Tag: M.W=200-300

Synthetic Route of 14741-71-0, The chemical industry reduces the impact on the environment during synthesis 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, I believe this compound will play a more active role in future production and life.

Example 64: Synthesis of 2-(2-Morpholin-4-yl-ethylamino)-l,7,llb-triaza- benzo[c]fluorene-6-carboxylic acid ethyl ester (Compound 11A) [0348] To a solution of compound SMI (147 mg) and compound SM2 (204 mg) in ethanol (10 mL) was added 2-Morpholin-4-yl-ethylamine (1 mmol) and the mixture was stirred at room temperature for 20 min. The reaction mixture was heated to reflux for 16h. After cooling, the mixture was filtered and washed with ethanol, dried to get compound 11 A as yellow solid (340 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008361-65-6, name is 5-Bromo-6-methoxy-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7BrN2O

Step 3: To a stirred mixture of DMF (3 mL) and NaH (60% in mineral oil, 67 mg, 1.6 mmol) at 0 C under argonwas added 5-bromo-6-methoxy-1H-benzo[d]imidazole (346 mg, 1.5 mmol) from Step 2 of this Example in one portion.The mixture was stirred for 5 min at 0 C. A solution of 6-(chloromethyl)-2-(methylthio)benzo[d]thiazole (500 mg, 2.2mmol) from Step 4 of Example 36 in DMF (3 mL) was added dropwise. The mixture was stirred at 0 C for 1 h, thenallowed to warm slowly to rt and stirred for 6 h. The mixture was then partitioned between EtOAc (100 mL) and water(50 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4, filtered, and concentrated underreduced pressure. The residue was purified by silica gel flash chromatography eluting with 100% EtOAc to afford thetwo regioisomers: Regioisomer 1; 6-((5-bromo-6-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole(127 mg, 20%). The structure was confirmed by comparison with NMR from the regiospecific synthesis of thesame compound described in Step 3 of Example 41. 1H NMR (300 MHz, CDCl3) delta 8.02 (s, 1H), 7.78 – 7.91 (m, 2H),7.47 (s, 1H), 7.25 (m, 1H), 6.70 (s, 1H), 5.43 (s, 2H), 3.82 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.Regioisomer 2; 6-((6-bromo-5-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole (81 mg, 13%).1H NMR (300 MHz, CDCl3) delta 7.92 (s, 1H), 7.84 (d, J = 8.5 Hz, 1H), 7.48 (m, 2H), 7.34 (s, 1H), 7.25 (m, 1H), 5.40 (s,2H), 3.94 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.

The synthetic route of 1008361-65-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

In a 250ml three-necked bottle, Under the protection of nitrogen, Add 0.01mol of raw material A-1, 0.012mol of raw material B-1, Stir and mix 150ml of toluene, Then add 0.03mol sodium tert-butoxide, 5×10-5molPd2(dba)3, 5×10-5mol tri-tert-butylphosphine, heated to 105C, refluxed for 24 hours, Sampling point plate, showing no bromide remaining, The reaction is complete; naturally cool to room temperature, filter, The filtrate was subjected to vacuum rotary evaporation (-0.09MPa, 85C), and passed through a neutral silica gel column to obtain the target product. The HPLC purity was 98.4%, and the yield was 89.2%; elemental analysis structure (molecular formula C25H16BrN3):

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.

Related Products of 255064-08-5,Some common heterocyclic compound, 255064-08-5, name is 6-Bromo-1H-benzo[d]imidazole-4-carboxylic acid, molecular formula is C8H5BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 4-carboxy-6-bromobenzimidazole (3.49 g, 14.5 mmol), 3-aminomethyl-4,6-dimethylpyridin-2-one (3.32 g, 21.75 mmol,), EDCI (4.18g, 21.75mmol) and HOBT (2.94g, 21.75mmol) DMSO (15ml) N-methylmorpholine (5.87 g, 58 mmol) was quickly added to the solution. The solid slowly dissolved and allowed to react overnight at room temperature. The reaction solution was poured into ice water, stirred, allowed to stand, solid filtered, washed with water and dried to give a solid.

The synthetic route of 255064-08-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2- (4-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-methylpyrimidine-5-carboxylic acid (0.2 g 0.506 mmol) in 1 4-dioxane (3 mL) stirred under N2at 20 was added Et3N (0.106 mL 0.759 mmol) and DPPA (0.167 g 0.607 mmol) in one charge. The reaction mixture was stirred at rt for 30 mins. To the mixture a solution of 3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (0.122 g 0.506 mmol) in 1 mL of 1 4-dioxane was added. The reaction solution was heated to 100 with stirring for 3 hr. The solution was concentrated in vacuo and the residue was purified by preparative TLC (DCM/MeOH 101 Rf 0.5) to yield a off white solid of 1- (2- (4-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-methylpyrimidin-5-yl) -3- (3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl) urea (60 mg 0.095 mmol 18.7yield) 1HNMR(400 MHz CD3OD) delta9.18 (s 1H) 9.15 (s 1H) 8.39 (s 1H) 8.25 (s 1H) 8.04 (s 1H) 7.81 (s 1H) 7.54 (s 1H) 7.25-7.23 (m 2H) 6.87-6.85 (m 2H) 6.48 (s 1H) 5.31 (s 2H) 4.13-4.10 (m 2H) 3.79 (s 3H) 2.82 (s 3H) 2.59 (s 3H) 1.40-1.36 (m 3H) ES-LCMS m/z 634.2 (M+H) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 152628-03-0, These common heterocyclic compound, 152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 15 g of 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid and 100 mL of sulfonyl chloride was allowed to stand at room temperature overnight, heated and stirred at an oil-bath temperature of 80C for five hours, then combined with 0.1 mL of dimethylformamide and again heated and stirred at 80C for five hours. After the sulfonyl chloride had been distilled off under reduced pressure, the residue was combined with 300 mL of dry dimethylformamide and 15 g of methylamine hydrochloride, then 40 g of triethylamine were dropped in while cooling with ice. The residue resulting from stirring at room temperature for two days, then distilling off the solvent was combined with ethyl acetate and physiological saline, and the ethyl acetate layer was separated. The ethyl acetate layer was washed with saturated physiological saline, then dried over anhydrous sodium sulfate. The residue resulting from distilling off the solvent was refined by silica gel column chromatography (elution solvent: ethyl acetate/methanol = 10/1) to give 4.4 g of the intended compound as a white solid. Mass spectrum: 232 (M+1)+.

The synthetic route of 152628-03-0 has been constantly updated, and we look forward to future research findings.

144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C12H20N2O3

70(a) Ethyl 1-(2′-cyanobiphenyl-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate Following a procedure similar to that as described in Example 68(a), but using 4.01 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9), 5.0 g of 4′-bromomethylbiphenyl-2-carbonitrile and 1.97 g of potassium t-butoxide, 6.86 g of the title compound were obtained as crystals, melting at 92-93 C. Nuclear Magnetic Resonance Spectrum (CDCl3) delta ppm: 0.97 (3H, triplet, J=7.5 Hz); 1.16 (3H, triplet, J=7 Hz); 1.65 (6H, singlet); 1.74 (2H, sextet, J=7.5 Hz); 2.67 (2H, triplet, J=7.5 Hz); 4.24 (2H, quartet, J=7 Hz); 5.52 (2H, singlet); 5.77 (1H, singlet); 7.05 (2H, doublet, J=8.5 Hz); 7.42-7.67 (5H, multiplet); 7.76 (1H, doublet, J=8 Hz).

The synthetic route of 144689-93-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid

General procedure: A mixture ofcompound 10 (0.15 g, 0.772 mmol), HOBt (0.23 g,1.70 mmol), EDCI (0.37 g, 1.93 mmol), benzoic acid(0.19 g, 1.54 mmol), and TEA (0.32 mL, 2.32 mmol) indry DMF (20 mL) was stirred at 80 C for 8 h. The mixturewas quenched with water (40 mL), then extracted withethyl acetate (3 x 40 mL). The combined organic layerextracts were washed with brine, dried over anhydrousMgSO4, filtered, and concentrated under reduced pressure.The residue was purified by flash column chromatography.The desired product was obtained as white solid (0.13 g,56.4 %).

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 5993-91-9, name is (1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of (1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride

a Methyl (+-)-7-[[[(2-benzimidazolyl)methyl]amino]carbonyl]-4-methyl-3-oxo-2,3,4,5 -tetrahydro-1H-1,4-benzodiazepine-2-acetate A mixture of methyl (+-)-7-carboxy-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2-acetate (0.57 g, 1.82 mmol) and thionyl chloride (15 mL) was refluxed for 1 h. The resulting orange solution was concentrated to dryness to leave a yellow-orange foam. This was dissolved in CH2Cl2 (10 mL) and added dropwise to a solution containing 2-(aminomethyl)benzimidazole dihydrochloride (1.2 g, 5.46 mmol), pyridine (0.72 g, 9.1 mmol), and triethylamine (0.55 g, 5.46 mmol) in CH2Cl2 (15 mL) at 0 C. under argon. The reaction mixture was then stirred in RT under argon. After 25.5 h, CH2Cl2 (200 mL) and 5% NaHCO3 (50 mL) were added to the reaction mixture to give a light yellow precipitate which was filtered and air-dried to give the title compound (0.11 g, 14%). The filtrate was separated and the organic layer was washed sequentially with 5% NaHCO3 (50 mL) and H2O (50 mL), then was concentrated on the rotavap. After trituration with CH2Cl2 and air-drying, a yellowish solid was collected to yield more of the title compound (0.35 g, 45%).

The synthetic route of (1H-Benzo[d]imidazol-2-yl)methanamine dihydrochloride has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40197-20-4, name is 5-Bromo-1H-benzo[d]imidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives

A mixture of 5-bromo-1H-benzimidazol-2-carboxylic acid (3.0 g), tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate (7.7 g), dichloro[1,1?-bis(di-tert-butylphosphino)ferrocene]palladium (410 mg), 2 M aqueous sodium carbonate solution (50 ml), and dioxane (75 ml) was stirred at 95 C. overnight in an argon atmosphere, and then cooled to room temperature. After water (170 ml) and ethyl acetate (200 ml) were added to the reaction mixture, the reaction mixture was stirred for 20 minutes, and then subjected to liquid-liquid partition. The aqueous layer was washed with ethyl acetate (50 ml), and then citric acid was added thereto to adjust pH to be 6 to 7. The resulting solid was collected by filtration, and then dried under reduced pressure, thereby obtaining 5-[1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-benzimidazole-2-carboxylic acid (2.7 g) as a solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.