Tag: M.W=200-300

Synthetic Route of 3543-72-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3543-72-4, name is Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a clean dry flask were charged Iron powder (85 g), Cone. HCI (12.5 ml), and 625 ml of methanol and stirred for 5 minutes at room temperature. The contents were heated to 60-65 C and maintained for 2 hours. At that temperature ammonium chloride solution was charged and maintained for 15 minutes and subsequently cooled to RT. Compound II (80g) was added and then the reaction mass was maintained at 60-65 C for 2h. The mass was cooled to room temperature, filtered and distilled. To the residue was charged water and The pH adjusted to 7-8 using sodium bicarbonate solution. The Aqueous layer is extracted with ethyl acetate and the organic layer is distilled out completely to the give the title compound as a solid (60 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate, other downstream synthetic routes, hurry up and to see.

28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole

A mixture of 5H-benzo[d]benzo[4,5]imidazo[1,2-a]imidazole (18 g, 87 mmol), 1-bromo-3-iodobenzene (27 g, 96 mmol), Cs2CO3 (57 g, 174 mmol), L-proline (6 g, 52 mmol), Cu(I)iodide (5 g, 26 mmol) in DMSO (170 mL) was degassed with N2 for 5 min at RT, then stirred at 100 C. for overnight. After the reaction was completed, the mixture was cooled to RT, diluted with DCM, washed by water, filtered through a short pad of celite, then triturated by DCM/heptanes to give intermediate compound 1 (mixture of Br- and I-product) as off-white solid 16 g.

The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53484-15-4, name is 5-Bromo-1-methyl-1H-benzo[d]Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H7BrN2

A microwave vial is charged with INTERMEDIATE J, 5-bromo-l-methyl- benzimidazole (12.1 mg, 0.0574 mmol), K3P04 (37.5 mg, 0.177 mmol), PdCl2(dppf)2 (3.6 mg, 0.0044 mmol), DMF (1 mL) and heated in the microwave for 15 minutes at 120C. The mixture is filtered on Millipore and concentrated to dryness. The residue is dissolved in MeOH (2 mL), treated with NaOMe (25% w/w, 10 0.044 mmol) and stirred overnight at room temperature. The mixture is then filter on SCX-2 SPE column, the column is wash with 2M NH3 in MeOH. The filtrate is concentrated to dryness and purified by reverse phase preparative HPLC to give the title compound (5.3 mg, 28%). XH NMR (400 MHz, Methanol-d4) delta 8.15 (s, 1H), 7.88 (m, 1H), 7.80 (m, 1H), 7.60 (m, 3H), 7.45 (m, 2H), 5.04 (d, J = 3.7 Hz, 1H), 4.50 (t, J = 3.5 Hz, 1H), 3.92 (s, 3H), 3.86 (m, 2H), 3.75 (t, J = 7.9 Hz, 1H), 3.65 (dd, J = 8.0, 3.1 Hz, 1H), 3.55 (m, 1H).

The synthetic route of 53484-15-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 73746-45-9, name is 5-Iodo-2-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Iodo-2-methyl-1H-imidazole

4-Iodo-2-methyl-1H-imidazole (5.44 g, 26.14 mmol) was addedto a suspension of sodium hydride (1.10 g, 27.4 mmol) and 18-crown-6-ether (0.691 g, 2.61 mmol) in NMP (85 mL) at 0 C. The mixture was stirred at room temperature under N2 atmosphere for 30 min. The solution of 42 (5.00 g, 27.4 mmol) in NMP(15 mL) was added dropwise to a solution of the mixture in at 0 C. The mixture was stirred at 110 C under N2 atmosphere overnight. After cooling, the mixture was poured into saturated aqueous NH4Cl solution at room temperature and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with10-50% EtOAc in hexane) to give 5.57 g (58%) of 43 as off-white solid. 1H NMR (300 MHz, CDCl3) d 1.42 (3H, t, J = 7.2 Hz), 2.38(3H, s), 2.66 (3H, s), 4.40 (2H, q, J = 7.2 Hz), 7.10 (1H, s), 7.12-7.19 (2H, m), 8.00-8.07 (1H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 39513-26-3,Some common heterocyclic compound, 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, molecular formula is C7H5BrN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-bromo-lH-benzo[d]imidazol-2(3H)-one80 (50 mg) in dioxane (1 ml) were added pyridin-3-ylboronic acid 81 (43.3 mg), [l,l-bis(diphenyl- phosphino)ferrocene]dichloropalladium(II) (17.2 mg) and 2 M aq. sodium carbonate solution (235 mu). The reaction mixture was heated at 100 C for 18 hours. The reaction mixture was then cooled to room temperature, diluted with water (50 ml), and extracted twice with ethyl acetate (2 x 30ml). The combined organic layers were dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (silica gel; 12 g; eluent: dichloromethane/methanol = 100/0 to 95/05 in 10 minutes) to afford 5-(pyridin-3-yl)-lH- benzo[d]imidazol-2(3H)-one (12 mg, 23%) as a red solid. MS (ISP): 212.1 ([M+H]+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1,3-dihydrobenzoimidazol-2-one, its application will become more common.

Synthetic Route of 150058-27-8, These common heterocyclic compound, 150058-27-8, name is Methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 500 mL flask was added 200 mL of acetone,Ethoxybenzimidazole-7-carboxylate (XIII, 22.0 g,0.10 mol),K2CO3 (17.9 g, 0.13 mol) and 4-bromomethyl-2′-cyanobiphenyl (28.6 g, 0.105 mol).The temperature was raised to reflux and reaction was complete until TLC disappeared (about 5 to 8 hours).

The synthetic route of 150058-27-8 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95470-42-1 as follows. Quality Control of Ethyl 2-bromo-4-methyl-1H-imidazole-5-carboxylate

A solution of 2-bromo-4-methyl-lH-imidazole-5- carboxylic acid ethyl ester (1.0 g, 4.29 mmol) in dimethylformamide (DMF, 30 ml) was cooled to O0C, added with 60percent sodium hydride (NaH, 343 mg, 8.58 mmol) and stirred for 30 min. Iodomethane (0.8 ml, 12.87 mmol) was slowly added in droplets to the resulting solution which was then heated from 00C to room temperature with stirring for 4 hrs and added with water, followed by extraction with ethyl acetate. The extract was dried over MgSO4, filtered and concentrated in a vacuum. The purification of the concentrate thus obtain through silica gel column chromatography(hexane : ethyl acetate=5:l) afforded the object compound as a white solid (693 mg, 2.81 mmol, 65percent) . 1H-NMROOO MHz, CDCl3) sigma 1.38 (t, 3H, J = 7.1 Hz) ,2.46(s, 3H) , 3.88(s, 3H) , 4.33(q, 2H, J = 7.1 Hz); MS 246 (M+) .

According to the analysis of related databases, 95470-42-1, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Recommanded Product: 641571-11-1

A mixture of 46 (100 mg, 0.39 mmoi) and LiOH (28 mg, 1.17 mmoi) in THF/H20 (2/1 mL) was stirred at room temperature for 8 hours. TLC indicated the reaction was compiete. The reaction mixture was diiuted with water and acidified to pH 3 with aqueous HCi. The resuiting precipitate was fiitered washed with water and dried to give 47 (90 mg, 95%) as a white soiid. To a soiution of 47 (100 mg, 0.41 mmoi) in NMP (1 .5mL) was added SOCi2 (74 mg, 0.62 mmoi). The reaction was heated at 60 C for 1 hour before 3 (100 mg, 0.41 mmoi) and Et3N (166 mg, 1 .64 mmoi) were added. The resuiting mixture was stirred at 60 C for 3 hours. The reaction was directiy purified by reverse prep-H PLC and then siiica gei prep-TLC to give 3-(benzyioxy)-4-methyi-N-(3-(4-methyi- 1 H-imidazoi-1 -yi)-5-(trifiuoromethyi)phenyi)benzamide (25 mg, 13%) as a white soiid.

The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 120781-02-4, name is Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H7BrN2O2

1 g (4.565 mmol) of methyl 1-methyl-2-bromoimi- dazole-5-carboxylate (Vu-i) was dissolved in 10 ml of ethanol, 5.48 ml of iN NaOH (aq.) was added and the mixture was stirred at room temperature for 60 mm. After addition of 5.5 ml of iN HC1 (aq.) (adjusted to pH .-3), a white precipitate is formed. The mixture was concentrated to dryness and, in an ultrasonic bath, suspended in 6 ml of watet The white crystals were filtered oil and washed with 2 ml of water. The mother liquor was concentrated almost to dryness. The crystals were filtered off with suction and washed with a little watet The combined crystals were dried under oil pump vacuum. Yield: 890 mg (95% of theory).log P[a]: 0.31; ?H-NMR (d5-DMSO, 400 MHz); oe=3.82 (s, 3H),7.60 (s, 1H), 13.15 (s, 1H) ppm.

The synthetic route of Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Electric Literature of 214147-60-1, These common heterocyclic compound, 214147-60-1, name is tert-Butyl 2-chloro-1H-benzo[d]imidazole-1-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B: 2-(2, 6-Dimethyl-phenoxy)-lH-benzoimidazole; Cesium carbonate (2.643 g, 8. 112 mmol) was added to a solution of 2-chloro- benzoimidazole-l-carboxylic acid tert-butyl ester (1.000 g, 3.957 mmol) and 2,6- dimethylphenol (3. 867 g, 31.66 mmol) in isopropanol (10 mL). The mixture was heated at 150 C for 22 h and then cooled to room temperature. The reaction mixture was partitioned between ethyl acetate and 2.0 N sodium hydroxide solution. The aqueous phase was separated and extracted with ethyl acetate and dichloromethane. The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated to afford an orange-brown solid. Trituration with dichloromethane and filtering afforded 2- (2, 6-dimethyl- phenoxy)-lH-benzoimidazole as an off-white solid. MS (MH+) 239.2 ; Calculated 238.11 forCl5Hl4N2O.

The synthetic route of 214147-60-1 has been constantly updated, and we look forward to future research findings.