Tag: M.W=150-200

Lee, Jyun-Ting published the artcileHigh-efficiency cycling piezo-degradation of organic pollutants over three liters using MoS₂ /carbon fiber piezocatalytic filter, Quality Control of 79917-90-1, the publication is Nano Energy (2022), 107280, database is CAplus.

Piezocatalysis has great potential com. application for the high-efficiency degradation of organic pollutants in a dark environment. However, the recycling of catalyst materials and the subsequent generation of secondary pollution remain challenging. In this study, MoS₂ nanoflowers (NFs)/carbon fiber was synthesized to develop a piezocatalytic filter that can recycle decomposed wastewater easily without generating secondary pollutants in treated water. The MoS₂/carbon fiber was constructed in pipelines to form the piezoelec. degradation system, which demonstrated a high efficiency in decomposing organic mols. in wastewater through natural water flow. The piezocatalytic filters in the circulatory system completely degraded a large amount of dye solution (1000 mL) in 40 min and can repeat three-times degradation with the total organic carbon value decreased by 90%. The theor. calculation indicated that MoS₂ grew on carbon fiber, which exhibited a bending moment effect under natural water-flow-induced pressure. This established considerable piezoelec. potential at MoS₂ NFs active edge sites and MoS₂-carbon fiber interfaces, triggering electron-hole pair separation under the internal elec. field. The MoS₂/carbon fiber piezoelec. catalyst is advantageous for its reusability and recyclability, thus preventing secondary pollution and adverse effects on water bodies during practical high-flux wastewater treatment.

Nano Energy published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Quality Control of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hughes, Gordon K. published the artcileThe synthesis of 2-aminomethylbenziminazole and related substances, Name: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Journal and Proceedings of the Royal Society of New South Wales (1938), 209-22, database is CAplus.

It appeared that 2-aminomethylbenziminazole (I) might prove worthy of investigation as a base for study of coordination problems, because the imino H of the benziminazole nucleus can be replaced by metals (cf. Bamberger and Lorenzen, Ann. 273, 271-9(1893)). Stable metallic complex compounds in which a central bivalent metallic element is bound to 2-aminomethylbenziminazole nucleii by 2 electrovalences and 2 coördination covalences should thus be obtainable. Synthesis of I was not easy; glycine could not be made to condense with o-(NH₂)₂C₆H₄ (II) according to the method of M. A. Phillips (cf. C. A. 23, 141). A method of preparation of I was therefore developed from 2-chloromethylbenziminazole (III), m. 160-1°, which was prepared in the following manner: 22 g. II and 20 g. ClCH₂CO₂H in 200 cc. 4 N HCl were refluxed for 40 min., and after filtering and cooling, the solution was neutralized with Na₂CO₃, giving a white solid which was recrystallized from EtOH and AcOEt. A better method for preparing III consisted in treating 2-hydroxymethylbenziminazole (IV) (Phillips, loc. cit.) with SOCl₂; yield, 71%. Various attempts to replace the Cl atom in III with an NH₂ group by means of NH₃ solutions were unsuccessful, the reaction being quite complex and yielding several substances. From III, the following benziminazole derivatives were prepd: from Me anthranilate, 2-o-carbomethoxyanilinomethyl, yellow, m. 216°; from PhNHMe, 2-methylanilinomethyl, yellow, m. 202°; from Ph₂NH, 2-diphenylaminomethyl, colorless, m. 215°; from (CH₂)₅NH, 2-piperidinomethyl, colorless, m. 193-4° (with previous softening at 180°); from morpholine, 2-morpholinomethyl, colorless, m. 211°; with C₅H₅N, III reacted violently giving a white solid which is probably a quaternary salt. IV and Me₂SO₄ gave 1-methyl-2-hydroxymethylbenziminazole, m. 105°, which with SOCl₂ yielded 1-methyl-2-chloromethylbenziminazole, m. 94°; the latter with PhNH₂ and PhNHMe gave 1-methyl-2-anilino-, m. 118°, and 1-methyl-2-methylanilinomethylbenziminazole, m. 145°, resp. Fusion of phenylglycine (3 g.) with II (2 g.) yielded 2-anilinomethylbenziminazole, m. 162°, which could not be prepared from III and PhNH₂. Fusion of phthalimidoacetic acid with II gave a white amorphous product containing no O and whose structure is not known. Fusion of equimol. quantities of hippuric acid and II gave 70% 2-benzoylaminomethylbenziminazole, m. 231°, which (33 g.) was hydrolyzed with concentrated HCl (75 cc.) for 5 h. to the di-HCl salt of I as a monohydrate which loses H₂O at 110°, giving an anhydrous salt, m. 263°. Attempts to isolate anhydrous I gave only brown gums; however, careful neutralization with Na₂CO₃ gave a hydrate, m. 53°; 2-acetylamino derivative, m. 200°. Condensation of HSCH₂CO₂H and II (50 g.) in 500 cc. 4 N HCl with heating for 60 min. gave 50 g. 2-sulfhydrylmethylbenziminazole (V), m. 158°; passage of air through an NH₃ solution of the latter is sufficient to oxidize it to a compound, C₁₆H₁₄O₂N₄S₂, m. 182°, which is probably the disulfoxide of V and which was also obtained by oxidation of V with dilute HNO₃. The following benziminazole derivatives were obtained from II, using Phillips’ method: from phenoxyacetic acid, 2-phenoxymethyl, white, m. 162°; from methoxyacetic acid, 2-methoxymethyl, yellow, m. 136°; from phenylacetic acid, 2-benzyl, colorless, m. 187°; from β-phenylpropionic acid, 2-β-phenylethyl, colorless, m. 186°; from p-nitrophenylacetic acid, 2-p-nitrobenzyl, yellow, m. 215°; from o-nitrophenylacetic acid, 2-o-nitrobenzyl, yellow, m. 217°; from p-aminophenylacetic acid, 2-p-aminobenzyl, yellow, m. 213°.

Journal and Proceedings of the Royal Society of New South Wales published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Name: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ding, Yangyang published the artcileDesign, synthesis, and antitumor activity of novel benzoheterocycle derivatives as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Journal of Chemical Research (2020), 44(5-6), 286-294, database is CAplus.

The vascular endothelial growth factor receptor-2 signaling pathway promotes the formation of new blood vessels, and vascular endothelial growth factor receptor-2 tyrosine kinase exists in both active and inactive conformations. Novel indole-benzimidazole and indole-benzothiazole derivatives joined by different linkers are designed and synthesized as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, HT29, A549, and MDA-MB-435) and human umbilical vein endothelial cell. Meanwhile, the inhibitory activities against vascular endothelial growth factor receptor-2 are estimated in vitro and the binding interactions with dual conformations of vascular endothelial growth factor receptor-2 tyrosine kinase are evaluated by mol. docking. Compounds 5a-c and 14 show inhibitory activity against vascular endothelial growth factor receptor-2 tyrosine kinase and promising cytotoxicity, specifically with IC₅₀ values ranging between 0.1 and 1μM, which imply broad-spectrum antitumor activity. These results provide a deep insight into potential structural modifications for developing potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.

Journal of Chemical Research published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ding, Yangyang published the artcileDesign, synthesis, and antitumor activity of novel benzoheterocycle derivatives as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase, HPLC of Formula: 7467-35-8, the publication is Journal of Chemical Research (2020), 44(5-6), 286-294, database is CAplus.

The vascular endothelial growth factor receptor-2 signaling pathway promotes the formation of new blood vessels, and vascular endothelial growth factor receptor-2 tyrosine kinase exists in both active and inactive conformations. Novel indole-benzimidazole and indole-benzothiazole derivatives joined by different linkers are designed and synthesized as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, HT29, A549, and MDA-MB-435) and human umbilical vein endothelial cell. Meanwhile, the inhibitory activities against vascular endothelial growth factor receptor-2 are estimated in vitro and the binding interactions with dual conformations of vascular endothelial growth factor receptor-2 tyrosine kinase are evaluated by mol. docking. Compounds 5a-c and 14 show inhibitory activity against vascular endothelial growth factor receptor-2 tyrosine kinase and promising cytotoxicity, specifically with IC₅₀ values ranging between 0.1 and 1μM, which imply broad-spectrum antitumor activity. These results provide a deep insight into potential structural modifications for developing potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.

Journal of Chemical Research published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xue, Yang published the artcileNovel hypoglycemic compound-synthesis of glycine derivatives and research on the role of PPARs, SDS of cas: 4760-35-4, the publication is Jiefangjun Yaoxue Xuebao (2009), 25(1), 5-10, database is CAplus.

The aim of this paper is to synthesize five novel hypoglycemic glycine-type drugs and research the role of PPARs. The synthesis started with the reaction between 4-hydroxybenzaldehyde and 3-[4-phenoxyphenoxy] propanol, 2-(4-phenoxyphenoxy) ethanol, benzimidazole derivatives The resulting compounds were condensed with proper aldehyde to give Schiff bases. The imine derivatives reacted with 4-methoxyphenyl carbonochloridate, followed by hydrolysis, to give the desired glycine analogs. The target’s role in the activation of PPARs was determined The results showed that the 5 novel compounds were synthesized and characterized by ¹HNMR. Targets show varying degrees of activation of PPARs. The bioassay indicated that five target compounds 6a, 6b, 6c, 6’a, 6’b were capable of activating PPARs. Among them, 6a, 6b, 6c are more effective. They can be good candidates for the therapy of insulin resistance and high blood sugar.

Jiefangjun Yaoxue Xuebao published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H7ClN2S, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chen, Hong published the artcileNew efficient copper(II)-catalyzed direct access to primary amide from aldehyde under solvothermal condition and related crystal structure study, Computed Properties of 7467-35-8, the publication is Chinese Journal of Structural Chemistry (2016), 35(5), 796-804, database is CAplus.

Two 1-methyl-1H-benzo[d]imidazole derivatives, C₁₈H₁₄CuN₄O₄·C₄H₈O₂ (1) and C₉H₉N₃O (2), were synthesized and characterized by NMR, MS, FT-IR, elementary anal. and x-ray single-crystal diffraction. Compound 1 crystallizes in monoclinic, space group P2₁/n with a = 9.6888(3), b = 7.3772(2), c = 14.3277(4) Å, β = 95.819(3)°, V = 1018.81(5) ų, M_r = 501.98, Z = 2, D_c = 1.636 g/cm³, F(000) = 518, μ = 1.123 mm^-1, MoKα radiation (λ = 0.71073 Å), the final R = 0.0325 and wR = 0.0859 for 1821 observed reflections with I > 2σ(I). Compound 2 crystallizes in monoclinic, space group C2/c with a = 14.2908(14), b = 14.4268(13), c = 8.4802(6) Å, β = 108.513(9)°, V = 1657.9(3) ų, M_r = 175.19, Z = 8, D_c = 1.404 g/cm³, F(000) = 736, μ = 0.097 mm^-1, MoKα radiation (λ = 0.71073 Å), the final R = 0.0563 and wR = 0.1531 for 1231 observed reflections with I > 2σ(I). Intermol. (N-H···N, N-H···O) and intramol. (N-H···N, C-H···O) hydrogen bonds, as well as C-H···π and π-π stacking interactions, help to stabilize the crystal structure of compound 2.

Chinese Journal of Structural Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Computed Properties of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jianming published the artcileEnvironmental Friendly Azide-Alkyne Cycloaddition Reaction of Azides, Alkynes, and Organic Halides or Epoxides in Water: Efficient “Click” Synthesis of 1,2,3-Triazole Derivatives by Cu Catalyst, SDS of cas: 4760-35-4, the publication is Chinese Journal of Chemistry (2012), 30(3), 644-650, database is CAplus.

An efficient click synthesis of 1,2,3-triazole derivatives from benzyl halides or alkyl halides, epoxides, terminal alkynes, and sodium azides in the presence of copper salts and relative benzimidazole salts have been developed. This procedure eliminates the need to handle potentially organic azides, which are generated in situ. A broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Chinese Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jianming published the artcileConstruction of the flavones and aurones through regioselective carbonylative annulation of 2-bromophenols and terminal alkynes, Synthetic Route of 4760-35-4, the publication is Tetrahedron Letters (2013), 54(14), 1802-1807, database is CAplus.

The easily available and efficient catalyst containing a benzimidazolium ligand and PdCl₂(PPh₃)₂ demonstrated excellent catalytic activity to construct the flavones and aurones, resp. This reaction can be operated under mild conditions, affording the desired products in moderate to good yields. This protocol was used to prepare the flavones and aurones by a slight modification of amines.

Tetrahedron Letters published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Im, Jaewan published the artcileStructural characteristics and thermal properties of regenerated cellulose, hemicellulose and lignin after being dissolved in ionic liquids, SDS of cas: 79917-90-1, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2022), 365-375, database is CAplus.

This study investigated the use of ionic liquids such as 1-butyl-3-methylimidazolium chloride, 4-butyl-4-Me morpholinium chloride, 1-butyl-1-methylpiperidinium chloride, and 1,3-dimethylimidazolium methylphosphite to dissolve cellulose, hemicellulose, and lignin biomass, as alternatives to highly toxic organic solvents. The biomass treated with the ionic liquids is characterized by SEM, X-ray diffraction, thermogravimetric anal., and Fourier-transform IR spectroscopy. The X-ray diffraction results revealed that most of the biomass treated with ionic liquids had low crystallinity after treatment with the ionic liquids Thermogravimetric anal. confirmed that the pyrolysis temperature of the biomass treated with the ionic liquid decreased. However, it was found that the pyrolysis temperature of the biomass was increased again after the ionic liquid was washed with an antisolvent. This result was interpreted using Fourier-transform IR spectroscopy to show that the O-H hydrogen bonding of cellulose was restored. The exptl. results from this study can help provide a better understanding of the biomass regeneration mechanism of ionic liquids and increase the applicability of biomass in various fields.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Villemejeanne, Benoit published the artcileHalide based ionic liquid mixture for a sustainable electrochemical recovery of precious metals, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Environmental Chemical Engineering (2022), 10(1), 107063, database is CAplus.

Precious metal refining from ore or electronic devices includes hydrometallurgical processes with major concern about toxicity or wastewater production As an alternative, one-step electroleaching-electrochem. deposition process (EL-ECD) using ionic liquid mixtures was evaluated for palladium and gold recovery. A halide based ionic liquid combined with a diluting ionic liquid was chosen among ten electrolytes after cyclic voltammetry and potentiostatic experiments These low viscous electrolytes allow complexing Au and Pd, leading to metal leaching at low anodic potential. Moreover, the complexes formed could be simultaneously deposited at the cathode. Metal behavior is similar for all halide anions tested (chloride, bromide and iodide). Results show that chloride based mixtures are the more suitable electrolyte providing the highest leaching faradic yield. This process appears more sustainable than conventional processes (chlorination, cyanide leaching) thanks to the electrolyte stability limiting solvent losses but also workers exposition.

Journal of Environmental Chemical Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C9H21NO3, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem