Tag: M.W=200-300

Application of 342789-81-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 342789-81-5, name is 1-Butyl-3-methylimidazolium methanesulfonate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5.1-1-butyl-3-methylimidazolium tetrafluoroborate (BMI.BF4)A mixture formed by 1,3-dimethyl imidazolium methanesulfonate (BMI.CH3SO3) (10.6 g; 45.0 mmol), sodium tetrafluoroborate (6.00 g; 54.5 mmol) and water (5.4 mL) was stirred at room temperature for 30 minutes. The resulting mixture, made up of two phases, was extracted with dichloromethane (3¡Á15 mL). The combined organic extract was dried with anhydrous sodium carbonate and the solvent was evaporated under vacuum and heated (80 C.), which produced the desired BMI.BF4 ionic liquid. (9.35 g; 92% yield).

The synthetic route of 1-Butyl-3-methylimidazolium methanesulfonate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PETROLEO BRASILEIRO S.A. – PETROBRAS; US2008/45723; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 72459-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72459-46-2, name is 1-(4-Bromobenzyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of 10 (1.00g, 4.00mmol) and K2CO3 (1.66g, 12.00mmol) in acetonitrile (20mL) was added dropwise diethylamine solution (1.20g, 16.00mmol) at room temperature for 2h. The solvent was evaporated in vacuo and the residue was then dissolved in EtOAc (50mL) and washed with water (20mL×3), the organic layers were washed with brine, and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure to provide the 11a (0.83g, 84.7% yield) as an off-white liquid. (0041) Then, a mixture of 11a (0.83g, 3.43mmol), bis(pinacolato)diboron (0.96g, 3.77mmol), PdCl2(dppf)-CH2Cl2 (0.084g, 0.103mmol) and potassium acetate (0.67g, 6.86mmol) in anhydrous 1,4-dioxane (15mL) was purged with argon and heated at 100C for 2.5h. The reaction was then treated with 6 (1.20g, 3.60mmol), 2.0M aqueous Na2CO3 (5mL) and another portion of PdCl2(dppf)-CH2Cl2 (0.084g, 0.103mmol), then heated at 110C for 12h under argon. The reaction mixture was cooled to room temperature, filtered, and concentrated. The final compound was purified by MPLC (ISCO CombiFlash purification system) (MeOH/DCM, eluted from 0% to 10%), The fractions were collected, concentrated to afford 12a (0.72g, 57.2% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Bromobenzyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 2622-63-1,Some common heterocyclic compound, 2622-63-1, name is 1-Methyl-2-phenyl-1H-benzo[d]imidazole, molecular formula is C14H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The synthesis of (L)2Ir(acac) is outlined in Scheme 13. To 2-ethoxyethanol (10 mL) was added 1 mmol of one of the compounds obtained in Examples 1, 2, or 4-9, and then added 1 mmol of iridium trichloride hydrate and water (3 mL). The reaction mixture was then stirred under nitrogen gas at 80° C. for 12 h. The mixture was cooled to room temperature and filtered. The collected solid was washed with ethanol and n-hexane several times, and dried under vacuum to produce cyclometalated Ir(II)-mu-chloro-bridged dimer. The iridium chloro-bridged dimer, acetylacetone (5 mmol), and Na2CO3 (10 mmol) was dissolved in 2-ethoxyethanol (15 mL) and the reaction mixture stirred under nitrogen at 80° C. for 6 h. The mixture was cooled to room temperature and filtered. The collected solid was sequentially washed with water, ethanol, and ether, and purified by vacuum sublimation to give the title compound. Example 14 Synthesis of Ir(Mpb)2(acac) (II-1) Mpb obtained in Example 1 was used as the ligand (L) to produce the title complex II-1 in a yield of 76percent according to the detailed steps described in Example 13. The X-ray structure of complex II-1 is shown in FIG. 2. The UV absorption spectrum and the phosphorescence emission spectrum of complex II-1 in dichloromethane are shown in FIG. 3. The complex II-1 emits a green light having a peak wavelength of 510 nm. 1H NMR (CDCl3, delta): 1.76 (s, 6 H), 4.25 (s, 6 H), 5.15 (s, 1 H), 6.38 (d, J=7.6 Hz, 2 H), 6.57 (t, J=8.0 Hz, 2 H), 6.78 (t, J=7.6 Hz, 2 H), 7.26 (t, J=8.4 Hz, 2 H), 7.37 (t, J=7.2 Hz, 2 H), 7.44 (d, J=8.4 Hz, 2 H), 7.65 (d, J=8.0 Hz, 2 H), 7.75 (d, J=8.4 Hz, 2 H). HRMS (EI): calculated for C33H29IrO2N4 (M+) 706.1920, measured 706.1926.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-2-phenyl-1H-benzo[d]imidazole, its application will become more common.

These common heterocyclic compound, 10057-46-2, name is 2-Amino-5-(trifluoromethyl)benzoimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6F3N3

48.8 mg (0.179 MMOL) 4,32. 8 mg (0.163 mmol) 5,68 mg (0.212 mmol) TBTU and 7.5 mg (0.049 MMOL) HOBT are dissolved in 1.8 ml DMF and treated with 0. 11 ML (0. 652 MMOL) DIPEA. After three hours of stirring at room temperature, approx. 2 ML water are added to the reaction mixture, whereby a precipitate is obtained. The precipitate is filtered by suction, washed with water and digested with little methanol. Yield : 27.5 mg (37%) 6, colourless solid

The synthetic route of 2-Amino-5-(trifluoromethyl)benzoimidazole has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 84712-08-3, name is 5-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84712-08-3, Product Details of 84712-08-3

Step 3: A mixture of 5-bromo-1-methyl-1H-benzo[d]imidazol-2(3H)-one (300 mg, 1.32 mmol), bis(pinacolato)diboron (403 mg, 1.58 mmol) and potassium acetate (389 mg, 3.96 mmol) in 1,4-dioxane (4.5 mL) was sparged with nitrogen while stirring for 10 min. Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) methylene chloride adduct (193 mg, 0.264 mmol) was then added and the reaction stirred at 100 C. for 1.5 h. After this time, the mixture was cooled to room temperature, partitioned between ethyl acetate and water and filtered through diatomaceous earth. The filter cake was washed with ethyl acetate and the filtrate layers separated. The organic phase was washed with water and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate concentrated under reduced pressure. The resulting residue was purified by chromatography (silica, gradient, methylene chloride to 1:1 methylene chloride/ethyl acetate) to afford 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2(3H)-one (7.44).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 256518-97-5, name is 2-Chloro-5-iodo-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-5-iodo-1H-benzo[d]imidazole

2-Chloro-6-iodo-1H-benzimidazole (2.34 g, 8.4 mmol), isopropylboronic acid (0.81 g, 9.2 mmol), tetrakistriphenylphosphine palladium (0.09 g, 0.08 mmol) were added to the reaction vessel. Potassium carbonate (3.48g,25.2 mmol), 60 mL of toluene, 20 mL of ethanol and 20 mL of distilled water were stirred at 120 C for 3 h. After the completion of the reaction, the reaction was quenched with distilled water, ethyl acetate was evaporated, and the organic layer was dried (MgSO4).(1.18g, 72%).

The synthetic route of 2-Chloro-5-iodo-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Electric Literature of 255064-10-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 255064-10-9 name is 6-Bromo-4-methyl-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(Bromomethyl) cyclopropane (3.75 mmol, 0.36 mL) was added drop-wise to mixture of 6-bromo-4-methyl-lH- benzo [d] imidazole (2.5 mmol) and potassium carbonate (3.75 mmol, 0.52 g, ) in DMF (8 mL). The mixture was stirred at room temperature for 48 hours and 60°C for 3 h. The mixture was diluted with ethyl acetate and water and the organic extract was washed with brine, dried (MgS04) and concentrated under reduced pressure. Purification of the crude product by column chromatography (silica gel, gradient of 30-100percent ethyl acetate in isohexane) gave the title compound (containing ~25percent of the isomeric 5-bromo- 1- (cyclopropylmethyl) -7-methyl-lH-benzo [d] imidazole) as an off-white solid (0.29 g, 44percent).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromo-4-methyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 152628-03-0

Compound IIc (534 mg, 2.45 mmol) was slowly added to polyphosphoric acid (15 mL) heated to 80 & lt; 0 & gt; C, stirred and heated to 150 & lt; 0 & gt; C.Compound IIIb (320 mg, 2.94 mmol) was slowly added to the polyphosphoric acid solution of the former several times, and the mixture was stirred at 150 C for 12 h. After completion of the reaction, the reaction solution was poured into 100 mL of ice water and adjusted to pH 8-10 with concentrated aqueous ammonia. A large amount of precipitate appeared, filtered and the filter cake was washed three times with 5% ethanol solution.After drying the filter cake, the resulting filter cake was purified by chromatography to give about 357 mg (yield 58.7%) of the pale yellow compound IVb.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 641571-13-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

6. 3-(4-Methyl-imidazol-l-yl)-N-[4-methyl-3-(9-methyl-8-oxo-3,6,8,9- tetrahydro-S^jy^-tetraaza-cyclopentafalnaphthalen-V-y^-phenyy-S-rrifluoromethyl- benzamide; [00103] 7-(5-Amino-2-methyl-rhohenyl)-9-methyl-3,6,7,9-tetrahydro-3,4,7,9- tetraaza-cyclopenta[a]naphthalen-8-one (10 mg, 0.032 mmol) is mixed with 3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-benzoic acid (10 mg, 0.037 mmol), DIEA (0.023 ml, 0.128 mmol) and HATU (13 mg, 0.035 mmol) in 0.4 ml DMF at room temperature. After stirring at room temperature for 4 hours, the reaction mixture is concentrated and purified by RP- HPLC to afford the title compound as TFA salt (12 mg, 71%): 1H NMR 400 MHz (DMSO- dbeta) delta 11.99(5, IH), 10.61(5, IH), 9.50(5, IH), 8.53(5, IH), 8.37(m, 2H), 8.07(5, IH), 8.03(5, IH), 7.72(J, IH, J= 2.0Hz), 7.62(d, IH, J= 2.0 Hz), 7.60(4 IH, J= 2.0 Hz), 7.44(f, IH, J= 2.8 Hz), 7.28(rf, IH, J= 8.4 Hz), 6.80(?, IH), 4.84(4 IH, J= 13.2 Hz), 4.63(4 IH, J=U Hz), 3.61(5, 3H), 2.29(5, 3H), 2.05(5, 3H); MS m/z 560.2 (M + 1).

The chemical industry reduces the impact on the environment during synthesis 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C12H14N2O2

Example 12Preparation of N,7-dimethyl-N-(2-nitrophenyl)-2-propyl-3H-benzo[d]imidazole-5- carboxamide (compound 15):To the mixture of 1.09 g (5 mmol) 2-propyl-3H-benzo[d]imidazole-5-carboxylic acid and 50 mi CH2Cl2, 7.26 mJ ( 100 mmol) SOCl2 was added. The mixture was stirred for 18 h and evaporated under reduced pressure.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 152628-03-0.