Tag: M.W=150-200

Butt, Fayaz Ahmad published the artcileImidazolium Based Surface Active Ionic Liquids: Promising Boosters to Enhance the Radical Scavenging and Antioxidant Activity of Conventional Surfactant Solubilised Quercetin, Computed Properties of 79917-90-1, the publication is Catalysis Letters (2022), 152(5), 1276-1285, database is CAplus.

Surface Active Ionic Liquids (SAILs) are emerging as promising alternatives to conventional amphiphiles. Their unique specialties endow the SAIL/SAIL plus conventional surfactant based micellar/mixed micellar systems with unique solubilization, catalytic and electrocatalytic properties. Herein we demonstrate that as a partner of conventional surfactant based mixed micellar systems, imidazolium based SAILs significantly boost the radical scavenging activity (RSA) and antioxidant activity of water insoluble flavonoids. Specifically, we report the RSA and antioxidant activity kinetics of quercetin toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) in aqueous micellar media of SAIL, 1-Butyl-3-methyl-imidazolium dodecylsulfate (BMIMDS), its conventional anionic surfactant analog-sodium dodecylsulfate (SDS), conventional nonionic surfactant-Brij56 and the variedly composed BMIMDS plus Brij56 mixed micellar solutions The presented results clearly suggest that in comparison to the conventional micellar systems, the radical scavenging ability and activity of quercetin for DPPH is appreciably better in appropriately composed SAIL plus conventional surfactant mixed micellar systems. These results further suggest that the RSA of quercetin toward DPPH is a function of its aqueous phase to micellar phase partitioning, locus of solubilization and more importantly its orientation vis-a-vis the later within the micelles. The 1:1 Brij56 plus BMIMDS mixed micellar system seems to offer the best environs for the optimal RSA and kinetics for antioxidant activity of quercetin toward DPPH. The kinetic details and the mechanistic insights presented herein shall stimulate an intense research activity toward use of SAIL and SAIL based micellar systems as promising delivery systems for water insoluble flavonoids for their potential applications as pharmaceuticals and food ingredients.

Catalysis Letters published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Thomas, Andrew P. published the artcileNew nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties and structure-activity relationships of 2-alkylbenzimidazole derivatives, Synthetic Route of 79047-41-9, the publication is Journal of Medicinal Chemistry (1992), 35(5), 877-85, database is CAplus and MEDLINE.

Based on 2-[4-{2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-ylmethyl}phenyl]benzoic acid, a known angiotensin II receptor antagonist, a series of 1H-benzimidazol-1-yl analogs and 4-[(2-alkyl-1H-benzimidazol-1-yl)methyl]benzoic acids (I, R¹ = alkyl; R² = H, Cl, F, OMe, NO₂; R³ = H, Br, Cl, F, Me, OMe) were prepared The antihypertensive structure-activity relationship of these benzimidazolyl derivatives and some rigid analogs, such as 2-(3-butyl-1-chloro-5H,11H-imidazo[5,1-c][1,4]benzoxazepin-8-yl)benzoic acid (II), was determined

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C3H9ClOS, Synthetic Route of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sloboda-Rozner, Dorit published the artcileA Water-Soluble and “Self-Assembled” Polyoxometalate as a Recyclable Catalyst for Oxidation of Alcohols in Water with Hydrogen Peroxide, COA of Formula: C8H13ClN2O, the publication is Journal of the American Chemical Society (2003), 125(18), 5280-5281, database is CAplus and MEDLINE.

A water-soluble polyoxometalate, Na₁₂[WZnZn₂(H₂O)₂(ZnW₉O₃₄)₂], synthesized from readily available zinc nitrate and sodium tungstate in the presence of nitric acid, is an effective catalyst for the preparation of ketones and carboxylic acids by selective alc. oxidation with hydrogen peroxide in biphasic (water-alc.) reaction media. Carboxylic acids are obtained by oxidation of primary alcs. with hydrogen peroxide in the presence of Na₁₂[WZnZn₂(H₂O)₂(ZnW₉O₃₄)₂]; addition of catalytic amounts of TEMPO to oxidation mixtures yields increased proportions of the aldehyde in addition to the carboxylic acid. Secondary alcs. are oxidized in preference to primary alcs. to give ketones; carbon-carbon bond cleavage byproducts are seen in one case. The catalyst generated in situ is as active as the isolated catalyst; in addition, the catalyst can be separated and recycled without losses in either selectivity or in activity.

Journal of the American Chemical Society published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C12H25Br, COA of Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sasaki, Tadashi published the artcileHeteroaromaticity. VII. Application of the Horner reaction to benzimidazoles, Application In Synthesis of 4760-35-4, the publication is Yuki Gosei Kagaku Kyokaishi (1968), 26(1), 70-4, database is CAplus.

2-(α-Hydroxyethyl)benzimidazole (2 g.) in 50 ml. tetrahydrofuran is stirred for 2 days with 15 g. activated MnO2 to give 1.4 g. I (R = Ac) (Ia), m. 194°. I (0.01 mole) in 50 ml. tetrahydrofuran is stirred for 30 min. with 0.015 mole AcCl to give the following II (R, m.p., and % yield given): H, 112-13°, 90; Me, 115-16°, 100; CH2Cl, 108-9°, 83; Ac, 120-1°, 42. Also prepared are 2-chloromethylbenzimidazole ethiodide (m. 185-92°), N-methyl-2-chloromethylbenzimidazole (m. 92-4°), and N-methyl-2-hydroxymethylbenzimidazole (m. 146-7°); Horner reaction was then carried out. Thus, 2 g. diethyl benzylphosphonate in 20 cc. tetrahydrofuran is refluxed for 2 hrs. with 0.7 g. 50% NaH and 3 g. II (R = Ac) to give 11% III (R1 = Ac, R2 = Me), m. 124-6°. Similarly prepared are the following compounds: trans-III (R1 = Et, R2 = H) (m. 207-8°); trans-p-dimethylaminostilbene; trans-stilbene.

Yuki Gosei Kagaku Kyokaishi published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application In Synthesis of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sasaki, Tadashi published the artcileHeteroaromaticity. VII. Application of the Horner reaction to benzimidazoles, HPLC of Formula: 7467-35-8, the publication is Yuki Gosei Kagaku Kyokaishi (1968), 26(1), 70-4, database is CAplus.

2-(α-Hydroxyethyl)benzimidazole (2 g.) in 50 ml. tetrahydrofuran is stirred for 2 days with 15 g. activated MnO2 to give 1.4 g. I (R = Ac) (Ia), m. 194°. I (0.01 mole) in 50 ml. tetrahydrofuran is stirred for 30 min. with 0.015 mole AcCl to give the following II (R, m.p., and % yield given): H, 112-13°, 90; Me, 115-16°, 100; CH2Cl, 108-9°, 83; Ac, 120-1°, 42. Also prepared are 2-chloromethylbenzimidazole ethiodide (m. 185-92°), N-methyl-2-chloromethylbenzimidazole (m. 92-4°), and N-methyl-2-hydroxymethylbenzimidazole (m. 146-7°); Horner reaction was then carried out. Thus, 2 g. diethyl benzylphosphonate in 20 cc. tetrahydrofuran is refluxed for 2 hrs. with 0.7 g. 50% NaH and 3 g. II (R = Ac) to give 11% III (R1 = Ac, R2 = Me), m. 124-6°. Similarly prepared are the following compounds: trans-III (R1 = Et, R2 = H) (m. 207-8°); trans-p-dimethylaminostilbene; trans-stilbene.

Yuki Gosei Kagaku Kyokaishi published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Rein, Jonas published the artcileUnlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor, Recommanded Product: 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile, the publication is ACS Central Science (2021), 7(8), 1347-1355, database is CAplus and MEDLINE.

Organic electrochem. has emerged as an enabling and sustainable technol. in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochem. in the synthetic community, and especially in industrial settings, has been hindered by the lack of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HTe^–Chem, a high-throughput microscale electrochem. reactor that is compatible with existing HTE infrastructure and enables the rapid evaluation of a broad array of electrochem. reaction parameters. Utilizing the HTe^–Chem to accelerate reaction optimization, reaction discovery, and chem. library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochem. conditions.

ACS Central Science published new progress about 1016841-67-0. 1016841-67-0 belongs to imidazoles-derivatives, auxiliary class Imidazoles, name is 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile, and the molecular formula is C10H8N4, Recommanded Product: 2-(2-Methyl-1H-imidazol-1-yl)pyridine-4-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pesson, Marcel published the artcileAntibacterials. 8-Alkyl-5,8-dihydro-5-oxo-6-pyrido[2,3-d]pyrimidinecarboxylic acids derivatives. III. 2-(4-Arylpiperazinyl)-, 2-(4-aralkylpiperazinyl)-, and 2-(2-imidazolinyl)- derivatives, SDS of cas: 4760-35-4, the publication is European Journal of Medicinal Chemistry (1975), 10(6), 567-72, database is CAplus.

Piperazinylpyridopyrimidinecarboxylic acids I (R = Ph, n = O; R = Ph, 4-ClC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 3,4-methylenedioxyphenyl, 2-furyl, 2-benzimidazolyl, 1-methyl-2-benzimidazolyl, n = 1; R = Ph, PhO, n = 2) were prepared by hydrolyzing the Et esters, obtained by treating the chloropyridopyrimidinecarboxylates with substituted piperazines. II (R1 = Me, Pr, Ph) were obtained by treating the methylsulfonylpyridopyrimidinecarboxylate with 2-imidazolines and hydrolyzing. I (R = Ph, n = 1) had the widest spectrum of bactericidal activity.

European Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ooki, Atsuhi published the artcileEstimation of a eutectic composition of imidazolium chloride ionic liquids using video imaging and impedance methods, Formula: C8H15ClN2, the publication is Fluid Phase Equilibria (2022), 113442, database is CAplus.

The eutectic temperature Te and composition Xe of binary systems composed of three ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C₂mim]Cl), 1-methyl-3-propylimidazolium chloride ([C₃mim]Cl), and 1-butyl-3-methylimidazolium chloride ([C₄mim]Cl), were estimated using a video imaging method, in which the formation of a liquid phase on solidified ionic liquids at a given composition stored in a vial was detected from time-lapse images taken during temperature scanning. The advantage of this method is that multiple samples (five samples in this study) could be measured simultaneously, whereas its disadvantage is a less accurate determination of the m.p. compared with the conventional differential scanning calorimetry (DSC) method. The Te and Xe of [C₂mim]Cl-[C₃mim]Cl, [C₂mim]Cl-[C₄mim]Cl, and [C₃mim]Cl-[C4mim]Cl binary systems were roughly estimated Furthermore, the Te of the ternary system of the [C2mim]Cl-[C3mim]Cl-[C4mim]Cl with limited compositions was estimated, which was lower than that of the binary systems. The transition of the electrochem. impedance of [C2mim]Cl ionic liquids was also measured using two Pt wire electrodes as a function of temperature The differential inversed resistance curve (dR-1/dT)-T shows an obvious peak corresponding to the phase transition from a low conductive solid phase to a highly conductive liquid phase. This peak was comparable with the peak obtained in the DSC measurement.

Fluid Phase Equilibria published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Haynes, Keith M. published the artcileIdentification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (2017), 60(14), 6205-6219, database is CAplus and MEDLINE.

In Gram-neg. bacteria, efflux pumps are able to prevent effective cellular concentrations from being achieved for a number of antibiotics. Small mol. adjuvants that act as efflux pump inhibitors (EPIs) have the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. Through a combination of rigorous exptl. screening and in silico virtual screening the authors recently identified novel classes of EPIs that interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in E. coli. Herein, the authors present initial optimization efforts and structure-activity relationships around one of those previously described hits, NSC 60339. From these efforts the authors identified two compounds, SLUPP-225 (II) and SLUPP-417 (III), which demonstrate favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, improved inhibition of efflux relative to (I) and potentiation of the activity of novobiocin and erythromycin.

Journal of Medicinal Chemistry published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sajith, A. M. published the artcileA Highly Efficient Catalyst for the Suzuki Cross-coupling Reaction of 3-Chloro-5-oxadiazol-2-yl Pyridine, COA of Formula: C7H7BN2O2, the publication is Journal of Heterocyclic Chemistry (2015), 52(6), 1748-1757, database is CAplus.

A facile access to diversely substituted 3-aryl/heteroaryl-5-oxadiazol-2-yl-pyridines using PdCl₂(dtbpf) as palladium precursor has been developed. The method is compatible with a wide range of aryl/heteroaryl boronic acids.

Journal of Heterocyclic Chemistry published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, COA of Formula: C7H7BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem