Tag: M.W=200-300

Dressman, Bruce A.; Tromiczak, Eric G.; Chappell, Mark D.; Tripp, Allie E.; Quimby, Steven J.; Vetman, Tatiana; Fivush, Adam M.; Matt, James; Jaramillo, Carlos; Li, Renhua; Khilevich, Albert; Blanco, Maria-Jesus; Smith, Stephon C.; Carpintero, Mercedes; de Diego, Jose Eugenio; Barberis, Mario; Garcia-Cerrada, Susana; Soriano, Jose F.; Schkeryantz, Jeffrey M.; Witkin, Jeffrey M.; Wafford, Keith A.; Seidel, Wesley; Britton, Thomas; Overshiner, Carl D.; Li, Xia; Wang, Xu-Shan; Heinz, Beverly A.; Catlow, John T.; Swanson, Steven; Bedwell, David; Ornstein, Paul L.; Mitch, Charles H. published an article about the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3,SMILESS:ClC1=C(C=C(CBr)C=C1)F ).Synthetic Route of C7H5BrClF. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:206362-80-3) through the article.

Neg. modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to prepare and optimize a series of conformationally constrained 3,4-disubstituted bicyclo[3.1.0]hexane glutamic acid analogs as orthosteric (glutamate site) mGlu2/3 receptor antagonists. This work led to the discovery of a highly potent and efficacious tool compound I (hmGlu2 IC50 46 ± 14.2 nM, hmGlu3 IC50 = 46.1 ± 36.2 nM). Compound I showed activity in the mouse forced swim test with a minimal ED (MED) of 1 mg/kg i.p. While in rat EEG studies it exhibited wake promoting effects at 3 and 10 mg/kg i.p. without any significant effects on locomotor activity. Compound I thus represents a novel tool mol. for studying the impact of blocking mGlu2/3 receptors both in vitro and in vivo.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ren, Li; Grina, Jonas; Moreno, David; Blake, James F.; Gaudino, John J.; Garrey, Rustam; Metcalf, Andrew T.; Burkard, Michael; Martinson, Matthew; Rasor, Kevin; Chen, Huifen; Dean, Brian; Gould, Stephen E.; Pacheco, Patricia; Shahidi-Latham, Sheerin; Yin, Jianping; West, Kristina; Wang, Weiru; Moffat, John G.; Schwarz, Jacob B. published an article about the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3,SMILESS:ClC1=C(C=C(CBr)C=C1)F ).Recommanded Product: 206362-80-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:206362-80-3) through the article.

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of I, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, I was selected for further preclin. evaluation.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro, published in 2017-01-29, which mentions a compound: 206362-80-3, Name is 4-(Bromomethyl)-1-chloro-2-fluorobenzene, Molecular C7H5BrClF, Application of 206362-80-3.

Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects. To address this concern, here we developed a potent “”hit”” compound, VSP-51, which is a novel selective PPARγ-modulating ligand with improved therapeutic profiles in vitro compared to the multi-billion dollar TZD drug rosiglitazone (Rosi). Unlike Rosi, VSP-51 is a partial agonist of PPARγ with improved insulin sensitivity due to its ability to bind PPARγ with high affinity without stimulating adipocyte differentiation and the expression of adipogenesis-related genes. We have determined the crystal structure of the PPARγ ligand-binding domain (LBD) in complex with VSP-51, which revealed a unique mode of binding for VSP-51 and provides the mol. basis for the discrimination between VSP-51 from TZDs and other ligands such as telmisartan, SR1663 and SR1664. Taken together, our findings demonstrate that: a. VSP-51 can serve as a promising candidate for anti-diabetic drug discovery; and b. provide a rational basis for the development of future pharmacol. agents targeting PPARγ with advantages over current TZD drugs.

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Reference:
Imidazole – Wikipedia,
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Guo, Zhi-Hua; Yin, Yong; Wang, Cong; Wang, Peng-Fei; Zhang, Xing-Tao; Wang, Zhong-Chang; Zhu, Hai-Liang published the article 《Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents》. Keywords: preparation salicylic acid metronidazole antibacterial; crystal structure; Antibacterial activity; Molecular docking; S. aureus TyrRS; Salicylic acid derivatives.They researched the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3 ).Formula: C7H5BrClF. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:206362-80-3) here.

A series of novel salicylic acid derivatives containing metronidazole as Staphylococcus aureus Tyrosyl-tRNA synthetase (TyrRS) inhibitors have been synthesized and evaluated their biol. activities as potential antibacterial agents. Among these compounds, compound I exhibited the most potent antibacterial activity against Gram-pos. (S. aureus ATCC 6538 and Bacillus subtilis ATCC 6633) and Gram-neg. (Escherichia coli ATCC 35218 and Pseudomonas aeruginosa ATCC 13525) with MICs of 0.39-1.57 μg/mL and showed the most potent S. aureus Tyrosyl-tRNA synthetase inhibitory with 2.3 μM. Docking simulation was performed to insert compound I into the crystal structure of S. aureus Tyrosyl-tRNA synthetase active site to determine the probable binding model. These results suggested that compound I may be a promising antibacterial agent.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Safety of 1-(2-Bromophenyl)-1H-pyrazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(2-Bromophenyl)-1H-pyrazole, is researched, Molecular C9H7BrN2, CAS is 87488-84-4, about Sodium Halides as Halogenating Reagents: Rhodium(III)-Catalyzed Versatile and Practical Halogenation of Aryl Compounds. Author is Zhang, Panpan; Hong, Liang; Li, Guofeng; Wang, Rui.

We report a concise, versatile and practical method for the ortho-chlorination, ortho-bromination and ortho-iodination of aryl compounds The significant advantage of this transformation is the creation of the carbon-halogen bond by use of readily available and cheap halide salts as formal nucleophilic halogenating reagents under mild reaction conditions.

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Imidazole – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 87488-84-4, is researched, Molecular C9H7BrN2, about Synthesis of pyrrolo[1,2-a]quinolines and ullazines by visible light mediated one- and twofold annulation of N-arylpyrroles with arylalkynes, the main research direction is pyrroloquinoline ullazine preparation; photochem annulation arylpyrrole aryl alkyne.Safety of 1-(2-Bromophenyl)-1H-pyrazole.

1-(2-Bromophenyl)-1H-pyrrole and 1-(2,6-dibromophenyl)-1H-pyrrole react in the presence of catalytic amounts of rhodamine 6G (Rh-6G) and N,N-diisopropylethylamine (DIPEA) under blue light irradiation with aromatic alkynes and subsequently cyclize intramolecularly to form pyrrolo[1,2-a]quinoline and ullazines. The reactions proceed at room temperature, avoid transition metal catalysts, and provide the target compounds in one pot in moderate to good yields. Mechanistic investigations suggest that the photo excited Rh-6G is reduced by DIPEA to form the corresponding radical anion Rh-6G•-, which is again excited by 455 nm light. The excited radical anion of Rh-6G donates an electron to the aryl bromide giving an aryl radical that is trapped by aromatic alkynes. The intermediate vinyl radical cyclizes intramolecularly and yields the product after rearomatization.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 206362-80-3, is researched, SMILESS is ClC1=C(C=C(CBr)C=C1)F, Molecular C7H5BrClFJournal, Article, Research Support, Non-U.S. Gov’t, Organic & Biomolecular Chemistry called Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPARγ modulator, Author is Shi, Jingjing; Zhao, Guanguan; Wang, Xiaowei; Xu, H. Eric; Yi, Wei, the main research direction is rhodium catalyst regioselective amidation indole trichlorobenzoyloxyamide; PPARgamma agonist indole trichlorobenzoyloxyamide.Name: 4-(Bromomethyl)-1-chloro-2-fluorobenzene.

A new and efficient method for the direct regioselective C2-amidation of various functionalized indoles with several N-(2,4,6-trichlorobenzoyloxy)amides via Rh(III)-catalyzed C-H activation/N-O cleavage/C-N formation using the pyrimidyl group as a readily installable and removable directing group has been developed. With this method, a variety of valuable 2-amido indoles can be easily prepared under mild conditions with broad functional group tolerance and excellent region-/site-specificities. The results from biol. evaluation showed that compound I had a partial PPARγ agonistic activity and a strong PPARγ binding affinity with an IC50 value of 120.0 nM, along with a less pronounced adipocyte differentiation ability compared to the currently marketed anti-diabetic drug rosiglitazone, suggesting that further development of such a compound might be of great interest.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 87488-84-4, is researched, SMILESS is BrC1=CC=CC=C1N2N=CC=C2, Molecular C9H7BrN2Journal, Article, Angewandte Chemie, International Edition called Cobalt(III)-Catalyzed Aryl and Alkenyl C-H Aminocarbonylation with Isocyanates and Acyl Azides, Author is Li, Jie; Ackermann, Lutz, the main research direction is arene heteroarene alkene isocyanate acyl azide aminocarbonylation cobalt catalyst; amide preparation; CH activation; amides; azides; cobalt; isocyanates.Application In Synthesis of 1-(2-Bromophenyl)-1H-pyrazole.

Expedient C-H aminocarbonylations of unactivated (hetero)arenes and alkenes were accomplished with a cobalt(III) catalyst that shows high functional group tolerance. The C-H functionalization occurred with excellent chemo-, site-, and diastereoselectivity and enabled step-economical reactions with isocyanates or acyl azides.

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Imidazole – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Development of a Phase-Transfer-Catalyzed, [2,3]-Wittig Rearrangement, Author is Denmark, Scott E.; Cullen, Lindsey R., which mentions a compound: 206362-80-3, SMILESS is ClC1=C(C=C(CBr)C=C1)F, Molecular C7H5BrClF, Product Details of 206362-80-3.

An investigation into the use of phase-transfer catalysis for the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds is described. Initial studies focused on identifying viable substrate classes that would undergo selective [2,3]-rearrangement under phase-transfer catalysis. Under certain conditions, the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds takes place in the presence of a phase-transfer agent, providing a rare example of a phase-transfer-catalyzed unimol. reaction. In the course of this investigation, it was found that catalysis is dependent on several variables including base concentration, catalyst structure, and substrate lipophilicity. Preliminary testing of chiral, nonracemic phase-transfer catalysts has shown promising levels of enantioselectivity for future development.

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Imidazole – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Li, Cally; Mellerup, Soren K.; Wang, Xiang; Wang, Suning researched the compound: 1-(2-Bromophenyl)-1H-pyrazole( cas:87488-84-4 ).Safety of 1-(2-Bromophenyl)-1H-pyrazole.They published the article 《Accessing Two-Stage Regioselective Photoisomerization in Unsymmetrical N,C-Chelate Organoboron Compounds: Reactivity of B(ppz)(Mes)Ar》 about this compound( cas:87488-84-4 ) in Organometallics. Keywords: regioselective photoisomerization uv vis fluorescence Zimmerman rearrangement organoboron; crystal structure mol optimized nitrogen carbon chelate organoboron preparation. We’ll tell you more about this compound (cas:87488-84-4).

A new family of unsym., N,C-chelate organoboron compounds B(ppz)(Mes)Ar have been synthesized and found to undergo a rare, regioselective two-stage photoisomerization, involving the Ar group only. The initial transformation is a Zimmerman rearrangement to afford yellow azaboratabisnorcaradiene isomers that are subsequently converted to unprecedented 14aH-diazaborepins via a photochem. “”walk”” rearrangement. Spectroscopic and computational studies provide insight into the formation and properties of these unique systems.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem