Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 65039-05-6, name is 1-Butyl-3-methylimidazolium iodide, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65039-05-6, Product Details of 65039-05-6

General procedure: 2.0mmol,0.5825gCo(NO3)2 6H2O and0.50mmol,0.0831gH2BDC wereplacedinacrystallisationvialplacedina25mLteflon-lined stainless-steelautoclavemixedwith1.005g[EMI]Cl.Themixturewaskeptinsidethe furnaceat160 C for5days,andthennaturallycooledtoambient temperature.Thebluecrystalsof 1 suitable forsinglecrystalX-raydiffractionwerecollectedaftersoakclearingwithacetone.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Butyl-3-methylimidazolium iodide, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Zong-Hui; Xu, Ling; Jiao, Huan; Journal of Solid State Chemistry; vol. 238; (2016); p. 217 – 222;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 68468-39-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68468-39-3, name is 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Description 19: S-Bromo-lH-benzoimidazole^-sulfonic acid; [00281] Thiocarbonyl diimidazole (0.95 g, 5.35 mmol) was added in one portion to a solution of 4-bromobenzene-l,2-diamine (1.00 g, 2.67 mmol) in TetaF (50 mL). The mixture was stirred for 6 h then the solvents were removed in vacuo. The residue was suspended in DCM and the product was collected by filtration as a white solid. This was dissolved in KOeta solution (IM, 10.7 mL, 10.7 mmol) and eta2O2 (30 %, 2.13 mL, 21.40 mmol) was added dropwise. The mixture was stirred for 14 h then concentrated HCl was added to pH 1. The mixture was cooled to 0 0C for 30 min then the white solid product was collected by filtration. This was dried at 40 0C under high vacuum (1.15 g, 77 %). MS (MH+, m/z) 275 (50 %), 277 (50 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS N.V.; WO2008/55959; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 5851-49-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5851-49-0 as follows.

General procedure: The respective 1H-benz[d]imidazole(2.50 mmol) was dissolved in 10 ml of abs. DMF. Sodium hydride(60 % dispersion in mineral oil) (0.2 g, 5 mmol) was added withcooling. After the gas formation stopped, 4?-bromomethyl-[1,1?-biphenyl]-2-carbonitrildissolved in 2 ml of abs. DMF was added dropwise and the solution wasstirred for 1 h under cooling in an ice bath and further 2h at RT. Water wasadded and after the solution was acidified with HCl the product was extractedthree times with methylene chloride. The combined organic layers were driedover Na2SO4 and evaporated to dryness in vacuo. The crudeproduct was purified by column chromatography on silica gel with methylenechloride/methanol (95:5) and if necessary recrystallized from diethyl ether/methanol.

According to the analysis of related databases, 5851-49-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Obermoser, Victoria; Urban, Margarethe E.; Murgueitio, Manuela S.; Wolber, Gerhard; Kintscher, Ulrich; Gust, Ronald; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 138 – 152;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 65039-05-6, name is 1-Butyl-3-methylimidazolium iodide, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65039-05-6, Safety of 1-Butyl-3-methylimidazolium iodide

General procedure: Catholyte (0.10 mol L1 of ionic liquid 1a-h in 5.0 mL of organicsolvent) and anolyte (2.0 mL same solvent/electrolyte) wereseparated through a porous glass fritfilled with methylcellulosein DMF-Et4N-BF4. The electrolysis was carried out, under N2atmosphere at 25 C, at a constant current (J = 15 mA cm2). Afterthe consumption of 31 C, the current was switched off, the anodiccompartment removed and the catholyte analyzed by cyclicvoltammetry at different time intervals from the end of theelectrolysis.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Feroci, Marta; Chiarotto, Isabella; D’Anna, Francesca; Forte, Gianpiero; Noto, Renato; Inesi, Achille; Electrochimica Acta; vol. 153; (2015); p. 122 – 129;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 106848-38-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106848-38-8, name is 1-Benzyl-4-bromo-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: PdCl2(dppf), PdCl2(tbpf) and (A.caPhos)PdCl2. A mixture of the halogenated heterocycle (0.66 mmol) in anhydrous THF (13.2 mL) was degassed by bubbling argon for few minutes. Then, PdCl2(dppf) (27.0 mg, 0.033 mmol, 5.0 mol%), TMEDA (0.130 g, 1.12 mmol, 1.7 equiv) and finally NaBH4 (42.4 mg, 1.12 mmol, 1.7 equiv) were introduced in sequence. The mixture was stirred at room temperature under argon for the proper time and then worked up as described above.

The chemical industry reduces the impact on the environment during synthesis 1-Benzyl-4-bromo-1H-imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Chelucci, Giorgio; Figus, Susanna; Journal of Molecular Catalysis A: Chemical; vol. 393; (2014); p. 191 – 209;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 72459-45-1,Some common heterocyclic compound, 72459-45-1, name is 1-(2-Bromobenzyl)-1H-imidazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1- (2-Bromo-benzyl) -1H-imidazole (20 g, 84.0 mmol),Palladium acetate (500 mg),Triphenylphosphine (500 mg),Potassium carbonate (23 g, 167 mmol) was dissolved in DMSO (200 mL)The mixture was heated to 140 C under nitrogen for 2 hours.LC-MS showed the reaction was complete,The reaction solution was concentrated to dryness,The residue was dissolved in ethyl acetate (200 mL)Water (2 × 100 mL),Saturated brine (50 mL).Organic phase filtration,concentrate.The residue obtained 5H- imidazo [5,1-a] isoindole (10.0 g) was purified by flash silica gel column.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Bromobenzyl)-1H-imidazole, its application will become more common.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60713-78-2, name is 5-Chloro-6-nitro-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H4ClN3O3

Step 2: 5-Chloro-l,3-dimethyl-6-nitro-lH-benzo[JJimidazol-2(3H)-one 5-Chloro-6-nitro-lH-benzo[ ]imidazol-2(3H)-one (1.00 g, 4.7 mmol) was stirred in DMF (50 niL) then potassium carbonate (1.29 g, 9.4 mmol) and iodomethane (2.66 g, 18.7 mmol) were added. The reaction was stirred at 75 C for 1.5 h. The reaction was allowed to cool and solvents were removed under reduced pressure. The residue was partitioned between water and ethyl acetate and the phases were separated. The aqueous phase was extracted with ethyl acetate and the combined organic extracts were through a phase separation cartridge and evaporated to afford a brown solid (1.07 g, 95%), which was taken through to the next step with no further purification.

According to the analysis of related databases, 60713-78-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; CHAMBERS, Mark; CHAN, Bryan K.; ESTRADA, Anthony; SWEENEY, Zachary Kevin; WO2013/79505; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 1207457-15-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1207457-15-5, name is tert-Butyl 2-bromo-1H-imidazole-1-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1. To a mixture of 1 (PCT Int. Appl. (2008), WO 2008079277 A, 4 g, 14 mmol) tert-butyl 2-bromo-lH-imidazole-l-carboxylate (FCH Group, 1.8 g, 7 mmol) and NaOH (3 mL,1.5 M) in toluene (20 mL) and ethanol (2 mL) was added Pd(PPh3)4 (0.084 g, 0.14 mmol) under N2. The resulting mixture was stirred at 120 C for 24 h. The mixture was cooled to RT, treated with water and extracted with EA. The combined organic extracts were washed with water, brine, dried over anhydrous Na2SC>4, filtered and concentrated to give a crude oil. The crude product was purified by recrystallization to afford 2 (1.1 g, 38 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromo-1H-imidazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; CHIANG, Lillian W.; MURPHY, Eain Anthony; KAYSER, Frank; SUN, Qun; FINK, Sarah Jocelyn; (128 pag.)WO2019/79519; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 84243-58-3, A common heterocyclic compound, 84243-58-3, name is 6-(4-(1H-Imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one, molecular formula is C13H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 4 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone Bromine (1.6 ml) is added dropwise to a solution of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone (3.5 g) in acetic acid (25 ml) at 80 C. The mixture is heated for 5 to 6 hours to complete the reaction. The solid is filtered, washed with ether and converted to the free base which is crystallized from ethanol to yield 1.1 g of the product 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone: mp. 244-245 C. Anal. calcd for C13 H10 N4 O.1/5H2 O; C, 64.56; H, 4.30; N, 23.17; H2 O, 1.49. Found; C, 64.30; H, 4.36; N, 23.04; H2 O, 1.11.

The synthetic route of 84243-58-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US4353905; (1982); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 65039-05-6, name is 1-Butyl-3-methylimidazolium iodide, molecular formula is C8H15IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Butyl-3-methylimidazolium iodide

To a Schlenk flask charged with 1-butyl-3-methylimidazolium iodide (128.0mg, 0.48mmol) and Ag2O (56.0mg, 0.24mmol) was added dry CH2Cl2 (10mL), the mixture was protected from light and stirred at room temperature for 20h, before the resulting yellow solution was cannula filtered and added to a red solution of [(HMB)Ru(mu2-eta1,3-exo-syn-CH2CHCHCHO)]2(BF4)2 (200mg, 0.24mmol) in dry acetone (10mL). A solid immediately precipitated and the red suspension was stirred at room temperature protected from light for 4h, followed by filtration through a celite bed and washed with dry NO2CH3. The amber coloured solution was concentrated in vacuo to 5mL followed by addition of 20mL of dry diethyl ether and stored at-10C for 18h. The amber solution was taken to dryness resulting in a brown oil, washed with 10mL of pentane, vacuum dried and extracted with 10mL of dry toluene. Pentane (50mL) was added to the yellow toluene solution resulting in a yellow suspension which was stored at-10C for 20h, following by separation of an amber oil by decantation characterised as [(HMB)Ru(BuImMe)(eta3-CH2CHCHCOOH)](BF4) in very low yield just enough for NMR experiments. 1H NMR (CDCl3, 500MHz, ppm): 6.96 (2×d, J=1.8Hz, 1H, 4,5-Im), 4.47 (dt, J=6.7, 0.7Hz, 1H, H3-heteropentadienyl), 4.11 (m, 3H, overlap CH2-N-Im and H2-heteropentadienyl), 3.84 (s, 3H, CH3-N-Im), 3.09 (ddd, J=7.2, 1.5, 0.8Hz, 1H, H1syn-heteropentadienyl), 2.17 (s, 18H, HMB), 1.87 (dt, J=10.8, 1.1Hz, 1H, H1anti-heteropentadienyl), 1.79 (q, J=7.5Hz, 2H, CH2-CH2-N-Im), 1.34 (q, J=7.6Hz, 2H, CH2-CH2-CH2-N-Im), 0.95 (t, J=7.4Hz, 3H, CH3-(CH2)3-N-Im). 13C{1H} NMR (acetone-d6, 75MHz, ppm): 182.0 (C-Ru), 122.0 and 120.9 (C4,C5-Im), 96.0 (HMB), 92.5 (C2-heteropentadienyl), 65.7 (C3-heteropentadienyl), 52.8 (C1-heteropentadienyl), 51.7 (CH2-N-Im), 38.8 (CH2-CH2-N-Im), 33.6 (CH3-N-Im), 19.8 (CH2-CH2-CH2-N-Im), 16.4 (CH3-HMB), 13.7 (CH3-(CH2)3-N-Im). ESI-TOF-MS(+) (m/z): Calcd for [C24H37N2O2Ru]+ 487.189302, found 487.189566; error-0.540454ppm, DBE 7.5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 65039-05-6, its application will become more common.

Reference:
Article; Olguin, Juan; Diaz-Fernandez, Monica; de la Cruz-Cruz, Jose Ignacio; Paz-Sandoval, M. Angeles; Journal of Organometallic Chemistry; vol. 824; (2016); p. 33 – 41;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem