNA and both [bmim]Cl and [omim]Cl.

International Journal of Biological Macromolecules published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem