Tag: M.W=150-200

G-Dayanandan, Narendran; Scocchera, Eric W.; Keshipeddy, Santosh; Jones, Heather F.; Anderson, Amy C.; Wright, Dennis L. published the artcile< Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks>, Electric Literature of 1003-21-0, the main research area is aryl propyne preparation reduction substitution arylalkynyl carbinol.

To develop next generation antifolates for the treatment of trimethoprim-resistant bacteria, synthetic methods were needed to prepare a diverse array of 3-aryl-propynes with various substitutions at the propargyl position. A direct route was sought whereby nucleophilic addition of acetylene to aryl carboxaldehydes would be followed by reduction or substitution of the resulting propargyl alc. The direct reduction, methylation, and dimethylation of these readily available alcs. provide efficient access to this uncommon functional array. In addition, an unusual silane exchange reaction was observed in the reduction of the propargylic alcs.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Electric Literature of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mergehenn, R.; Haase, W.; Allmann, R. published the artcile< Crystal structures of chloro- and γ-bromo-(2-dibutylaminoethanolato)copper(II)>, Related Products of 1003-21-0, the main research area is mol structure copper aminoethanolato halo; chloro copper aminoethanolato structure; bromo copper aminoethanolato structure.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. The crystal structures of halo-(2-dibutylaminoethanolato)copper(II) [(C10H22NOCuX)4, X = Cl (I), Br (II) were determined by single-crystal x-ray diffractometer methods using 4331 and 3915 independent reflections, resp., from 3-dimensional diffractometer data (Mo Ka radiation). The isomorphous compounds belong to space group P1̅ with a 15·563(10), b 16·280(11), c 11·659(8) Å, α 93·49(10), β 100·32(10), γ 112·51(10)° for I and a 15·539(10), b 16·452(11), c 11·766(8) Å, α 94·58(10), β 100·65(10), γ 111·67(10)° for II. The structures were refined by least-squares methods to final residuals of 0.084 and 0.071, resp. The tetrameric clusters of cubane-type mol. structures have mean Cu-Cu separations of 3·240(3) and 3·268(3) Å. The Cu coordination is distorted square pyramidal with Cu bonded to 3 O, 1N, and 1 halogen. The distance to the apical O is longer than to the other 2 O. The average bond lengths are Cu-O 1·9778) and 1·963(10) Å (short Cu-O separations), Cu-O 2·424(8) and 2·480(10) Å (long-Cu-O separations), Cu-N 2·054(11) and 2·066(13) Å, and Cu-hal 2·234(4) and 2·382(3) Å.

Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry published new progress about Crystal structure. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Mo; Zhang, Zhenfeng; Xie, Fang; Zhang, Wanbin published the artcile< Cu-catalyzed amidation of halogenated imidazoles>, Reference of 1003-21-0, the main research area is imidazole halo amide cyclic copper amidation catalyst; amido imidazole preparation; amide cyclic heterocycle halo copper amidation catalyst; heterocycle amido preparation.

An efficient methodol. involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcs.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amidation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Reference of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Huang, Bao Shan; Lauzon, Mary Jane; Parham, James C. published the artcile< Synthesis and properties of alkylated imidazoles>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is alkylation nitroimidazolesulfonamide; benzylation nitroimidazolesulfonamide; NMR pK nitroimidazolesulfonamide; UV nitroimidazolesulfonamide; imidazolesulfonamide nitro spectra; sulfonamide imidazole nitro spectra.

Alkylation of 4(5)-nitroimidazole-5(4)-sulfonamide with PhCH2Br occurred on both ring N. The structures of the products were determined by comparing the chem. shifts of the sulfonamide H with those of the Me derivatives UV and NMR data are reported for Br-, O2N-, HS-, NH2SO3-, and H2N-substituted imidazoles and some of their methylated derivatives

Journal of Heterocyclic Chemistry published new progress about Ionization. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Qu, Bo; Haddad, Nizar; Han, Zhengxu S.; Rodriguez, Sonia; Lorenz, Jon C.; Grinberg, Nelu; Lee, Heewon; Busacca, Carl A.; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. published the artcile< Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene>, Related Products of 1003-21-0, the main research area is heteroaryl halide amine aminocarbonylation phosphinoferrocene palladium catalyst; hetarom amide preparation.

Pd-catalyzed aminocarbonylation of heteroaryl halides, using the monodentate ligand (di-tert-butylphosphino)ferrocene tetrafluoroborate is reported. Good to high yields were obtained with chiral amines on a variety of substrates including 2-bromo heteroaryls.

Tetrahedron Letters published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Perchacz, Magdalena; Matejka, Libor; Konefal, Rafal; Seixas, Leandro; Livi, Sebastien; Baudoux, Jerome; Benes, Hynek; Donato, Ricardo K. published the artcile< Self-Catalyzed Coupling between Bronsted-Acidic Imidazolium Salts and Epoxy-Based Materials: A Theoretical/Experimental Study>, Related Products of 700370-07-6, the main research area is self catalysis Bronsted acidic imidazolium salt epoxide coupling.

Herein we present a comprehensive study on the role of Bronsted-acidic imidazolium ionic liquids (ILs) and imidazolium salts promoting the reaction between carboxyl and epoxide groups in a controlled manner at solvent-free and mild conditions. ILs were evaluated toward their ability to self-catalyze reactions between carboxyl groups and epoxy rings. Thus, an epoxy model reactant denoted Ph glycidyl ether (PGE) was reacted with different ILs, and the reaction kinetics was followed by time-dependent FTIR spectroscopy. The resulting products were characterized by 1H NMR and MALDI-TOF, which also allowed a comprehensive investigation of the reaction mechanism by following the reaction intermediates formation. The detected intermediates were then evaluated by d. functional theory (DFT) simulations to calculate their energy profiles, revealing the preferred mechanism pathways. These mono-, bi-, and tetra-functionalized ILs (with carboxyl groups) acted as all-in-one reaction systems for materials synthesis or modification, with the potential of producing a broad range of epoxy based materials via metal catalyst-free coupling reactions. A solvent-free self-catalyzed platform for reactions with epoxy materials at mild temperatures based on Bronsted-acidic imidazolium salts.

ACS Sustainable Chemistry & Engineering published new progress about Carboxylic acids Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Related Products of 700370-07-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Penn, Kyle R.; Anders, Evan J.; Lindsay, Vincent N. G. published the artcile< Expedient Synthesis of Bis(imidazolium) Dichloride Salts and Bis(NHC) Complexes from Imidazoles Using DMSO as a Key Polar Additive>, Related Products of 1003-21-0, the main research area is alkanediimidazolium salt preparation cyclometalation gold silver palladium chloride; palladium alkanebisimidazolylidene complex; silver alkanebisimidazolylidene complex preparation; gold alkanebisimidazolylidene complex preparation; imidazole condensation reaction alkanedichloride.

A general approach for the synthesis of bis(imidazolium) dichloride salts from imidazoles and dichloroalkanes is reported. Typical limitations of this reaction for the formation of methylene-bridged derivatives are addressed herein through the use of excess CH2Cl2 in the presence of DMSO as a polar cosolvent, significantly improving the conversion rates presumably via stabilization of the initial SN2 transition state. The method also is applicable to the formation of bis(pyridinium) dichloride salts from pyridine derivatives, and to the direct synthesis of metal-bis(NHC) complexes from imidazoles.

Organometallics published new progress about Carbene complexes Role: SPN (Synthetic Preparation), PREP (Preparation) (Pd, Ag and Au alkanebis(imidazolylidene) complexes). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Related Products of 1003-21-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

El Borai, M.; Moustafa, A. H.; Anwar, M.; Abdel Hay, F. I. published the artcile< Synthesis of halogen derivatives of N-methylimidazole>, Category: imidazoles-derivatives, the main research area is halogenation methylimidazole; halomethylimidazole; imidazole halo methyl.

1-Methylimidazole (I) was converted to 2-halo-, 2,5-dihalo-, 5-halo-, 2,4-dihalo-, 4,5-dihalo-, 4-halo-, and 2,4,5-trihalo-1-methylimidazoles. I was treated with BuLi and Br2 to give 2-bromo-1-methylimidazole. The reaction of I with N-bromosuccinimide gave 5-bromo-1-methylimidazole. I reacted with iodine and HIO3 to give 4,5-diiodo-1-methylimidazole.

Polish Journal of Chemistry published new progress about Halogenation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Barlin, Gordon B.; Batterham, Thomas J. published the artcile< The proton magnetic resonance spectra of some diazoles, triazoles, and tetrazoles>, Application of C4H5BrN2, the main research area is NMR AZOLES; TRIAZOLES NMR; DIAZOLES NMR; AZOLES NMR; TETRAZOLES NMR; PROTONATION METHYLIMIDAZOLES; IMIDAZOLES PROTONATION.

The N.M.R. spectra of various charged species from 33 azoles have been measured. In N-methyl-imidazoles and -1,2,4-triazoles the sites of protonation have been determined, and the cations appear to be stabilized by amidinium type resonance. Solvent effects are discussed. 27 references.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about NMR (nuclear magnetic resonance). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Application of C4H5BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cai, Long; Zhang, Ying; Hu, Gang; Guo, Yuanlong; Jin, Longming; Xu, Qinqin; Liu, Zhanpeng; Xie, Haibo published the artcile< A Single Step Fractionation of Lignocellulose in Aqueous Solutions of a Carboxylic Acid-Functionalized Ionic Liquid>, Safety of 1-carboxymethyl-3-methylimidazolium chloride, the main research area is fractionation lignocellulose aqueous solution carboxylic acid functionalized ionic liquid.

This paper presents the features of corn stover pretreated under mild conditions in aqueous solution of a carboxylic acid functionalized ionic liquids 1-carboxymethyl-3-methylimidazolium chloride (IL-COOH). The results revealed that such pretreatment selectively removed hemicelluloses in corn stover, resulting in cellulose- and lignin-rich pulps with moderate enzymic reactivity. The corn stover pretreated in 40 wt% IL-COOH at 120 °C for 4 h demonstrated increases in cellulose and lignin contents from 37.9% to 55.6%, and 21.1% to 26.5%, resp., while decrease in the content of hemicellulose from 24.4% to 9.34%. Subsequent enzymic hydrolysis of the pulps achieved from pretreatment in 50 wt% IL-COOH aqueous solution at 105 °C for 4 h produced 0.32 g.g-1 glucose and 0.45 g.g-1 total reducing sugars. The recyclability and reusability of IL-COOH in the pretreatment system was also investigated.

ChemistrySelect published new progress about Corn straw. 700370-07-6 belongs to class imidazoles-derivatives, and the molecular formula is C6H9ClN2O2, Safety of 1-carboxymethyl-3-methylimidazolium chloride.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem